CN220293974U

CN220293974U - Fumigating crystallization device

Info

Publication number: CN220293974U
Application number: CN202321424030.6U
Authority: CN
Inventors: 朱熠门; 段志邦; 闵思佳
Original assignee: Shanghai Changde Medical Technology Co ltd
Current assignee: Shanghai Changde Medical Technology Co ltd
Priority date: 2023-06-06
Filing date: 2023-06-06
Publication date: 2024-01-05
Anticipated expiration: 2033-06-06

Abstract

The utility model belongs to the technical field of medical appliances, and discloses a fumigation crystallizing device. This fumigating crystallization device is used for handling medicine coating sacculus, medicine coating sacculus includes sacculus portion, sacculus pipe and lining silk, sacculus portion connects the sacculus pipe, the lining silk wears to locate the inside of sacculus portion and sacculus pipe, this fumigating crystallization device includes box and temperature control subassembly, the inside chamber that holds of crystallization reagent that holds that has of box, sacculus portion is located the chamber entirely, temperature control subassembly includes heating element, temperature sensor and controller, the controller is all electrically connected with heating element and temperature sensor, temperature sensor is used for detecting the temperature that holds the intracavity, the temperature of controller control heating element, so that the temperature that holds the chamber is in preset temperature range. The temperature of the accommodating cavity is controlled, so that the stability of crystallization is improved; the fumigation time can be well determined by controlling the accommodating cavity to be at the set temperature, and the required crystal form size can be obtained.

Description

Fumigating crystallization device

Technical Field

The utility model relates to the technical field of medical instruments, in particular to a fumigation crystallizing device.

Background

Vascular stenosis can result in poor blood flow and once the vessel is severely stenosed, only surgical treatment can be performed. In surgical treatment, a balloon is delivered through a catheter to a stenosed site of a vessel, thereby supporting the vessel wall at the stenosed site. However, after the operation is performed on the blood vessel by using the balloon, the probability of restenosis of the narrow position of the blood vessel reaches 30% -50%. In order to prevent restenosis of the inner wall of the blood vessel, a layer of medicine is coated on the surface of the balloon to prepare a medicine coating balloon. In the process of expanding the blood vessel by adopting the drug coating saccule, the drug rapidly and uniformly acts on the cells on the inner wall of the blood vessel to play a role in inhibiting restenosis on the inner wall of the blood vessel.

The drug-coated balloon comprises a balloon catheter, a balloon portion positioned on the balloon catheter, and a lining wire penetrating through the balloon catheter and the balloon portion. When the balloon with the medicine coating is processed, firstly, medicine spraying is carried out on the balloon part, and then crystallization treatment is carried out on the medicine liquid coating to form crystals attached to the balloon part. Among the prior art, fumigation crystallization processing apparatus is provided with the sacculus portion that holds the chamber in order to hold medicine coating sacculus, fumigates medicine coating sacculus in holding the intracavity, holds the outside environment of chamber and causes the influence to fumigation process easily, and then changes and holds the temperature in the chamber and destroy the stability of crystallization even, and the time of fumigation is difficult for controlling.

That is, in the use process of the fumigation crystallization treatment device in the prior art, the environment outside the accommodating cavity is easy to influence the fumigation process, and the defects that the fumigation temperature is easy to change, the crystallization stability is poor and the fumigation time is not easy to control exist.

Disclosure of Invention

The utility model aims to provide a fumigation crystallization device, which solves the problems that the fumigation temperature of a fumigation crystallization treatment device is easy to change, the crystallization stability is poor and the fumigation time is difficult to control in the prior art.

To achieve the purpose, the utility model adopts the following technical scheme:

the utility model provides a fumigation crystallization device, which is used for treating a drug coating balloon, the drug coating balloon comprises a balloon part, a balloon catheter and a lining wire, two ends of the balloon part are connected with the balloon catheter, and the lining wire is penetrated in the balloon part and the balloon catheter, and the fumigation crystallization device is characterized by comprising:

the box body is provided with a containing cavity for containing crystallization reagent, and the balloon part is completely positioned in the containing cavity;

the temperature control assembly is used for controlling the temperature of the accommodating cavity within a preset temperature range and comprises a heating piece, a temperature sensor and a controller, wherein the controller is electrically connected with the heating piece and the temperature sensor, the temperature sensor is used for detecting the temperature in the accommodating cavity, and the controller controls the temperature of the heating piece.

As an alternative technical scheme of the fumigation crystallization device, the heating element is a temperature control thermocouple.

As an alternative technical scheme of fumigation crystallization device, the bottom of holding the chamber is equipped with the constant head tank, the heating piece with the constant head tank one-to-one sets up, the heating piece is installed in the constant head tank.

As an alternative technical scheme of fumigation crystallization device, hold the chamber bottom and be provided with a plurality of side by side the constant head tank, the constant head tank is U-shaped or V-arrangement, adjacent two the opening orientation of constant head tank is opposite.

As an optional technical scheme of fumigation crystallization device, the controller is the display controller, the display controller sets up in the box outside, the display controller includes main control board, display and control button, the display the control button temperature sensor reaches the heating element is all connected with the main control board communication, the display is used for showing the temperature in holding the intracavity, the control button is used for adjusting the temperature in holding the intracavity.

As an alternative technical scheme of the fumigation crystallization device, the preset temperature range is 10-30 ℃.

As an optional technical scheme of fumigation crystallization device, the box includes detachable body and lid, be equipped with the holding tank on the body, the holding tank has upper end opening, the lid in upper end opening part is in order to seal upper end opening and enclose to establish and form hold the chamber.

As an alternative technical scheme of the fumigation crystallization device, a convex box part is formed by the upward protrusion of the cover body at the position corresponding to the upper end opening, the convex box part is provided with a containing concave cavity communicated with the upper end opening, and the containing concave cavity and the containing groove jointly form the containing cavity; the balloon catheter is supported on the end face where the upper end opening is located, and the balloon portion is located in the accommodating concave cavity.

As an alternative technical scheme of the fumigation crystallization device, the fumigation crystallization device further comprises a sealing piece, wherein the sealing piece is arranged on the body or the cover body and is used for sealing the body or the cover body.

As an alternative technical scheme of the fumigation crystallization device, the fumigation crystallization device further comprises a locking structure, wherein the locking structure is used for fastening the body and the cover body.

The beneficial effects are that:

according to the fumigation crystallization device provided by the utility model, the accommodating cavity is arranged to accommodate the balloon part, the heating element is arranged at the bottom of the accommodating cavity when fumigation crystallization treatment is carried out, and the controller controls the temperature of the heating element, so that the temperature of the accommodating cavity is kept stable and is not easy to be influenced by the surrounding environment to generate temperature fluctuation; the temperature of the accommodating cavity is controlled, so that the temperature change is reduced, and the stability of crystallization is improved; by controlling the accommodating cavity to be at the set temperature, the fumigation time at different temperatures can be well determined, and the required crystal form size can be obtained.

Drawings

Fig. 1 is a schematic diagram of the overall structure of a fumigating crystallization device according to an embodiment of the present utility model.

FIG. 2 is a schematic view of a drug-coated balloon according to an embodiment of the present utility model;

fig. 3 is a schematic structural diagram of a fumigating crystallization device in an open state according to a first embodiment of the present utility model;

fig. 4 is a schematic structural view of a cover according to a first embodiment of the present utility model;

fig. 5 is a schematic structural diagram of a body and a positioning slot according to an embodiment of the utility model.

In the figure:

100. a drug coated balloon; 101. a balloon portion; 102. a balloon catheter; 103. lining wires;

200. a fumigation crystallizing device; 210. a case; 211. a body; 212. a cover body; 2121. a convex box part; 220. a positioning groove; 230. a controller; 231. a start-stop switch; 232. a temperature adjusting key; 233. a display; 240. a handle.

Detailed Description

The utility model is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the utility model and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present utility model are shown in the drawings.

In the description of the present utility model, unless explicitly stated and limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

In the present utility model, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.

In the description of the present embodiment, the terms "upper", "lower", "right", etc. orientation or positional relationship are based on the orientation or positional relationship shown in the drawings, and are merely for convenience of description and simplicity of operation, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the utility model. Furthermore, the terms "first," "second," and the like, are used merely for distinguishing between descriptions and not for distinguishing between them.

Example 1

As shown in fig. 1 to 5, the present utility model provides a fumigation crystallization device 200 for treating a drug coated balloon 100 to crystallize a drug coating in a fumigation manner. The drug-coated balloon 100 comprises a balloon portion 101, a balloon catheter 102 and a lining wire 103, wherein the balloon catheter 102 is connected to two ends of the balloon portion 101, and the lining wire 103 penetrates through the balloon portion 101 and the balloon catheter 102.

