CN220274688U - Freezing box for hematopoietic stem cell multi-chamber freezing bag - Google Patents
Freezing box for hematopoietic stem cell multi-chamber freezing bag Download PDFInfo
- Publication number
- CN220274688U CN220274688U CN202322069077.1U CN202322069077U CN220274688U CN 220274688 U CN220274688 U CN 220274688U CN 202322069077 U CN202322069077 U CN 202322069077U CN 220274688 U CN220274688 U CN 220274688U
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- Prior art keywords
- freezing
- bag
- box
- cryopreservation
- stem cell
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- 238000007710 freezing Methods 0.000 title claims abstract description 73
- 230000008014 freezing Effects 0.000 title claims abstract description 73
- 210000003958 hematopoietic stem cell Anatomy 0.000 title claims abstract description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000005138 cryopreservation Methods 0.000 claims abstract description 20
- 238000005070 sampling Methods 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
- 238000001514 detection method Methods 0.000 claims description 14
- 238000005192 partition Methods 0.000 claims description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- WZSDNEJJUSYNSG-UHFFFAOYSA-N azocan-1-yl-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)N2CCCCCCC2)=C1 WZSDNEJJUSYNSG-UHFFFAOYSA-N 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses a cryopreservation box for a hematopoietic stem cell multi-chamber cryopreservation bag, which comprises a hinged box body and a cover body, wherein side walls are arranged on two opposite sides of the cover body along the length direction of the cover body, and the free end of the box body is bent upwards to form a U-shaped folded edge; the freezing storage box is characterized in that a freezing storage bag placing cavity is arranged in the box body, a buckle is fixedly arranged on the inner side of the bottom wall of the freezing storage bag placing cavity, and a sampling port of the freezing storage bag is clamped in the buckle. The advantages are that: the bottom of the freezing bag placing cavity is fixedly provided with the buckle, the sampling port of the freezing bag is fixed through the buckle, the freezing bag is effectively prevented from shaking in the box body, and the sample storage quality is guaranteed. The side wall of the freezing box is provided with the liquid nitrogen through hole, so that liquid nitrogen can conveniently enter the freezing box, and the freezing bag can be cooled more quickly and more uniformly.
Description
Technical field:
the utility model relates to the field of stem cell cryopreservation, in particular to a cryopreservation box for a hematopoietic stem cell multi-chamber cryopreservation bag.
The background technology is as follows:
with the development of hematopoietic stem cell technology, the demand of stem cell cryopreservation is gradually increased, and for blood products such as adult peripheral blood, umbilical cord blood and the like which need long-term preservation, the treated sample is required to be preserved into a special cryopreservation bag, and then the cryopreservation bag is placed in a storage box and is preserved in a liquid nitrogen tank at minus 196 ℃. The conventional freezing bag is an integrated bag body, and the matched freezing box is a single aluminum freezing box. The patent with publication number CN202269322U discloses a hematopoietic stem cell cryopreservation aluminum box, which mainly comprises a box cover and a box body, wherein the box body comprises a box bottom, the two opposite sides of the box bottom are provided with strip-shaped side wall box covers extending along side lines, each strip-shaped side wall box cover comprises a top cover, and the two opposite sides of the top cover are provided with strip-shaped side walls extending along the side lines. The box cover and the box bottom are hinged at one end of the side wall, the two side walls of the box cover can contain the two side walls of the box bottom, the free end of the box bottom is bent twice to form a U-shaped folded edge with an opening facing the box cover, and when the box cover and the box bottom are closed, the free end of the box cover is attached to the upper straight part of the U-shaped folded edge, so that the freezing box is the most commonly adopted freezing box style at present.
The capacity of the freezing bag matched with the freezing box is larger and is generally larger than 50mL, the sampling of small samples and the detection of the samples are inconvenient for many times, the OriGen company develops a novel multi-chamber freezing bag which consists of a plurality of connected smaller freezing chambers, a plurality of sections of hoses are connected to the freezing chambers at the end parts for storing independent detection samples, each independent freezing chamber can be independently taken out for resuscitation after being sealed, other chamber samples are not influenced, and a section of hose for storing the detection samples can be simultaneously taken out during sampling, so that the detection samples are convenient to be independently detected.
