CN219830980U - Liquid chromatograph sample injection bottle for radioactive solution sample injection - Google Patents
Liquid chromatograph sample injection bottle for radioactive solution sample injection Download PDFInfo
- Publication number
- CN219830980U CN219830980U CN202320576797.4U CN202320576797U CN219830980U CN 219830980 U CN219830980 U CN 219830980U CN 202320576797 U CN202320576797 U CN 202320576797U CN 219830980 U CN219830980 U CN 219830980U
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- China
- Prior art keywords
- bottle
- sample injection
- liquid chromatograph
- cavity
- utility
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- 238000002347 injection Methods 0.000 title claims abstract description 38
- 239000007924 injection Substances 0.000 title claims abstract description 38
- 239000007788 liquid Substances 0.000 title claims abstract description 25
- 230000002285 radioactive effect Effects 0.000 title claims abstract description 25
- 239000000243 solution Substances 0.000 title claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 22
- 239000012528 membrane Substances 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 7
- -1 polytetrafluoroethylene Polymers 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 5
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 239000011133 lead Substances 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 3
- 229910052721 tungsten Inorganic materials 0.000 claims description 3
- 239000010937 tungsten Substances 0.000 claims description 3
- 230000005855 radiation Effects 0.000 abstract description 8
- 230000006378 damage Effects 0.000 abstract description 4
- 238000001514 detection method Methods 0.000 abstract description 4
- 238000005259 measurement Methods 0.000 abstract description 4
- 239000004033 plastic Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Abstract
The utility model discloses a liquid chromatograph sample injection bottle for radioactive solution sample injection, which comprises an external shielding body, an internal bottle and a bottle cap; the outer shielding body is internally provided with a containing cavity for containing an inner bottle, and the inner bottle is arranged in the containing cavity; the detachable cover of bottle lid is established in the top of outside shield, and the bottle lid corresponds the position of inside bottle and is equipped with the filtration subassembly that is used for filtering the sample. According to the utility model, the outer shielding body is arranged, the inner bottle is arranged in the outer shielding body, and the bottle cap is matched, so that the damage of radioactivity to surrounding personnel and instruments and equipment can be avoided, the background rise of the radioactive detection instrument caused by radiation is reduced, and the measurement accuracy is improved.
Description
Technical Field
The utility model relates to the technical field of production and manufacturing of sample injection bottles for liquid chromatographs, in particular to a sample injection bottle for a liquid chromatograph for radioactive solution sample injection.
Background
In the analysis 18 F、 68 Ga、 177 Lu、 64 Cu、 99m Tc、 89 Zr、 131 I、 123 The liquid chromatograph is required for the content of the radionuclide solution such as I or the radiopharmaceutical solution containing the above nuclides, impurities, radiochemical purity, and other indicators. The existing liquid chromatograph is provided with an automatic sampler, and before testing, a sample is only required to be filled into a sample injection bottle of the liquid chromatograph, and then the sample injection bottle is placed in a sample injection disc, and automatic analysis can be realized through instrument software control. However, the current sample injection bottles of the liquid chromatograph are all universal glass sample injection bottles, and are not suitable for radioactive solution sample injection, because the glass bottles have smaller radiation shielding to the radioactive solution, the radiation can cause injury to laboratory staff, and the radiation can also cause the background of the radioactive detection instrument to rise, so that the measurement error is increased. It is therefore necessary to design a liquid chromatograph sample bottle suitable for radioactive solution sample.
Disclosure of Invention
Aiming at the defects existing in the prior art, the utility model provides a liquid chromatograph sample injection bottle for radioactive solution sample injection.
The utility model discloses a liquid chromatograph sample injection bottle for radioactive solution sample injection, which comprises an external shielding body, an internal bottle and a bottle cap;
the outer shielding body is internally provided with a containing cavity for containing the inner bottle, and the inner bottle is arranged in the containing cavity;
the bottle cap is detachably covered above the outer shielding body, and a filter assembly for filtering samples is arranged at the position of the bottle cap corresponding to the inner bottle.
As a further improvement of the utility model, the external shielding body comprises a bottle body, a bottle body opening is arranged above the bottle body, external threads are arranged on the outer side of the bottle body opening, and internal threads matched with the external threads are arranged on the inner side of the edge of the bottle cap.
As a further improvement of the utility model, the bottom of the bottle body is a flat bottom, and the bottom of the bottle body of the internal bottle is an arc bottom;
the bottom shape of the accommodating cavity is matched with the bottom shape of the internal bottle;
after the internal bottle is placed in the accommodating cavity, the top of the bottle mouth of the internal bottle and the top of the opening of the bottle body are in the same plane.
As a further improvement of the present utility model, the filter assembly includes a filter membrane and a filter membrane support;
a cavity is formed in the filtering membrane support piece, a sample injection hole is formed in the bottle cap at a position corresponding to the cavity, and the bottom of the cavity is matched with the opening of the bottle body;
the filtering membrane is arranged in the cavity and used for isolating the sample injection hole from the opening of the bottle body.
As a further improvement of the present utility model, the materials of the outer shield include, but are not limited to, lead, iron and tungsten steel.
As a further improvement of the utility model, the materials of the bottle cap include but are not limited to polytetrafluoroethylene, polypropylene and aluminum.
As a further improvement of the present utility model, the inner bottle is a glass bottle body.
Compared with the prior art, the utility model has the beneficial effects that:
according to the utility model, the outer shielding body is arranged, the inner bottle is arranged in the outer shielding body, and the bottle cap is matched, so that the damage of radioactivity to surrounding personnel and instruments and equipment can be avoided, the background rise of the radioactive detection instrument caused by radiation is reduced, and the measurement accuracy is improved.
Drawings
FIG. 1 is a schematic diagram of a sample injection bottle for a liquid chromatograph for radioactive solution injection according to an embodiment of the present utility model;
FIG. 2 is a side cross-sectional view of an external shield of a liquid chromatograph sample vial for radioactive solution sample introduction according to one embodiment of the present utility model;
fig. 3 is a schematic view of a shielding sample pan structure of a sample bottle for a liquid chromatograph for radioactive solution sample injection according to an embodiment of the present utility model.
In the figure:
1. a bottle cap; 2. an inner bottle; 3. an outer shield; 4. a filter assembly; 5. and a sample feeding disc.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments of the present utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should also be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
The utility model is described in further detail below with reference to the attached drawing figures:
as shown in fig. 1-2, the utility model provides a liquid chromatograph sample injection bottle for radioactive solution sample injection, which comprises an external shielding body 3, an internal bottle 2 and a bottle cap 1; the outer shielding body 3 is internally provided with a containing cavity for containing the inner bottle 2, and the inner bottle 2 is arranged in the containing cavity; the bottle cap 1 is detachably covered above the outer shielding body, and a filter assembly 4 for filtering samples is arranged at the position of the bottle cap 1 corresponding to the inner bottle 2.
According to the utility model, the outer shielding body 3 is arranged, the inner bottle 2 is arranged in the outer shielding body 3, and the bottle cap 1 is matched, so that the damage of radioactivity to surrounding personnel and instruments and equipment can be avoided, the background rise of a radioactive detection instrument caused by radiation is reduced, and the measurement accuracy is improved.
Specific:
as shown in fig. 1-2, the external shielding body 3 in the utility model comprises a bottle body, a bottle body opening is arranged above the bottle body, external threads are arranged on the outer side of the bottle body opening, and internal threads matched with the external threads are arranged on the inner side of the edge of the bottle cap 1. The bottle body of the outer shield 3 in the present utility model is preferably a cylindrical bottle body.
Furthermore, the bottom of the bottle body of the external shielding body 3 is a flat bottom, the bottom of the bottle body of the internal bottle 2 is an arc bottom, and the arrangement of the arc bottom can facilitate the cleaning of operators on the internal bottle 2 without dead angles, and the top of the internal bottle 2 is in an opening shape; the bottom shape of the accommodating cavity is matched with the bottom shape of the internal bottle 2, so that the stability of the internal bottle 2 after being placed in the accommodating cavity can be ensured; after the internal bottle 2 is placed in the accommodating cavity, the top of the bottle mouth of the internal bottle 2 and the top of the opening of the bottle body are in the same plane.
Further, the filtering component 4 in the utility model comprises a filtering membrane and a filtering membrane supporting piece; the filtering membrane is used for filtering samples, the filtering membrane supporting piece is matched with the opening of the bottle body and used for supporting the filtering membrane, a cavity is formed in the filtering membrane supporting piece, a sample injection hole is formed in the position, corresponding to the cavity, of the bottle cap 1, and the bottom of the cavity is matched with the opening of the bottle body; the filtering membrane is arranged in the cavity and used for isolating the sample injection hole from the opening of the bottle body. The combination mode of the filtering membrane and the filtering membrane supporting piece is the existing design and is not described in detail herein.
Further, the filtering membrane in the utility model is made of silica gel, and the filtering membrane supporting piece is made of polytetrafluoroethylene.
Further, since the radiation mainly emitted by different types of radioactive solution samples may be different, and the common radiation with larger energy is β -radiation and γ -radiation, the material of the outer shielding body 3 in the present utility model may be adjusted according to the characteristics of the radioactive solution samples, and the material of the outer shielding body 3 in the present utility model includes but is not limited to heavy metals such as lead, iron, tungsten steel, etc., and may also be plastic, aluminum, graphite, etc.
Further, the material of the bottle cap 1 in the utility model can be plastic or metal, and polytetrafluoroethylene and polypropylene are preferable when plastic is selected, and aluminum is preferable when metal is selected. The bottle cap 1 can effectively prevent the sample inside the inner bottle 2 from volatilizing.
Further, the inner bottle 2 in the present utility model is a glass bottle, and borosilicate glass bottle is preferable as the inner bottle 2 in the present utility model.
Further, the dimensions and wall thickness of the outer shield 3 and the inner bottle 2 in the present utility model can be set according to the activity of the radioactive solution sample and the dimensions of the matching liquid chromatograph sample tray 5.
As shown in fig. 3, the height of the sample tray 5 can be increased in the utility model, so that sample bottles containing radioactive solution samples are placed in the sample tray 5 as much as possible, and only the sample bottle cap 1 is kept to expose the sample tray 5 or the sample bottles are completely below the height of the sample tray 5, so as to realize shielding of the sample tray 5 on the radioactive solution samples.
The application method of the embodiment comprises the following steps:
1) The sizes of the inner bottle 2 and the outer shielding body 3 are manufactured according to the characteristics of the radioactive solution sample to be accommodated and the size of the liquid chromatograph sample injection disc 5;
2) Placing the inner bottle 2 in the outer shielding body 3, injecting a proper amount of radioactive solution into the inner bottle 2 by using a syringe, and then screwing the bottle cap;
3) And placing the sample injection bottle with the bottle cap screwed in an automatic sample injector for chromatographic analysis.
The above is only a preferred embodiment of the present utility model, and is not intended to limit the present utility model, but various modifications and variations can be made to the present utility model by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.
Claims (7)
1. The liquid chromatograph sample injection bottle for radioactive solution sample injection is characterized by comprising an external shielding body, an internal bottle and a bottle cap;
the outer shielding body is internally provided with a containing cavity for containing the inner bottle, and the inner bottle is arranged in the containing cavity;
the bottle cap is detachably covered above the outer shielding body, and a filter assembly for filtering samples is arranged at the position of the bottle cap corresponding to the inner bottle.
2. The liquid chromatograph sample injection bottle of claim 1, wherein the external shield comprises a bottle body, a bottle body opening is arranged above the bottle body, an external thread is arranged on the outer side of the bottle body opening, and an internal thread matched with the external thread is arranged on the inner side of the edge of the bottle cap.
3. The liquid chromatograph sample injection bottle of claim 2, wherein the bottom of the bottle body is a flat bottom, and the bottom of the bottle body of the inner bottle is an arc bottom;
the bottom shape of the accommodating cavity is matched with the bottom shape of the internal bottle;
after the internal bottle is placed in the accommodating cavity, the top of the bottle mouth of the internal bottle and the top of the opening of the bottle body are in the same plane.
4. The liquid chromatograph sample bottle of claim 2, wherein said filter assembly comprises a filter membrane and a filter membrane support;
a cavity is formed in the filtering membrane support piece, a sample injection hole is formed in the bottle cap at a position corresponding to the cavity, and the bottom of the cavity is matched with the opening of the bottle body;
the filtering membrane is arranged in the cavity and used for isolating the sample injection hole from the opening of the bottle body.
5. The liquid chromatograph sample bottle of claim 1, wherein the material of said external shield comprises but is not limited to lead, iron and tungsten steel.
6. The liquid chromatograph sample injection bottle of claim 1, wherein the material of the bottle cap comprises but is not limited to polytetrafluoroethylene, polypropylene and aluminum.
7. The liquid chromatograph sample injection vial of claim 1, wherein said inner vial is a glass vial.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320576797.4U CN219830980U (en) | 2023-03-22 | 2023-03-22 | Liquid chromatograph sample injection bottle for radioactive solution sample injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320576797.4U CN219830980U (en) | 2023-03-22 | 2023-03-22 | Liquid chromatograph sample injection bottle for radioactive solution sample injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219830980U true CN219830980U (en) | 2023-10-13 |
Family
ID=88274198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320576797.4U Active CN219830980U (en) | 2023-03-22 | 2023-03-22 | Liquid chromatograph sample injection bottle for radioactive solution sample injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219830980U (en) |
-
2023
- 2023-03-22 CN CN202320576797.4U patent/CN219830980U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |