CN219846745U - Absorbable interface screw - Google Patents
Absorbable interface screw Download PDFInfo
- Publication number
- CN219846745U CN219846745U CN202123359718.4U CN202123359718U CN219846745U CN 219846745 U CN219846745 U CN 219846745U CN 202123359718 U CN202123359718 U CN 202123359718U CN 219846745 U CN219846745 U CN 219846745U
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- China
- Prior art keywords
- screw
- hole
- absorbable
- screw rod
- slow release
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 15
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 12
- 239000004626 polylactic acid Substances 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 26
- 230000012010 growth Effects 0.000 abstract description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 210000002435 tendon Anatomy 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000012667 polymer degradation Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
The utility model discloses an absorbable interface screw, which comprises a screw rod; the screw rod is made of absorbable materials, an external thread is formed in the circumferential direction of the screw rod, a first through hole is formed in the screw rod and located at the position of the root of the external thread, and the first through hole is used for filling functional medicines. Therefore, after the absorbable interface screw is implanted into the body, the absorbable interface screw can promote the growth of bone tissues along with the continuous release of the functional medicine in the first through hole; and after the functional medicine is released, the first through hole is empty, so that the bone tissue in-growth of the screw can be accelerated, and the screw can be completely replaced by the bone tissue finally.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to an absorbable interface screw.
Background
Polylactic acid material is synthesized by lactic acid monomer, has good biocompatibility, for example, polylactic acid can be degraded into lactic acid in vivo, enters tricarboxylic acid circulation, and is then changed into carbon dioxide and water through metabolism of human body so as to be discharged out of body. Polylactic acid has been approved by the FDA for authentication as a human implantable article. In the medical field, polylactic acid materials have been manufactured into medical materials such as bone nails, bone plates, vascular stents, surgical sutures, surgical guide plates, drug release materials, and artificial skin dressings, and thus applied to medical uses. At present, the bone nail made of polylactic acid can be directly implanted into a human body for treating diseased bone and can be naturally degraded in the human body, so that the problem that the bone nail needs to be taken out by secondary operation due to the fact that the bone nail cannot be degraded in the prior art is solved. Meanwhile, the utility model improves the growth speed of bone tissues of the traditional bone nails after being implanted into human bodies, which is a problem to be solved urgently.
Disclosure of Invention
Aiming at the problems in the prior art, the utility model provides an absorbable interface screw which can effectively improve the growth speed of bone tissues after the screw is implanted.
The present utility model provides an absorbable interface screw comprising: a screw; the screw rod is made of absorbable materials, an external thread is formed in the circumferential direction of the screw rod, a first through hole is formed in the screw rod and located at the position of the root of the external thread, and the first through hole is used for filling functional medicines.
Optionally, a second through hole is formed in the center of the screw rod and along the axial direction of the screw rod, and the second through hole is used for accommodating a support piece for supporting the screw rod; the second through hole is communicated with the first through hole.
Optionally, the first through holes are multiple; the plurality of first through holes are uniformly distributed along the axial direction of the screw rod and symmetrically distributed along the circumferential direction of the screw rod.
Optionally, the functional medicine is a slow release medicine and/or a growth active factor.
Optionally, the absorbable interface screw further comprises: a slow release carrier made of an absorbable polymer, the slow release carrier being disposed in the first through hole, the functional drug being filled in the slow release carrier.
Optionally, the slow release carrier is a block made of polylactic acid material and/or polyamino acid.
Optionally, the absorbable material comprises the following raw materials in parts by weight: 20-60 parts of absorbable polymer; 40-80 parts of hydroxyapatite.
Optionally, the absorbable polymer is any one or more of polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer and polycaprolactone.
Optionally, an included angle a between the axis of the first through hole and the axis of the second through hole is 0 ° < a.ltoreq.90.
Optionally, the diameter of the second through hole is 1/30 to 1/10 times of the diameter of the screw.
Compared with the prior art, the embodiment of the utility model has at least the following beneficial effects:
the absorbable interface screw comprises a screw rod; the screw is made of an absorbable material; the screw rod is provided with the external thread, and the first through hole is formed in the screw rod and positioned at the position of the root of the external thread, and the functional medicine is filled in the first through hole, so that the growth of bone tissues can be promoted along with the continuous release of the functional medicine in the first through hole after the absorbable interface screw is implanted into a body; and after the functional medicine is released, the first through hole is empty, so that the bone tissue in-growth of the screw can be accelerated, and the screw can be completely replaced by the bone tissue finally.
Drawings
The drawings are included to provide a better understanding of the present utility model and are not to be construed as limiting the utility model. Wherein:
FIG. 1 is a schematic view of a resorbable interface screw according to an embodiment of the present utility model;
FIG. 2 is a schematic view of a resorbable interface screw according to another embodiment of the present utility model.
Wherein, 10, screw rod, 20, external screw thread, 30, first through-hole, 40, second through-hole.
Detailed Description
In order to make the objects, technical solutions and advantages of the present utility model more apparent, the technical solutions of the present utility model will be clearly and completely described below in connection with the embodiments of the present utility model. It will be apparent that the described embodiments are some, but not all, embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
FIG. 1 is a schematic view of a resorbable interface screw according to an embodiment of the present utility model.
An absorbable interface screw comprising: a screw 10; the screw 10 is made of absorbable materials, an external thread 20 is formed in the circumferential direction of the screw 10, a first through hole 30 is formed in the screw 10 and located at the position of the root of the external thread 20, and the first through hole 30 is used for filling functional medicines. The shank 10 of the absorbable interface screw of the present embodiment is made of an absorbable material. The screw rod 10 is provided with the external thread 20, and the first through hole 30 is formed in the screw rod 10 and positioned at the position of the root of the external thread 20, and the functional medicine is filled in the first through hole 30, so that after the absorbable interface screw is implanted into a body, the functional medicine is released continuously along with the first through hole 30, and the growth of bone tissues can be promoted; and after the functional medicine is released, the first through hole 30 is empty, so that the in-growth of bone tissue into the screw can be accelerated, and the bone tissue can be completely replaced finally.
Here, the shape of the first through hole 30 is not limited, and the first through hole 30 may be any shape; for example, the screw may be a transverse hole perpendicular to the axial direction of the screw 10, or an inclined hole having a specific angle with respect to the axial direction of the screw 10.
In a preferred embodiment, a second through hole 40 is opened at the center of the screw 10 and along the axial direction of the screw 10, the second through hole 40 being for accommodating a support member supporting the screw 10; the second through hole 40 communicates with the first through hole 30. When implanting the absorbable interface screw into the tendon site, it is necessary to insert the support member fitted with the second through hole 40 into the second through hole 40 first, thereby improving the implantation strength of the absorbable interface screw. After the absorbable interface screw is implanted into the fractured portion, the support member needs to be withdrawn from the second through hole 40, and as the functional drug in the first through hole 30 is continuously released, the first through hole 30 becomes empty, thereby facilitating the penetrating flow of the tissue fluid between the first through hole 30 and the second through hole 40, and accelerating the ingrowth of bone tissue into the screw, thereby facilitating the final complete replacement of the screw by bone tissue.
In a preferred embodiment, the first through holes 30 are plural; the plurality of first through holes 30 are uniformly distributed along the axial direction of the screw 10 and symmetrically distributed along the circumferential direction of the screw 10. Specifically, the external thread 20 of the screw 10 extends in the circumferential direction of the screw 10 with the axis of the screw 10 as a center line; the plurality of first through holes 30 are distributed along the extending direction of the external thread 20, and the plurality of first through holes 30 positioned in the same circumferential direction of the screw 10 are symmetrically distributed; thereby, the plurality of first through holes 30 located in the same circumferential direction of the screw 10 are communicated through the second through holes 40, so that the penetrating flow of the tissue fluid is facilitated, and the repair of the bone tissue is improved.
In a preferred embodiment, the functional drug is a slow release drug and/or a growth active factor. The slow release drug may be, for example, a drug for tissue inflammation diminishing. Therefore, the preparation method can be used for fixing the tendon by selecting the medicament which is favorable for tissue growth and recovery, and is favorable for healing between the tendon and bone tissue; but also can relieve local inflammatory reaction of tissues caused by acidic products generated after degradation of the absorbable material.
In a preferred embodiment, the absorbable interface screw further comprises a slow release carrier made of an absorbable polymer, the slow release carrier being disposed within the first through hole, the functional drug being filled within the slow release carrier. Therefore, the absorbable polymer is adopted as the slow release carrier, so that the slow release carrier has the characteristics of controllable degradation speed and high speed, and can also wrap the functional medicine, thereby playing a supporting role on the functional medicine. In a more preferred embodiment, the slow release carrier is a block of polylactic acid material and/or polyamino acid. The block has a large porosity.
In a preferred embodiment, the absorbable material comprises the following raw materials in parts by weight: 20-60 parts of absorbable polymer; 40-80 parts of hydroxyapatite.