The fumigation crystallization device 200 comprises a box 210 and a temperature control component, wherein the box 210 is provided with a containing cavity for containing crystallization reagent, and the balloon part 101 is completely positioned in the containing cavity; the temperature control assembly is used for controlling the temperature of the accommodating cavity within a preset range, the temperature control assembly comprises a heating piece, a temperature sensor and a controller 230, the controller 230 is electrically connected with the heating piece and the temperature control sensor, the temperature sensor is used for detecting the temperature in the accommodating cavity, and the controller 230 controls the temperature of the heating piece.

According to the fumigation crystallization device 200 provided by the utility model, the accommodating cavity is arranged to accommodate the balloon part 101, and the heating element is arranged at the bottom of the accommodating cavity when fumigation crystallization treatment is carried out, and the controller 230 controls the temperature of the heating element, so that the temperature of the accommodating cavity is kept stable and is not easy to be influenced by the surrounding environment to generate temperature fluctuation; the temperature of the accommodating cavity is controlled, so that the temperature change is reduced, and the stability of crystallization is improved; by controlling the accommodating cavity to be at the set temperature, the fumigation time at different temperatures can be well determined, and the required crystal form size can be obtained.

Further, the case 210 includes a detachable body 211 and a cover 212, the body 211 is provided with a receiving groove, the receiving groove has an upper opening, and the cover 212 covers the upper opening to close the upper opening and enclose the receiving cavity. By providing the body 211 and the cover 212, the drug-coated balloon 100 can be placed in or removed from the receiving chamber by removing the cover 212.

In order to adapt to the structure of the balloon portion 101, a convex box portion 2121 is formed by the cover 212 in an upward protruding mode at a position corresponding to the upper end opening, the convex box portion 2121 is provided with a containing cavity communicated with the upper end opening, and the containing cavity and the containing groove jointly form a containing cavity; balloon catheter 102 is supported on the end face where the upper end opening is located, and balloon portion 101 is partially located in the receiving cavity. When the drug coated balloon 100 is fumigated, the cover 212 is opened, the drug coated balloon 100 is placed on the body 211, the balloon portion 101 is located at the upper end opening, and when the cover 212 is covered on the body 211, part of the balloon catheter 102 and the lining wire 103 inside are sandwiched between the body 211 and the cover 212. The provision of the convex box portion 2121 prevents a part of the balloon portion 101 from interfering with the cover 212.

In this embodiment, handles 240 are provided on opposite sides of the male box portion 2121 to facilitate opening or closing the cover 212. The case 210 has four sides and encloses and establishes to be the rectangle, and lid 212 and opening are the rectangle also, through setting up the case 210, lid 212 and upper end opening all to the rectangle, and the shape is regular, when placing medicine coating sacculus 100, makes things convenient for sacculus pipe 102 to take on the both sides edge of body 211.

Further, the fumigating crystallization device 200 further includes a sealing member disposed on the body 211 or the cover 212 for sealing between the body 211 or the cover 212. Through setting up the sealing member, improved the leakproofness that holds the chamber, further guaranteed to hold the stability of intracavity temperature, improved crystallization effect.

In the present embodiment, an annular seal groove is provided at an end surface of the body 211 facing the cover 212, the annular seal groove being provided around an outside of the opening, and the seal being installed in the seal groove. When the cover 212 is closed onto the body 211, a portion of the balloon catheter 102 and the inner liner wire 103 are both placed over the seal and sandwiched between the cover 212 and the body 211. In other embodiments, an annular seal groove may be provided in the end face of cover 212 facing body 211 and a seal may be installed within the seal groove.

Further, the fumigating crystallization device 200 further includes a locking structure for fastening the body 211 and the cover 212. By providing the locking structure, the cover 212 is prevented from being separated from the body 211, so that the cover 212 and the body 211 are more firmly connected. In this embodiment, any existing locking structure may be used, as long as the cover 212 and the body 211 are firmly covered and the locking structure is detachable.

Further, the heating element is a temperature control thermocouple. Through setting up the control by temperature change thermocouple, when holding chamber surrounding environment temperature and being higher than the required temperature of fumigation, adopt other cooling substances to carry out temperature control, and when holding chamber surrounding environment temperature and being lower than the required temperature of fumigation, adopt the control by temperature change thermocouple to heat to improve temperature control's accuracy. The cooling substance may be, but not limited to, ice cubes, cooling liquid, or the like.

In order to limit the installation position of the heating element, the bottom of the accommodating cavity is provided with a positioning groove 220, the heating element and the positioning groove 220 are arranged in a one-to-one correspondence manner, and the heating element is installed in the positioning groove 220. By arranging the positioning grooves 220 to accurately limit the installation positions of the heating elements, the arrangement stability of the heating elements is improved, and the accuracy of temperature control is improved.

Further, a plurality of positioning grooves 220 are arranged at the bottom of the accommodating cavity side by side, the positioning grooves 220 are U-shaped or V-shaped, and the openings of two adjacent positioning grooves 220 face opposite directions. By arranging a plurality of positioning grooves 220 side by side, a plurality of heating elements are arranged at the bottom of the accommodating cavity, so that the uniformity of temperature control in the accommodating cavity is improved; by providing the positioning groove 220 with openings facing opposite directions, the heating elements which are positioned inside the positioning groove 220 and are in a U shape or V shape are distributed in the accommodating cavity as uniformly as possible.

In order to ensure the stability of crystallization, the preset temperature range is 10-30 ℃. The fumigating crystallization effect is improved by arranging the containing cavity at a specific temperature. In the embodiment, the temperature of the accommodating cavity is set to be different, the temperature of the accommodating cavity is set to be 0-10 ℃, the temperature of the accommodating cavity is set to be 10-20 ℃ and the temperature of the accommodating cavity is set to be 20-30 ℃ respectively, three fumigation crystallization tests are carried out respectively, and the obtained crystals after each fumigation crystallization are measured. When the temperature required for fumigation is in the range of 0-10 ℃, if the temperature in the accommodating cavity needs to be reduced, a cooling substance such as ice cubes can be added into the accommodating cavity. The crystal form size is 75 um-82 um in the temperature range of 0-10 ℃. The size of the crystal form is 53um to 59um in the temperature range of 10 ℃ to 20 ℃. The size of the crystal form is 94 um-141 um in the temperature range of 20-30 ℃. From this, it is clear that the crystal form size is smaller in the range of 0 ℃ to 10 ℃, the crystal form size is larger in the range of 20 ℃ to 30 ℃, and the crystal form size is moderate in the range of 10 ℃ to 20 ℃ and the crystallization effect is best.

Further, as shown in fig. 1 and 2, the temperature control assembly further includes at least one temperature sensor, all of which are electrically connected to the controller 230, for detecting the temperature in the accommodating chamber. Temperature sensor detects the temperature that holds the intracavity through setting up, and the real-time supervision holds the inside temperature state of intracavity to be convenient for adjust stifling temperature and stifling time at any time, improve the stability of crystallization.

Further, the controller 230 is a display controller, the display controller is disposed outside the box 210, the display controller includes a main control board, a display 233 and a control button, the display 233, the control button, the temperature sensor and the heating element are all connected with the main control board in a communication manner, the display 233 is used for displaying the temperature in the accommodating cavity, and the control button is used for adjusting the temperature in the accommodating cavity. Through set up the display controller in the box 210 outside, the temperature in the convenient demonstration and the regulation holding chamber in time monitors the inside condition of holding the chamber to guarantee the stability of holding intracavity temperature.

In this embodiment, the control buttons include a start-stop switch 231 and a temperature adjustment button 232, where the start-stop switch 231 controls the controller 230 to be turned on and off, and the temperature adjustment button 232 is used for adjusting the temperature.

In this embodiment, the plurality of drug-coated balloons 100 are placed on the body 211, and since the temperature in the accommodating chamber is controlled by the temperature control component, whether the plurality of drug-coated balloons 100 are uniformly placed does not affect the crystallization effect, only the balloon portions 101 of the plurality of drug-coated balloons 100 need to be ensured not to contact each other.

In this embodiment, when using the fumigation crystallization device 200, the cover 212 is opened, the drug coating balloon 100 coated with the drug coating is placed on the body 211, and the crystallization reagent is added into the accommodation chamber; opening the controller 230, covering the container cover 212 and locking by a locking structure, adjusting the temperature by a temperature adjusting key 232, starting fumigation, closing the controller 230 after fumigation for a period of time, removing the locking structure and opening the cover 212, taking out the drug coating balloon 100, and wiping the accommodating cavity.

Example two

The present embodiment provides a fumigating crystallization device 200, and the basic structure of the fumigating crystallization device 200 provided in the present embodiment is the same as that of the first embodiment, only the arrangement of the heating element is different, and the description of the same structure of the first embodiment is omitted.

In this embodiment, the heating element is a temperature control tube, a temperature control medium is introduced into the temperature control tube, a portion of the temperature control tube is disposed at the bottom of the accommodating cavity and a portion of the temperature control tube extends out of the accommodating cavity to be connected with the medium circulation supply pipeline to form a medium circulation pipeline, the controller 230 is electrically connected with the temperature control tube and the temperature sensor, the controller 230 controls the temperature of the temperature control medium, and the temperature control medium is conveyed into the circulation pipeline to further control the temperature inside the accommodating cavity.

The temperature control tube can be arranged in a temperature control manner and principle of temperature adjusting medium in the temperature control tube by referring to the prior art. The temperature adjusting medium may be water, or may be a refrigerant.

It is to be understood that the above examples of the present utility model are provided for clarity of illustration only and are not limiting of the embodiments of the present utility model. Various obvious changes, rearrangements and substitutions can be made by those skilled in the art without departing from the scope of the utility model. It is not necessary here nor is it exhaustive of all embodiments. Any modification, equivalent replacement, improvement, etc. which come within the spirit and principles of the utility model are desired to be protected by the following claims.

Claims

1. Fumigating crystallization device for handle medicine coating sacculus (100), medicine coating sacculus (100) includes sacculus portion (101), sacculus pipe (102) and lining silk (103), sacculus portion (101) are connected at both ends sacculus pipe (102), lining silk (103) wear to locate sacculus portion (101) with the inside of sacculus pipe (102), its characterized in that, fumigating crystallization device includes:

a housing (210), the housing (210) having a receiving cavity for receiving a crystallization reagent, the balloon portion (101) being entirely located within the receiving cavity;

the temperature control assembly is used for controlling the temperature of the accommodating cavity within a preset temperature range, the temperature control assembly comprises a heating piece, a temperature sensor and a controller (230), the controller (230) is electrically connected with the heating piece and the temperature sensor, the temperature sensor is used for detecting the temperature in the accommodating cavity, and the controller (230) controls the temperature of the heating piece.

2. The fumigating crystallization device of claim 1 wherein the heating element is a temperature controlled thermocouple.

3. The fumigation crystallization device according to claim 1, wherein a positioning groove (220) is formed in the bottom of the accommodating cavity, the heating elements and the positioning groove (220) are arranged in a one-to-one correspondence manner, and the heating elements are installed in the positioning groove (220).

4. A fumigation crystallization device according to claim 3, wherein a plurality of positioning grooves (220) are arranged side by side at the bottom of the accommodating cavity, the positioning grooves (220) are U-shaped or V-shaped, and the openings of two adjacent positioning grooves (220) face opposite directions.

5. The fumigation crystallization device according to claim 1, wherein the controller (230) is a display controller, the display controller is arranged outside the box body (210), the display controller comprises a main control board, a display (233) and control keys, the display (233), the control keys, the temperature sensor and the heating element are all in communication connection with the main control board, the display (233) is used for displaying the temperature in the accommodating cavity, and the control keys are used for adjusting the temperature in the accommodating cavity.

6. The fumigation crystallization device according to any one of claims 1-5, wherein the box (210) comprises a detachable body (211) and a cover (212), wherein a containing groove is formed in the body (211), the containing groove is provided with an upper end opening, and the cover (212) covers the upper end opening to close the upper end opening and enclose the containing cavity.

7. The fumigation crystallization device according to claim 6, wherein a convex box portion (2121) is formed by the cover body (212) in an upward protruding manner at a position corresponding to the upper end opening, the convex box portion (2121) is provided with a containing cavity communicated with the upper end opening, and the containing cavity and the containing groove jointly form the containing cavity; the balloon catheter (102) is supported on the end face where the upper end opening is located, and the balloon part (101) is partially located in the containing concave cavity.

8. The fumigation and crystallization device of claim 6, further comprising a seal disposed on said body (211) or said cover (212) for sealing between said body (211) or said cover (212).

9. The fumigating crystallization device of claim 6, further comprising a locking structure for securing the body (211) and cover (212).