However, at present, there is no special freezing box for storing multi-chamber freezing bags, when the existing freezing aluminum box is used, after taking out one or more chambers of freezing bags, the volume of the remaining freezing bags is reduced, so that the bag body is easy to shake in the freezing box, the activity of freezing cells is affected, and the risk of leakage caused by the tearing of corners of the freezing box is increased.
The utility model comprises the following steps:
the utility model aims to provide a freezing box which can effectively fix a multi-chamber freezing bag and prevent the freezing bag from shaking in the box body.
The utility model is implemented by the following technical scheme: the freezing box for the hematopoietic stem cell multi-chamber freezing bag comprises a hinged box body and a cover body, wherein side walls are arranged on two opposite sides of the cover body along the length direction of the cover body, and the free end of the box body is bent upwards to form a U-shaped folded edge; the box body is internally provided with a freezing bag placing cavity, the inner side of the bottom wall of the freezing bag placing cavity is fixedly provided with a buckle, and a sampling port of the freezing bag is clamped in the buckle.
Preferably, a detection sample storage cavity is formed in the box body, the detection sample storage cavity and the freezing storage bag storage cavity are divided by a partition plate, and a groove is formed in the bottom surface of the partition plate.
Preferably, liquid nitrogen through holes corresponding to the positions are formed in the side wall of the box body and the side wall of the cover body.
Preferably, the cover body is provided with an observation port.
Preferably, the buckle is a U-shaped groove, the outer side of the groove bottom of the U-shaped groove is fixedly connected with the inner side of the bottom wall of the placing cavity, and the side wall of one side of the opening of the U-shaped groove is bent towards the inner side direction of the groove bottom.
Preferably, a limiting plate is arranged in the U-shaped groove, and two ends of the limiting plate are respectively connected with two ends of the U-shaped groove.
The utility model has the advantages that: compared with the prior art, the bottom of the freezing bag placing cavity is fixedly provided with the buckle, the sampling port of the freezing bag is fixed through the buckle, the shaking of the freezing bag in the box body is effectively avoided, and the sample storage quality is guaranteed. The side wall of the freezing box is provided with the liquid nitrogen through hole, so that liquid nitrogen can conveniently enter the freezing box, and the freezing bag can be cooled more quickly and more uniformly.
Description of the drawings:
in order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic view of the structure of the freezing storage box body of the present utility model.
Fig. 2 is a schematic view of a storage structure of a freezing storage bag according to the present utility model.
Fig. 3 is a schematic view of a buckle structure of embodiment 1.
Fig. 4 is a schematic view of a buckle structure of embodiment 2.
The box body 1, the U-shaped folded edge 1.1, the freezing storage bag placing cavity 1.2, the detection sample storing cavity 1.3, the partition board 1.4, the groove 1.5, the cover body 2, the observation port 2.1, the liquid nitrogen through hole 3, the buckle 4, the groove bottom 4.1, the limiting plate 4.2, the freezing storage bag 5, the sampling port 5.1, the cavity 5.2 and the hose 5.3.
The specific embodiment is as follows:
the following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1:
the freezing box for the hematopoietic stem cell multi-chamber freezing bag shown in fig. 1-3 comprises a hinged box body 1 and a cover body 2, wherein the cover body 2 is provided with side walls at two opposite sides along the length direction of the cover body, the free end of the box body 1 is bent upwards to form a U-shaped folded edge 1.1, and when the cover body 2 is buckled with the box body 1, the free end of the cover body 2 is positioned at the top of the U-shaped folded edge 1.1. The side wall of the box body 1 and the side wall of the cover body 2 are provided with liquid nitrogen through holes 3 corresponding to the positions, and the cover body 2 is provided with an observation port 2.1.
In order to facilitate the simultaneous storage of the chamber 5.2 and the hose 5.3 of the freezing bag 5, the box body 1 is internally provided with a freezing bag storage chamber 1.2 and a detection sample storage chamber 1.3, and the detection sample storage chamber 1.3 and the freezing bag storage chamber 1.2 are divided by a partition board 1.4. A groove 1.5 is formed in the bottom surface of the partition board 1.4, and one end of the hose 5.3 passes through the groove 1.5 and is placed in the detection sample storage cavity 1.3.
In order to prevent the freezing bag 5 from shaking in the box body 1, a buckle 4 is fixedly arranged on the inner side of the bottom wall of the placing cavity 1.2, and a sampling port 5.1 of the freezing bag 5 is clamped in the buckle 4, so that the cavity 5.2 of the freezing bag 5 is effectively fixed.
