CN220111042U - Continuous high-temperature decarboxylation reactor suitable for sodium valproate key intermediate production - Google Patents
Continuous high-temperature decarboxylation reactor suitable for sodium valproate key intermediate production Download PDFInfo
- Publication number
- CN220111042U CN220111042U CN202321684723.9U CN202321684723U CN220111042U CN 220111042 U CN220111042 U CN 220111042U CN 202321684723 U CN202321684723 U CN 202321684723U CN 220111042 U CN220111042 U CN 220111042U
- Authority
- CN
- China
- Prior art keywords
- conveying pipeline
- section
- storage tank
- sodium valproate
- finished product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 229940084026 sodium valproate Drugs 0.000 title claims abstract description 13
- 238000006114 decarboxylation reaction Methods 0.000 title claims abstract description 12
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 title claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 239000000463 material Substances 0.000 claims abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims abstract description 19
- 238000010438 heat treatment Methods 0.000 claims abstract description 17
- 239000011229 interlayer Substances 0.000 claims abstract description 16
- 238000003860 storage Methods 0.000 claims abstract description 16
- 238000001816 cooling Methods 0.000 claims abstract description 15
- 239000011261 inert gas Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 claims description 3
- 239000010410 layer Substances 0.000 claims description 2
- 238000010924 continuous production Methods 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960000604 valproic acid Drugs 0.000 description 2
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Landscapes
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model discloses a continuous high-temperature decarboxylation reactor suitable for producing a key intermediate of sodium valproate, which belongs to the technical field of chemical pharmaceutical processing, and comprises a feeding section of a head part connected with a raw material bin and a finished product storage tank of a tail part, wherein the middle part of the reactor is provided with a reaction section, the reaction section comprises a material conveying pipeline with a medium interlayer, the two ends of the material conveying pipeline are respectively connected with the raw material bin and the finished product storage tank, the material conveying pipeline is sequentially provided with a star-shaped rotary valve and an inert gas feeding device connected with the inside of the material conveying pipeline from head to tail, the finished product storage tank is connected with a variable-frequency fan, and the front section of the material conveying pipeline is a heating section and the rear section of the material conveying pipeline is a cooling section. The utility model improves the processing capacity and sealing performance of materials, realizes automatic continuous production, and reduces the labor intensity of workers.
Description
Technical Field
The utility model relates to the technical field of chemical medicine processing, in particular to a high-temperature decarboxylation reaction device.
Background
The sodium valproate is 2-sodium valproate, is an antiepileptic drug widely used clinically, and is suitable for preventing and treating various epilepsy and personality behavior disorder caused by epilepsy. The production of the key intermediate valproic acid needs to adopt a high-temperature method to remove carboxyl in the raw material structure, and the reaction temperature needs to reach more than 170 ℃. At present, the synthesis of the valproic acid in China adopts traditional reaction equipment, namely a reaction kettle, and the synthesis method has the defects of poor heat exchange efficiency, poor sealing performance, poor stirring effect, intermittent operation and the like. Because the stirring effect of the reaction kettle is poor, and the reaction is not uniform due to the fact that the heat exchange of the kettle wall is only relied on, the reacted materials are easy to decompose and produce impurities after being retained in the kettle for a long time, the purity and the color of the obtained product are poor, and the product can be qualified by further rectifying. The reaction process is as follows:
disclosure of Invention
The utility model aims to solve the technical problem of providing the continuous high-temperature decarboxylation reactor suitable for producing the key intermediate of sodium valproate, so that the processing capacity and sealing performance of materials are improved, the automatic continuous production is realized, and the labor intensity of workers is reduced.
In order to solve the technical problems, the utility model adopts the following technical scheme:
the utility model provides a continuous type high temperature decarboxylation reactor suitable for production of sodium valproate key intermediate, includes the finished product storage tank of the feed zone and afterbody that the head is connected with former feed bin, and the middle part is provided with the reaction section, the reaction section includes that both ends are connected with former feed bin and finished product storage tank respectively have medium intermediate layer to realize heating and refrigerated conveying pipeline, and the conveying pipeline has set gradually star-shaped rotary valve, with conveying pipeline internal connection's inert gas air supply unit from head to tail, is connected with variable frequency fan on the finished product storage tank, and conveying pipeline anterior segment is the heating segment, the rear segment is the cooling segment.
The technical scheme of the utility model is further improved as follows: a cyclone separator is arranged between the variable frequency fan and the finished product storage tank.
The technical scheme of the utility model is further improved as follows: the material conveying pipeline is a serpentine pipeline with a medium interlayer on the outer side, heat conduction oil or circulating water is arranged in the medium interlayer, and the center of the inner part of the material conveying pipeline is a material channel.
The technical scheme of the utility model is further improved as follows: the medium interlayer of the heating section and the cooling section is of a separation structure, the heating section is longer than the cooling section, heat conduction oil is arranged in the medium interlayer of the heating section, and circulating water is arranged in the medium interlayer of the cooling section.
The technical scheme of the utility model is further improved as follows: the feeding section comprises a feeding cylinder connected with the raw material bin, and a spiral feeder and a buffer bin with a funnel-shaped inside are arranged between the feeding cylinder and the material conveying pipeline.
By adopting the technical scheme, the utility model has the following technical progress:
1. the utility model sequentially comprises a feeding section, a reaction section and a finished product storage tank, wherein the reaction section is provided with a star-shaped rotary valve and an inert gas feeding device, so that a continuous feeding and discharging mode is formed, and the treatment capacity is greatly better than that of an intermittent production reaction kettle.
2. The raw materials enter the material conveying pipeline in sequence, the residence time of the materials in the material conveying pipeline can be controlled by adjusting the flow of inert gas and the air quantity of the variable-frequency fan, the materials can enter the cooling section after the reaction is finished, the products are prevented from being heated and decomposed for a long time, and the purity and the color of the products are good.
3. Unreacted raw materials are separated and recovered at the front end of the variable frequency fan through a cyclone separator in the form of solid powder, and the yield is higher than that of a kettle reactor.
4. The utility model can realize automatic continuous production and reduce the labor intensity of workers.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the present utility model, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art;
FIG. 1 is a schematic diagram of an embodiment of the present utility model;
FIG. 2 is a schematic diagram of a second embodiment of the present utility model;
the device comprises a finished product storage tank 1, a finished product pipeline 2, a conveying pipeline 21, a heating section 22, a cooling section 3, a star-shaped rotary valve 4, an inert gas feeding device 5, a variable frequency fan 6, a cyclone separator 7, a charging barrel 8, a spiral feeder 9 and a buffer bin.
Detailed Description
The utility model is further illustrated by the following examples:
example 1
A continuous high-temperature decarboxylation reactor suitable for producing a sodium valproate key intermediate is shown in fig. 1, and sequentially comprises a feeding section, a reaction section and a finished product storage tank 1 from head to tail, wherein the feeding section comprises a feeding barrel 7 connected with a raw material bin, and a screw feeder 8 is arranged between the feeding barrel 7 and the reaction section. The reaction section comprises a conveying pipeline 2, the outer wall of the conveying pipeline 2 is provided with a medium interlayer for heating and refrigerating, the front section of the conveying pipeline 2 is a heating section 21, and the rear section of the conveying pipeline 2 is a cooling section 22. The material conveying pipeline 2 is sequentially provided with a star-shaped rotary valve 3 and an inert gas feeding device 4 which are connected with the inside of the material conveying pipeline 2 from head to tail, the inert gas feeding device 4 comprises a pipeline connected with inert gas, and a valve is arranged on the pipeline to control the gas flow and the gas flow speed. The finished product storage tank 1 at the tail part is connected with a variable frequency fan 5.
Wherein, preferably, the conveying pipeline 2 is a serpentine pipeline, heat conduction oil or circulating water is arranged in the medium interlayer, and the center of the inner part of the conveying pipeline 2 is a material channel. The medium interlayer of the heating section 21 and the cooling section 22 is of a separation structure, the heating section 21 is longer than the cooling section 22, heat conduction oil is arranged in the medium interlayer of the heating section 21, and circulating water is arranged in the medium interlayer of the cooling section 22.
Example two
The difference between the embodiment and the first embodiment is that a cyclone separator 6 is arranged between the variable frequency fan 5 and the finished product storage tank 1, as shown in fig. 2, unreacted raw materials are separated and recovered at the front end of the variable frequency fan in the form of solid powder through the cyclone separator, and the yield is higher than that of a kettle reactor.
Preferably, a buffer bin 9 with a funnel-shaped inside is further arranged between the spiral feeder 8 and the star-shaped rotary valve 3, namely, the inside of the buffer bin 9 is big-end-up, so that buffering is realized.
The above examples are only illustrative of the preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model, and various modifications and improvements made by those skilled in the art to the technical solution of the present utility model should fall within the scope of protection defined by the claims of the present utility model without departing from the spirit of the design of the present utility model.
Claims (5)
1. Continuous high temperature decarboxylation reactor suitable for production of sodium valproate key intermediate, including the feed zone that head is connected with former feed bin and finished product storage tank (1) of afterbody, its characterized in that: the middle part is provided with the reaction section, the reaction section is including the both ends respectively with former feed bin and the material storage tank (1) of finished product is connected have medium intermediate layer realize heating and refrigerated conveying pipeline (2), conveying pipeline (2) set gradually star rotary valve (3), with conveying pipeline (2) internally connected inert gas air supply device (4) from the head to the tail, be connected with variable frequency fan (5) on the material storage tank (1), conveying pipeline (2) anterior segment is heating section (21), the back end is cooling section (22).
2. The continuous high temperature decarboxylation reactor suitable for the production of sodium valproate key intermediate according to claim 1, wherein: a cyclone separator (6) is arranged between the variable frequency fan (5) and the finished product storage tank (1).
3. The continuous high temperature decarboxylation reactor suitable for the production of sodium valproate key intermediate according to claim 1, wherein: the conveying pipeline (2) is a serpentine pipeline with a medium interlayer on the outer side, heat conduction oil or circulating water is arranged in the medium interlayer, and the center of the inner part of the conveying pipeline (2) is a material channel.
4. A continuous high temperature decarboxylation reactor suitable for the production of sodium valproate key intermediate according to claim 3, wherein: the medium interlayer of heating section (21) and cooling section (22) is the separate structure, and heating section (21) are longer than cooling section (22), are provided with the conduction oil in the medium interlayer of heating section (21), are provided with circulating water in the medium interlayer of cooling section (22).
5. The continuous high temperature decarboxylation reactor suitable for the production of sodium valproate key intermediate according to claim 1, wherein: the feeding section comprises a feeding cylinder (7) connected with a raw material bin, and a spiral feeder (8) and a buffer bin (9) with a funnel-shaped inside are arranged between the feeding cylinder (7) and the material conveying pipeline (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321684723.9U CN220111042U (en) | 2023-06-30 | 2023-06-30 | Continuous high-temperature decarboxylation reactor suitable for sodium valproate key intermediate production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321684723.9U CN220111042U (en) | 2023-06-30 | 2023-06-30 | Continuous high-temperature decarboxylation reactor suitable for sodium valproate key intermediate production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220111042U true CN220111042U (en) | 2023-12-01 |
Family
ID=88916390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321684723.9U Active CN220111042U (en) | 2023-06-30 | 2023-06-30 | Continuous high-temperature decarboxylation reactor suitable for sodium valproate key intermediate production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220111042U (en) |
-
2023
- 2023-06-30 CN CN202321684723.9U patent/CN220111042U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102580347B (en) | Continuous crystallization method of tetraacetylethylenediamine | |
| CN220111042U (en) | Continuous high-temperature decarboxylation reactor suitable for sodium valproate key intermediate production | |
| CN109650359B (en) | Industrial continuous production equipment and method for black phosphorus | |
| CN113185047A (en) | Method for producing low-sodium salt from potassium-rich brine | |
| CN218554091U (en) | Device for producing powdery solid phosphoric acid | |
| CN103948511A (en) | Medicated leaven granulator and granulating method thereof | |
| CN214390174U (en) | Continuous synthesis device for metformin hydrochloride | |
| CN107447057A (en) | A kind of biomass continuous hydrolysis and the device of compression forming | |
| CN2834659Y (en) | Apparatus for preparing high-purity organism by fusion crystallization method | |
| CN102553291A (en) | Cooling crystallization method | |
| CN109942014A (en) | A kind of electron level barium hydroxide production technology of continous way cooling | |
| CN206428008U (en) | A kind of process units for improving medicinal sodium bicarbonate product granularity | |
| EP0365260A3 (en) | Apparatus and method for the production of oxides of lead | |
| CN110433522B (en) | Production method for continuous crystallization of thiourea | |
| CN203400523U (en) | Crystallization kettle | |
| CN209778705U (en) | calcium gluconate continuous crystallization system | |
| CN203530325U (en) | Acrylamide continuous catalytic hydration preparation system | |
| CN208115748U (en) | A kind of chemosynthesis reaction device of medicine intermediate pyridinedicarboxylic acid | |
| CN208288193U (en) | Integration polymerization grinding device | |
| CN105566093B (en) | A kind of method of continuous manufacture potassium diformate | |
| CN110844924B (en) | Method for producing food-grade and feed-grade anhydrous magnesium sulfate | |
| CN205903658U (en) | Crystallization device is used in production of cysteine concentrate | |
| CN220990762U (en) | Production system for preparing liquid sodium bis (fluorosulfonyl) imide | |
| CN210438665U (en) | Production system for preparing potassium diformate | |
| CN204958426U (en) | Nanometer titanium dioxide apparatus for producing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |