CN220309211U - Pressure-sensitive brain stereotactic instrument - Google Patents

Abstract

The utility model discloses a pressure-sensitive brain stereotactic instrument, belonging to the technical field of medical research and medical equipment; it comprises the following steps: a base plate, a rotating assembly, and a marking assembly; the bottom plate can be provided with a fixing device for fixing the animal head; the rotating assembly comprises a substrate capable of moving vertically, a rotating disc rotationally connected with the substrate and a rotating unit, and a groove body is arranged on the rotating disc; the rotating unit comprises a gear ring and a rack which are coaxially connected with the rotating disk, the rack is meshed with the gear ring and is in sliding connection with the base plate, and the rack can drive the rotating disk to rotate by 180 degrees; the marking component comprises a pressure sensing unit, a cranial drill and a cranial needle, wherein the pressure sensing unit is arranged on the groove body, the cranial drill and the cranial needle are coaxially arranged at two ends of the pressure sensing unit, and the pressure sensing unit can sense pressure change of the cranial drill or the cranial needle; the rotating disk can drive the cranial drill or the cranial needle to be vertically arranged downwards. The utility model can accurately and accurately identify the contact between the craniocerebral needle and the furnace body.

Description

Pressure-sensitive brain stereotactic instrument

Technical Field

The utility model relates to the technical fields of medical research and medical equipment, in particular to a pressure-sensitive brain stereotactic instrument.

Background

Brain is the most complex organ of the human body, revealing that brain's mysterious is considered the "ultimate territory" of life science research. To date, brain science research has made a series of significant advances at both the microscopic and macroscopic levels. In fact, the structure and function of the brain are complex, and during the course of the study, some tools and techniques are needed to better study the brain. And the brain stereotactic technology provides a powerful tool for brain science research.

The utility model with publication number of CN111888036B discloses a fixing structure of a three-dimensional brain positioning instrument for a large mouse, which adopts a mode that a lead screw rotates to drive a sliding block to move on an operation plate, so that the positions of two ear rods can be accurately adjusted, the effect of propping against ear canals of the large mouse and the small mouse is achieved, the adjusting precision is high, and the situation that the ear rods poke ear membranes of the large mouse and the small mouse is avoided.

The utility model of publication number CN112807122B discloses a positioning arm with a cranial drill, comprising: the positioning and fixing assembly is used for positioning the cranial drill; the positioning and fixing assembly is provided with a connecting sleeve which can be loosened and tightened; the cranial drill is detachably connected with the positioning and fixing assembly in a mode of being sleeved in the connecting sleeve and being fastened by the connecting sleeve. Through the positioning arm, holes can be drilled directly after positioning in the experimental operation process of the heads of the rats and the mice, the positioning arm is not required to be dismantled, manual marking is not required, and the whole process is convenient, accurate and rapid; the operation is simple and convenient, and the operation positioning and drilling time can be effectively shortened; the universal brain stereotactic device has strong universality and can be installed on most of the rat brain stereotactic devices on the market for use.

In the using process of the existing brain stereotactic apparatus, after the skull is drilled, the injector is needed to be used for positioning injection into the skull, and the phenomenon of inaccurate positioning easily occurs when the zero point of the Z axis is determined. During the actual positioning, the injector may feel that it has hit the skull but has not, or because of some elasticity, actually has fallen to a slight depression of the skull, when observed with the naked eye.

Disclosure of Invention

In view of the foregoing, it is desirable to provide a pressure-sensitive brain stereotactic apparatus for solving the problem that the existing brain stereotactic apparatus is difficult to determine the zero point of the Z axis.

The utility model provides a pressure-sensitive brain stereotactic apparatus, comprising:

a base plate on which a fixing device for fixing the head of the animal can be provided;

the rotating assembly comprises a substrate capable of moving vertically, a rotating disc rotationally connected with the substrate and a rotating unit, and a groove body is arranged on the rotating disc; the rotating unit comprises a gear ring and a rack which are coaxially connected with the rotating disk, the rack is meshed with the gear ring and is in sliding connection with the base plate, and the rack can drive the rotating disk to rotate by 180 degrees;

the marking assembly comprises a pressure sensing unit, a cranial drill and a cranial needle, wherein the pressure sensing unit is arranged on the groove body, the cranial drill and the cranial needle are coaxially arranged at two ends of the pressure sensing unit, and the pressure sensing unit can sense pressure change of the cranial drill or the cranial needle;

the rotating disc can drive the cranial drill or the craniocerebral needle to be vertically arranged downwards.

In some embodiments, the pressure sensing unit comprises a sleeve detachably connected with the groove body and a pressure sensor, the pressure sensor is arranged in the middle of the sleeve and fixedly connected with the sleeve, and the ends of the cranial drill and the cranial needle are respectively inserted into the sleeve from two ends and are abutted with the pressure sensor.

In some embodiments, the ends of the burr and the craniocerebral needle are respectively connected with the sleeve in a transition fit manner, and friction grease is arranged between the ends of the burr and the craniocerebral needle and the sleeve.

In some embodiments, a sliding unit is arranged between the rack and the base plate, the sliding unit comprises a guide rail fixedly connected with the base plate, a sliding frame body in sliding clamping connection with the guide rail and a limiting piece, the rack is installed on the sliding frame body, and the limiting piece is arranged on two sides of the base plate and used for limiting the moving range of the sliding frame body.

In some embodiments, a hollow groove is formed in the middle of the sliding frame body, and the rotating disc is arranged in the hollow groove.

In some embodiments, a fastening bolt is disposed on one side of the sliding frame body, and the fastening bolt abuts against the guide rail through the sliding frame body so as to lock the sliding frame body.

In some embodiments, the cranial needle is a microinjector.

In some embodiments, the device further comprises a driving assembly, wherein the driving assembly comprises a vertical driving unit and a horizontal driving unit, the vertical driving unit and the horizontal driving unit are arranged parallel to the substrate, the horizontal driving unit is connected with the vertical driving unit, the horizontal driving unit can drive the vertical driving unit to move relative to two sides of the substrate, the substrate is connected with the vertical driving unit, and the vertical driving unit can drive the substrate to move vertically.

In some embodiments, the device further comprises a support, wherein the vertical driving unit is fixedly connected with the support through the horizontal driving unit, and the horizontal driving unit can drive the vertical driving unit to move relative to the support.

In some embodiments, the driving assembly further includes a longitudinal driving unit, the base plate is connected to the support by the longitudinal driving unit, and the longitudinal driving unit is capable of driving the base plate to move in a direction perpendicular to the substrate.

Compared with the prior art, the utility model has the following beneficial effects:

(1) The pressure-sensitive brain stereotactic instrument is provided with a rotating unit, the rotating unit comprises a gear ring and a rack which are coaxially connected with a rotating disc, the rack is meshed with the gear ring and is in sliding connection with a base plate, the rack can drive the rotating disc to rotate 180 degrees by precisely controlling the stroke of the rack, a skull drill or a skull needle can be respectively driven to vertically downwards arrange, after the skull drill drills a skull, the skull drill is not required to be disassembled and then the skull needle is arranged, the rotating disc rotates 180 degrees, the skull needle coaxially arranged with the skull drill is directly adjusted to vertically downwards face, the testing steps can be simplified, the testing precision is improved, and the skull needle can be ensured to be accurately inserted into a hole machined by the skull drill. Thereby avoiding the damage of the cranium needle and inaccurate positioning caused by various errors and the non-concentricity of the hole.

(2) The pressure-sensitive brain stereotactic instrument is provided with a marking component, the marking component comprises a pressure sensing unit, a cranial drill and a cranial needle, the pressure sensing unit is arranged on a groove body, the cranial drill and the cranial needle are coaxially arranged at two ends of the pressure sensing unit, and the pressure sensing unit can identify in real time after the external pressure born by the cranial drill or the cranial needle slightly changes, so that the cranial needle is judged to be in contact with a cranium body, the zero point of a Z axis is accurately determined, and the subsequent brain science research is facilitated.

Drawings

The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this application, illustrate embodiments of the utility model and together with the description serve to explain the utility model and do not constitute a limitation on the utility model. In the drawings:

FIG. 1 is a schematic view of the overall structure of the present utility model;

FIG. 2 is a schematic view of the construction of the glide unit and flag assembly of the present utility model;

FIG. 3 is a schematic view of the construction of the marking assembly of the present utility model;

FIG. 4 is a schematic view of the structure of the carriage body in the first limit position according to the present utility model;

FIG. 5 is a schematic view of the structure of the sliding frame body at the second limit position in the present utility model;

FIG. 6 is a schematic view of the connection structure of the support and the marking assembly of the present utility model;

FIG. 7 is a scan of a brain region of a mouse according to the present utility model;

in the drawing, a base plate 100, a rotating assembly 200, a base plate 210, a rotating disk 220, a groove body 221, a rotating unit 230, a gear ring 231, a rack 232, a sliding unit 240, a guide rail 241, a sliding frame body 242, a limiting member 243, a hollowed groove 244, a fastening bolt 245, a marking assembly 300, a pressure sensing unit 310, a sleeve 311, a pressure sensor 312, a cranial drill 320, a cranial needle 330, a driving assembly 400, a vertical driving unit 410, a horizontal driving unit 420, a longitudinal driving unit 430 and a support 500.

Detailed Description

Preferred embodiments of the present utility model will now be described in detail with reference to the accompanying drawings, which form a part hereof, and together with the description serve to explain the principles of the utility model, and are not intended to limit the scope of the utility model.

The pressure-sensitive brain stereotactic instrument in the embodiment relates to the technical field of medical research and medical equipment, is applied to brain experiments of animals, and can be used for experiments of mammals represented by mice, birds represented by birds or fish represented by carp. In the present application, a mouse is described as a test animal, and the test animal is not limited to the mouse. The brain stereotactic instrument in the present application can accurately measure slight pressure between the craniocerebral needle 330 and the cranium, thereby accurately determining the zero point of the Z axis.

Referring to fig. 1 to 6, a pressure-sensitive brain stereotactic apparatus according to the present embodiment includes: base plate 100, swivel assembly 200, and marker assembly 300, wherein:

the base plate 100 can be provided with a fixing device for fixing the heads of animals, and the fixing device can be selected according to the needs to clamp the heads of different test animals.

The rotating assembly 200 includes a base plate 210, a rotating disc 220, and a rotating unit 230, wherein the base plate 210 is used as a carrier and can move vertically, thereby driving other components to move relative to the base plate 100, and performing drilling and injection operations on the cranium of an animal.

The rotating disc 220 is rotatably connected with the base plate 210, the rotating disc 220 can rotate freely relative to the base plate 210, a groove body 221 is arranged on the rotating disc 220, and the groove body 221 can be used for installing the cranial drill 320 and the cranial needle 330.

The rotation unit 230 includes a gear ring 231 coaxially connected with the rotation disk 220 and a rack 232, the rack 232 is engaged with the gear ring 231 and slidably connected with the base plate 210, and by precisely controlling the stroke of the rack 232, the rack 232 can drive the rotation disk 220 to achieve 180 ° rotation, thereby turning the orientation of the groove 221 upside down.

The marking assembly 300 comprises a pressure sensing unit 310, a burr 320 and a skull needle 330, wherein the pressure sensing unit 310 is arranged on the groove 221, the burr 320 and the skull needle 330 are coaxially arranged at two ends of the pressure sensing unit 310, and after the external pressure born by the burr 320 or the skull needle 330 slightly changes, the pressure sensing unit 310 can identify in real time, so that the skull needle 330 is judged to be in contact with the skull, the zero point of the Z axis is accurately determined, and the subsequent brain science study is facilitated.

The rotating disk 220 can respectively drive the cranial drill 320 or the cranial needle 330 to vertically downwards set under the action of the rotating disk 220, after the cranial drill 320 drills the cranium, the cranial needle 330 is not required to be installed after the cranial drill 320 is detached, the rotating disk 220 rotates 180 degrees, the cranial needle 330 coaxially arranged with the cranial drill 320 is directly adjusted to vertically downwards face, the test steps can be simplified, the test precision is improved, and the cranial needle 330 can be ensured to be accurately inserted into a hole machined by the cranial drill 320. Thereby avoiding misalignment of the craniocerebral needle 330 and even damage to the craniocerebral needle 330 due to various errors and misalignment of the hole.

Referring to fig. 2 and 3, the pressure sensing unit 310 includes a sleeve 311 and a pressure sensor 312, the sleeve 311 is detachably connected to the slot 221, in some embodiments, the sleeve 311 is directly clamped in the slot 221, and two sides of the slot 221 are pressed against the sleeve 311 to fix the sleeve 311 in the rotating disc 220. In some embodiments, screw holes may be formed at both sides of the slot 221, and screws may be screwed into the screw holes to effectively fix the sleeve 311 installed in the slot 221.

The pressure sensor 312 is arranged in the middle of the sleeve 311 and is fixedly connected with the sleeve 311, the pressure sensor 312 is fixedly connected with the inner wall of the sleeve 311, the ends of the cranial drill 320 and the cranial needle 330 are respectively inserted into the sleeve 311 from two ends and are abutted with the pressure sensor 312, and when the cranial drill 320 or the cranial needle 330 receives the reverse acting force of a cranium, the pressure sensor 312 can sensitively identify and display the specific value of the abutment force. The operator can adjust the drill pressure based on the values and determine the zero point for the Z-axis.

In some embodiments, referring to fig. 3, the ends of the burr 320 and the burr 330 are respectively connected with the sleeve 311 in a transition fit manner, and the end of the burr 320 away from the drill bit is inserted into the sleeve 311 and is connected with the sleeve 311 in a transition fit manner, so that corresponding friction force is maintained, and the burr 320 is ensured not to be separated from the sleeve 311. Meanwhile, one end of the cranium needle 330 far away from the needle head is inserted into the sleeve 311 and is connected with the sleeve 311 in a transition fit manner, so that corresponding friction force is maintained, and the cranium drill 320 is ensured not to be separated from the sleeve 311.

It should be noted that: friction grease is arranged between the ends of the burr 320 and the craniocerebral needle 330 and the sleeve 311, and can enhance the friction force between the burr 320 and the craniocerebral needle 330 and the inner wall of the sleeve 311, and prevent the burr 320 and the craniocerebral needle 330 from falling out. Meanwhile, the drill bit of the cranial drill 320 and the needle head of the cranial needle 330 are coaxially arranged in the middle, so that the positions of the drill bit and the needle head during switching can be ensured to be accurate.

In some embodiments, referring to fig. 2, a sliding unit 240 is disposed between the rack 232 and the base plate 210, the sliding unit 240 includes a guide rail 241 fixedly connected to the base plate 210, a sliding frame body 242 slidably clamped to the guide rail 241, and a limiting member 243, the cross section of the guide rail 241 may be T-shaped, trapezoidal or dovetail-shaped, a corresponding chute is disposed at the bottom of the sliding frame body 242, the chute may be slidably clamped to the guide rail 241, and the sliding frame body 242 may move along the guide rail 241 in a defined direction.

In a further embodiment, the rack 232 is mounted on the sliding frame 242, and the sliding frame 242 can drive the rack 232 to move, so as to drive the gear ring 231 to rotate, and finally drive the rotating disc 220 to rotate. In addition, by arranging the limiting members 243 on two sides of the base plate 210, the distance between the limiting members 243 and the sliding frame 242 is adjusted, so that the rotation angle of the gear ring 231 and the rotating disc 220 is precisely controlled, and the rotating disc 220 can realize 180 ° rotation and switching.

With continued reference to fig. 2, a fastening bolt 245 is disposed on one side of the sliding frame 242, a screw hole is disposed on the sliding frame 242, the fastening bolt 245 is screwed into the screw hole, and the fastening bolt 245 abuts against the guide rail 241 through the screw hole, so that the sliding frame 242 can be locked, and the sliding frame 242 is ensured to be stationary relative to the guide rail 241.

As a preferred embodiment, the carriage body 242 has two extreme positions on the rail 241.

Referring to fig. 4, in the first limit position, the right side of the sliding frame 242 is abutted against the limiting member 243 on the right side, the craniocerebral needle 330 and the craniocerebral drill 320 are kept vertically, wherein the drill bit of the craniocerebral drill 320 is vertically downward, the sliding frame 242 is locked by the fastening bolt 245, and the craniocerebral drill 320 can drill the craniocerebral body.

Referring to fig. 5, in the second extreme position, the left side of the carriage body 242 abuts the left-side stopper 243, and the cranium needle 330 and the cranium drill 320 are kept in a vertical position, wherein the needle tip of the cranium needle 330 is disposed vertically downward. The cranium needle 330 may mark the cranium by locking the carriage 242 with the fastening bolt 245.

Movement of the carriage 242 between the two extreme positions may drive 180 ° switching of the rotating disk 220 to achieve access to the craniocerebral needle 330 and the craniocerebral drill 320, respectively.

In some embodiments, the cranial needle 330 is a microinjector with a maximum injection volume of 10u l.

Referring to fig. 6, a pressure-sensitive brain stereotactic apparatus further includes a driving assembly 400, wherein the driving assembly 400 includes a vertical driving unit 410 and a horizontal driving unit 420 disposed parallel to the substrate 210, the horizontal driving unit 420 is connected with the vertical driving unit 410, the horizontal driving unit 420 can drive the vertical driving unit 410 to move relative to two sides of the substrate 210, the substrate 210 is connected with the vertical driving unit 410, and the vertical driving unit 410 can drive the substrate 210 to move vertically.

In a specific implementation process, the vertical driving unit 410 includes a screw rod, a guide rod and a nut member, wherein the screw rod, the guide rod and the screw rod are vertically arranged, the support plates are arranged at two ends of the guide rod and the screw rod, one end of the nut member is screwed with the screw rod, and the nut member is slidably connected with the guide rod. The nut member can be pushed to move by rotating the screw. The nut member is fixedly connected with the base plate 210, and the base plate 210 can be moved in a vertical direction by the vertical driving unit 410.

Likewise, the horizontal driving unit 420 has a similar structure to the vertical driving unit 410, and the screw of the horizontal driving unit 420 is disposed perpendicular to the screw of the vertical driving unit 410 and parallel to the base plate 210, and the nut member of the horizontal driving unit 420 is fixedly connected with the support plate in the vertical driving unit 410, thereby achieving the overall driving of the vertical driving unit 410.

The pressure-sensitive brain stereotactic instrument further comprises a support 500, wherein the support 500 comprises a base and side plates which are arranged at intervals in opposite directions, and the side plates are perpendicular to the base and fixedly connected with the base. The support plate of the horizontal driving unit 420 is fixedly connected with the side plate, and the horizontal driving unit 420 can drive the vertical driving unit 410 to move relative to the support 500.

The driving assembly 400 further includes a longitudinal driving unit 430, the longitudinal driving unit 430 having a structure similar to that of the vertical driving unit 410, a screw of the longitudinal driving unit 430 being disposed perpendicular to the base plate 210, a nut member of the longitudinal driving unit 430 being fixedly coupled with the base plate 100, and a support plate of the longitudinal driving unit 430 being fixedly coupled with the base plate. The longitudinal driving unit 430 may drive the base plate 100 to move in a direction perpendicular to the substrate 210.

The horizontal driving unit 420 and the vertical driving unit 410 cooperate with each other to drive the burr 320 and the cranium needle 330 to move on a vertical plane parallel to the base plate 210, thereby positioning each functional region of the cranium. The longitudinal driving unit 430 is independently arranged relative to the horizontal driving unit 420 and the vertical driving unit 410, so that the fixing device for fixing the head of the animal can move along with the bottom plate 100, and is separated from the positive head shadow of the rotating assembly 200, thereby facilitating the operation of the staff on the test animal in a larger range and avoiding the interference of the marking assembly 300 and the rotating assembly 200 on the staff.

What needs to be specifically stated is: the screws of the horizontal driving unit 420, the vertical driving unit 410, and the longitudinal driving unit 430 may be coaxially connected to a servo motor, and driven by the servo motor. In addition, a hand wheel can be arranged at the end part of the screw rod, and the hand wheel can be manually rotated to operate.

The working flow is as follows: the experimental mice were weighed, anesthetized, and the mice head prepared. Sterilizing with 75% alcohol.

1. The anesthetized mice were fixed on the fixing device of the base plate 100, and the specific operations are as follows: the upper door tooth of the mouse is clamped into the cross rod, and the nose rod is pressed by the adjusting knob; the ear rod is inserted into the ear canal of the mouse, the left ear rod and the right ear rod are regulated in a balanced way, the connecting line between the two ears of the mouse and the ear rod are on the same straight line, and the ear rod is locked by the regulating knob after the scale positions of the left ear rod and the right ear rod are the same. Judgment criteria for completion of mouse fixation: the nose is centered, the head is motionless, the tail is not lifted, and the brain placement level (the skull level) is visually observed.

2. The skin of the head of the mouse is cut longitudinally by an ophthalmic scissors for about 3cm, periosteum connective tissue is peeled off along the surface of the skull by forceps and sheared off, the leached blood is dipped by a sterile cotton ball, the surface of the skull is cleaned, and the front and back fontanels are exposed.

3. First, the longitudinal driving unit 430 is activated, the base plate 100 is moved to a position right under the marking assembly 300, and the horizontal driving unit 420 is adjusted. The slide frame 242 is moved to the first limit position, locking the slide frame 242. The horizontal driving unit 420 is adjusted so that the drill bit of the burr 320 is located at a predetermined position of the head of the mouse, and the vertical driving unit 410 is adjusted so that the drill bit is close to the head of the mouse, and the pressing force is monitored by the pressure sensor 312 to ensure that the drill bit drills a set depth at the head of the mouse with the predetermined pressing force.

Referring to fig. 7, in positioning, the skull is required to be adjusted to be horizontal, the Bregma site is determined first, and then the target site is positioned according to the corresponding site coordinates on the brain map. Wherein, adjusting the skull to be horizontal requires that the two sites of Bregma and Lambda are on the same horizontal plane, and the left brain and the right brain are symmetrically on the same horizontal plane. The injection coordinates were different depending on the injection location and the weight of the mice. And determining the position of the nuclear mass to be positioned by inquiring the brain stereotactic map, and determining coordinate values, namely ML value (X axis), AP value (Y axis) and DV value (Z axis).

5. The sliding frame 242 is adjusted to a second limit position, the craniocerebral needle 330 is vertically arranged downwards, the position of the craniocerebral needle 330 is the same as that of the previous drilling, and the needle head of the craniocerebral needle 330 of the vertical driving unit 410 is adjusted to be inserted into the target nucleus. Slow injections were made, with the dose injected depending on the particular experiment. After the injection is completed, the needle is left to stand for 10min so that the liquid medicine is fully absorbed. Slowly adjusting the Z-axis knob to pull out the needle head upwards, and smearing bone wax at the drilling position.

6. And suturing the skin to complete brain stereotactic injection.

While the utility model has been described with respect to the preferred embodiments, the scope of the utility model is not limited thereto, and any changes or substitutions that would be apparent to those skilled in the art are intended to be included within the scope of the utility model.

Claims (10)

1. A pressure sensitive brain stereotactic apparatus, comprising:

a base plate on which a fixing device for fixing the head of the animal can be provided;

the rotating assembly comprises a substrate capable of moving vertically, a rotating disc rotationally connected with the substrate and a rotating unit, and a groove body is arranged on the rotating disc; the rotating unit comprises a gear ring and a rack which are coaxially connected with the rotating disk, the rack is meshed with the gear ring and is in sliding connection with the base plate, and the rack can drive the rotating disk to rotate by 180 degrees;

the marking assembly comprises a pressure sensing unit, a cranial drill and a cranial needle, wherein the pressure sensing unit is arranged on the groove body, the cranial drill and the cranial needle are coaxially arranged at two ends of the pressure sensing unit, and the pressure sensing unit can sense pressure change of the cranial drill or the cranial needle;

the rotating disc can drive the cranial drill or the craniocerebral needle to be vertically arranged downwards.

2. The pressure-sensitive brain stereotactic apparatus according to claim 1, wherein said pressure sensing unit comprises a sleeve detachably connected to said groove body and a pressure sensor provided in the middle of said sleeve and fixedly connected to said sleeve, and the ends of said burr and said craniocerebral needle are respectively inserted into said sleeve from both ends and abutted to said pressure sensor.

3. The pressure-sensitive brain stereotactic apparatus of claim 2, wherein said ends of said burr and said burr are respectively in transition fit with said sleeve, and wherein friction grease is provided between said ends of said burr and said sleeve.

4. The pressure-sensitive brain stereotactic apparatus according to claim 1, wherein a sliding unit is arranged between the rack and the base plate, the sliding unit comprises a guide rail fixedly connected with the base plate, a sliding frame body in sliding clamping connection with the guide rail and a limiting piece, the rack is mounted on the sliding frame body, and the limiting piece is arranged on two sides of the base plate and used for limiting the moving range of the sliding frame body.

5. The pressure-sensitive brain stereotactic apparatus according to claim 4, wherein a hollow groove is formed in the middle of said carriage body, and said rotary disk is disposed in said hollow groove.

6. The pressure-sensitive brain stereotactic apparatus according to claim 5, wherein a fastening bolt is provided on one side of said carriage body, said fastening bolt being abutted to said guide rail via said carriage body for locking said carriage body.

7. The pressure sensitive brain stereotactic apparatus of claim 1, wherein said craniocerebral needle is a microinjector.

8. The pressure-sensitive brain stereotactic apparatus of claim 1, further comprising a driving assembly comprising a vertical driving unit and a horizontal driving unit disposed parallel to said base plate, said horizontal driving unit being connected to said vertical driving unit, said horizontal driving unit being capable of driving said vertical driving unit to move relative to both sides of said base plate, said base plate being connected to said vertical driving unit, said vertical driving unit being capable of driving said base plate to move vertically.

9. The pressure sensitive brain stereotactic apparatus of claim 8, further comprising a support, said vertical drive unit being fixedly connected to said support by said horizontal drive unit, said horizontal drive unit being capable of driving said vertical drive unit to move relative to said support.

10. The pressure sensitive brain stereotactic instrument of claim 9, wherein said drive assembly further comprises a longitudinal drive unit, said base plate being connected to said support by said longitudinal drive unit, said longitudinal drive unit being capable of driving said base plate to move in a direction perpendicular to said base plate.