CN219810732U - Device for reducing infectious disease urine detection lower limit - Google Patents
Device for reducing infectious disease urine detection lower limit Download PDFInfo
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- CN219810732U CN219810732U CN202321179894.6U CN202321179894U CN219810732U CN 219810732 U CN219810732 U CN 219810732U CN 202321179894 U CN202321179894 U CN 202321179894U CN 219810732 U CN219810732 U CN 219810732U
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- chamber
- sample
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- urine
- lower limit
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- 210000002700 urine Anatomy 0.000 title claims abstract description 73
- 238000001514 detection method Methods 0.000 title claims abstract description 59
- 208000035473 Communicable disease Diseases 0.000 title claims abstract description 22
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 22
- 210000005239 tubule Anatomy 0.000 claims abstract description 40
- 238000005374 membrane filtration Methods 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000002274 desiccant Substances 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 241000700605 Viruses Species 0.000 abstract description 12
- 230000002458 infectious effect Effects 0.000 abstract description 7
- 230000035945 sensitivity Effects 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 description 25
- 239000012528 membrane Substances 0.000 description 22
- 230000000694 effects Effects 0.000 description 8
- 208000006379 syphilis Diseases 0.000 description 5
- 208000030507 AIDS Diseases 0.000 description 4
- 229910017053 inorganic salt Inorganic materials 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model belongs to the field of detection instruments, and provides a device for reducing the lower limit of urine detection of infectious diseases, which comprises a bottle body provided with a sample inlet and a sample outlet, wherein the bottle body is sequentially provided with a pressurizing chamber, a concentrating chamber and a storage chamber from top to bottom; a pressurizing piston is arranged in the pressurizing chamber, and a sample inlet penetrates through the side wall of the pressurizing chamber; a spiral coiled membrane filtration tubule is arranged in the concentration chamber; the storage chamber is provided with a sample outlet; the pressurizing chamber is communicated with the storage chamber through the membrane filtration tubule, and an exhaust valve is arranged at the top of the storage chamber. The device for reducing the lower detection limit of infectious disease urine provided by the utility model has the advantages of small volume, light weight and low cost, and a single urine sample is used as a single device, so that the urine sample is prevented from being polluted interactively, the concentration of the urine sample is realized, the lower detection limit of infectious virus antibodies is reduced, the detection sensitivity is improved, namely the detection is carried out after sample addition, and the detection accuracy and the detection efficiency are improved.
Description
Technical Field
The utility model belongs to the field of detection instruments, and particularly relates to a device for reducing the lower limit of detection of infectious disease urine.
Background
At present, aiming at the method for detecting infectious diseases such as syphilis, AIDS and the like through urine, a certain amount of urine sample is generally taken, the antibody content of the urine sample virus is detected, and the detection sensitivity is lower due to the fact that the sample adding amount is certain and the virus antibody content is low in detection, and when the urine sample is detected, the detection result is easily distorted and inaccurate due to the fact that the content of a target object to be detected is lower than the detection lower limit, so that the detection accuracy is influenced.
Therefore, it is necessary to design a device with high detection sensitivity, high accuracy and low detection limit of infectious disease urine.
Disclosure of Invention
The utility model provides a device for reducing the lower limit of infectious disease urine detection, which has the advantages of small volume, light weight and low cost, and a single urine sample is concentrated and detected by using a single device, so that the cross pollution of the urine sample is avoided, meanwhile, the concentration of the urine sample is realized, the lower limit of detection of infectious virus antibodies is reduced, the detection sensitivity is improved, namely the sample is added, namely the detection is performed, the concentration time is short, the detection accuracy is improved, the detection time is shortened, the sample adding amount of the urine sample is not required to be increased, and the detection efficiency is high.
The technical scheme of the utility model is as follows:
the utility model provides a device for reducing the lower limit of infectious disease urine detection, which comprises a bottle body provided with a sample inlet and a sample outlet, wherein the bottle body is sequentially provided with a pressurizing chamber, a concentrating chamber and a storage chamber from top to bottom;
a pressurizing piston is arranged in the pressurizing chamber, and a sample inlet penetrates through the side wall of the pressurizing chamber;
the inside of the concentration chamber is provided with a spiral coiled membrane filtration tubule, the membrane filtration tubule is a tubule with the function of filtering and penetrating the membrane, only water molecules and a small amount of inorganic salt can pass through the membrane filtration tubule to reach the outside of the membrane filtration tubule, and infectious virus antibodies in urine such as syphilis, AIDS and other virus antibodies can not pass through the membrane filtration tubule, so that the effect of filtering out the water molecules, a small amount of inorganic salt and concentrating a detected object is achieved, meanwhile, the pipe diameter is not easy to be set too large, a certain pressure is generated on the wall of the membrane filtration tubule when urine passes through, a certain pressure difference is ensured between the inside and outside of the membrane filtration tubule, and a sufficient contact area is ensured between the urine and the tubule, so that the filtering and concentrating effect is improved;
the storage chamber is provided with a sample outlet;
the pressurizing chamber is communicated with the storage chamber through the membrane filtration tubule, the top of the storage chamber is provided with an exhaust valve, when urine sample is added through the sample inlet, the exhaust valve is opened, and the sample is filtered and concentrated in the membrane filtration tubule.
Preferably, the sample inlet is provided with a check valve, so that partial urine is prevented from flowing back to the outside in the pressurizing process.
Preferably, the interior of the concentration chamber is filled with a drying agent, and moisture and part of inorganic salt filtered out by absorption and filtration are guaranteed to have a certain pressure difference between the inside and the outside of the membrane filtration tubule.
Preferably, the sample outlet is provided with a first control valve, the urine after filtration and concentration is stored in the storage chamber, the first control valve is opened for sampling, and the urine is used for the sample adding of the subsequent detection, or the urine is directly detected through the sample outlet connected with the detection equipment.
Preferably, a water outlet is arranged at the bottom of the concentration chamber, so that the water filtered out of the concentration chamber can be discharged, and a certain pressure difference between the inside and the outside of the membrane filter tubule is ensured.
Preferably, the outer wall of the storage chamber is provided with scale marks, so that quantitative and accurate sampling, detection and sample adding are convenient.
Compared with the prior art, the utility model has the following advantages and effects:
(1) The spiral coiled membrane filter tubule is adopted to filter out the water in the urine, so that the concentration of the infectious virus antibodies in the urine is realized, the detection lower limit is reduced, and the detection sensitivity and accuracy are improved;
(2) The single urine detection sample is concentrated and filtered by one device, namely, the single urine detection sample is a disposable filtering and concentrating device, so that the urine sample is prevented from being polluted interactively;
(3) The urine sample filtering and concentrating device has the advantages of small volume, simple structure, low manufacturing cost and short filtering and concentrating time for urine samples, namely, the urine sample is detected after being added, so that the detection time is shortened, and the detection efficiency is improved;
(4) The urine is pressurized by the pressurizing piston, so that the filtering effect of the urine in the membrane filtering tubule is improved, partial water and impurities are filtered, and infectious virus antibodies to be detected in the urine such as virus antibodies of syphilis, AIDS and the like are reserved;
(5) The concentration chamber is filled with the desiccant to absorb filtered water, so that the pressure difference between the inner side and the outer side of the membrane filtration tubule is increased, and the reduction of the filtration concentration effect of the membrane filtration tubule caused by excessive water accumulation is avoided.
Drawings
FIG. 1 is a schematic diagram of a device for reducing the lower limit of detection of infectious disease urine in embodiment 1 of the present utility model;
FIG. 2 is a schematic diagram of a device for reducing the lower limit of detection of infectious disease urine in embodiment 2 of the present utility model;
FIG. 3 is a schematic diagram of a device for reducing the lower limit of detection of infectious disease urine in embodiment 3 of the present utility model.
Reference numerals: 1-bottle, 11-pressurizing chamber, 111-pressurizing piston, 12-concentrating chamber, 121-membrane filter tubule, 122-drier, 13-storage chamber, 131-emptying valve, 2-sample inlet, 21-check valve, 3-sample outlet, 31-first control valve, 4-water outlet.
Detailed Description
The present utility model will now be described further in connection with specific embodiments for a better understanding of the present utility model by those skilled in the art.
Example 1:
as shown in fig. 1, the present utility model provides a device for reducing the lower limit of detection of urine of infectious disease, which is characterized in that: the device comprises a bottle body 1 provided with a sample inlet 2 and a sample outlet 3, wherein the bottle body 1 is sequentially provided with a pressurizing chamber 11, a concentrating chamber 12 and a storage chamber 13 from top to bottom;
the pressurizing chamber 11 is internally provided with a pressurizing piston 111 and a sample inlet 2 penetrating through the side wall of the pressurizing chamber 11;
the membrane filter tubule 121 is spirally wound in the concentration chamber 12, the membrane filter tubule 121 is a tubule with filtering and penetrating membrane functions, namely, the wall of the membrane filter tubule is provided with a filtering tubule with a penetrating membrane structure, only water molecules and a small amount of small molecular inorganic salts can pass through the wall of the membrane filter tubule 121 to reach the outside of the membrane filter tubule 121, and infectious virus antibodies in urine such as syphilis, AIDS and other virus antibodies can not pass through the membrane filter tubule 121, so that the effects of filtering partial moisture and a small amount of impurities in urine and concentrating target detection objects are achieved;
the storage chamber 13 is provided with a sample outlet 3;
the pressurizing chamber 11 is communicated with the storage chamber 13 through the membrane filtration tubule 121, the top of the storage chamber is provided with an evacuation valve 131, when urine sample is added through the sample inlet 2, the evacuation valve 131 is opened, air in the storage chamber 13 is discharged, and the sample flows into the storage chamber for storage after being filtered and concentrated in the membrane filtration tubule 121.
The sample inlet 2 is provided with a check valve 21 to prevent part of urine from flowing back to the outside in the pressurizing process.
The sample outlet 3 is provided with a first control valve 31, the urine after filtration and concentration is stored in the storage chamber 13, the first control valve 31 is opened for sampling, and the urine is used for the sample adding of the subsequent detection, or the urine is directly detected by connecting detection equipment through the sample outlet 3.
When the urine sample collecting device is specifically used, the collected urine sample is injected into the pressurizing chamber 11 through the sample inlet 2, the emptying valve 131 is opened, the first control valve 31 is closed, the pressurizing piston 111 is pressed downwards, the urine sample in the pressurizing chamber 11 flows into the membrane filtering tubule 121 under the action of pressure, when the urine sample flows through the membrane filtering tubule 121, the urine sample generates pressure on the pipe wall of the membrane filtering tubule 121 due to the fact that the pipe neck of the membrane filtering tubule 121 is smaller and the urine sample is pushed by the pressurizing piston 111, so that part of water and a small amount of inorganic salt in the urine sample flow to the outside through the pipe wall of the membrane filtering tubule 121 under the action of pressure, the pressurizing piston 111 reaches the bottom to finish filtering concentration, the urine sample after filtering concentration is stored in the storage chamber 13, if the sample amount is insufficient, the sample is selected to continue to be fed through the sample inlet 2, if the sample is sufficient, the pressurizing piston 111 is reset, the first control valve 31 is opened, the emptying valve 131 is closed, and the urine sample after concentration and the concentration in the storage chamber 13 is dripped into the urine sample detecting device after concentration is finished.
Example 2:
example 2 of the present utility model will be described with reference to fig. 2. In addition, the description of the parts not different from those of embodiment 1 will be omitted, and the same reference numerals will be given.
As shown in fig. 2, in the device for reducing the lower limit of detection of urine of infectious disease according to the present utility model, the desiccant 122 is filled in the concentration chamber 12, and most of the water and inorganic salts removed by filtration can be absorbed and filtered by the desiccant 122, so that a certain pressure difference between the inside and the outside of the membrane filter tubule 121 is ensured, and the condition that too much water is accumulated in the concentration chamber 12 to reduce the pressure difference between the inside and the outside of the membrane filter tubule 121, affect the filtration concentration effect, and even the condition that part of the water flows back to the membrane filter tubule 121 is avoided.
Example 3:
example 3 of the present utility model will be described with reference to fig. 3. In addition, the description of the parts not different from those of embodiment 1 will be omitted, and the same reference numerals will be given.
As shown in fig. 3, the device for reducing the lower limit of infectious disease urine detection according to the present utility model is provided with the water outlet 4 at the bottom of the concentration chamber 12, so that the filtered water in the concentration chamber 12 can be discharged in real time, and excessive accumulation of water in the concentration chamber 12 is avoided, so that a certain pressure difference between the inside and the outside of the pipe wall of the thin membrane filter pipe 121 is ensured, and the effect of filtering most of water and inorganic salts in the urine sample is realized.
The outer wall of the storage chamber 13 is provided with scale marks, and an operator can conduct quantitative, accurate sampling or sample adding detection according to the scale marks, so that whether the sample amount is enough or not can be accurately judged.
In summary, the device for reducing the lower limit of infectious disease urine detection provided by the utility model has the advantages of small volume, light weight and low cost, and a single urine sample is concentrated and detected by using a single device, so that the urine sample is prevented from being polluted interactively, meanwhile, the concentration of the urine sample is realized, the lower limit of detection of infectious viruses such as syphilis and HIV antibodies is reduced, the detection sensitivity is improved, namely the sample is added, the detection is carried out, the concentration time is short, the detection accuracy is improved, the detection time is shortened, the sample adding amount of the urine sample is not required to be increased, and the detection efficiency is high.
The foregoing is only illustrative of the present utility model and is not to be construed as limiting the scope of the utility model, which is defined by the appended claims.
Claims (6)
1. The utility model provides a reduce device of infectious disease urine detection lower limit, includes bottle (1) that is equipped with sample inlet (2) and goes out appearance mouth (3), its characterized in that: the bottle body (1) is sequentially provided with a pressurizing chamber (11), a concentrating chamber (12) and a storage chamber (13) from top to bottom;
a pressurizing piston (111) and a sample inlet (2) penetrating through the side wall of the pressurizing chamber (11) are arranged in the pressurizing chamber (11);
a spiral coiled membrane filtration tubule (121) is arranged in the concentration chamber (12);
the storage chamber (13) is provided with a sample outlet (3);
the pressurizing chamber (11) is communicated with the storage chamber (13) through the membrane filtration tubule (121), and an exhaust valve (131) is arranged at the top of the storage chamber (13).
2. The device for reducing the lower limit of urine detection for infectious diseases according to claim 1, wherein: the sample inlet (2) is provided with a check valve (21).
3. The device for reducing the lower limit of urine detection for infectious diseases according to claim 1, wherein: the interior of the concentrating chamber (12) is filled with a desiccant (122).
4. The device for reducing the lower limit of urine detection for infectious diseases according to claim 1, wherein: the sample outlet (3) is provided with a first control valve (31).
5. The device for reducing the lower limit of urine detection for infectious diseases according to claim 1, wherein: a water outlet (4) is arranged at the bottom of the concentration chamber (12).
6. The device for reducing the lower limit of urine detection for infectious diseases according to claim 1, wherein: the outer wall of the storage chamber (13) is provided with scale marks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321179894.6U CN219810732U (en) | 2023-05-16 | 2023-05-16 | Device for reducing infectious disease urine detection lower limit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321179894.6U CN219810732U (en) | 2023-05-16 | 2023-05-16 | Device for reducing infectious disease urine detection lower limit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219810732U true CN219810732U (en) | 2023-10-10 |
Family
ID=88217441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321179894.6U Active CN219810732U (en) | 2023-05-16 | 2023-05-16 | Device for reducing infectious disease urine detection lower limit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219810732U (en) |
-
2023
- 2023-05-16 CN CN202321179894.6U patent/CN219810732U/en active Active
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