CN219758006U - Device for measuring molecular weight of sodium hyaluronate dry powder - Google Patents
Device for measuring molecular weight of sodium hyaluronate dry powder Download PDFInfo
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- CN219758006U CN219758006U CN202321024405.XU CN202321024405U CN219758006U CN 219758006 U CN219758006 U CN 219758006U CN 202321024405 U CN202321024405 U CN 202321024405U CN 219758006 U CN219758006 U CN 219758006U
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- barrel
- cover body
- inner barrel
- buffer tube
- sodium hyaluronate
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- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 51
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 51
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 51
- 239000000843 powder Substances 0.000 title claims abstract description 28
- 238000003756 stirring Methods 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 4
- 239000010935 stainless steel Substances 0.000 claims abstract description 4
- 239000012780 transparent material Substances 0.000 claims abstract description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 14
- 229910052742 iron Inorganic materials 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 64
- 239000011148 porous material Substances 0.000 abstract description 24
- 238000012360 testing method Methods 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 13
- 238000005259 measurement Methods 0.000 abstract description 7
- 230000000694 effects Effects 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 5
- 229920002674 hyaluronan Polymers 0.000 description 5
- 229960003160 hyaluronic acid Drugs 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- GQWNECFJGBQMBO-UHFFFAOYSA-N Molindone hydrochloride Chemical compound Cl.O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 GQWNECFJGBQMBO-UHFFFAOYSA-N 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 125000000600 disaccharide group Chemical group 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002633 protecting effect Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 159000000000 sodium salts Chemical group 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000000196 viscometry Methods 0.000 description 1
Landscapes
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
Abstract
The utility model discloses a device for measuring molecular weight of sodium hyaluronate dry powder, which comprises an outer barrel and an inner barrel, wherein the inner barrel is suspended in the outer barrel, a jacket cavity is formed between the inner barrel and the outer barrel, the barrel wall and the inner barrel of the outer barrel are made of transparent materials, a bottom plate of the outer barrel is made of stainless steel materials, a thermocouple extending into the jacket cavity is arranged on the bottom plate, a first cover body covers an upper port of the inner barrel, a first pore passage, a second pore passage and a third pore passage are arranged on the first cover body, a buffer tube, a Ubbelohde viscometer and a thermometer are all positioned in the inner barrel, the buffer tube corresponds to the first pore passage, a plurality of through holes are formed in the buffer tube, a stirring paddle is positioned in the buffer tube, and driving motors at the upper ends of the thermocouple, the thermometer and the stirring paddle are all connected with a control system. In the viscosity test process, the temperature of the water body where the Ubbelohde viscometer is positioned always keeps controlled in a stable state, so that interference to a viscosity test result is avoided, and the accuracy of a molecular weight measurement result of sodium hyaluronate dry powder is ensured.
Description
Technical Field
The utility model relates to the technical field of molecular weight measurement auxiliary equipment, in particular to a device for measuring molecular weight of sodium hyaluronate dry powder.
Background
Hyaluronic Acid (HA), also known as Hyaluronic Acid, is a mucopolysaccharide formed by alternately connecting glucuronic Acid and N-acetamido glucosamine as disaccharide units. Hyaluronic acid is widely present in connective, epithelial and nervous tissues. Commercially available hyaluronic acid will be present in its sodium salt form, known as sodium hyaluronate.
Sodium hyaluronate has strong lubricating feel and film forming property. The skin care product added with the sodium hyaluronate has obvious lubrication effect and good hand feeling when being smeared, for example, the hair care product containing the sodium hyaluronate can form a layer of film on the surface of hair, thereby playing roles of moisturizing, lubricating, protecting hair, eliminating static electricity and the like.
Sodium hyaluronate has high viscosity in aqueous solution, and 1% aqueous solution thereof can be added into cosmetics in gel form to achieve thickening and stabilizing effects. Sodium hyaluronate belongs to a high molecular polymer, the molecular weight of the sodium hyaluronate is a key factor which is particularly important in determining the use effect of the sodium hyaluronate, and the moisturizing, thickening and film forming effects of sodium hyaluronate with different molecular weights are different. Sodium hyaluronate, which is common in the market, has a molecular weight ranging from thousands to millions, and the price is also very different because of the molecular weight, and the larger the molecular weight is, the more expensive the sales price is.
Sodium hyaluronate (sodium hyaluronate) is a macromolecular linear polysaccharide whose average molecular weight can be determined by methods such as viscometry, gel chromatography, light scattering and ultracentrifugation. The viscosity method is to measure the intrinsic viscosity of a sample and calculate the average molecular weight by using an empirical formula, and the average molecular weight is called viscosity average molecular weight. The viscosity method is the most commonly used molecular weight measuring method because the instrument is simple, the reference substance with known molecular weight is not needed, and the operation is simple and easy.
Currently, methods for measuring intrinsic viscosity generally include a one-point method and a multi-point dilution method. According to the literature, it is reported that when certain conditions are met, the intrinsic viscosity of the polymer can be measured by a one-point method, which is relatively simple to operate compared with a multi-point method, and therefore, is a more commonly used molecular weight measurement method.
Because the sodium hyaluronate needs to be subjected to an intrinsic viscosity test under a specific temperature condition, the temperature control is realized through a water bath when the intrinsic viscosity of a substance at a certain temperature is measured in the prior art, namely, the Ubbelohde viscometer is placed in the water bath. In order to keep the water temperature in the water bath uniform and constant, a rotor is usually added into the water bath, and the rotor is driven to rotate by the magnetic field in the water bath to stir the water body. The method for measuring the material viscosity at a certain temperature by adopting the water bath temperature control has the following problems: (1) The heating coil in the water bath directly heats the outer side of the water in the water bath, and the non-uniform heating effect of the water in the water bath is obvious, so that the accuracy of the material viscosity measurement result at a certain temperature is poor; (2) The rotor stirring enables the water body to keep in a relatively severe rotating state, influences the viscosity measurement result of the Ubbelohde viscometer, and also leads to inaccurate viscosity measurement result.
Disclosure of Invention
The utility model aims to overcome the defects in the prior art, and provides a device for measuring the molecular weight of sodium hyaluronate dry powder, when the device is used, a certain amount of water is contained in a jacket cavity and an inner barrel, a temperature value is set through a control system, a working switch is started, a thermocouple heats the water in the jacket cavity, the water in the jacket cavity heats the water in the inner barrel, a stirring paddle continuously stirs the water in a buffer tube, so that the water in the inner barrel is kept in a stable state, when the temperature of the water in the inner barrel reaches the set temperature value, the viscosity of sodium hyaluronate at the temperature can be measured, the molecular weight of sodium hyaluronate dry powder is calculated according to measured viscosity data, wherein the temperature of the water in the inner barrel is always kept in the stable state, the temperature of the water in the inner barrel is effectively prevented from being uneven, and meanwhile, the water in the Ubbelohde viscometer is always in the stable state through the buffering function of the buffer tube, the interference on a viscosity test result is avoided, and the accurate sodium hyaluronate viscosity measurement result is ensured, namely the viscosity of sodium hyaluronate is accurately measured; the whole structure is simple in design, high in preparation and implementation feasibility and high in practicability.
In order to achieve the above purpose, the technical scheme of the utility model is to design a device for measuring the molecular weight of sodium hyaluronate dry powder, which comprises an outer barrel, an inner barrel, a cover body I, a buffer tube, a Ubbelohde viscometer, a thermometer, a stirring paddle, a iron stand and a control system, wherein the upper end of the wall of the inner barrel is provided with a first eave body extending outwards, the inner barrel is positioned inside the outer barrel, the first eave body is in suspension lap joint with the upper end edge of the outer barrel, a jacket cavity is formed between the inner barrel and the outer barrel, the barrel wall and the inner barrel of the outer barrel are made of transparent materials, the bottom plate of the outer barrel is made of stainless steel materials, the bottom plate is provided with a thermocouple extending to the inside of the jacket cavity, the cover body I is covered on the upper port of the inner barrel, the cover body I is provided with a pore channel with an inner diameter which is sequentially reduced, the buffer tube, the Ubbelohde viscometer and the thermometer are positioned inside the inner barrel, the buffer tube corresponds to the upper end edge of the outer barrel, the first heat sink motor is fixedly arranged on the first heat sink, the second heat sink motor is fixedly arranged on the top of the buffer tube, the second heat sink motor is fixedly arranged on the upper end of the buffer tube, the buffer tube is fixedly arranged on the upper end of the buffer body, the buffer meter is fixedly arranged on the upper end of the buffer body, and the upper end of the buffer meter is fixedly arranged at the end of the buffer meter, and the buffer meter is fixedly penetrates through the upper end, and the upper end of the buffer meter.
When the device for measuring the molecular weight of the sodium hyaluronate dry powder is used, a certain amount of water is contained in a jacket cavity and an inner barrel, a temperature value is set through a control system, a working switch is started, a thermocouple heats the water in the jacket cavity, the water in the jacket cavity heats the water in the inner barrel, meanwhile, a stirring paddle continuously stirs the water in a buffer tube, so that the water in the inner barrel is kept at a stable state, when the temperature of the water in the inner barrel reaches a set temperature value, the viscosity of sodium hyaluronate at the temperature can be measured, the molecular weight of the sodium hyaluronate dry powder is calculated according to measured viscosity data, wherein the temperature of the water in the stable state is always kept in the viscosity test process, the temperature of the water in the inner barrel is effectively prevented from being uneven, and meanwhile, the water in the stable state is always kept through the buffer effect of the buffer tube, the viscosity test result is prevented from being disturbed, and the accuracy of the sodium hyaluronate viscosity test result is ensured, namely the accuracy of the sodium hyaluronate dry powder is ensured; the whole structure is simple in design, high in preparation and implementation feasibility and high in practicability.
The preferred technical scheme is that the clamping assembly comprises a second cover body, the outer diameter of the second cover body is larger than the inner diameter of the second pore canal, a plurality of second through holes are formed in the second cover body, a second clamp is arranged on the lower end face of the second cover body, a clamping head of the second clamp corresponds to one of the second through holes, the second cover body covers the second pore canal, and the upper end of the Ubbelohde viscometer penetrates through the second through holes in the second cover body and is clamped and fixed on the clamping head of the second clamp. The clamping assembly is ingenious and reasonable in structural design, convenient for taking and placing the Ubbelohde viscometer in the inner barrel, and beneficial to improving convenience of operation of a viscosity measurement experiment.
Further preferably, the buffer tube is provided with a second eave extending outwards at its upper end, and the buffer tube is suspended on the outer periphery of the first hole in the first cover through the second eave. The buffer tube hangs on the outer periphery of first pore in lid one, and the buffer tube of being convenient for is got and is put, makes buffer tube lower extreme and interior barrel bottom unsettled a section of distance simultaneously, and the water series flow of being convenient for further ensures the constant temperature effect of water.
In order to facilitate the operators to observe the temperature of the water body in the inner barrel in real time, a further preferable technical scheme is that the thermometer is a digital display thermometer.
In order to prevent the thermocouple from being crushed and improve the convenience of thermocouple wiring derivation, a further preferred technical scheme is that a plurality of supporting legs are arranged on the bottom plate of the outer barrel.
The utility model has the advantages and beneficial effects that:
when the device for measuring the molecular weight of the sodium hyaluronate dry powder is used, a certain amount of water is contained in a jacket cavity and an inner barrel, a temperature value is set through a control system, a working switch is started, a thermocouple heats the water in the jacket cavity, the water in the jacket cavity heats the water in the inner barrel, meanwhile, a stirring paddle continuously stirs the water in a buffer tube, so that the water in the inner barrel is kept at a stable state, when the temperature of the water in the inner barrel reaches a set temperature value, the viscosity of sodium hyaluronate at the temperature can be measured, the molecular weight of the sodium hyaluronate dry powder is calculated according to measured viscosity data, wherein the temperature of the water in the stable state is always kept in the viscosity test process, the temperature of the water in the inner barrel is effectively prevented from being uneven, and meanwhile, the water in the stable state is always kept through the buffer effect of the buffer tube, the viscosity test result is prevented from being disturbed, and the accuracy of the sodium hyaluronate viscosity test result is ensured, namely the accuracy of the sodium hyaluronate dry powder is ensured; the whole structure is simple in design, high in preparation and implementation feasibility and high in practicability.
Drawings
FIG. 1 is a top perspective view of an apparatus for measuring molecular weight of sodium hyaluronate dry powder according to the present utility model (with a cover II removed);
FIG. 2 is a resolution diagram (cover II is removed) of the device for measuring molecular weight of sodium hyaluronate dry powder according to the present utility model;
FIG. 3 is a longitudinal cross-sectional view of the device for measuring molecular weight of sodium hyaluronate dry powder (with cover two removed) according to the present utility model;
FIG. 4 is an enlarged view of a portion of H in FIG. 3;
FIG. 5 is a schematic structural view of a buffer tube;
fig. 6 is a schematic bottom view of the second cover.
In the figure: 1. an outer tub; 2. an inner barrel; 3. a first cover body; 4. a buffer tube; 5. an Ubbelohde viscometer; 6. a thermometer; 7. stirring paddles; 8. a driving motor; 9. an iron stand; 10. a first clamp; 11. a second cover body; 1-1, a bottom plate; 1-2, supporting legs; 1-3, thermocouple; 2-1, eave body I; 3-1, a first pore canal; 3-2, a second pore canal; 3-3, a pore canal III; 4-1, a first through hole; 4-2, eave body II; 11-1, clip II; 11-2, a second through hole.
Detailed Description
The following describes the embodiments of the present utility model further with reference to the drawings and examples. The following examples are only for more clearly illustrating the technical aspects of the present utility model, and are not intended to limit the scope of the present utility model.
Examples
As shown in figures 1-6, the utility model relates to a device for measuring molecular weight of sodium hyaluronate dry powder, which comprises an outer barrel 1, an inner barrel 2, a cover body I3, a buffer tube 4, an Ubbelohde viscometer 5, a thermometer 6, a stirring paddle 7, an iron stand table 9 and a control system, wherein the upper end of the barrel wall of the inner barrel 2 is provided with an eave body I2-1 extending outwards, the inner barrel 2 is positioned in the outer barrel 1, the eave body I2-1 is hung and overlapped on the upper end edge of the outer barrel 1, a jacket cavity is formed between the inner barrel 2 and the outer barrel 1, the barrel wall and the inner barrel 2 of the outer barrel 1 are both made of transparent materials, a bottom plate 1-1 of the outer barrel 1 is made of stainless steel materials, the bottom plate 1-1 is provided with a thermocouple 1-3 extending into the jacket cavity, the cover body I3 is covered on the upper port of the inner barrel 2, the cover body I3 is provided with a first pore canal 3-1, a second pore canal 3-2 and a third pore canal 3-3 with sequentially reduced inner diameters, the buffer tube 4, the Ubbelohde viscometer 5 and the thermometer 6 are all positioned in the inner barrel 2, the buffer tube 4 corresponds to the first pore canal 3-1, the buffer tube 4 is provided with a plurality of through holes I4-1, the stirring paddle 7 is positioned in the buffer tube 4, the driving motor 8 at the upper end of the stirring paddle 7 clamps and is fixedly arranged on the clamp I10 on the iron stand 9, the upper end of the Ubbelohde viscometer 5 passes through the second pore canal 3-2 to extend to the upper end of the cover body I3, the Ubbelohde viscometer 5 is hung on the outer periphery of the second pore canal 3-2 through a clamping component, the upper end of the thermometer 6 passes through the third pore canal 3-3 to extend to the upper end of the cover body I3, the thermocouples 1-3, the thermometer 6 and the driving motor 8 are all connected with the control system.
Preferably, the clamping assembly comprises a second cover body 11, the outer diameter of the second cover body 11 is larger than the inner diameter of the second pore canal 3-2, a plurality of second through holes 11-2 are formed in the second cover body 11, a second clamp 11-1 is arranged on the lower end face of the second cover body 11, the clamping head of the second clamp 11-1 corresponds to one second through hole 11-2, the second cover body 11 covers the second pore canal 3-2, and the upper end of the Ubbelohde viscometer 5 penetrates through the plurality of second through holes 11-2 in the second cover body 11 and is clamped and fixed on the clamping head of the second clamp 11-1.
Further preferably, the buffer tube 4 is provided with an eave body two 4-2 extending outwards, and the buffer tube 4 is hung on the outer periphery of the hole channel one 3-1 on the cover body one 3 through the eave body two 4-2.
Further preferably, the thermometer 6 is a digital display thermometer.
Further preferably, the bottom plate 1-1 of the outer barrel 1 is provided with a plurality of supporting legs 1-2.
The utility model relates to a device for measuring the molecular weight of sodium hyaluronate dry powder, which adopts the principle that:
the inner barrel 2 is hung in the outer barrel 1 through the eave body I2-1, a certain amount of water is respectively added into the outer barrel 1 and the inner barrel 2, the cover body I3 is covered on the upper port of the inner barrel 2, the buffer tube 4 is hung on the outer periphery of the pore canal I3-1 on the cover body I3 through the eave body II 4-2, the stirring slurry 7 is placed in the buffer tube 4, the driving motor 8 is clamped on the clamping head of the clamp I10 on the iron stand 9, the lower end of the thermometer 6 penetrates through the pore canal III 3-3 on the cover body I3 and extends into the water body of the inner barrel 2; setting a temperature value through a control system, starting a working switch, driving a stirring paddle 7 to rotate by a driving motor 8, heating a water body in a jacket cavity between an outer barrel 1 and an inner barrel 2 by a thermocouple 1-3, and heating a water body in the jacket cavity between the outer barrel 1 and the inner barrel 2 by the water body in the jacket cavity between the outer barrel 1 and the inner barrel 2; when the temperature of the thermometer 6 reaches a set temperature value, the lower end of the Ubbelohde viscometer 5 passes through a pore canal II 3-2 on a cover body I3 and extends into the water body of the inner barrel 2, then the cover body II 11 covers the pore canal II 3-2, the upper end of the tube body of the Ubbelohde viscometer 5 passes through a corresponding through hole II 11-2, and the Ubbelohde viscometer 5 is clamped and fixed on a chuck of a clamp II 11-1; and (3) starting the sodium hyaluronate viscosity test at the temperature, and converting the viscosity data obtained by the test into the corresponding molecular weight of sodium hyaluronate dry powder.
When the device for measuring the molecular weight of the sodium hyaluronate dry powder is used, a certain amount of water is contained in a jacket cavity and an inner barrel, a temperature value is set through a control system, a working switch is started, a thermocouple heats the water in the jacket cavity, the water in the jacket cavity heats the water in the inner barrel, meanwhile, a stirring paddle continuously stirs the water in a buffer tube, so that the water in the inner barrel is kept at a stable state, when the temperature of the water in the inner barrel reaches a set temperature value, the viscosity of sodium hyaluronate at the temperature can be measured, the molecular weight of the sodium hyaluronate dry powder is calculated according to measured viscosity data, wherein the temperature of the water in the stable state is always kept in the viscosity test process, the temperature of the water in the inner barrel is effectively prevented from being uneven, and meanwhile, the water in the stable state is always kept through the buffer effect of the buffer tube, the viscosity test result is prevented from being disturbed, and the accuracy of the sodium hyaluronate viscosity test result is ensured, namely the accuracy of the sodium hyaluronate dry powder is ensured; the whole structure is simple in design, high in preparation and implementation feasibility and high in practicability.