The absorbable polymer is excellent in biocompatibility; but has poor mechanical strength and insufficient hydrophilicity, has weak cell adhesion, and can absorb acidic products generated after polymer degradation, so that local inflammatory reaction in vivo is easy to be caused, thereby being unfavorable for bone cell growth and the like. However, the hydroxyapatite material is alkaline and can alleviate local inflammatory reactions of tissues due to acidic products generated after degradation of the resorbable material, while also providing a source of calcium as well as a source of phosphorus. Therefore, the hydroxyapatite material is combined with the absorbable polymer to prepare the absorbable interface screw, and the absorbable interface screw has good biocompatibility, bone conductivity and bone induction. Moreover, since the absorbable polymer has good biodegradability, pain to the patient caused by the secondary operation can be avoided.
According to the embodiment, the degradation rate of the prepared absorbable interface screw material can be kept consistent with the growth rate of natural bone tissues of tendon parts by reasonably configuring the ratio of the polymer material to the hydroxyapatite, so that healing between the tendon and the bone tissues is realized.
In a preferred embodiment, the absorbable polymer is polylactic acid, polyglycolic acid, polycaprolactone, or a combination thereof; in a more preferred embodiment, the mass ratio of polylactic acid to hydroxyapatite is 1 to 8:10. By adjusting the mass ratio of polylactic acid to hydroxyapatite, absorbable interface screws with different strength and degradation performance can be prepared.
In a preferred embodiment, the angle A between the axis of the second through hole 40 and the axis of the first through hole 30 is 0 DEG < A.ltoreq.90 deg.
In a preferred embodiment, the diameter of the second through hole 40 is 1/30 to 1/10 times the diameter of the screw 10. When the included angle A between the axis of the second through hole 40 and the axis of the first through hole 30 is 90 degrees, the first through hole 30 is a transverse hole, and the diameter of the transverse hole is 1/15-1/10 times of the diameter of the screw 10.
In a preferred embodiment, the number of first through holes 40 is 1 to 15; therefore, on the premise of ensuring the strength of the absorbable interface screw, the growth of tissues around the absorbable interface screw can be effectively promoted.
In the implantation stage, the absorbable interface screw filled with the functional medicine has better mechanical properties than the absorbable interface screw not filled with the functional medicine in the first through hole 30.
FIG. 2 is a schematic view of a resorbable interface screw according to another embodiment of the present utility model;
an absorbable interface screw otherwise constructed as in the embodiment of fig. 1; the only difference is that: when the included angle A between the axis of the second through hole 40 and the axis of the first through hole 30 is 0 DEG < A < 90 DEG, the first through hole 30 is an inclined hole, and the diameter of the inclined hole is 1/30-1/15 times of the diameter of the screw 10.
In the description of the present specification, a particular feature, structure, material, or characteristic described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present utility model, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
The foregoing is merely illustrative of the present utility model, and the present utility model is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present utility model. Therefore, the protection scope of the present utility model shall be subject to the protection scope of the claims.
Claims (7)
1. An absorbable interface screw, comprising: a screw;
the screw is made of an absorbable material, an external thread is formed in the circumferential direction of the screw, a first through hole is formed in the screw and located at the position of the root of the external thread, and the first through hole is used for filling functional medicines;
a second through hole is formed in the center of the screw rod and along the axial direction of the screw rod, and the second through hole is used for accommodating a supporting piece for supporting the screw rod;
the second through hole is communicated with the first through hole.
2. The absorbable interface screw of claim 1, wherein the angle a of the axis of the first through hole to the axis of the second through hole is 0 ° < a ∈90.
3. The absorbable interface screw of claim 1 or 2, wherein the diameter of the second through hole is 1/30 to 1/10 times the diameter of the screw shaft.
4. The absorbable interface screw of claim 1, wherein the first through hole has a plurality of holes; the plurality of first through holes are uniformly distributed along the axial direction of the screw rod and symmetrically distributed along the circumferential direction of the screw rod.
5. The absorbable interface screw of claim 1, wherein the functional drug is a slow release drug and/or a growth-active factor.
6. The absorbable interface screw of claim 1, further comprising:
a slow release carrier made of an absorbable polymer, the slow release carrier being disposed in the first through hole, the functional drug being filled in the slow release carrier.
7. The absorbable interface screw of claim 6, wherein the slow release carrier is a block of polylactic acid material and/or polyamino acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123359718.4U CN219846745U (en) | 2021-12-29 | 2021-12-29 | Absorbable interface screw |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123359718.4U CN219846745U (en) | 2021-12-29 | 2021-12-29 | Absorbable interface screw |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219846745U true CN219846745U (en) | 2023-10-20 |
Family
ID=88325444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202123359718.4U Active CN219846745U (en) | 2021-12-29 | 2021-12-29 | Absorbable interface screw |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219846745U (en) |
-
2021
- 2021-12-29 CN CN202123359718.4U patent/CN219846745U/en active Active
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