CN220393743U - Gene detection equipment of fluorescein marked DNA probe - Google Patents
Gene detection equipment of fluorescein marked DNA probe Download PDFInfo
- Publication number
- CN220393743U CN220393743U CN202321124236.7U CN202321124236U CN220393743U CN 220393743 U CN220393743 U CN 220393743U CN 202321124236 U CN202321124236 U CN 202321124236U CN 220393743 U CN220393743 U CN 220393743U
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- gene
- fluorescein
- dna probe
- detecting
- motor
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- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 50
- 108020003215 DNA Probes Proteins 0.000 title claims abstract description 15
- 239000003298 DNA probe Substances 0.000 title claims abstract description 15
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 238000001514 detection method Methods 0.000 title abstract description 29
- 230000007246 mechanism Effects 0.000 claims abstract description 49
- 239000000523 sample Substances 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 27
- 238000004140 cleaning Methods 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 12
- 238000005192 partition Methods 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims description 14
- 238000012360 testing method Methods 0.000 claims description 11
- 238000009434 installation Methods 0.000 abstract description 10
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000000428 dust Substances 0.000 abstract description 2
- 238000001802 infusion Methods 0.000 description 7
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Abstract
The utility model discloses a gene detection device of a DNA probe marked by fluorescein, which comprises a main body, an installation box and a case, wherein the installation box and the case are arranged on two sides of the outer part of the main body, a detection chamber is arranged in the main body, the upper end of the detection chamber is provided with an installation plate through an adjusting mechanism, the lower surface of the installation plate is provided with a plurality of gene probes through an installation seat, the inner part of the detection chamber is provided with a liquid collecting tank and a bearing plate below the adjusting mechanism, the inner part of the lower end of the installation box is provided with a liquid storage tank, the inner part of the installation box is provided with a cleaning mechanism and a drying mechanism above the liquid storage tank through a partition plate, the inner part of the case is provided with a motor and a control box, and an output shaft of the motor is connected with the adjusting mechanism, and the utility model has the beneficial effects that: the gene probe is effectively protected through the movable sleeve, and dust or foreign matters are prevented from adhering to the surface, so that the accuracy of a detection result is ensured.
Description
Technical Field
The utility model relates to the technical field of gene detection, in particular to a gene detection device of a DNA probe marked by fluorescein.
Background
The gene is a basic unit of inheritance, and a DNA or RNA sequence carrying genetic information is replicated to transfer the genetic information to the next generation, so that the synthesis of proteins is guided to express the genetic information carried by the gene, and the expression of the characteristics of an individual organism is controlled. The gene detection is a technology for detecting DNA by blood, other body fluids or cells, and is a common detection device for detecting DNA molecular information in cells of a detected person by specific equipment after taking peripheral venous blood or other tissue cells of the detected person and amplifying the gene information of the peripheral venous blood or other tissue cells of the detected person.
The existing gene detection equipment of the DNA probe marked by fluorescein has the following defects when in use: after the single detection is completed, the gene probe is not cleaned, so that liquid residues exist on the surface of the gene probe, and the subsequent detection result is affected.
Disclosure of Invention
The present utility model has been made in view of the above-mentioned problems occurring in the prior art, and an object of the present utility model is to provide a gene detection apparatus for a fluorescein-labeled DNA probe.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a gene check out test set of DNA probe of fluorescein mark, includes the main part, sets up at the mounting box, the quick-witted case of the outside both sides of main part, detection cavity has been seted up to the inside of main part, detection cavity's upper end is provided with the mounting panel through adjustment mechanism, the lower surface of mounting panel is provided with a plurality of gene probes through the mount pad, detection cavity's inside is provided with collecting tank, carrier plate in adjustment mechanism's below, the inside reservoir that is provided with of lower extreme of mounting box, the inside of mounting box is in the top of reservoir is provided with wiper mechanism and stoving mechanism through the baffle, the inside of machine case is provided with motor and control box, the output shaft of motor with adjustment mechanism connects, the control box with wiper mechanism, stoving mechanism and motor pass through the wire and are connected.
Preferably, the adjusting mechanism comprises a screw rod, a guide rod and a moving frame, wherein the screw rod and the guide rod are arranged in parallel, the moving frame is arranged outside the screw rod and the guide rod, and one end of the screw rod is connected with an output shaft of the motor.
Preferably, the upper end of the movable frame is provided with a fixed plate, the upper surface of the fixed plate is provided with an electric telescopic rod, the mounting plate is arranged on one side, far away from the screw rod, of the fixed plate, and the upper surface of the mounting plate is fixedly connected with the lower end of the electric telescopic rod.
Preferably, the outside of mount pad is provided with movable sleeve through seting up the spout, movable sleeve is in the outside of gene probe, just movable sleeve's outside is provided with the connecting pipe.
Preferably, an air duct and an infusion tube are arranged in the connecting tube, the air duct is connected with the drying mechanism, and the infusion tube is connected with the cleaning mechanism.
Preferably, the cleaning mechanism comprises a pump body arranged on the upper surface of the partition plate, a liquid inlet pipe of the pump body extends to the inside of the liquid storage tank, and a liquid outlet end of the pump body is communicated with the liquid delivery pipe.
Preferably, the drying mechanism comprises a fan and a heating box, wherein the fan and the heating box are arranged above the partition plate, a guide pipe communicated with the heating box is arranged at an air outlet of the fan, and the inside of the heating box is communicated with the air guide pipe.
Compared with the prior art, the utility model has the beneficial effects that:
1. the gene probe is arranged on the mounting seat on the lower surface of the mounting plate through the adjusting mechanism, and meanwhile, the movable sleeve is arranged on the outer side of the lower end of the mounting seat, so that the movable sleeve is integrally sleeved on the outer side of the gene probe;
2. the connecting pipe is arranged outside the movable sleeve, and the air duct and the infusion pipe inside the connecting pipe are respectively connected with the drying mechanism and the cleaning mechanism inside the installation box, so that in the use process, the cleaning mechanism and the drying mechanism are respectively started through the control box, the infusion pipe is used for conveying cleaning liquid, the gene probe inside the movable sleeve is effectively cleaned, the air duct is used for conveying hot air, the cleaned gene probe is quickly dried, liquid residues on the surface of the gene probe are effectively removed, and the influence on the subsequent detection result is avoided;
3. because cleaning and drying are carried out in the movable sleeve, cleaning liquid splashing can not be generated in the cleaning process, and the cleaning of the inside of the detection cavity is ensured.
Drawings
FIG. 1 is a schematic overall structure of the present utility model;
FIG. 2 is a schematic view of the installation of the movable sleeve of the present utility model;
FIG. 3 is a schematic view showing the installation of the gene probe of the present utility model;
fig. 4 is a schematic view of the internal structure of the mounting box of the present utility model.
In the figure: 1. a main body; 2. a mounting box; 3. a chassis; 4. a detection chamber; 5. a mounting plate; 6. a mounting base; 7. a gene probe; 8. a liquid collecting tank; 9. a carrier plate; 10. a liquid storage tank; 11. a partition plate; 12. a screw rod; 13. a guide rod; 14. a moving rack; 15. a fixing plate; 16. an electric telescopic rod; 17. a movable sleeve; 18. a connecting pipe; 19. an air duct; 20. an infusion tube; 21. a pump body; 22. a blower; 23. a heating box.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-4, the present utility model provides a technical solution: the utility model provides a gene check out test set of DNA probe of fluorescein mark, includes main part 1, sets up mounting box 2, the quick-witted case 3 in the outside both sides of main part 1, detection cavity 4 has been seted up to the inside of main part 1, detection cavity 4's upper end is provided with mounting panel 5 through adjustment mechanism, mounting panel 5's lower surface is provided with a plurality of gene probes 7 through mount pad 6, detection cavity 4's inside is provided with collecting tank 8, carrier plate 9 in adjustment mechanism's below, mounting box 2's lower extreme inside is provided with reservoir 10, mounting box 2's inside is in the top of reservoir 10 is provided with wiper mechanism and stoving mechanism through baffle 11, machine case 3's inside is provided with motor and control box, the output shaft of motor with adjustment mechanism connects, the control box with wiper mechanism, stoving mechanism and motor pass through the wire and be connected.
Wherein the test tube rack is placed on the upper surface of the carrier plate 9, and the interval distance between two adjacent test tubes on the test tube rack is equal to the distance between two adjacent gene probes 7.
The adjusting mechanism comprises a screw rod 12, a guide rod 13 and a moving frame 14 which are arranged outside the screw rod 12 and the guide rod 13 in parallel, and one end of the screw rod 12 is connected with an output shaft of the motor.
The upper end of the movable frame 14 is provided with a fixed plate 15, the upper surface of the fixed plate 15 is provided with an electric telescopic rod 16, the mounting plate 5 is arranged on one side of the fixed plate 15 away from the screw rod 12, and the upper surface of the mounting plate 5 is fixedly connected with the lower end of the electric telescopic rod 16.
The outside of mount pad 6 is provided with movable sleeve 17 through seting up the spout, movable sleeve 17 is in the outside of gene probe 7, just the outside of movable sleeve 17 is provided with connecting pipe 18.
It will be appreciated that the aperture of the movable sleeve 17 is smaller than the caliber of the test tube, and that in the process of synchronously moving downwards the mounting seat 6, the movable sleeve 17 and the gene probe 7, after the lower end surface of the movable sleeve 17 contacts with the mouth of the test tube, the gene probe 7 can continuously move and extend into the test tube.
An air duct 19 and an infusion tube 20 are arranged in the connecting tube 18, the air duct 19 is connected with the drying mechanism, and the infusion tube 20 is connected with the cleaning mechanism.
The cleaning mechanism comprises a pump body 21 arranged on the upper surface of the partition plate 11, a liquid inlet pipe of the pump body 21 extends to the inside of the liquid storage tank 10, and a liquid outlet end of the pump body 21 is communicated with the liquid delivery pipe 20.
The drying mechanism comprises a fan 22 and a heating box 23, wherein the fan 22 is arranged above the partition plate 11, a guide pipe communicated with the heating box 23 is arranged at an air outlet of the fan 22, and the inside of the heating box 23 is communicated with the end of the air guide pipe 19.
It can be appreciated that the drying mechanism further comprises a filter box arranged at the air inlet of the fan, and is used for effectively filtering the air entering the detection chamber 4, so as to prevent dust or foreign matters from adhering to the surface of the gene probe 7 and affecting the detection result.
Specifically, when the utility model is used, the reagent tube is arranged on the test tube rack, the motor is controlled by the control box to drive the screw rod to rotate, the movable frame 14 drives the mounting plate 5 and the gene probe 7 on the lower surface of the mounting plate 5 to move to the position right above the carrier plate 9, the electric telescopic rod 16 is subsequently controlled to work, the gene probe 7 moves downwards and stretches into the test tube to carry out gene detection, after the detection is finished, the control box is controlled by the control motor and the electric telescopic rod 16 to reset the gene probe 7 and is positioned right above the liquid collecting tank 8, and the gene probe 7 is subsequently cleaned and dried by the control of the cleaning mechanism and the drying mechanism, so that the influence of residual liquid on the surface of the gene probe 7 on the subsequent detection is avoided.
When the control box starts the pump body 21, the pump body 21 pumps the cleaning liquid in the liquid storage tank 10 into the movable sleeve 17 and discharges the cleaning liquid, so that the gene probe 7 on the inner side of the movable sleeve 17 is quickly cleaned, and the cleaned waste water flows into the liquid collection tank 8 from the lower end of the movable sleeve 17.
The subsequent control box starts the fan 22 and the heating wires in the heating box 23, the fan 22 works to generate air flow, and the air flow is heated in the heating box 23 and then is conveyed into the movable sleeve 17 to dry the gene probe 7 inside.
In the description of the present utility model, it should be understood that the terms "coaxial," "bottom," "one end," "top," "middle," "another end," "upper," "one side," "top," "inner," "front," "center," "two ends," etc. indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model.
Furthermore, the terms "first," "second," "third," "fourth," and the like are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, whereby features defining "first," "second," "third," "fourth" may explicitly or implicitly include at least one such feature.
In the present utility model, unless explicitly specified and limited otherwise, the terms "mounted," "configured," "connected," "secured," "screwed," and the like are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intermediaries, or in communication with each other or in interaction with each other, unless explicitly defined otherwise, the meaning of the terms described above in this application will be understood by those of ordinary skill in the art in view of the specific circumstances.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The utility model provides a gene check out test set of DNA probe of fluorescein mark, its characterized in that, including main part (1), install bin (2), quick-witted case (3) of setting in main part (1) outside both sides, detect cavity (4) have been seted up to the inside of main part (1), the upper end of detecting cavity (4) is provided with mounting panel (5) through adjustment mechanism, the lower surface of mounting panel (5) is provided with a plurality of gene probes (7) through mount pad (6), the inside of detecting cavity (4) is provided with collecting tank (8), carrier plate (9) in adjustment mechanism's below, the inside reservoir (10) that is provided with of lower extreme of install bin (2), the inside of install bin (2) is in the top of reservoir (10) is provided with wiper mechanism and stoving mechanism through baffle (11), the inside of machine case (3) is provided with motor and control box, the output shaft of motor with adjustment mechanism connects, control box with wiper mechanism, stoving mechanism and motor pass through the wire and are connected.
2. The apparatus for detecting a gene of a fluorescein-labeled DNA probe according to claim 1, wherein: the adjusting mechanism comprises a screw rod (12), a guide rod (13) and a moving frame (14) which are arranged in parallel, wherein the moving frame (14) is arranged outside the screw rod (12) and the guide rod (13), and one end of the screw rod (12) is connected with an output shaft of the motor.
3. The apparatus for detecting a gene of a fluorescein-labeled DNA probe according to claim 2, wherein: the upper end of movable frame (14) is provided with fixed plate (15), the upper surface of fixed plate (15) is provided with electric telescopic handle (16), mounting panel (5) set up one side that lead screw (12) were kept away from to fixed plate (15), just the upper surface of mounting panel (5) with the lower extreme fixed connection of electric telescopic handle (16).
4. The apparatus for detecting a gene of a fluorescein-labeled DNA probe according to claim 1, wherein: the outside of mount pad (6) is provided with movable sleeve (17) through seting up the spout, movable sleeve (17) are in the outside of gene probe (7), and the outside of movable sleeve (17) is provided with connecting pipe (18).
5. The apparatus for detecting a gene of a fluorescein-labeled DNA probe according to claim 4, wherein: an air duct (19) and a transfusion tube (20) are arranged in the connecting tube (18), the air duct (19) is connected with the drying mechanism, and the transfusion tube (20) is connected with the cleaning mechanism.
6. The apparatus for detecting a gene of a fluorescein-labeled DNA probe according to claim 1, wherein: the cleaning mechanism comprises a pump body (21) arranged on the upper surface of the partition plate (11), a liquid inlet pipe of the pump body (21) extends to the inside of the liquid storage tank (10), and a liquid outlet end of the pump body (21) is communicated with the liquid delivery pipe (20).
7. The apparatus for detecting a gene of a fluorescein-labeled DNA probe according to claim 1, wherein: the drying mechanism comprises a fan (22) and a heating box (23), wherein the fan (22) is arranged above the partition plate (11), a guide pipe communicated with the heating box (23) is arranged at an air outlet of the fan (22), and the inside of the heating box (23) is communicated with the end of the air guide pipe (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321124236.7U CN220393743U (en) | 2023-05-11 | 2023-05-11 | Gene detection equipment of fluorescein marked DNA probe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321124236.7U CN220393743U (en) | 2023-05-11 | 2023-05-11 | Gene detection equipment of fluorescein marked DNA probe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220393743U true CN220393743U (en) | 2024-01-26 |
Family
ID=89612129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321124236.7U Active CN220393743U (en) | 2023-05-11 | 2023-05-11 | Gene detection equipment of fluorescein marked DNA probe |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220393743U (en) |
-
2023
- 2023-05-11 CN CN202321124236.7U patent/CN220393743U/en active Active
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