The foregoing is merely a preferred embodiment of the present utility model, and it should be noted that it will be apparent to those skilled in the art that several modifications and variations can be made without departing from the technical principle of the present utility model, and these modifications and variations should also be regarded as the scope of the utility model.
Claims (5)
1. A device for measuring the molecular weight of sodium hyaluronate dry powder is characterized by comprising an outer barrel (1), an inner barrel (2), a cover body I (3), a buffer tube (4), a Ubbelohde viscometer (5), a thermometer (6), a stirring paddle (7), an iron stand table (9) and a control system, wherein the upper end of the barrel wall of the inner barrel (2) is provided with an eave body I (2-1) extending outwards, the inner barrel (2) is positioned inside the outer barrel (1), the eave body I (2-1) is hung and overlapped on the upper end edge of the outer barrel (1), a jacket cavity is formed between the inner barrel (2) and the outer barrel (1), the barrel wall of the outer barrel (1) and the inner barrel (2) are made of transparent materials, a base plate (1-1) of the outer barrel (1) is made of stainless steel materials, a thermocouple (1-3) extending to the inside of the jacket cavity is arranged on the upper end of the base plate (1-1), the cover body I (3) is covered on the upper end edge of the inner barrel (2), the inner barrel I (3) is provided with a hole channel II-3, the inner diameter of the buffer tube II-3 and the inner bore channel (3) are sequentially formed between the inner barrel (3) and the buffer tube (3), the buffer tube (4) is corresponding to the first hole channel (3-1), a plurality of first through holes (4-1) are formed in the buffer tube (4), the stirring paddles (7) are located in the buffer tube (4), the driving motor (8) at the upper end of the stirring paddles (7) is fixedly clamped on the first clamp (10) on the iron stand (9), the upper end of the Ubbelohde viscometer (5) penetrates through the second hole channel (3-2) to extend to the upper end of the first cover body (3), the Ubbelohde viscometer (5) is suspended on the outer periphery of the second hole channel (3-2) through the clamping assembly, the upper end of the thermometer (6) penetrates through the third hole channel (3-3) to extend to the upper end of the first cover body (3), and the thermocouple (1-3), the thermometer (6) and the driving motor (8) are connected with the control system.
2. The device for measuring the molecular weight of sodium hyaluronate dry powder according to claim 1, wherein the clamping assembly comprises a second cover body (11), the outer diameter of the second cover body (11) is larger than the inner diameter of the second hole channel (3-2), a plurality of second through holes (11-2) are formed in the second cover body (11), a second clamp (11-1) is arranged on the lower end face of the second cover body (11), the clamping head of the second clamp (11-1) corresponds to one of the second through holes (11-2), the second cover body (11) covers the second hole channel (3-2), and the upper end of the Ubbelohde viscometer (5) penetrates through the second through holes (11-2) in the second cover body (11) and is clamped and fixed on the clamping head of the second clamp (11-1).
3. The device for measuring molecular weight of sodium hyaluronate dry powder as set forth in claim 2, wherein the buffer tube (4) is provided with a second eave body (4-2) extending outwards at the upper end, and the buffer tube (4) is hung on the outer periphery of the first hole (3-1) on the first cover body (3) through the second eave body (4-2).
4. A device for determining the molecular weight of sodium hyaluronate dry powder as in claim 3, characterized in that said thermometer (6) is a digital display thermometer.
5. The device for measuring the molecular weight of sodium hyaluronate dry powder according to claim 4, wherein a plurality of supporting legs (1-2) are arranged on the bottom plate (1-1) of the outer barrel (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321024405.XU CN219758006U (en) | 2023-05-04 | 2023-05-04 | Device for measuring molecular weight of sodium hyaluronate dry powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321024405.XU CN219758006U (en) | 2023-05-04 | 2023-05-04 | Device for measuring molecular weight of sodium hyaluronate dry powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219758006U true CN219758006U (en) | 2023-09-26 |
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| CN202321024405.XU Active CN219758006U (en) | 2023-05-04 | 2023-05-04 | Device for measuring molecular weight of sodium hyaluronate dry powder |
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