CN219940887U - An animal portal vein drug delivery and blood collection device - Google Patents
An animal portal vein drug delivery and blood collection device Download PDFInfo
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- CN219940887U CN219940887U CN202321220639.1U CN202321220639U CN219940887U CN 219940887 U CN219940887 U CN 219940887U CN 202321220639 U CN202321220639 U CN 202321220639U CN 219940887 U CN219940887 U CN 219940887U
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Abstract
本实用新型涉及动物穿刺技术领域，特别公开了一种动物门静脉给药和采血装置，包括穿刺管、皮下隧道扩展器和接头；穿刺管可拆卸式内套有导管的一端，穿刺管用于穿刺动物门静脉并将导管留置于动物门静脉内；皮下隧道扩展器可拆卸式内套导管的另一端，皮下隧道扩展器设有第一防脱凸起，第一防脱凸起与导管内壁弹性贴合，皮下隧道扩展器用于将导管引出动物体外；接头的两端设有接管口和注射器接口，接管口可拆卸连接导管。通过所述穿刺管、所述导管、所述皮下隧道扩展器和所述接头的相互配合，以解决现有装置无法在体外对门静脉进行反复或持续给药及采血的问题。
The utility model relates to the technical field of animal puncture, and particularly discloses an animal portal vein drug administration and blood collection device, which includes a puncture tube, a subcutaneous tunnel expander and a connector; the puncture tube is detachably covered with one end of a catheter, and the puncture tube is used to puncture animals. The portal vein and the catheter is left in the portal vein of the animal; the other end of the detachable inner sheath catheter of the subcutaneous tunnel expander is provided with a first anti-detachment protrusion, and the first anti-detachment protrusion elastically fits the inner wall of the catheter. The subcutaneous tunnel expander is used to lead the catheter out of the animal's body; both ends of the connector are equipped with a connecting port and a syringe interface, and the connecting port can be detachably connected to the catheter. Through the mutual cooperation of the puncture tube, the catheter, the subcutaneous tunnel expander and the connector, the problem that the existing device cannot perform repeated or continuous administration of medication and blood collection to the portal vein outside the body is solved.
Description
Technical Field
The utility model relates to the technical field of administration and blood sampling, in particular to an animal portal vein administration and blood sampling device.
Background
The portal vein is an independent venous system in a living body, is formed by merging mesenteric veins, gastric veins and spleen veins, is distributed in the liver in the deep part of the abdominal cavity and is not communicated with the outside. The collection of animal hepatic portal blood is a common technique for detecting portal blood components in animal pharmacokinetic studies and different studies; portal vein drug injection also plays an important role in the construction and treatment of various models of rat liver cancer, liver fibrosis, portal hypertension, immune tolerance and the like.
In practical operation, in order to administer drug and inject or collect blood to the portal vein, it is often necessary to search for the portal vein and then puncture the portal vein, but when administration and collection are performed multiple times, multiple times of laparotomy and portal vein puncture are required, and the adhesion and disorder of the anatomical structure caused by previous laparotomy and puncture often increase difficulty and even cause failure for subsequent puncture operation, so that repeated or continuous administration and collection of the portal vein cannot be performed in vitro, and multiple times of laparotomy and puncture can cause great damage to experimental animals.
Therefore, in order to solve the conventional difficulty in repeatedly administering and collecting blood to the portal vein, it is very valuable to study a device for repeatedly or continuously administering and collecting blood to the portal vein in vitro, while reducing the influence and damage to animals.
Disclosure of Invention
The utility model aims to provide an animal portal vein administration and blood sampling device, which aims to solve the problem that the existing device can not repeatedly or continuously administer and sample the portal vein in vitro.
In order to solve the technical problems, the utility model provides an animal portal vein drug administration and blood sampling device, which comprises a puncture tube, a subcutaneous tunnel expander and a joint; one end of the catheter is detachably sleeved in the puncture tube, and the puncture tube is used for puncturing the portal vein of the animal and retaining the catheter in the portal vein of the animal; the subcutaneous tunnel expander is detachably sleeved at the other end of the catheter, is provided with a first anti-falling protrusion, is elastically attached to the inner wall of the catheter, and is used for leading the catheter out of the animal body; and two ends of the connector are provided with connector ports and injector connectors, and the connector ports are detachably connected with the guide pipe.
In one embodiment, the puncture tube comprises a puncture section, a conical connecting section and a handle section which are sequentially connected and conducted, wherein the puncture section is fixedly connected with the narrow end of the conical connecting section, and the wide end of the conical connecting section is fixedly connected with the handle section.
In one embodiment, the piercing end of the piercing section is beveled.
In one embodiment, the connection port is provided with a second anti-drop protrusion.
In one embodiment, the connection port is provided with a fixing buckle for buckling the conduit connected with the connector.
In one embodiment, butterfly plates are arranged on two sides of the joint, and fixing through holes are formed in the butterfly plates.
In one embodiment, the syringe interface is sealingly connected with a screw cap.
In one embodiment, the catheter is a transparent tube.
The beneficial effects of the utility model are as follows:
because the detachable inner sleeve of the puncture tube is provided with one end of the catheter, the detachable inner sleeve of the subcutaneous tunnel expander is provided with the other end of the catheter, and the subcutaneous tunnel expander is used for leading the catheter out of the animal body, when the device is used, the inner sleeve of the catheter is arranged in the puncture tube, the puncture tube punctures the portal vein and then withdraws the puncture tube, one end of the catheter is arranged in the portal vein, the other end of the catheter is connected with the subcutaneous tunnel expander, the subcutaneous tunnel expander leads the catheter out of the skin together, one end of the catheter is reserved in the portal vein, and the other end of the catheter is arranged outside the animal skin, so that a foundation can be provided for repeated or continuous drug administration and blood sampling of the portal vein of the animal.
And because the two ends of the connector are provided with the connector port and the injector interface, the connector port can be detachably connected with the catheter, when the connector is applied, after the catheter stretches out of the animal skin, one end of the catheter stretching out of the animal skin can be selectively connected with the connector port of the connector, and the repeated or continuous administration and blood sampling can be carried out on the portal vein of the animal.
In summary, through the cooperation of the puncture tube, the catheter, the subcutaneous tunnel expander and the connector, the problem that the existing device cannot repeatedly or continuously administer medicine to the portal vein and collect blood in vitro is solved.
Drawings
In order to more clearly illustrate the technical solutions of the present utility model, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic view of a puncture tube according to the present utility model;
FIG. 2 is a schematic view of a catheter structure provided by the present utility model;
FIG. 3 is a schematic view of the structure of the subcutaneous tunnel expander provided by the present utility model;
fig. 4 is a schematic view of a joint structure according to the present utility model.
The reference numerals are as follows:
1. a puncture tube; 10. a piercing section; 11. a tapered connection section; 12. a grip section;
2. a conduit;
3. a subcutaneous tunnel expander; 30. a first anti-drop protrusion;
4. a joint; 40. a pipe connecting port; 400. a second anti-drop protrusion; 401. a fixing buckle; 41. a syringe interface; 42. a butterfly plate; 43. screw sealing cap.
Detailed Description
The technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model.
The utility model discloses an animal portal vein administration and blood sampling device, a first embodiment of which is shown in fig. 1 to 4, comprising a puncture tube 1, a subcutaneous tunnel expander 3 and a joint 4; one end of the catheter 2 is detachably sleeved in the puncture tube 1, and the puncture tube 1 is used for puncturing the portal vein of the animal and retaining the catheter 2 in the portal vein of the animal; the subcutaneous tunnel expander 3 is detachably arranged at the other end of the inner sleeve catheter 2, the subcutaneous tunnel expander 3 is provided with a first anti-falling protrusion 30, the first anti-falling protrusion 30 is elastically attached to the inner wall of the catheter 2, and the subcutaneous tunnel expander 3 is used for leading the catheter 2 out of the animal body; the joint 4 is provided with a nozzle 40 and a syringe interface 41 at both ends, and the nozzle 40 is detachably connected with the catheter 2.
The first anti-drop protrusion 30 on the subcutaneous tunnel expander 3 forms an interference fit with the inner wall of the catheter 2, that is, the outer wall of the subcutaneous tunnel expander 3 is sealed and elastically clung to the inner wall of the catheter 2, so that on one hand, the subcutaneous tunnel expander can drive the catheter 2 to move between the abdomen of the animal and the skin on the back to make a subcutaneous tunnel and pass through the skin with the subcutaneous tunnel, and on the other hand, the catheter 2 can be kept sealed.
When the device is applied, the puncture tube 1 is detachably sleeved with the catheter 2 to form a puncture kit, the puncture kit punctures the portal vein of an animal, one end of the catheter 2 is reserved in the portal vein of the animal, the other end of the catheter 2 is detachably sleeved with the subcutaneous tunnel expander 3, the subcutaneous tunnel expander 3 leads the catheter 2 from the abdomen of the animal to the back of the animal and penetrates out of the skin from the back of the animal, the connection between the catheter 2 and the subcutaneous tunnel expander 3 is disconnected after the catheter 2 penetrates out of the skin, then the injector and the nozzle 40 in the connecting joint 4 of the catheter 2 can be detachably connected to perform drug injection or blood collection, so that the difficulty in repeated drug administration and blood collection of the portal vein in the past are solved, the influence and harm to the animal are reduced, and the repeated or continuous drug administration and blood collection of the portal vein in vitro are thoroughly realized.
Further, in order to facilitate the operation of the puncture tube 1 by a user, as shown in fig. 1, the puncture tube 1 includes a puncture section 10, a tapered connection section 11 and a grip section 12, which are sequentially connected, the puncture section 10 is fixedly connected with the narrow end of the tapered connection section 11, and the wide end of the tapered connection section 11 is fixedly connected with the grip section 12.
The radial length of the grip section 12 is greater than that of the puncture section 10, and two pipe sections with different radial lengths are connected through the conical section, so that a user can control the puncture end of the puncture pipe 1 to puncture the portal vein of an animal by holding the grip section 12, the operation difficulty of the user is reduced, and the puncture precision of the portal vein is improved.
It should be noted that the material of the puncture tube 1 includes, but is not limited to, stainless steel, and the shape of the puncture tube 1 includes, but is not limited to, a round shape, and those skilled in the art can select according to their actual needs.
Further, in order to achieve a good piercing function, as shown in fig. 1, the piercing end of the piercing section 10 is a beveled surface.
When the puncture needle is applied, the included angle between the puncture end of the bevel and the blood vessel to be punctured is 30-60 degrees, the success rate of puncturing the blood vessel is high, and the blood vessel is not easy to penetrate.
Further, in order to realize the function of visual observation, as shown in fig. 2, the radial distance of the catheter 2 is 0 to 3mm, and the catheter 2 is a transparent tube.
In application, the transparent catheter 2 is convenient for a user to observe the condition of blood sampling or drug administration, and the transparent material adopted in the embodiment includes, but is not limited to, one of Polyethylene (PE), polypropylene (PP), polyvinyl chloride (Polyvinyl Chloride, PVC), polyurethane (Polyurethane, PU), polytetrafluoroethylene (Poly Tetra Fluoroethylene, PTFE), polycarbonate (PC), and Polystyrene (PS) transparent tube, which can be selected by those skilled in the art according to their actual requirements.
Further, in order to realize the detachable connection between the catheter 2 and the connector 4, as shown in fig. 3, a second anti-release protrusion 400 is disposed on the connector opening 40 of the connector 4, and the catheter 2 and the connector 4 form elastic fitting connection.
The second anti-release protrusion 400 of the connector 40 forms an interference fit with the inner wall of the conduit 2, that is, the connector 40 of the connector 4 is tightly sealed with the inner wall of the conduit 2, so that the friction force between the conduit 2 and the connector 40 of the connector 4 is increased, and the conduit 2 can be kept sealed.
When the device is applied, after the catheter 2 is led out of the skin by the subcutaneous tunnel expander 3, the catheter 2 is elastically attached and sealed with the connector orifice 40 of the connector 4, and the connector 4 can be externally connected with a drug administration device or a blood sampling device, so that the administration or blood sampling of the portal vein in vitro can be realized.
Further, in order to achieve the function of fastening connection of the catheter 2 to the connector 4 port, as shown in fig. 3 and 4, the connector port 40 is provided with a fixing clip 401, and the fixing clip 401 is used for clipping the catheter 2 connected to the connector 4.
When the detachable fixing device is applied, the inner wall of the conduit 2 is in sealing elastic adhesion with the outer wall of the take-over port 40 of the joint 4, and after the end part of the conduit 2 is abutted against the left end part of the fixing buckle 401, a user pushes the fixing buckle 401 to enable the inner wall of the fixing buckle 401 to be in elastic adhesion with the outer wall of the conduit 2, so that the detachable fixing of the conduit 2 and the take-over port 40 of the joint 4 is realized.
Further, in order to realize the function of fixing the joint 4 on the skin of the animal, as shown in fig. 4, butterfly plates 42 are provided on both sides of the joint 4, and fixing through holes are provided on the butterfly plates 42.
In application, the butterfly plate 42 is tightly adhered to the skin, and the butterfly plate is fixed by threading through the fixing through hole and stitching with the skin, so that the medicine injection or blood collection of the animal portal vein can be conveniently carried out by a user.
Further, in order to realize the sealing and dust-proof functions of the connector 4, as shown in fig. 4, a screw cap 43 is sealingly connected to the syringe port 41.
When the device is applied, after a user finishes medicine injection or blood collection on the portal vein of an animal, the screw sealing cap 43 screws the injector interface 41 of the connector 4, so that dust can be effectively prevented from entering or blood can be effectively prevented from overflowing.
In summary, when the device is applied, a user punctures the portal vein by using the puncture tube 1, and leaves the catheter 2 in the portal vein, then the other end of the catheter 2 is detachably connected with the subcutaneous tunnel expander 3, the catheter 2 is led out of the body, after the catheter 2 is led out of the body, the catheter 2 is detachably connected with the connection tube 40 of the connector 4, and after the syringe interface 41 of the connector 4 is connected with the syringe, repeated or continuous drug injection or blood collection can be performed on the animal portal vein.
Example two
The second embodiment of an animal portal vein administration and blood collection device of the present utility model, which is substantially identical to the first embodiment, differs in the manner in which the catheter 2 is connected to the connector 4, the main difference being that the connection of the catheter 2 to the connector 4 is not an elastic snug connection of the catheter 2 to the connector 4, but rather that the catheter 2 is threaded with the connector 4.
Wherein, the joint 4 with external threads is arranged at the end of the conduit 2 extending out of the body, the joint orifice 40 of the joint 4 is arranged as an internal thread interface, and the external threads at the end of the conduit 2 extending out of the body are screwed with the internal threads of the joint orifice 40 of the joint 4 during operation, so that the conduit 2 is connected with the joint 4.
As can be seen from the first embodiment and the second embodiment, the first embodiment has the pipe orifice 40 and the pipe 2 in elastic fitting connection, and the second embodiment has the pipe 2 and the joint 4 in threaded connection, both of which are detachable connection, i.e. detachable connection is feasible.
Example III
A third embodiment of an animal portal vein administration and blood collection device according to the present utility model, which is basically identical to the first embodiment, is different from the butterfly plate 42 of the connector 4 in that the butterfly plate 42 is not provided with a fixing through hole, but the bottom of the butterfly plate 42 is provided with a skin adhesive.
In application, the user applies the butterfly plate 42 to the skin via the skin adhesive, which secures the fitting 4.
The specific structure and principle of the present utility model will be known from the first to third embodiments, and working steps of the present utility model will be described in detail below.
S1, preparing operation before operation, performing high-pressure sterilization on related surgical instruments such as forceps, tissue forceps, needle holders, surgical knives, vein clamps and the like, and packaging the sterilized instruments in a sterile oven for 12 hours at 80 ℃ for later use;
s2, animal preoperative anesthesia and skin preparation: anesthetizing the animal with 2% isoflurane, and dehairing the abdomen and back of the animal after anesthesia;
s3, fixing the animal in a supine position on a specific fixing device, and sterilizing the abdomen and back skin with 75% alcohol for 3 times; taking the navel as a central point, and cutting the navel along the upper and lower parts of the midline of the abdomen by 0-1.5 cm to expose the abdominal cavity;
s4, assembling the puncture tube 1 and the catheter 2, sucking 2mL of heparin physiological saline with the concentration of 125U/mL, and checking the quality and the tightness of the catheter 2;
s5, lightly poking the jejunum and ileum of the animal, searching superior mesenteric veins and splenic veins, and inserting a puncture cannula containing a puncture tube 1 and a catheter 2 with the diameter of 0-2.0 mm into the junction of the superior mesenteric veins and the splenic veins in the direction of 0-1.5 cm towards the liver;
s6, pulling out the puncture tube 1 after the syringe is pulled back to see venous blood, continuously inserting the catheter 2 to the hepatic portal for 0.5cm, suturing the vascular puncture part by using vascular suture lines and fixing the catheter 2;
s7, making a subcutaneous tunnel between the abdomen and the back skin of the animal by using the subcutaneous tunnel expander 3, leading the catheter 2 to the back skin through the subcutaneous tunnel expander 3, penetrating out of the body and connecting with the joint 4;
s8, resetting the jejunum and the ileum, and closing the abdominal cavity;
s9, sewing the butterfly plate 42 on the back skin by using a suture line on the butt joint 4;
s10, slowly drawing 0.3ml of blood after connecting a 2ml syringe;
s11, injecting 0-3ml heparin physiological saline, and sealing the end connector 4 by using a screw cap 10.
While the foregoing is directed to the preferred embodiments of the present utility model, it will be appreciated by those skilled in the art that changes and modifications may be made without departing from the principles of the utility model, such changes and modifications are also intended to be within the scope of the utility model.
Claims (8)
1. An animal portal vein administration and blood sampling device is characterized in that,
comprises a puncture tube, a subcutaneous tunnel expander and a joint;
one end of the catheter is detachably sleeved in the puncture tube, and the puncture tube is used for puncturing the portal vein of the animal and retaining the catheter in the portal vein of the animal;
the subcutaneous tunnel expander is detachably sleeved at the other end of the catheter, is provided with a first anti-falling protrusion, is elastically attached to the inner wall of the catheter, and is used for leading the catheter out of the animal body;
and two ends of the connector are provided with connector ports and injector connectors, and the connector ports are detachably connected with the guide pipe.
2. An animal portal vein administration and blood collection device according to claim 1 wherein,
the puncture tube comprises a puncture section, a conical connecting section and a handle section which are connected in sequence, wherein the puncture section is fixedly connected with the narrow end of the conical connecting section, and the wide end of the conical connecting section is fixedly connected with the handle section.
3. An animal portal vein administration and collection device as claimed in claim 2, wherein the piercing end of the piercing section is beveled.
4. The device of claim 1, wherein the mouthpiece is provided with a second anti-slip tab.
5. An animal portal vein administration and blood collection device as claimed in claim 4, wherein said adapter port is provided with a securing clip for clipping said catheter connected to said connector.
6. The device for administering and taking blood from an animal portal vein according to claim 1, wherein butterfly plates are provided on both sides of the connector, and fixing through holes are provided on the butterfly plates.
7. The device of claim 1, wherein the syringe port is sealingly connected with a screw cap.
8. The device of claim 1, wherein the catheter is a transparent tube.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320265593 | 2023-02-21 | ||
| CN2023202655939 | 2023-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219940887U true CN219940887U (en) | 2023-11-03 |
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ID=88545503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321220639.1U Active CN219940887U (en) | 2023-02-21 | 2023-05-19 | An animal portal vein drug delivery and blood collection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219940887U (en) |
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2023
- 2023-05-19 CN CN202321220639.1U patent/CN219940887U/en active Active
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