CN220091073U - Biopharmaceutical acid treatment appliance - Google Patents
Biopharmaceutical acid treatment appliance Download PDFInfo
- Publication number
- CN220091073U CN220091073U CN202320691987.0U CN202320691987U CN220091073U CN 220091073 U CN220091073 U CN 220091073U CN 202320691987 U CN202320691987 U CN 202320691987U CN 220091073 U CN220091073 U CN 220091073U
- Authority
- CN
- China
- Prior art keywords
- infusion pump
- mixing barrel
- blending tank
- fixed mounting
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000010306 acid treatment Methods 0.000 title claims abstract description 17
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 73
- 238000001802 infusion Methods 0.000 claims abstract description 32
- 239000002253 acid Substances 0.000 claims abstract description 28
- 238000003756 stirring Methods 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000007790 scraping Methods 0.000 claims description 24
- 239000012530 fluid Substances 0.000 claims description 21
- 238000007689 inspection Methods 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 11
- 238000010030 laminating Methods 0.000 claims 1
- 239000003513 alkali Substances 0.000 abstract description 20
- 239000007788 liquid Substances 0.000 description 34
- 230000000694 effects Effects 0.000 description 7
- 239000012535 impurity Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Abstract
The utility model discloses a biopharmaceutical acid treatment tool, which belongs to the technical field of acid treatment and comprises a mounting seat, wherein two supporting frames are fixedly arranged on the upper surface of the mounting seat, the same mixing barrel is fixedly arranged on the two supporting frames, an acid liquor tank is arranged on the mixing barrel, an infusion pump I is fixedly arranged on one side of the acid liquor tank, a water inlet pipe of the infusion pump I penetrates through the outer surface of the acid liquor tank and extends to below the water surface in the acid liquor tank, a water outlet pipe of the acid liquor tank penetrates through the outer surface of the mixing barrel and extends into the mixing barrel, and by arranging the mixing barrel, a motor, a stirring rod, the acid liquor tank, the infusion pump I, the alkali liquor tank and the infusion pump II, the acid liquor and the alkali liquor can be pumped into the mixing barrel by using the infusion pump I and the infusion pump II so as to achieve the emission standard, and the mixing work of the acid liquor and the alkali liquor can be realized by using the motor to drive the stirring rod to rotate.
Description
Technical Field
The utility model relates to the technical field of acid treatment, in particular to a biopharmaceutical acid treatment tool.
Background
The acid treatment can change the structure of the protein, thereby adjusting the physicochemical properties and pharmacological characteristics thereof. In some cases, the acid treatment may directly enhance the potency of the protein or may make it easier to bind the drug to the receptor by altering the activity of the receptor. Some important biopharmaceuticals, such as recombinant human insulin and interferon, use acid treatment techniques to increase their activity and/or stability.
When the acid is treated, the acid liquid and the alkali liquid are poured into the mixing barrel to be mixed, but the liquid in the mixing is inconvenient to sample, the mixed liquid is easy to be unqualified, a large amount of liquid is remained in the liquid when the liquid is discharged, the liquid discharge is not thorough enough, and the follow-up work is influenced.
Disclosure of Invention
The biopharmaceutical acid treatment tool provided by the utility model solves the problems that partial waste acid is generated during production of the antagonist drugs, the direct discharge is easy to cause harm to the working environment, most of the waste acid is treated, acid liquor and alkali liquor are poured into a mixing barrel to be mixed, liquid in the mixing is inconvenient to sample, the mixed liquid is not up to standard easily, a large amount of liquid remains in the liquid during discharge, the liquid discharge is not thorough enough, and the follow-up working is affected.
In order to achieve the above purpose, the present utility model adopts the following technical scheme: the utility model provides a bio-pharmaceuticals acid treatment apparatus, includes the mount pad, the upper surface fixed mounting of mount pad has two support frames, two fixed mounting has same blending tank on the support frame, install the acidizing fluid case on the blending tank, one side fixed mounting of acidizing fluid case has infusion pump one, the inlet tube of infusion pump one runs through the surface of acidizing fluid case and extends to below the acidizing fluid incasement water surface, the outlet pipe of infusion pump one runs through the surface of blending tank and extends to in the blending tank, the below of blending tank is provided with the lye case, the water adding bucket is installed to one side of lye case, the opposite side fixed mounting of lye case has infusion pump two, the inlet tube of infusion pump two runs through the lye case and extends to in the lye case, the outlet pipe of infusion pump two runs through the blending tank and extends to in the blending tank, the puddler is installed to the blending tank internal rotation, the side fixed mounting of blending tank has the motor, the tip and the output shaft fixed connection of motor, the drain pipe is installed to one side of blending tank.
By adopting the scheme, through setting up mixing drum, motor, puddler, acidizing fluid case, transfer pump one, lye case and transfer pump two, utilize transfer pump one and transfer pump two can be with acidizing fluid and lye suction mixing drum in, make acidizing fluid can mix with lye to reach emission standard, utilize the motor to drive the puddler and rotate, can realize the mixed work of acidizing fluid and lye, thereby realize the treatment work to the acidizing fluid, further improve the mixed effect of acidizing fluid and lye, through work efficiency.
In the above scheme, it should be noted that the motor, the first infusion pump and the second infusion pump are electrically connected with an external power supply.
As a preferable scheme of the utility model, a scraping frame is arranged in the mixing drum, the scraping frame is arranged on the outer surface of the stirring rod in a sealing sliding manner, the outer surface of the scraping frame is mutually attached to the inner wall of the mixing drum, a plurality of springs are fixedly arranged on the inner wall of the mixing drum, and the other ends of the springs are arranged on the scraping frame in a sliding manner.
By adopting the scheme, through setting up the spring and scraping the work or material rest, utilize the spring to order about when discharging liquid and scrape the work or material rest and get back to the normal position fast, scrape the work or material rest and can help liquid to discharge fast, improve liquid emission efficiency, can scrape out the liquid that remains on mixing drum inner wall and puddler surface simultaneously, make the liquid discharge more thoroughly, alleviate the pressure of follow-up clearance work simultaneously.
As a preferable scheme of the utility model, the other ends of the springs are fixedly provided with arc-shaped sliding blocks, the scraping rack is provided with arc-shaped sliding grooves, and the sliding blocks are slidably arranged in the sliding grooves.
By adopting the scheme, through setting up the slider, utilize the slider to slide in the spout for scrape the work or material rest and can follow puddler synchronous rotation, avoid influencing and scrape the normal motion of work or material rest.
As a preferable scheme of the utility model, a plurality of telescopic rods are arranged in the springs, and two ends of each telescopic rod are respectively and fixedly arranged on the inner wall of the mixing barrel and the sliding block.
By adopting the scheme, through setting up the telescopic link, utilize the telescopic link can play spacing guide's effect to the spring, can effectively avoid appearing rocking the skew condition in the spring motion process to improve spring motion's stability, further guarantee the normal motion of scraping the work or material rest.
As a preferable scheme of the utility model, the upper surface of the mixing barrel is fixedly provided with the inspection bucket, the inspection bucket is provided with the cover plate, and the mixing barrel is provided with the inspection port matched with the inspection bucket.
By adopting the scheme, through setting up the inspection fill, can take a sample the liquid in the mixing drum through the inspection fill, be convenient for judge whether the acidizing fluid after mixing can reach emission standard to guarantee the effect to the acidizing fluid treatment.
As a preferable scheme of the utility model, the acid liquor box is slidably provided with the filter screen, and the side surface of the filter screen is provided with the handle.
By adopting the scheme, through setting up the filter screen, utilize the filter screen to filter the impurity in the acidizing fluid, be convenient for carry out further collection processing work to the impurity.
In the utility model, the following components are added:
according to the biopharmaceutical acid treatment tool, the spring and the scraping frame are arranged, when liquid is discharged, the scraping frame can be driven to quickly return to the original position by the spring, the scraping frame can help the liquid to be discharged quickly, the liquid discharging efficiency is improved, meanwhile, the liquid remained on the inner wall of the mixing barrel and the outer surface of the stirring rod can be scraped, the liquid is discharged more thoroughly, and meanwhile, the pressure of subsequent cleaning work is relieved;
this bio-pharmaceuticals acid treatment apparatus is through setting up the inspection fill, can take a sample the liquid in the mixing drum through the inspection fill, and the acidizing fluid after the judgement after being convenient for mix can reach emission standard to guarantee the effect to the acidizing fluid is handled.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic view of another angle of the present utility model;
FIG. 3 is a schematic cross-sectional view of a mixing drum according to the present utility model;
fig. 4 is a schematic structural view of the scraping frame of the present utility model.
In the figure: 1. a mounting base; 2. a support frame; 3. a mixing drum; 4. an acid liquor tank; 5. a filter screen; 6. an infusion pump I; 7. a scraping frame; 8. a water adding hopper; 9. an alkali liquor tank; 10. an infusion pump II; 11. a motor; 12. a stirring rod; 13. a telescopic rod; 14. a spring; 15. a slide block; 16. checking a bucket; 17. and (5) a water drain pipe.
Detailed Description
Examples
Referring to fig. 1-4, the utility model provides a biopharmaceutical acid treatment tool, which comprises a mounting seat 1, wherein two support frames 2 are fixedly arranged on the upper surface of the mounting seat 1, the same mixing drum 3 is fixedly arranged on the two support frames 2, a scraping frame 7 is arranged in the mixing drum 3, the scraping frame 7 is hermetically and slidably arranged on the outer surface of a stirring rod 12, the outer surface of the scraping frame 7 is mutually attached to the inner wall of the mixing drum 3, a plurality of springs 14 are fixedly arranged on the inner wall of the mixing drum 3, the other ends of the springs 14 are slidably arranged on the scraping frame 7, and by arranging the springs 14 and the scraping frame 7, the scraping frame 7 can be driven to quickly return to the original position by utilizing the springs 14 when liquid is discharged, so that the liquid discharge efficiency is improved, meanwhile, the liquid remained on the inner wall of the mixing drum 3 and the outer surface of the stirring rod 12 can be scraped, the liquid discharge is more thorough, and the pressure of the subsequent cleaning work is relieved;
the other ends of the springs 14 are fixedly provided with arc-shaped sliding blocks 15, the scraping rack 7 is provided with arc-shaped sliding grooves, the sliding blocks 15 are slidably arranged in the sliding grooves, and the sliding blocks 15 are utilized to slide in the sliding grooves by arranging the sliding blocks 15, so that the scraping rack 7 can synchronously rotate along with the stirring rod 12, and the influence on the normal movement of the scraping rack 7 is avoided;
the telescopic rods 13 are arranged in the springs 14, two ends of each telescopic rod 13 are respectively and fixedly arranged on the inner wall of the mixing barrel 3 and the sliding block 15, and the telescopic rods 13 are used for limiting and guiding the springs 14, so that the shaking and shifting conditions in the moving process of the springs 14 can be effectively avoided, the moving stability of the springs 14 is improved, and the normal movement of the scraping rack 7 is further ensured;
the acid liquor tank 4 is arranged on the mixing barrel 3, the filter screen 5 is slidably arranged in the acid liquor tank 4, and the handle is arranged on the side surface of the filter screen 5, so that impurities in the acid liquor can be filtered by the filter screen 5 through arranging the filter screen 5, and further collection and treatment work of the impurities are facilitated;
an infusion pump I6 is fixedly arranged on one side of the acid liquor tank 4, a water inlet pipe of the infusion pump I6 penetrates through the outer surface of the acid liquor tank 4 and extends to below the water surface in the acid liquor tank 4, a water outlet pipe of the infusion pump I6 penetrates through the outer surface of the mixing barrel 3 and extends into the mixing barrel 3, an alkali liquor tank 9 is arranged below the mixing barrel 3, a water adding hopper 8 is arranged on one side of the alkali liquor tank 9, an infusion pump II 10 is fixedly arranged on the other side of the alkali liquor tank 9, a water inlet pipe of the infusion pump II 10 penetrates through the alkali liquor tank 9 and extends into the alkali liquor tank 9, a water outlet pipe of the infusion pump II 10 penetrates through the mixing barrel 3 and extends into the mixing barrel 3, a stirring rod 12 is rotatably arranged in the mixing barrel 3, a motor 11 is fixedly arranged on the side surface of the mixing barrel 3, the end part of the stirring rod 12 is fixedly connected with an output shaft of the motor 11, a water outlet pipe 17 is arranged on one side of the mixing barrel 3, and the first and second infusion pumps 10 are used for pumping acid liquor and the alkali liquor into the mixing barrel 3 by arranging the mixing barrel 3, the motor 11, the stirring rod 12, the first and the second infusion pump 6 and the second infusion pump 10, so that the acid liquor and the alkali liquor can be conveniently mixed with the stirring rod 12 can be discharged, and the alkali liquor can be further mixed by the stirring rod 12, and the alkali liquor can be conveniently discharged, and the working efficiency can be further, and the working efficiency can be improved;
the upper surface fixed mounting of mixing drum 3 has the inspection to fight 16, and is provided with the apron on the inspection fight 16, has offered the inspection mouth that the cooperation inspection fight 16 used on the mixing drum 3, through setting up the inspection fight 16, can take a sample the liquid in the mixing drum 3 through the inspection fight 16, and the acidizing fluid after being convenient for judge whether to mix can reach emission standard to guarantee the effect to the acidizing fluid treatment.
