CN220141694U - Tear sample collection system - Google Patents
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- CN220141694U CN220141694U CN202320801329.2U CN202320801329U CN220141694U CN 220141694 U CN220141694 U CN 220141694U CN 202320801329 U CN202320801329 U CN 202320801329U CN 220141694 U CN220141694 U CN 220141694U
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- 230000004936 stimulating effect Effects 0.000 claims description 15
- 239000000126 substance Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 11
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- 239000002085 irritant Substances 0.000 claims description 8
- 231100000021 irritant Toxicity 0.000 claims description 8
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 8
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 8
- 238000004321 preservation Methods 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 8
- 241000021559 Dicerandra Species 0.000 claims description 5
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 5
- 239000003292 glue Substances 0.000 claims description 5
- 239000000865 liniment Substances 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000004816 latex Substances 0.000 claims description 3
- 229920000126 latex Polymers 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 210000000744 eyelid Anatomy 0.000 abstract description 9
- 210000003128 head Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 238000005070 sampling Methods 0.000 description 10
- 229920001971 elastomer Polymers 0.000 description 9
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000001860 Eye Infections Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
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- 238000004806 packaging method and process Methods 0.000 description 2
- 239000003761 preservation solution Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 208000023715 Ocular surface disease Diseases 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005183 environmental health Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model provides a tear sample collection device, which comprises a sample collection device and a sample storage device; the sample collection device comprises a collector, a fixed container and a stimulator, and the sample storage device comprises a collecting pipe and a storage pipe; the fixed container is an arc-shaped device with a cavity, the bottom of the fixed container is detachably connected with the top of the collecting pipe, the side surface of the collecting pipe is connected with an elastic limiting piece, and a conical limiting hole parallel to the collecting pipe is formed in the limiting piece. The fixed container is detachably connected with the collecting pipe, and the collecting pipe is used for replacing a bracket, so that collected samples can be stored, and the fixed container has the function of the bracket; the fixed container can be used for pulling out the lower eyelid to provide support for a collector, and the cavity of the fixed container can be used for temporarily storing collected tears; the collecting pipe, the stimulator and the storage pipe are flat, so that the device is convenient to hold; the limiting piece has elasticity, can limit the collector, can also allow the collector to move to finely tune the collection position.
Description
Technical Field
The utility model belongs to the technical field of clinical proteomics experiments or medical detection, and particularly relates to a tear sample sampling device.
Background
In recent years, proteomics research based on mass spectrometry technology is increasingly applied to clinical research. Acquisition of proteomic clinical samples is of paramount importance. Tear is closely related to occurrence and development of diseases and molecular mechanisms, contains a large amount of factors and proteins, ingested drugs or drugs can be secreted and discharged through tear secretion, detection of disease biomarkers is carried out by acquiring tear, and the method has important significance for diagnosis and treatment of eye diseases, especially drug analysis, drug detection, environmental health and ocular surface diseases, and prognosis prediction. Our understanding of ocular and systemic diseases can be enhanced by establishing a non-invasive diagnostic method with tears.
The two most common tear sample collection methods in the prior art include the stimulated tear method and the capillary method.
1. Stimulation tear method: and collecting more tears for multiple test applications. A thin layer of essential balm is applied to the skin of the lower eyelid or acupuncture points are used to suck tears at the outer canthus by capillary after reflecting tears. 2. Capillary method: the tip of the glass capillary tube was placed on the lower edge of the lacrimal river, and tears were collected from the conjunctival sac by capillary action. This approach requires more experience from the acquisition personnel, is particularly challenging to operate for dry eye patients with less tear fluid and has a poor patient experience. However, this approach can minimize contact irritation to ocular surface tissue.
The tear is collected and tested in the mode, and the following problems exist:
1. the tear collection method is to suck tears at the outer canthus, the inferior lacrimal lake or the inferior fornix conjunctival sac by using a needleless injector or a suction tube, and the eyes can be carelessly injured by a purely manual operation method without fixed setting, and the collection amount is small.
2. The tear sample collecting device needs to touch the eyes by hands, but because the eyes are very sensitive organs, when the eyes are collected by holding the collector, the eyes can be poked by the hands, so that discomfort and even damage to the eyes of patients can be caused.
3. After the tears are sucked, additional devices (such as rubber ear-washing balls) are usually needed to be temporarily assembled for the next examination in order to blow out the liquid in the lumen, so that the operation steps of operators are increased, and the operation is more complicated.
The Chinese patent application No. CN202122064026.0 discloses a tear safety collecting device, which prevents the potential damage to eyes caused by hand shake to the greatest extent by designing a blocking piece to prop against the lower eyelid; and the fine adjustment of the position of the capillary collection tube is realized by optimizing the support structure and adding a slide bar, a slide groove and an elastic piece. However, there is no tear sample storage device, tear in the rubber head is not easy to store or transfer, and the design of the support, the slide bar, the sliding groove and the elastic piece for fine adjustment is complex.
Disclosure of Invention
In order to solve the problems in the prior art, the utility model provides a tear sample collecting device, which uses a collecting pipe to replace a bracket, so that the collected sample can be stored, and the function of the bracket is realized; has elastic limiting piece, is convenient to finely adjust the position of the collector, and has simple structure. Meanwhile, other improvements are made in order to perfect the functions of the sample collection device.
The technical scheme adopted for solving the technical problems is as follows:
a tear sample collection device comprises a sample collection device and a sample storage device; the sample collection device comprises a collector, a fixed container and a stimulator, and the sample storage device comprises a collecting pipe and a storage pipe; the fixed container is an arc-shaped device with a cavity, the bottom of the fixed container is detachably connected with the top of the collecting pipe, the side face of the collecting pipe is connected with an elastic limiting piece, and a conical limiting hole parallel to the collecting pipe is formed in the limiting piece.
Preferably, in the tear sample collecting device, the bottom of the collecting tube is detachably connected with the top of the stimulator, and the bottom of the stimulator is detachably connected with the top of the storage tube.
Preferably, in the tear sample collecting device, the tapered limiting hole on the limiting member is not lower than the fixed container, and the fixed container, the collecting tube, the stimulator and the storage tube are flat.
Preferably, the tear sample collecting device comprises a capillary tube and a rubber head, wherein the tail part of the capillary tube is connected with the rubber head.
Preferably, in the tear sample collecting device, a sponge or a paste containing a stimulating substance is placed in the stimulator, a sealing film is connected to a bottle opening of the stimulator, and a sample preservation liquid is placed in the storage tube.
Preferably, in the tear sample collecting device, the collecting tube and the storage tube are connected with an anti-slip strip and a scale mark.
Preferably, in the tear sample collecting device, the bottom of the fixed container is connected with the collecting pipe in a plugging, clamping or magnetic mode, the bottom of the collecting pipe is connected with the stimulator in a plugging, clamping or magnetic mode, and the bottom of the stimulator is connected with the top of the storage pipe in a plugging, clamping or magnetic mode.
Preferably, in the tear sample collecting device, the front surface of the fixing container is flush with the front surface of the collecting tube, and the irritant substance is essential balm or other nontoxic irritant substances.
Preferably, in the tear sample collecting device, the collecting tube top cover is connected with a collecting tube cover, the stimulator top cover is connected with a stimulator cover, and the storage tube top cover is connected with a storage tube cover.
Preferably, in the tear sample collecting device, the fixing container is made of soft plastic, silica gel or PDMS, and the elastic limiting member is made of latex, sponge or PDMS. The PDMS is polydimethylsiloxane.
The beneficial effects of the utility model are as follows: the fixed container is detachably connected with the collecting pipe, and the collecting pipe is used for replacing the bracket, so that the collected sample can be stored, and the bracket function is realized; the fixed container can be used for pulling out the lower eyelid to provide support for a collector, and the cavity of the fixed container can be used for temporarily storing collected tears; the collecting pipe is provided with a collecting pipe, and can store more tears; the fixed container is arc-shaped, so that the fixed container can be attached to eyes more; the device is provided with a storage tube, wherein a sample preservation liquid is arranged in the storage tube, and when the tear is small, the sample preservation liquid can be mixed and preserved; the collecting pipe and the storage pipe are provided with scale marks and anti-slip strips, the scale marks can be used for conveniently observing the acquired tear quantity, and the anti-slip strips can be used for preventing slipping; the storage tube cover is convenient for covering the storage tube, and the stimulator cover and the sealing film are convenient for storing the stimulating substances; the collecting pipe, the stimulator and the storage pipe are flat, so that the device is convenient to hold; when the tears are smaller, the collector is convenient for collecting tears at the inner canthus angle; the limiting piece has elasticity, can limit the collector, can also allow the collector to move to finely tune the collection position.
Drawings
FIG. 1 is a schematic view of the overall structure of a tear sample collection device according to the present utility model;
FIG. 2 is a schematic diagram showing a front view of a tear sample acquiring device according to the present utility model;
FIG. 3 is a schematic right-side view of a tear sample collection device according to the present utility model;
FIG. 4 is a schematic left-hand view of a tear sample collection device according to the present utility model;
fig. 5 is a schematic diagram of the overall structure of the stimulator.
In the figure 1, a sample collection device; 11. a collector; 111. a capillary tube; 112. a rubber head; 12. a fixed container; 13. a stimulator; 131. a stimulator cap; 132. sealing film; 133. a stimulating substance; 2. a sample storage device; 21. a collection pipe; 211. a collection tube cap; 212. a limiting piece; 213. scale marks; 214. an anti-slip strip; 22. a storage tube; 221. a storage tube cover; 222. sample preservation solution.
Detailed Description
Example 1: a tear sample collecting device comprises a sample collecting device 1 and a sample storing device 2; the sample collection device 1 comprises a collector 11, a fixed container 12, a stimulator 13, and the sample storage device 2 comprises a collection tube 21 and a storage tube 22; the fixed container 12 is an arc-shaped device with a cavity, the bottom of the fixed container 12 is detachably connected with the top of the collecting pipe 21, the side surface of the collecting pipe 21 is connected with an elastic limiting piece 212, and the limiting piece 212 is provided with a conical limiting hole parallel to the collecting pipe.
Example 2: based on the above embodiment, the difference between the present embodiment is that the bottom of the collecting pipe 21 is detachably connected to the top of the stimulator 13, and the bottom of the stimulator 13 is detachably connected to the top of the storage pipe 22.
Example 3: based on the above embodiment, the present embodiment is different in that the tapered limiting hole on the limiting member 212 is not lower than the fixed container 12, and the fixed container 12, the collecting tube 21, the stimulator 13 and the storage tube 22 are flattened.
Example 4: based on the above embodiment, the difference between the present embodiment is that the collector 11 includes a capillary 111 and a glue head 112, and the tail of the capillary 111 is connected to the glue head 112.
Example 5: based on the above embodiment, the difference of this embodiment is that the sponge or paste containing the stimulating substance 133 is placed in the stimulator 13, the sealing film 132 is connected to the mouth of the stimulator 13, and the sample storage liquid 222 is contained in the storage tube 22.
Example 6: based on the above embodiment, the difference between the present embodiment is that the collecting pipe 21 and the storage pipe 22 are connected with the anti-slip strip 214 and the graduation marks 213. Graduation marks are painted, engraved or hot pressed on the collection tube 21 and the storage tube 22.
Example 7: based on the above embodiment, the difference between the present embodiment is that the bottom of the fixed container 12 is connected with the collecting tube 21 by plugging, clamping or magnetic force, the bottom of the collecting tube 21 is connected with the stimulator 13 by plugging, clamping or magnetic force, and the bottom of the stimulator 13 is connected with the top of the storage tube 22 by plugging, clamping or magnetic force.
Example 8: based on the above embodiment, the difference between the present embodiment is that the front surfaces of the fixed container 12 and the collecting tube 21 are flush, and the irritant substance is essential balm.
Example 9: based on the above-described embodiment, the present embodiment is different in that the collection tube top cap is connected with the collection tube cap 211, the stimulator 13 top cap is connected with the stimulator cap 131, and the storage tube 22 top cap is connected with the storage tube cap 221.
Example 10: based on the above embodiment, the present embodiment is different in that the fixed container 12 is made of soft plastic, silicone or PDMS, and the stopper 212 having elasticity is made of latex, sponge or PDMS. The sample preservation solution comprises the following components: 5% SDC/500mM Tris-HCl.
Example 11: the utility model provides a tear sample collection device, which comprises a sample collection device and a sample storage device. The sample collection device comprises a collector, a fixed container and a stimulator. The fixed container is arranged to provide support for a sampler who directly sucks tears by hand operation, is convenient to operate, prevents eye infection possibly brought by hands, and can collect more tear samples stimulated by irritant substances. The collector consists of a capillary tube and a rubber head, wherein the tail part of the capillary tube is connected with the rubber head to form a whole, and after the capillary tube is used for collecting tear, a tear sample in the capillary tube can be transferred into a storage tube or other storage devices by pressing the rubber head. The collector is provided with the limiting piece, the limiting piece is of an elastic design, the collector can be pushed back and forth in the limiting piece, and the collector can be taken down from the limiting piece to be independently operated during collection; the sampling device can be used for collecting the sample by limiting the position of the sampling device through the limiting piece without taking down the sampling device, and effectively helping the collecting personnel to determine the sampling position. The two using modes can be convenient for sampling personnel to select according to the self conditions. The fixed container is a circular arc container with a cavity at the lower part, and the fixed container can be made of materials with hydrophobicity and safety such as soft plastic, silica gel, PDMS and the like, and can be transparent or opaque. When the collection personnel gathers tears, can support convex end under the eyes, be convenient for operating personnel sample, effectively prevent the direct eye infection that the operation of finger probably brought. And when the stimulating tear is needed, the stimulating tear can be directly collected through the circular arc-shaped container (generally, the stimulating tear is secreted more, and the stimulating tear can not be sucked by a capillary tube, so that the loss of a sample is caused). The stimulator is located the one end that is close to the collecting pipe of reservoir pipe, can dismantle connection collecting pipe and reservoir pipe. The stimulator has sealing film, and when the stimulating tear sample is needed, the storage tube and the stimulator can be detached together, and then the sealing film is torn off to expose the stimulating substance (essential balm or other harmless stimulating substance), and the stimulating substance is smeared on the lower eyelid by holding the storage tube, so that the stimulating tear can be stimulated to be produced by eyes. The stimulator may be removed from the storage tube after use. The sample storage device comprises a collecting pipe and a storage pipe, wherein the collecting pipe and the storage pipe are both in transparent flat shapes, and the pipe body is provided with an anti-slip strip, so that the collection personnel can conveniently hold the sample storage device by hand; meanwhile, scale marks are arranged, and the collection amount can be clearly known during collection. The collecting pipe side is connected with the collector, the bottom of the collecting pipe is detachably connected with the stimulator, the bottom of the stimulator is detachably connected with the storage pipe, and the stimulator, the storage pipe and the storage pipe form a whole. The storage tube is provided with a sample preservation liquid, and the collected tear sample can be preserved in the preservation liquid. The whole tear sample collection device is sleeved with a vacuum sterile packaging bag, and the packaging bag is torn open when in use.
A method of collecting a non-irritating tear sample: the vacuum sterile package of the tear sample acquiring device is opened by hand, then the fixed container 12 is pressed against the lower eyelid near the lacrimal river, the collector 12 is moved to acquire tear from the conjunctival sac by capillary action, the collected tear sample can be stored in the storage tube 22 containing the sample storage liquid 222, the storage tube cover 221 is opened, the glue head 112 of the collector 11 is pressed, and the sucked tear sample is transferred into the storage tube 22. The sampler 11 can be taken off the limiting member 212 by sampling personnel with different habits, and can be independently operated.
The method for collecting the stimulating tear sample comprises the following steps: the vacuum sterile package of the tear sample collecting device is opened by hand, then the storage tube and the stimulator are detached from the collecting tube together, the stimulator cover is opened to tear off the sealing film to expose the irritant substances, the irritant substances are smeared on the skin of the lower eyelid at one end of the storage tube far away from the stimulator, then the collecting tube is held at one end of the collecting tube far away from the fixed container, the fixed container is abutted against the position of the lower eyelid close to the lacrimal river, and after the reflected tear appears, the tear directly flows into the fixed container, so that the collection of the irritant tear sample is completed. Considering the conditions of different patients, if the tears of the patients are relatively less, the tear can be collected by the collector, and if sampling personnel are used to separation operation, the collector can be taken down from the limiting piece, and the collector is used alone for absorbing tear samples; for unskilled sampling personnel, the fixed container is abutted against the position of the lower eyelid close to the outer canthus, the collector is inserted on the limiting piece, the position of the collector is limited by the limiting piece, and the collector is moved up and down to suck tear at the outer canthus by the capillary tube of the collector. If the collected samples are more, the collecting pipe can be detached from the fixed container, the collecting pipe cover is opened, the tear samples are poured into the collecting pipe for storage, the scale marks are convenient for observing the collected tear liquid amount, and the anti-slip strips are convenient for sampling staff to operate. If the quantity of the tear sample is small, the sample can be directly stored in the storage tube containing the sample storage liquid, the cover of the storage tube is opened, the rubber head of the collector is pressed, and the sucked tear sample is transferred into the storage tube.
The above examples describe the practice of the utility model in detail, however, the utility model is not limited to the specific details of the above embodiments. Many simple modifications and variations of the technical solution of the present utility model are possible within the scope of the claims and technical idea of the present utility model, which simple modifications are all within the scope of the present utility model.
Claims (10)
1. A tear sample collecting device, which is characterized by comprising a sample collecting device (1) and a sample storing device (2); the sample collection device (1) comprises a collector (11), a fixed container (12) and a stimulator (13), and the sample storage device (2) comprises a collecting pipe (21) and a storage pipe (22); the fixed container (12) is an arc-shaped device with a cavity, the bottom of the fixed container (12) is detachably connected with the top of the collecting pipe (21), the side surface of the collecting pipe (21) is connected with an elastic limiting piece (212), and the limiting piece (212) is provided with a conical limiting hole parallel to the collecting pipe.
2. A tear sample collecting device according to claim 1, characterized in that the bottom of the collecting tube (21) is detachably connected to the top of the stimulator (13), and the bottom of the stimulator (13) is detachably connected to the top of the storage tube (22).
3. A tear sample collecting device according to claim 1, wherein the tapered limiting aperture in the limiting member (212) is not lower than the fixed container (12), and the fixed container (12), the collecting tube (21), the stimulator (13) and the reservoir tube (22) are flattened.
4. A tear sample collecting device according to claim 1, wherein the collector (11) comprises a capillary tube (111) and a glue head (112), and the tail of the capillary tube (111) is connected to the glue head (112).
5. The tear sample collecting device according to claim 1, wherein a sponge or a paste containing a stimulating substance (133) is placed in the stimulator (13), a sealing film (132) is connected to a bottle mouth of the stimulator (13), and a sample preservation liquid (222) is placed in the storage tube (22).
6. A tear sample collecting device according to claim 1, wherein the collecting tube (21) and the storage tube (22) are connected with an anti-slip strip (214) and graduation marks (213).
7. A tear sample collecting device according to claim 2, wherein the bottom of the fixed container (12) is connected with the collecting tube (21) by plugging, clamping or magnetic force, the bottom of the collecting tube (21) is connected with the stimulator (13) by plugging, clamping or magnetic force, and the bottom of the stimulator (13) is connected with the top of the storage tube (22) by plugging, clamping or magnetic force.
8. A tear sample acquiring device according to claim 5, wherein the fixed container (12) is flush with the front face of the collecting tube (21), and the irritant substance is essential balm.
9. A tear sample collecting device according to claim 1, wherein the collecting tube top cover is connected with a collecting tube cover (211), the stimulator (13) top cover is connected with a stimulator cover (131), and the storage tube (22) top cover is connected with a storage tube cover (221).
10. A tear sample acquiring device according to claim 1, wherein the fixed container (12) is made of soft plastic, silicone or PDMS, and the elastic stopper (212) is made of latex, sponge or PDMS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320801329.2U CN220141694U (en) | 2023-04-07 | 2023-04-07 | Tear sample collection system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320801329.2U CN220141694U (en) | 2023-04-07 | 2023-04-07 | Tear sample collection system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220141694U true CN220141694U (en) | 2023-12-08 |
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ID=89022437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320801329.2U Active CN220141694U (en) | 2023-04-07 | 2023-04-07 | Tear sample collection system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220141694U (en) |
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2023
- 2023-04-07 CN CN202320801329.2U patent/CN220141694U/en active Active
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