Further, the buckle 4 is of a U-shaped groove structure, the outer side of the groove bottom 4.1 of the U-shaped groove is fixedly connected with the inner side of the bottom wall of the placing cavity 1.2, and the side wall of one side of the opening of the U-shaped groove is bent towards the inner side of the groove bottom 4.1.
Example 2:
the overall structure of this embodiment is the same as that of embodiment 1, except that a limiting structure is provided in the buckle 4 to limit the position of the sampling port 5.1 of the freezing bag 5, as shown in fig. 4. Specifically, be equipped with limiting plate 4.2 in the U type inslot, limiting plate 4.2's both ends are connected with two lateral walls in U type groove respectively, and sampling port 5.1 is established between limiting plate 4.2 and the opening in U type groove by the card, can play the fastening effect to sampling port 5.1, further prevents that freezing bag 5 from rocking.
Description of use: when the multi-chamber freezing storage bag 5 is required to be stored by using the freezing storage box, firstly, one end of the hose 5.3 penetrates through the groove 1.5 and is placed in the detection sample placing cavity 1.3, then the sampling port 5.1 corresponding to each cavity 5.2 of the freezing storage bag 5 is placed at the opening of the corresponding buckle 4, the sampling port 5.1 is pressed down by using the pressure, the sampling port 5.1 enters the buckle 4 under the action of external force and is clamped between the limiting plate 4.2 and the opening of the buckle 4, and shaking cannot occur.
When sampling is needed, one or more chambers 5.2 of the freezing storage bag 5 are taken out from the buckle 4 and are separated from other chambers 5.2, meanwhile, the corresponding sections of hoses 5.3 can be taken, samples in the hoses 5.3 are independently used for detection, and after sampling is finished, the freezing storage box is placed in liquid nitrogen again for storage.
The foregoing description of the preferred embodiments of the utility model is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the utility model.
Claims (6)
1. The freezing box for the hematopoietic stem cell multi-chamber freezing bag comprises a hinged box body and a cover body, wherein side walls are arranged on two opposite sides of the cover body along the length direction of the cover body, and the free end of the box body is bent upwards to form a U-shaped folded edge; the freezing storage box is characterized in that a freezing storage bag placing cavity is arranged in the box body, a buckle is fixedly arranged on the inner side of the bottom wall of the freezing storage bag placing cavity, and a sampling port of the freezing storage bag is clamped in the buckle.
2. The cryopreservation cassette for a multi-chamber hematopoietic stem cell cryopreservation bag according to claim 1, wherein a detection sample storage chamber is provided in the cassette body, the detection sample storage chamber and the cryopreservation bag storage chamber are partitioned by a partition plate, and a groove is provided on the bottom surface of the partition plate.
3. The cryopreservation cassette for a multichamber hematopoietic stem cell cryopreservation bag according to claim 1 or 2, wherein liquid nitrogen through holes corresponding to the positions are arranged on the side wall of the cassette body and the side wall of the cover body.
4. The cryopreservation cassette for a multichamber hematopoietic stem cell cryopreservation bag according to claim 1 or 2, wherein the cover is provided with a viewing port.
5. The cryopreservation cassette for a multichamber hematopoietic stem cell cryopreservation bag according to claim 4, wherein the buckle is a U-shaped groove, the outside of the groove bottom of the U-shaped groove is fixedly connected with the inside of the bottom wall of the placing cavity, and the side wall of the opening side of the U-shaped groove is bent towards the inside of the groove bottom.
6. The cryopreservation cassette for a multichamber hematopoietic stem cell cryopreservation bag of claim 5 wherein a limiting plate is disposed in the U-shaped groove, and two ends of the limiting plate are respectively connected with two ends of the U-shaped groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322069077.1U CN220274688U (en) | 2023-08-02 | 2023-08-02 | Freezing box for hematopoietic stem cell multi-chamber freezing bag |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322069077.1U CN220274688U (en) | 2023-08-02 | 2023-08-02 | Freezing box for hematopoietic stem cell multi-chamber freezing bag |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220274688U true CN220274688U (en) | 2024-01-02 |
Family
ID=89325631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322069077.1U Active CN220274688U (en) | 2023-08-02 | 2023-08-02 | Freezing box for hematopoietic stem cell multi-chamber freezing bag |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220274688U (en) |
-
2023
- 2023-08-02 CN CN202322069077.1U patent/CN220274688U/en active Active
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