Working principle: firstly, acid liquor to be treated is filtered through a filter screen 5 and poured into an acid liquor box 4, then alkali liquor is poured into an alkali liquor box 9, then an infusion pump I6 and an infusion pump II 10 are opened, acid liquor and alkali liquor with corresponding proportions are pumped into a mixing barrel 3, then a motor 11 is opened, the motor 11 drives a stirring rod 12 to rotate, the stirring rod 12 rotates to drive the acid liquor and the alkali liquor to mix, the mixed liquid is sampled through a test bucket 16, whether the liquid reaches the standard or not is judged, then a drain pipe 17 is opened to drain the alkali liquor, and when the drain pipe 17 is discharged, a scraping rack 7 moves towards the drain pipe 17 under the action of elastic force of a spring 14, so that the liquid on the mixing barrel 3 and the stirring rod 12 can be scraped, and the liquid is discharged more thoroughly.
Claims (3)
1. The utility model provides a bio-pharmaceuticals acid treatment apparatus, its characterized in that includes mount pad (1), the upper surface fixed mounting of mount pad (1) has two support frames (2), two fixed mounting has same blending tank (3) on support frame (2), install acidizing fluid case (4) on blending tank (3), one side fixed mounting of acidizing fluid case (4) has infusion pump one (6), the inlet tube of infusion pump one (6) runs through the surface of acidizing fluid case (4) and extends to below the surface of water in acidizing fluid case (4), the outlet pipe of infusion pump one (6) runs through the surface of blending tank (3) and extends to blending tank (3) in, the below of blending tank (3) is provided with lye case (9), one side of lye case (9) is installed and is added water bucket (8), the opposite side fixed mounting of lye case (9) has infusion pump two (10), the inlet tube of infusion pump two (10) runs through lye case (9) and extends to in (9), the outlet pipe two (10) runs through the surface of blending tank (3) and extends to below the surface of water in blending tank (3), the outlet pipe (3) is installed and is mixed in blending tank (3), the utility model discloses a stirring rod, including stirring rod (12) and motor (11), output shaft fixed connection of tip and motor (11) of puddler (12), drain pipe (17) are installed to one side of mixing barrel (3), be provided with in mixing barrel (3) and scrape work or material rest (7), scrape the surface of work or material rest (7) sealed slidable mounting at puddler (12), just scrape the surface of work or material rest (7) and the inner wall of mixing barrel (3) laminating each other, mixing barrel (3) inner wall fixed mounting has a plurality of spring (14), the other end slidable mounting of spring (14) is on scraping work or material rest (7), a plurality of the other end of spring (14) is all fixed mounting has curved slider (15), scrape and seted up curved spout on material rest (7), slider (15) slidable mounting is in the spout, a plurality of all be provided with telescopic link (13) in spring (14), the both ends of telescopic link (13) are fixed mounting respectively on mixing barrel (3) inner wall and slider (15).
2. The biopharmaceutical acid treatment appliance according to claim 1, wherein an inspection bucket (16) is fixedly mounted on the upper surface of the mixing drum (3), a cover plate is arranged on the inspection bucket (16), and an inspection port matched with the inspection bucket (16) is formed in the mixing drum (3).
3. The biopharmaceutical acid treatment appliance according to claim 1, wherein a filter screen (5) is slidably mounted in the acid tank (4), and a handle is mounted on a side of the filter screen (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320691987.0U CN220091073U (en) | 2023-04-01 | 2023-04-01 | Biopharmaceutical acid treatment appliance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320691987.0U CN220091073U (en) | 2023-04-01 | 2023-04-01 | Biopharmaceutical acid treatment appliance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220091073U true CN220091073U (en) | 2023-11-28 |
Family
ID=88845695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320691987.0U Active CN220091073U (en) | 2023-04-01 | 2023-04-01 | Biopharmaceutical acid treatment appliance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220091073U (en) |
-
2023
- 2023-04-01 CN CN202320691987.0U patent/CN220091073U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |