CN219921829U - Oral cavity slow release administration spherical device - Google Patents
Oral cavity slow release administration spherical device Download PDFInfo
- Publication number
- CN219921829U CN219921829U CN202321314160.4U CN202321314160U CN219921829U CN 219921829 U CN219921829 U CN 219921829U CN 202321314160 U CN202321314160 U CN 202321314160U CN 219921829 U CN219921829 U CN 219921829U
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- China
- Prior art keywords
- spherical
- spherical body
- fibronectin
- freeze
- diameter
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- 210000000214 mouth Anatomy 0.000 title claims abstract description 18
- 239000011148 porous material Substances 0.000 claims abstract description 46
- 102000016359 Fibronectins Human genes 0.000 claims abstract description 38
- 108010067306 Fibronectins Proteins 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 21
- 239000002775 capsule Substances 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 5
- 230000005855 radiation Effects 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims description 14
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- 230000003000 nontoxic effect Effects 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 claims 10
- 238000013268 sustained release Methods 0.000 claims 10
- 239000012730 sustained-release form Substances 0.000 claims 10
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 abstract description 12
- 231100000397 ulcer Toxicity 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 6
- 238000003860 storage Methods 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 3
- 238000004806 packaging method and process Methods 0.000 abstract description 3
- 239000002504 physiological saline solution Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 208000007117 Oral Ulcer Diseases 0.000 description 2
- 208000020670 canker sore Diseases 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 208000003265 stomatitis Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010028034 Mouth ulceration Diseases 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The oral cavity slow release administration spherical device comprises a spherical body, wherein the central part of the spherical body is hollow capsule, the hollow capsule is communicated with the surface of the spherical body through a cylindrical pore canal, a plurality of tiny conical pore canals which are distributed in radiation are also arranged between the hollow capsule and the surface of the spherical body, and the hollow capsule is filled with freeze-dried powder medicine. The device is characterized in that the fibronectin freeze-dried powder is contained in the hollow capsule of the spherical body, physiological saline is injected into the hollow capsule of the spherical body through a cylindrical pore canal when the device is used, the fibronectin freeze-dried powder is dissolved and contained in the oral cavity, and the fibronectin solution is extruded to the surface of the oral mucosa ulcer in a way of extruding the spherical body through the occlusion of the oral cavity and the teeth, so that a good treatment effect is achieved. The utility model has the advantages of delaying the administration time, increasing the administration frequency and ensuring the treatment effect; the method is characterized in that the fibronectin can be stored in a freeze-dried form at normal temperature, the fibronectin, the packaging device and the using device are integrated, and the whole process of production, storage and use is integrated, so that the limitations of the fibronectin in storage, transportation and use are overcome.
Description
Technical Field
The utility model relates to the field of packaging equipment and medical equipment, in particular to an oral cavity slow-release administration spherical device, and particularly relates to a fibronectin oral cavity slow-release administration spherical device.
Background
Canker sores (mouth ulcer) are one of the most common oral mucosal diseases, with prevalence of up to 20%. The pain of the ulcer part affects normal feeding when the patient is ill, and part of the patient has fever symptoms, so that the patient is very painful in physical and psychological aspects. Oral inflammation has also become one of the important diseases that plague people. The research, development and application exploration of the fibronectin are carried out for a long time, and the research discovers that the fibronectin has the effects of repairing canker sore, diminishing inflammation, inhibiting bacteria and relieving stomatitis, and the related research results are published in the 12 th stage of the 34 th volume of the 12 th edition of basic medicine and clinic 2014 of the national core journal of the treatment of canker sore by the paper with the name of Fibronectin (FN).
However, in practical and in-depth application research, we found that fibronectin has the following limitations in treating canker sores and oral inflammations: (1) The oral tissue structure is special, the ulcer is formed on the surface of the oral mucosa, if the fibronectin in the liquid form is sprayed on the surface of the ulcer, the fibronectin liquid tends to flow down from the surface of the ulcer quickly, the contact time of the fibronectin and the surface of the ulcer is shortened, and the treatment effect is influenced; (2) Fibronectin is a highly active protein, and in order to maintain its activity, fibronectin in liquid form needs to be stored by freezing at low temperature, which is inconvenient for storage and transportation, and has a certain limitation in use.
The utility model is based on the technical problems, and makes a great innovation and ingenious design, and the fibronectin is stored in the device in the form of freeze-dried powder, so that the fibronectin is delivered to the surface of the oral mucosa ulcer by the device when in use, the administration frequency is increased, the contact time of the fibronectin and the ulcer is prolonged, and the treatment effect of the fibronectin on the oral ulcer and the stomatitis is ensured.
Disclosure of Invention
The utility model aims to overcome the technical problems and provide the fibronectin oral cavity slow-release administration spherical device which has the advantages of simple structure, convenient use, and integrated three functions of production, storage and use.
The aim of the utility model is realized by the following technical scheme:
the utility model provides a spherical device of oral cavity slow release administration, includes the spheroid, and spheroid central part is empty sacculus, and empty sacculus communicates with the spheroid surface through a cylindricality pore, is equipped with the pore sealing plug on the cylindricality pore mouth on spheroid surface, still is equipped with a plurality of tiny cone-shaped pore that are radiation distribution between empty sacculus and the spheroid surface, empty sacculus is filled with freeze-dried powder medicine.
The spherical body and the pore canal sealing plug are elastic and chewable, and are prepared from nontoxic and harmless food-grade thermoplastic elastomer (TPE) materials.
The freeze-dried powder is fibronectin freeze-dried powder, and based on the freeze-dried powder, the oral cavity slow-release administration spherical device is fibronectin oral cavity slow-release administration spherical device.
The pore canal sealing plug is in threaded fit with the cylindrical pore canal.
The diameter of the spherical body is 1-3cm. The diameter of the hollow capsule at the central part of the spherical body is 1/2-1/4 of the diameter of the spherical body, preferably 1/3. The diameter of the cylindrical pore canal is 1/10-1/20 of the diameter of the spherical body.
The diameter of the tiny conical pore canal at the outlet position of the surface of the spherical body is 0.1-0.6 mm.
When the utility model is produced, the fibronectin freeze-dried powder liquid is contained in the hollow bag at the center of the spherical device, the pore canal plug is opened, freeze-drying is carried out according to the fibronectin freeze-dried powder production process, and after freeze-drying is finished, the pore canal plug is plugged, so that the utility model is obtained.
When the utility model is used, the pore canal plug is opened, physiological saline is injected into the central hollow bag along the cylindrical pore canal, freeze-dried powder is dissolved, the cylindrical pore canal is plugged by the pore canal plug, the whole spherical device is put into the oral cavity, and the spherical device is extruded in a mode of chewing teeth and oral muscle tissues, so that the fibronectin solution in the central hollow bag of the spherical device flows out to the surface of the spherical device through the tiny conical pore canal and then contacts with the surface of the oral mucosa ulcer, and the purpose of drug administration is achieved.
The utility model has the advantages that: the fibronectin freeze-dried powder is stored in a hollow bag at the center of the spherical device, is dissolved by normal saline, is extruded to the surface of the spherical device and is contacted with the ulcer surface of the oral mucosa, so that the administration time is delayed, the administration frequency is increased, the contact time of fibronectin and ulcer is prolonged, and the treatment effect is ensured.
The utility model has the advantages that the fibronectin can be stored in a freeze-dried form at normal temperature, and is integrated with packaging and use, the whole process of production, storage and use is integrated, and the limitations of the fibronectin in storage, transportation and use are overcome.
Drawings
FIG. 1 is a schematic view of the overall structure of the present utility model;
FIG. 2 is a schematic cross-sectional view of the present utility model;
in the figure: 1-spherical body, 2-pore canal sealing plug, 3-column pore canal, 4-tiny cone pore canal and 5-empty capsule.
Detailed Description
The technical scheme of the present utility model will be clearly and completely described below with reference to the accompanying drawings.
As shown in fig. 1: the utility model relates to a fibronectin oral cavity slow release administration spherical device, which comprises a spherical body 1, wherein the central part of the spherical body is in an empty capsule shape, an empty capsule 5 is communicated with the surface of the spherical body through a cylindrical pore canal 3, a pore canal sealing plug 2 is arranged on the cylindrical pore canal opening of the surface of the spherical body, a plurality of tiny conical pore canals 4 which are distributed in radiation are also arranged between the empty capsule and the surface of the spherical body, and fibronectin freeze-dried powder is filled in the empty capsule 5.
The spherical body 1 and the pore canal sealing plug 2 are elastic and chewable, and are prepared from nontoxic and harmless food-grade thermoplastic elastomer (TPE) materials.
The pore canal sealing plug 2 is in threaded fit with the cylindrical pore canal 3.
The diameter of the spherical body 1 is 1-3cm, and the diameter of the empty capsule 5 is 1/3 of the diameter of the spherical body 1.
The diameter of the cylindrical pore canal 3 is 1/10 of the diameter of the spherical body 1. The diameter of the tiny conical pore canal at the outlet position of the surface of the spherical body is 0.1-0.6 mm.
When the utility model is produced, the fibronectin freeze-dried powder feed liquid is filled in the empty bag through the cylindrical pore canal of the spherical body, the pore canal sealing plug is opened, freeze-drying production is carried out according to the fibronectin freeze-dried powder production process (namely freezing and vacuumizing), the produced freeze-dried powder can be directly filled in the empty bag, and after the freeze-drying is finished, the pore canal sealing plug 2 is plugged, so the utility model is obtained.
In addition, the hollow spherical body with the cylindrical pore canal and the tiny conical pore canal is formed by bonding two hollow hemispheres.
When the utility model is used, the pore canal sealing plug 2 is opened, then physiological saline is injected into the central hollow bag along the cylindrical pore canal 3, dry powder is dissolved and thawed, the cylindrical pore canal opening is plugged by the pore canal sealing plug 3, the whole spherical device is put into the oral cavity, and the spherical device is extruded in a mode of chewing teeth and oral muscle tissues, so that fibronectin solution in the central hollow bag of the spherical device flows out to the surface of the spherical device through the tiny conical pore canal 4 and then contacts with the surface of the oral mucosa ulcer, and the purpose of drug administration is achieved.
What is not described in detail in this specification is prior art known to those skilled in the art.
While the structure and operation of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations may be made to these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (11)
1. An oral cavity slow release administration spherical device, which is characterized in that: the freeze-dried powder medicine injection device comprises a spherical body, wherein the center part of the spherical body is in an empty capsule shape, the empty capsule is communicated with the surface of the spherical body through a cylindrical hole, a hole sealing plug is arranged on the cylindrical hole opening on the surface of the spherical body, a plurality of tiny conical holes which are distributed in a radiation way are also arranged between the empty capsule and the surface of the spherical body, and the empty capsule is filled with freeze-dried powder medicine.
2. The oral sustained release drug delivery spherical device of claim 1, wherein: the spherical body and the pore canal sealing plug have elasticity and can chew, and are prepared from nontoxic and harmless food-grade thermoplastic elastomer materials.
3. The oral sustained release drug delivery spherical device of claim 1, wherein: the freeze-dried powder is fibronectin freeze-dried powder.
4. The oral sustained release drug delivery spherical device according to claim 1 or 2, wherein: the pore canal sealing plug is in threaded fit with the cylindrical pore canal.
5. The oral sustained release drug delivery spherical device of claim 1, wherein: the diameter of the spherical body is 1-5cm.
6. The oral sustained release drug delivery spherical device of claim 5, wherein: the diameter of the spherical body is 1-3cm.
7. The oral sustained release drug delivery spherical device of claim 1, wherein: the diameter of the empty capsule is 1/2-1/4 of the diameter of the spherical body.
8. The oral sustained release drug delivery spherical device of claim 7, wherein: the diameter of the empty capsule is 1/3 of the diameter of the spherical body.
9. The oral sustained release drug delivery spherical device of claim 1, wherein: the diameter of the cylindrical pore canal is 1/10-1/20 of the diameter of the spherical body.
10. The oral sustained release drug delivery spherical device of claim 1, wherein: the diameter of the tiny conical pore canal at the outlet position of the surface of the spherical body is 0.1-0.6 mm.
11. The oral sustained release drug delivery spherical device of claim 1, wherein: the oral cavity slow-release administration spherical device is a fibronectin oral cavity slow-release administration spherical device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321314160.4U CN219921829U (en) | 2023-05-29 | 2023-05-29 | Oral cavity slow release administration spherical device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321314160.4U CN219921829U (en) | 2023-05-29 | 2023-05-29 | Oral cavity slow release administration spherical device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219921829U true CN219921829U (en) | 2023-10-31 |
Family
ID=88497477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321314160.4U Active CN219921829U (en) | 2023-05-29 | 2023-05-29 | Oral cavity slow release administration spherical device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219921829U (en) |
-
2023
- 2023-05-29 CN CN202321314160.4U patent/CN219921829U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant |