CN220343382U - Device for processing biological samples - Google Patents

Abstract

The present application relates to the technical field of biological sample preservation, and in particular to a device for processing a biological sample, comprising a first container, a second container and a closure; the closure comprises a first element and a second element, wherein the first element is provided with a first upper base part, the second element is provided with a second upper base part which is used for propping against the first upper base part, the first upper base part is provided with an annular block, the second upper base part is provided with an annular groove for the annular block to slide, the annular block is provided with a limiting block, the side wall of the annular groove is provided with a limiting groove, the second element is connected with the first element by embedding the limiting block into the limiting groove after being pressed by the first element, the first upper base part is provided with a first through hole, the second upper base part is provided with a second through hole, the closure is provided with a longitudinal axis, the first element and the second element relatively rotate around the longitudinal axis, and the closure further comprises a sealing element for sealing the first through hole and the second through hole. The application has the effect of reducing the complexity of use of the biological sample device itself.

Description

Device for processing biological samples

Technical Field

The present application relates to the field of biological sample preservation, and in particular to a device for processing a biological sample.

Background

Currently, in the field of case analysis of pathology, the methods of research on pathology are diverse, and the research materials mainly come from human pathological materials and experimental animals, and other experimental pathological materials such as tissue culture, cell culture, and the like. Biopsy is a routine procedure in pathology research to obtain study material for examination diagnosis, where a pathological examination is performed by taking diseased tissue from a patient's living body to determine the diagnosis, which may also be referred to as biopsy.

Biopsy collected samples need to be treated with fixative before being sent to the laboratory responsible for testing for further processing steps. For example formaldehyde, which is a commonly used fixative in laboratory everyday practice, and the toxic effects are known. For this purpose, it is necessary to avoid, on the one hand, alterations or contamination of the sample itself and, on the other hand, exposure of the operator to toxic substances.

In the prior art, the sample is placed in a container sealed with a lid, while the fixative is held in a specific housing in the lid of the container, which housing is closed by a separation membrane, allowing the fixative to flow to the sample after rupture of the membrane by an actuator, reducing the probability of the operator getting in contact with toxic substances. However, the structure of the container is complex, the use by operators is inconvenient, and the manufacturing cost is quite high, so that the situation needs to be improved.

Disclosure of Invention

In order to reduce the cumbersome use of the biological sample device itself, the present application provides a device for processing biological samples.

The application provides a device for handling biological sample adopts following technical scheme:

a device for processing a biological sample, comprising a first container for holding a fixative, a second container for holding a biological sample, a closure disposed between the first container and the second container; the closure comprises a first element for closing the first container and a second element for connecting with the second container, wherein a first upper base is arranged on one side of the first element, which is close to the second element, a second upper base which is used for abutting against the first upper base is arranged on one side of the second element, an annular block is arranged on one side of the first upper base, which is close to the second upper base, an annular groove for sliding the annular block is arranged on the second upper base, a limit block is arranged on one side, which is close to the side wall of the annular groove, a limit groove for sliding the limit block is arranged on the side wall of the annular groove, a first through hole is arranged on the first upper base, a second through hole is arranged on the second upper base, the closure is provided with a longitudinal axis, the first element and the second element relatively rotate around the longitudinal axis, when the first through hole and the second through hole are communicated, the first container and the second container are communicated, and the closure further comprises a first through hole and a second through hole for sealing the first through hole and the second through hole.

By adopting the technical scheme, the fixing agent is stored in the first container, the first container is sealed through the first element in the sealing element, then the biological sample is put into the second container, the first container is connected with the second container through the second element, at the moment, the first through hole is not communicated with the second through hole, and the fixing agent cannot flow into the second container from the first container; when the first element and the second element are rotated relatively around the longitudinal axis, the first through hole and the second through hole are communicated with each other, and the fixing machine can flow from the first container to the second container; when the second container has sufficient fixative, the first through hole and the second through hole are not communicated after the first element is rotated, and the first through hole and the second through hole are sealed by the sealing piece, so that the device can be transported to a laboratory responsible for testing; according to the scheme, the first container is sealed through the first element, and the first through hole and the second through hole can be communicated or not communicated only through relative rotation of the first element and the second element around the longitudinal axis, so that the probability that an operator touches the fixing agent is reduced, and the complexity of using the biological sample device is reduced.

Optionally, the sealing member include set up in the second through-hole be close to first seal groove of one side opening week side of base, set up in the first seal groove and with first sealing washer that goes up the base and support tightly, set up in the first through-hole be close to one side opening week side of sealing washer and supply the second seal groove of sealing washer embedding, set up in the first base be close to one side of the sealing washer and supply the third seal groove of sealing washer embedding, the height of first seal groove is greater than the height of second seal groove, the second seal groove height with the height of third seal groove equals, works as sealing washer one end embedding in the first seal groove and the other end embedding in the second seal groove, first through-hole with the second through-hole intercommunication, works as sealing washer one end embedding in the first seal groove and the other end embedding in the third seal groove, first through-hole with the second through-hole does not communicate.

By adopting the technical scheme, most of the sealing ring is embedded in the first sealing groove, the small part of the sealing ring protrudes out of the first sealing groove, and the sealing ring is made of elastic materials, so that the rotation of the first element and the second element is not influenced; when one end of the sealing ring is positioned in the first sealing groove and the other end of the sealing ring is positioned in the second sealing groove, the first through hole is communicated with the second through hole; when first component and second component rotate once more around the longitudinal axis, when the one end of sealing washer is located first seal groove and another is located the third seal groove, first through-hole and second through-hole do not communicate, and seal the second through-hole through the sealing washer, improve the leakproofness of the device, reduce the probability that the fixative revealed.

Optionally, the sealing element includes set up in first recess on the second goes up the basal portion, set up in first recess and with the elastic ball that the basal portion supported tightly on the first, set up in on the first basal portion and supply the second recess that the elastic ball embedded, the height of first recess is greater than the height of second recess, when elastic ball one end embedding first recess and the other end embedding in the second recess, first through-hole with the second through-hole communicates, when elastic ball one end embedding in the first recess and the other end embedding in the first through-hole, the second through-hole with the second recess communicates, first through-hole with the second through-hole does not communicate.

By adopting the technical scheme, most of the elastic ball is embedded in the first groove, the small part of the elastic ball protrudes out of the first groove, after the first element and the second element relatively rotate around the longitudinal axis, the elastic ball elastically deforms, and when the first groove corresponds to the first through hole, the elastic ball is elastically embedded in the first through hole again, and the first through hole is sealed, so that the fixing agent cannot flow out of the first container; and when the first groove is communicated with the second groove, the first through hole is communicated with the second through hole, and the fixing agent can flow from the first container to the second container.

Optionally, a first arc block and a second arc block are arranged on one side, close to the second element, of the first element, the first arc block and the second arc block are symmetrically arranged along the linear direction of the first upper base, a first sliding groove for sliding the first arc block is arranged on one side, close to the first arc block, of the second element, and a second sliding groove for sliding the second arc block is arranged on one side, close to the second arc block; the first end of first arc piece with the line between the first end of second arc piece is parallel with the line between the second end of first arc piece with the second end of second arc piece, when first end of first arc piece with the lateral wall butt of first sliding groove, the second end of second arc piece with the lateral wall butt of second sliding groove, first through-hole with the second through-hole does not communicate, when the second end of first arc piece with the lateral wall butt of first sliding groove, the first end of second arc piece with the lateral wall butt of second sliding groove, first through-hole with the second through-hole communicates.

Through adopting above-mentioned technical scheme, slide in first sliding groove through first arc piece, the second arc piece slides in the second sliding groove, the rotatory angle of first component and second component has been restricted, be favorable to improving the rotatory efficiency of first component and second component, also play the effect of revealing to operating personnel, when the first end of first arc piece and the lateral wall butt of first sliding groove, the first end of second arc piece and the lateral wall butt of second sliding groove, first through-hole and second through-hole do not communicate, the second end of first arc piece and the lateral wall butt of first sliding groove, the second end of second arc piece and the lateral wall butt of second sliding groove, first through-hole and second through-hole communicate, make operating personnel not need blind correspondence of looking for the hole site, operating personnel's work efficiency is improved.

Optionally, the first through holes are provided with N on the first upper base, and the second through holes are provided with N on the second upper base, where N is an integer greater than or equal to 2.

Through adopting above-mentioned technical scheme, when needs introduce the second container with the curing agent from first container, can set up a plurality of first through-holes and a plurality of second through-holes for the flow efficiency of fixing agent.

Optionally, a first annular flange is disposed on one side of the first upper base portion, which is close to the first container, a second annular flange is disposed on one side of the second upper base portion, which is close to the second container, a first accommodating groove for embedding the first container is formed between the inner side wall of the first element and the first annular flange, a second accommodating groove for embedding the second container is formed between the inner side wall of the second element and the second annular flange, a first guiding inclined plane is disposed on one side of the first annular flange, which is close to the first accommodating groove, and a second guiding inclined plane is disposed on one side of the second annular flange, which is close to the second accommodating groove.

By adopting the technical scheme, the opening of the first container is embedded into the first accommodating groove, so that the first container and the first element are assembled; the opening of the second container is embedded into the second accommodating groove, so that the second container and the second element are assembled; and through being equipped with first direction inclined plane and second direction inclined plane, be convenient for to first container and second container installation direction, also be convenient for with fixative drainage for the inner chamber of first container and/or the inner chamber of second container is flowed to the fixative.

Optionally, a first reflux groove is disposed on a side of the first annular flange, which is close to the second upper base, a second reflux groove is disposed on a side of the second annular flange, which is close to the second upper base, and the first reflux groove is communicated with the second reflux groove.

Through adopting above-mentioned technical scheme, when equipment live time is long, if the curing agent is revealed away from the gap of base on first and the second, can hold the curing agent of revealing through first reflux tank and second reflux tank, also can place the material that has hydroscopicity such as cotton in first reflux tank and second reflux tank, absorb the curing agent of revealing to reduce the probability that the fixing agent was revealed outside the device, improve operating personnel's security.

Optionally, the closure further comprises a thread for closing the first container and/or the second container, the first container being screwed with the first element and the second container being screwed with the second element.

Through adopting above-mentioned technical scheme, first container and first component pass through threaded connection, and second container and second component pass through threaded connection, and the operating personnel of being convenient for can remove the fixed of second container and second component through rotatory mode, and the operating personnel of being convenient for takes the sample.

Optionally, a cambered surface is arranged on one side of the limiting block, which is close to the limiting groove.

Through adopting above-mentioned technical scheme, exert force to first component and imbed the spacing inslot with the stopper for first component and second component rotate and connect, through the setting of cambered surface, the stopper of being more convenient for imbeds in the spacing inslot.

In summary, the present application includes at least one of the following beneficial technical effects:

1. according to the scheme, the first container is sealed through the first element, and the first through hole and the second through hole can be communicated or not communicated only through the relative rotation of the first element and the second element around the longitudinal axis, so that the probability that an operator touches the fixing agent is reduced, and the complexity of using the biological sample device is reduced;

2. when first component and second component rotate once more around the longitudinal axis, when the one end of sealing washer is located first seal groove and another is located the third seal groove, first through-hole and second through-hole do not communicate, and seal the second through-hole through the sealing washer, improve the leakproofness of the device, reduce the probability that the fixative revealed.

Drawings

FIG. 1 is a schematic overall structure of an embodiment of the present application;

FIG. 2 is a cross-sectional view of a device for processing biological samples according to an embodiment of the present application;

FIG. 3 is a cross-sectional view of a first member and a second member according to an embodiment of the present application;

FIG. 4 is an exploded view of a first element and a second element in an embodiment of the present application;

FIG. 5 is a cross-sectional view of a first upper base and a second upper base in an embodiment of the present application;

FIG. 6 is a schematic view of a first arcuate block and a first member in an embodiment of the present application;

FIG. 7 is a schematic view of the structure of a first arcuate block and a second arcuate block in an embodiment of the present application;

FIG. 8 is a cross-sectional view of the seal and closure of example 2 of the present application;

fig. 9 is a schematic view of the seal and closure structure in embodiment 2 of the present application.

Reference numerals illustrate:

1. a first container; 2. a second container; 3. a closure; 4. a first element; 5. a second element; 6. a first upper base; 7. a second upper base; 8. an annular block; 9. a ring groove; 10. a limiting block; 11. a limit groove; 12. a first through hole; 13. a second through hole; 14. a longitudinal axis; 15. a first seal groove; 16. a seal ring; 17. a second seal groove; 18. a third seal groove; 19. a first groove; 20. a second groove; 21. an elastic ball; 22. a first arc block; 23. a second arc block; 24. a first sliding groove; 25. a second sliding groove; 26. a first annular flange; 27. a second annular flange; 28. a first accommodation groove; 29. a second accommodation groove; 30. a first guiding inclined surface; 31. a second guiding inclined surface; 32. a first reflow tank; 33. a second reflux groove; 34. a cambered surface.

Detailed Description

The present application is described in further detail below.

Example 1

The embodiment of the application discloses a device for processing biological samples. Referring to fig. 1 and 2, the container comprises a first container 1, a second container 2 and a closure 3. The fixative is poured into the first container 1, the first container 1 is sealed by the sealing piece 3, then the biological sample is put into the second container 2, and the second container 2 is connected by one end, far away from the first container 1, of the sealing piece 3, so that the structures of the sample processing device are sequentially ordered into the first container 1, the sealing piece 3 and the second container 2. The closure 3 comprises a first element 4, a second element 5, a thread and a sealing element, the first element 4 being shaped like a bottle cap for sealing the first container 1, the first element 4 and the second element 5 being rotatably connected, via the second element 5, to the second container 2. The screw thread is used for closing the first container 1 and/or the second container 2, the first container 1 being screwed to the first element 4 and the second container 2 being screwed to the second element 5. The closure 3 has a longitudinal axis 14 allowing the first element 4 to reciprocally rotate about the longitudinal axis 14 relative to the second element 5 or allowing the second element 5 to reciprocally rotate about the longitudinal axis 14 relative to the first element 4.

Referring to fig. 2 and 3, a first upper base 6 is provided on a side of the first element 4 adjacent to the second element 5, a second upper base 7 is provided on a side of the second element 5 adjacent to the first element 4, and the first upper base 6 and the second upper base 7 are abutted against each other. In order to realize the relative rotation of the first element 4 and the second element 5, an annular block 8 is arranged on one side of the first upper base 6 close to the second upper base 7, an annular groove 9 into which the annular block 8 is embedded is formed in the second upper base 7, and the annular block 8 slides in the annular groove 9, so that the first upper base 6 can reciprocally rotate around a longitudinal axis 14 relative to the second upper base 7. In order to improve the stability of the relative rotation of the first upper base 6 and the second upper base 7, a limiting block 10 is installed on one side, close to the side wall of the annular groove 9, of the annular block 8, a limiting groove 11 in which the limiting block 10 is embedded is formed in the side wall of the annular groove 9, and the second element 5 is connected with the first element 4 by embedding the limiting block 10 into the limiting groove 11 after being pressed by the first element 4. In order to facilitate the insertion of the limiting block 10 into the limiting groove 11, a smooth cambered surface 34 is arranged on one side of the limiting block 10 close to the limiting groove 11. The stopper 10 slides in the stopper groove 11 while the first member 4 and the second member 5 relatively rotate.

Referring to fig. 4, in order to allow the fixative to flow from the first container 1 into the second container 2 storing the biological sample, N first through holes 12 are opened in the first upper base 6, and N second through holes 13 are opened in the second upper base 7, wherein N is an integer greater than or equal to 2. The first element 4 rotates with respect to the second element 5 about the longitudinal axis 14 such that the first through hole 12 and the second through hole 13 communicate, thereby bringing the first container 1 and the second container 2 into communication, when the fixing agent flows from the first container 1 to the second container 2; the fixing agent cannot flow from the first container 1 to the second container 2 by rotating the first element 4 relative to the second element 5 about the longitudinal axis 14 again such that the first through hole 12 and the second through hole 13 are not in communication and the first through hole 12 and the second through hole 13 are sealed by the seal.

In the present embodiment, the device provides a first container 1 and a second container 2, the first container 1 having been pre-filled with a fixing agent, such as formaldehyde, by the manufacturer and then closed by a closure 3. Subsequently, the operator turns the first container 1 with the closure 3 onto the second container 2, in which second container 2 the sample to be processed is placed, so that the second container 2 is also closed. At this point, the operator rotates the first element 4 and the second element 5 in opposite directions about the longitudinal axis 14 until the first through hole 12 and the second through hole 13 communicate. In this way, the fixative may flow to the sample by tilting the device. Then by rotating the first and second members 4, 5 in opposite directions such that the first and second through holes 12, 13 are not in communication, the first and second through holes 12, 13 are sealed by the sealing member to prevent the fixative or the small biological sample from accidentally entering the first container 1. After a sufficient time, the device can be turned upside down, the first element 4 and the second element 5 can be rotated again so that the first through hole 12 and the second through hole 13 are communicated, the fixative is collected in the first container 1, the first element 4 and the second element 5 can be rotated again so that the sealing member seals the first through hole 12 and the second through hole 13, and the second container 2 can be opened to take out the biological sample. In the scheme in this application, with the sealed processing of first container 1 through first component 4, and just through first component 4 and second component 5 around the relative rotation of longitudinal axis 14, can realize the intercommunication or not the intercommunication of first through-hole 12 and second through-hole 13, not only reduced the probability that operating personnel contacted the fixative, also reduced the loaded down with trivial details nature that biological sample device itself was used.

Referring to fig. 2 and 3, the first upper base 6 is provided with a first annular flange 26 on the side of the first container 1 and the second upper base 7 is provided with a second annular flange 27 on the side of the second container 2. A first receiving groove 28 into which the first container 1 is fitted is formed between the inner side wall of the first element 4 and the first annular flange 26, and a second receiving groove 29 into which the second container 2 is fitted is formed between the inner side wall of the second element 5 and the second annular flange 27. The first container 1 is screwed with the inner wall of the first accommodating groove 28, and the second container 2 is screwed with the inner wall of the second accommodating groove 29. After the flow of the fixing agent is completed, in order to reduce the accumulation of the fixing agent in the first receiving groove 28 and/or the second receiving groove 29, a first guide slope 30 is provided on the side of the first annular flange 26 close to the first receiving groove 28, and a second guide groove is provided on the side of the second annular flange 27 close to the second receiving groove 29. The flow direction of the fixing agent is guided by the first guiding inclined surface 30 and the second guiding inclined surface 31, and the fixing agent is guided to the bottom of the inner cavity of the first container 1 and/or the bottom of the inner cavity of the second container 2. In order to reduce the probability of direct leakage of fixative at the outer walls of the device. The first annular flange 26 is provided with the first reflux groove 32 near the second on the base 7 side, and the second annular flange 27 is provided with the second reflux groove 33 near the second on the base 7 side, and first reflux groove 32 and second reflux groove 33 intercommunication, when the fixative is leaked through first on the base 6 and the second on the base 7, can supply the fixative storage of revealing through first reflux groove 32 and second reflux groove 33.

In the present embodiment, the closure 3 is provided with a first guiding ramp 30 and a second guiding ramp 31, which facilitate guiding the mounting of the first container 1 and the second container 2, as well as draining the fixative such that the fixative flows to the inner cavity of the first container 1 and/or the inner cavity of the second container 2. When the equipment is long in service time, if the curing agent leaks out from the gaps of the first upper base 6 and the second upper base 7, the leaked curing agent can be contained through the first reflux groove 32 and the second reflux groove 33, and materials with water absorbability such as cotton can be placed in the first reflux groove 32 and the second reflux groove 33 to absorb the leaked curing agent, so that the probability that the curing agent leaks outside the device is reduced, and the safety of operators is improved.

Referring to fig. 5 and 6, the seal includes a first seal groove 15, a seal ring 16, a second seal groove 17, and a third seal groove 18. The first sealing groove 15 is formed on the periphery of the opening of the second through hole 13, which is close to one side of the first upper base 6, and the second through hole 13 is supported by the second upper base 7, so that the first sealing groove 15 is formed on the second upper base 7, and the first sealing groove 15 is not communicated with the second through hole 13. The sealing ring 16 is embedded in the first sealing groove 15, and a small part of the sealing ring 16 protrudes out of the first sealing groove 15, and the sealing ring 16 is abutted against the first upper base 6 because the sealing ring 16 is made of elastic materials. The second sealing groove 17 is formed in the periphery of the opening of the first through hole 12, which is close to the sealing ring 16, and is used for embedding the sealing ring 16, and the first through hole 12 is supported by the first upper base 6, so that the second sealing groove 17 is formed in the first upper base 6, and the first through hole 12 is not communicated with the second sealing groove 17. The third sealing groove 18 is formed on the first upper base 6 and is embedded by the sealing ring 16, and the third sealing groove 18 is not communicated with the second sealing groove 17. The height of the first sealing groove 15 is greater than that of the second sealing groove 17, the height of the second sealing groove 17 is equal to that of the third sealing groove 18, so that most of the area of the sealing ring 16 is positioned in the first sealing groove 15, and the sealing ring 16 is deformed under pressure when the first upper base 6 is rotated, but the sealing ring 16 can rebound when encountering the second sealing groove 17 or the third sealing groove 18. When one end of the seal ring 16 is located in the first seal groove 15 and the other end is located in the second seal groove 17, the first through hole 12 and the second through hole 13 are communicated; when one end of the seal ring 16 is located in the embedded first seal groove 15 and the other end is located in the third seal groove 18, the first through hole 12 and the second through hole 13 do not communicate.

In the embodiment of the present application, most of the sealing ring 16 is embedded in the first sealing groove 15, a small part of the sealing ring 16 protrudes out of the first sealing groove 15, and the sealing ring 16 is made of an elastic material, so that the rotation of the first element 4 and the second element 5 is not affected. When one end of the seal ring 16 is located in the first seal groove 15 and the other end is located in the second seal groove 17, the first through hole 12 and the second through hole 13 communicate. When the first element 4 and the second element 5 rotate again around the longitudinal axis 14, the first through hole 12 and the second through hole 13 are not communicated when one end of the sealing ring 16 is located in the first sealing groove 15 and the other end is located in the third sealing groove, and the second through hole 13 is sealed through the sealing ring 16, and the first through hole 12 is also sealed by the third sealing groove 18, so that the sealing performance of the device is improved, and the leakage probability of the fixing agent is reduced.

Referring to fig. 6 and 7, the angle of rotation of the first member 4 and the second member 5 is limited for easier operation by a worker. The first element 4 is provided with a first arc-shaped block 22 and a second arc-shaped block 23 on one side close to the second element 5, and the first arc-shaped block 22 and the second arc-shaped block 23 are symmetrically arranged along the straight line direction of the first upper base 6. The first sliding groove 24 for sliding the first arc-shaped block 22 is formed in one side, close to the first arc-shaped block 22, of the second element 5, the second sliding groove 25 for sliding the second arc-shaped block 23 is formed in one side, close to the second arc-shaped block 23, of the second element 5, when the arc lengths of the first arc-shaped block 22 and the second arc-shaped block 23 are equal, the first sliding groove 24 and the second sliding groove 25 are also formed with equal arc lengths, so that the first element 4 only needs to rotate an angle corresponding to the arc of the second sliding groove 25, or rotate an angle corresponding to the arc of the second sliding groove 25, so that the communication and closing of the first through hole 12 and the second through hole 13 are realized. When the line connecting the first end of the first arc-shaped block 22 and the first end of the second arc-shaped block 23 is parallel to the line connecting the second end of the first arc-shaped block 22 and the second end of the second arc-shaped block 23. When the first end of the first arc-shaped block 22 is abutted with the side wall of the first sliding groove 24 and the second end of the second arc-shaped block 23 is abutted with the side wall of the second sliding groove 25, the first through hole 12 and the second through hole 13 are not communicated; when the second end of the first arc-shaped block 22 abuts against the side wall of the first sliding groove 24 and the first end of the second arc-shaped block 23 abuts against the side wall of the second sliding groove 25, the first through hole 12 and the second through hole 13 communicate.

In this embodiment of the present application, the first arc-shaped block 22 slides in the first sliding groove 24, and the second arc-shaped block 23 slides in the second sliding groove 25, so that the rotation angle of the first element 4 and the second element 5 is limited, the rotation angle of the second element 5 of the first element 4 is smaller than 90 °, which is beneficial to improving the rotation efficiency of the first element 4 and the second element 5, and also plays a role in enlightening the operator. For example, when the first end of the first arc block 22 abuts against the side wall of the first sliding groove 24, it means that the first through hole 12 and the second through hole 13 are not communicated, and when the second end of the first arc block 22 abuts against the side wall of the first sliding groove 24, it means that the first through hole 12 and the second through hole 13 are communicated. Therefore, operators do not need to blindly find the correspondence of hole sites, and the working efficiency of the operators is improved. A simple indication device can be designed on the outer wall of the closure 3 to reduce the probability of misoperation of operators.

Embodiment 1 of the present application provides a device for processing biological samples, which is implemented by: the device provides a first container 1 and a second container 2, the first container 1 having been pre-filled with a fixing agent, such as formaldehyde, by the manufacturer and then closed by a closure 3. Subsequently, the operator turns the first container 1 with the closure 3 onto the second container 2, in which second container 2 the sample to be processed is placed, so that the second container 2 is also closed. At this point, the operator rotates the first element 4 and the second element 5 in opposite directions about the longitudinal axis 14 until the first through hole 12 and the second through hole 13 communicate. In this way, the fixative may flow to the sample by tilting the device. Then by rotating the first and second members 4, 5 in opposite directions such that the first and second through holes 12, 13 are not in communication, the first and second through holes 12, 13 are sealed by the sealing member to prevent the fixative or the small biological sample from accidentally entering the first container 1. After a sufficient time, the device can be turned upside down, the first element 4 and the second element 5 can be rotated again so that the first through hole 12 and the second through hole 13 are communicated, the fixative is collected in the first container 1, the first element 4 and the second element 5 can be rotated again so that the sealing member seals the first through hole 12 and the second through hole 13, and the second container 2 can be opened to take out the biological sample. In the scheme in this application, with the sealed processing of first container 1 through first component 4, and just through first component 4 and second component 5 around the relative rotation of longitudinal axis 14, can realize the intercommunication or not the intercommunication of first through-hole 12 and second through-hole 13, not only reduced the probability that operating personnel contacted the fixative, also reduced the loaded down with trivial details nature that biological sample device itself was used.

Example 2

Referring to fig. 2, embodiment 2 is different from embodiment 1 in that the structure of the seal is different and the remaining features are the same. The seal comprises a first groove 19, a resilient ball 21 and a second groove 20. The first groove 19 is formed on the second upper base 7, the elastic ball 21 is embedded in the first groove 19 and abuts against the first upper base 6, and the second groove 20 is mounted on the first upper base 6 and is used for embedding the elastic ball 21. The elastic ball 21 may be made of a deformable material, for example, an elastic polymer, or a silicon material. The height of the first groove 19 is larger than that of the second groove 20, and when one end of the elastic ball 21 is positioned in the first groove 19 and the other end is positioned in the second groove 20, the first through hole 12 is communicated with the second through hole 13; when one end of the elastic ball 21 is located in the first groove 19 and the other end is located in the first through hole 12, the first through hole 12 and the second through hole 13 are not communicated. Wherein at least two elastic balls 21 may be provided, the elastic balls 21 being adapted to close the first through hole 12.

Embodiment 2 of the present application is a device for processing biological samples, which is implemented by: the elastic ball 21 is mostly embedded in the first groove 19, a small part of the elastic ball 21 protrudes out of the first groove 19, after the first element 4 and the second element 5 relatively rotate around the longitudinal axis 14, the elastic ball 21 is elastically deformed, and when the first groove 19 corresponds to the first through hole 12, the elastic ball 21 is elastically embedded in the first through hole 12 again to seal the first through hole 12, so that the fixing agent cannot flow out of the first container 1. When the first groove 19 and the second groove 20 are communicated, the first through hole 12 and the second through hole 13 are communicated, and the fixing agent can flow from the first container 1 to the second container 2, so that the probability of leakage of the fixing agent can be reduced through simple and easy rotation of the first element 4 and the second element 5 and the sealing effect of the elastic ball 21, the operation of the using device is simpler, and the manufacturing cost is low.

The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.

In the description of the present utility model, it should be understood that the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

Claims (9)

1. A device for processing biological samples, characterized by comprising a first container (1) for the placement of a fixative, a second container (2) for the placement of a biological sample, a closure (3) arranged between the first container (1) and the second container (2); the closure (3) comprises a first element (4) for closing the first container (1) and a second element (5) for connecting with the second container (2), the first element (4) is provided with a first upper base (6) near one side of the second element (5), the second element (5) is provided with a second upper base (7) for abutting against the first upper base (6) near one side of the first element (4), the first upper base (6) is provided with an annular block (8) near one side of the second upper base (7), the second upper base (7) is provided with an annular block (9) for sliding the annular block (8), one side of the annular block (8) near the side wall of the annular block (9) is provided with a limiting block (10), the side wall of the annular block (9) is provided with a limiting groove (11) for limiting the limiting block (10), the first upper base (6) is provided with a first through hole (12), the second upper base (7) is provided with a limiting block (8) and the second upper base (7) is provided with a limiting block (10) and the second through hole (13) is provided with a limiting block (9) and the second through hole (14) is in sliding along the side wall, which is provided with a longitudinal direction opposite to the first through hole (13) and the second element (4), the first container (1) and the second container (2) are in communication, the closure (3) further comprising a seal for sealing the first through hole (12) and the second through hole (13).

2. The device for processing biological samples according to claim 1, wherein the sealing member comprises a first sealing groove (15) arranged on the side of the second through hole (13) close to the opening circumference side of the first upper base (6), a sealing ring (16) arranged in the first sealing groove (15) and abutted against the first upper base (6), a second sealing groove (17) arranged on the side of the first through hole (12) close to the sealing ring (16) opening circumference side and used for embedding the sealing ring (16), a third sealing groove (18) arranged on the side of the first upper base (6) close to the sealing ring (16) and used for embedding the sealing ring (16), the height of the first sealing groove (15) is larger than the height of the second sealing groove (17), the height of the second sealing groove (17) is equal to the height of the third sealing groove (18), when one end of the sealing ring (16) is embedded in the first sealing groove (15) and the other end is embedded in the second sealing groove (17), and when the other end of the sealing ring (16) is embedded in the first sealing groove (15), the height of the first sealing groove (15) is larger than the height of the second sealing groove (17), the first through hole (12) and the second through hole (13) are not communicated.

3. The device for processing biological samples according to claim 1, characterized in that the sealing member comprises a first groove (19) arranged on the second upper base (7), an elastic ball (21) arranged in the first groove (19) and abutted against the first upper base (6), and a second groove (20) arranged on the first upper base (6) and embedded by the elastic ball (21), wherein the height of the first groove (19) is larger than the height of the second groove (20), the first through hole (12) and the second through hole (13) are communicated when one end of the elastic ball (21) is embedded in the first groove (19) and the other end is embedded in the second groove (20), and the second through hole (13) is communicated with the second groove (20) when one end of the elastic ball (21) is embedded in the first groove (19) and the other end is embedded in the first through hole (12), and the first through hole (12) is not communicated with the second through hole (13).

4. A device for processing biological samples according to any one of claims 1 to 3, characterized in that a first arc-shaped block (22) and a second arc-shaped block (23) are arranged on one side of the first element (4) close to the second element (5), the first arc-shaped block (22) and the second arc-shaped block (23) are symmetrically arranged along the straight line direction of the first upper base (6), a first sliding groove (24) for sliding the first arc-shaped block (22) is arranged on one side of the second element (5) close to the first arc-shaped block (22), and a second sliding groove (25) for sliding the second arc-shaped block (23) is arranged on one side of the second element (5) close to the second arc-shaped block (23); the connecting line between the first end of the first arc-shaped block (22) and the first end of the second arc-shaped block (23) is parallel to the connecting line between the second end of the first arc-shaped block (22) and the second end of the second arc-shaped block (23), when the first end of the first arc-shaped block (22) is abutted with the side wall of the first sliding groove (24) and the second end of the second arc-shaped block (23) is abutted with the side wall of the second sliding groove (25), the first through hole (12) and the second through hole (13) are not communicated, and when the second end of the first arc-shaped block (22) is abutted with the side wall of the first sliding groove (24) and the first end of the second arc-shaped block (23) is abutted with the side wall of the second sliding groove (25), the first through hole (12) and the second through hole (13) are communicated.

5. Device for processing biological samples according to claim 1, characterized in that said first through holes (12) are provided with N on said first upper base (6) and said second through holes (13) are provided with N on said second upper base (7), wherein N is an integer greater than or equal to 2.

6. Device for processing biological samples according to claim 1, characterized in that the first upper base (6) is provided with a first annular flange (26) on the side close to the first container (1), the second upper base (7) is provided with a second annular flange (27) on the side close to the second container (2), a first receiving groove (28) for the first container (1) to be inserted is formed between the inner side wall of the first element (4) and the first annular flange (26), a second receiving groove (29) for the second container (2) to be inserted is formed between the inner side wall of the second element (5) and the second annular flange (27), a first guiding inclined surface (30) is provided on the side of the first annular flange (26) close to the first receiving groove (28), and a second guiding inclined surface (31) is provided on the side of the second annular flange (27) close to the second receiving groove (29).

7. A device for processing biological samples according to claim 6, characterized in that the first annular flange (26) is provided with a first reflow groove (32) on the side close to the second upper base (7), the second annular flange (27) is provided with a second reflow groove (33) on the side close to the second upper base (7), and the first reflow groove (32) and the second reflow groove (33) are in communication.

8. A device for processing biological samples according to claim 1, characterized in that the closure (3) further comprises a thread for closing the first container (1) and/or the second container (2), the first container (1) being screwed with the first element (4) and the second container (2) being screwed with the second element (5).

9. Device for processing biological samples according to claim 1, characterized in that the stopper (10) is provided with a cambered surface (34) on the side close to the limiting groove (11).