CN219580547U

CN219580547U - Stirring device for preparing novel antituberculosis drug intermediate

Info

Publication number: CN219580547U
Application number: CN202320866235.3U
Authority: CN
Inventors: 陈文阳; 李康
Original assignee: CHANGZHOU HUAREN CHEMICAL CO LTD
Current assignee: CHANGZHOU HUAREN CHEMICAL CO LTD
Priority date: 2023-04-18
Filing date: 2023-04-18
Publication date: 2023-08-25
Anticipated expiration: 2033-04-18

Abstract

The utility model discloses a stirring device for preparing an anti-tuberculosis new drug intermediate, which comprises a main body frame, a tank body, a stirrer, a lifting mechanism for driving the stirrer to lift along the guide shaft, and a stirrer counterweight device, wherein the main body frame is provided with the guide shaft, one end of the stirrer is connected with the output end of the stirrer, the other end of the stirrer stretches into the tank body, the lifting mechanism comprises a lifting driver, a lifting sleeve and a connecting plate, the lifting driver is arranged on the main body frame, the lifting sleeve is in sliding fit with the guide shaft, one end of the connecting plate is fixedly connected with the stirrer, and the other end of the connecting plate is matched with the lifting driver. The utility model solves the problem that stirring kettles with different sizes need to be corresponding to a set of special stirring devices in the prior art, saves resources and reduces the preparation cost of glycidol pivalate.

Description

Stirring device for preparing novel antituberculosis drug intermediate

Technical Field

The utility model relates to the technical field of chemical production equipment, in particular to a stirring device for preparing an anti-tuberculosis new drug intermediate.

Background

Glycidyl pivalate is an intermediate material for preparing new antitubercular drugs, and belongs to chiral intermediates of the new antitubercular drugs. The glycidol pivalate is mainly prepared by the procedures of washing, dehydration and the like after esterification reaction of glycidol, special acyl chloride and an acid binding agent, and in the esterification reaction process, the glycidol, the special acyl chloride and the acid binding agent are firstly added into a stirring kettle, then are stirred, and then are subjected to the next procedure after the stirring is completed.

In the production process of glycidol pivalate, stirring kettles with different volumes are used, when stirring kettles with different volumes are used, a proper stirring device needs to be selected, and stirring cannot be performed, for example: when the volume of stirred tank is bigger, need select the agitating unit that length is longer, stirring vane is wider, otherwise, can lead to when stirring the stirred tank of bigger volume, the stirring is inhomogeneous, when the volume of stirred tank is smaller, then need select the agitating unit that length is short, stirring vane is narrow, otherwise, can lead to agitating unit unable to stretch into in the stirred tank.

Currently, the methods for solving the above problems are: different stirring kettles are specially provided with or purchased with special stirring devices, so that not only is the resource wasted, but also the cost for producing glycidol pivalate is increased.

Disclosure of Invention

Aiming at the problems, the utility model provides a stirring device for preparing an anti-tuberculosis new drug intermediate, which effectively solves the problems of resource waste and increased production cost of glycidol pivalate caused by the fact that stirring kettles with different sizes are required to correspond to a set of special stirring devices in the prior art.

The technical scheme for solving the technical problems is as follows:

the utility model provides a stirring device of preparation antituberculosis new medicine midbody, includes main part frame, jar body, be equipped with the guiding axle on the main part frame, still include mixer, agitator, drive mixer along elevating system, the mixer counter weight device of guiding axle lift, the one end of agitator is connected with the output of mixer, the other end of agitator stretches into in the jar, elevating system includes lift driver, lift cover, the connecting plate, lift driver arranges on the main part frame, lift cover and guiding axle sliding fit, connecting plate one end and mixer fixed connection, the other end cooperates with lift driver, the mixer counter weight device includes balancing weight, pulley, adapting unit, the pulley is fixed on the main part frame, adapting unit and pulley sliding fit, adapting unit's one end is connected with the connecting plate, adapting unit's the other end and balancing weight fixed connection, the mixer is located one side of main part frame, the balancing weight is located the opposite side of main part frame, lift driver drive lift cover slides along guiding axle axial end, the mixer is followed lift cover and is to the same direction motion, adapting unit slides on the pulley, the opposite direction motion to the mixer motion.

Further, the main body frame is also provided with a limiting component.

Further, the stirring machine also comprises a righting mechanism, wherein the righting mechanism is positioned below the stirring machine and is fixedly connected with the main body frame.

Further, righting mechanism includes bottom plate, top positive ware, left arm, right arm, and the bottom plate is fixed on main part frame, and top positive ware telescopic arrangement is on the bottom plate, and left arm and right arm cooperation to hold tightly the jar body of mixer stirring.

According to the stirring device for preparing the anti-tuberculosis new drug intermediate, the stirrer is connected with the stirrer, the lifting sleeve is driven to slide along the guide shaft through the lifting driver, so that the stirrer is positioned at any position on the guide shaft, the stirring of glycidyl pivalate in tanks with different sizes is met, the position of the stirrer positioned on the guide shaft is limited through the counterweight device of the stirrer, and any position on the guide shaft where the stirrer is positioned is stabilized. The utility model solves the problem that stirring kettles with different sizes need to be corresponding to a set of special stirring devices in the prior art, saves resources and reduces the preparation cost of glycidol pivalate.

Drawings

FIG. 1 is a front view of a stirring device for preparing an antitubercular novel drug intermediate according to the present utility model.

Fig. 2 is a schematic diagram showing the cooperation of the lifting mechanism of the stirring device and the stirrer for preparing the intermediate of the antitubercular novel drug.

Fig. 3 is a schematic structural view of a stirrer weight device of the stirring device for preparing an antitubercular novel drug intermediate.

FIG. 4 is a cross-sectional view of the stirrer and tank of the stirring device for preparing the intermediate of the antitubercular novel drug of the present utility model.

FIG. 5 is a schematic diagram showing the cooperation of the righting mechanism of the stirring device for preparing the anti-tuberculosis new drug intermediate and the tank body.

FIG. 6 is a partial perspective view of the righting mechanism of the stirring device for preparing the antitubercular novel drug intermediate of the present utility model.

The reference symbols in the drawings:

bracket a, main body frame 1, tank 2, guide shaft 3, mixer 4, mixer 5, lift driver 6, lift cover 7, connecting plate 8, balancing weight 9, pulley 10, connecting part 11, limiting part 12, bottom plate 13, top positive 14, left arm 15, right arm 16, lift driver connecting shaft 17, adapter sleeve 18, stirring shaft 19, stirring vane 20, cylinder 21, top positive drive shaft 22, screw handle 23, slotted plate 24, screw cover 25, first short arm 26, first long arm 27, second short arm 28, second long arm 29, screw 30.

Detailed Description

The utility model will be described in further detail with reference to the drawings and the detailed description. The following embodiments relate to chiral intermediates for antitubercular new drugs, referred to as glycidol pivalates.

Firstly, it is to be noted that: for the purpose of making the technical solution of the present utility model clearer, the technical solution of the present utility model will be more clearly and completely described below with reference to the attached drawings, and it is obvious that the words of "upper", "lower" and the like used in the description merely describe the technical solution of the present utility model further and more clearly according to the attached drawings, and do not represent all the embodiments of the present utility model. All other embodiments, based on the embodiments of the utility model, which are apparent to those of ordinary skill in the art without inventive faculty, are intended to be within the scope of the utility model. Thus, the following detailed description of the embodiments of the utility model, as presented in the figures, is not intended to limit the scope of the utility model, as claimed, but is merely representative of selected embodiments of the utility model.

As shown in fig. 1 to 6, the stirring device for preparing the anti-tuberculosis new drug intermediate comprises a main body frame 1 and a tank body 2, wherein a guide shaft 3 is arranged on the main body frame 1, the stirring device further comprises a stirrer 4, a stirrer 5, a lifting mechanism for driving the stirrer 4 to lift along the guide shaft 3 and a stirrer counterweight device, one end of the stirrer 5 is connected with the output end of the stirrer 4, the other end of the stirrer 5 stretches into the tank body 2, the lifting mechanism comprises a lifting driver 6, a lifting sleeve 7 and a connecting plate 8, the lifting driver 6 is arranged on the main body frame 1, the lifting sleeve 7 is in sliding fit with the guide shaft 3, one end of the connecting plate 8 is fixedly connected with the stirrer 4, the other end of the connecting plate 8 is matched with the lifting driver 6, the stirrer counterweight device comprises a counterweight 9, a pulley 10 and a connecting part 11, one end of the connecting part 11 is connected with the connecting plate 8, the other end of the connecting part 11 is fixedly connected with the counterweight 9, the stirrer 4 is positioned on one side of the main body frame 1, the counterweight 9 is positioned on the other side of the main body frame 1, the lifting driver 6 is in sliding fit with the guide shaft 7, and the lifting driver 7 moves in the same direction as the pulley 10 along the axial direction of the guide shaft 4, and is in sliding fit with the pulley 10.

In this embodiment, the stirrer 4 adopts a servo motor, the stirrer 4 also comprises a connecting sleeve 18, the stirrer 5 comprises a stirring shaft 19 and a stirring blade 20, the connecting sleeve 18 is connected with the output end of the stirrer 4, one end of the stirring shaft 19 is in threaded connection with the connecting sleeve 18, the other end of the stirring shaft 19 is in threaded connection with the stirring blade 20, the lifting driver 6 adopts a cylinder, the lifting driver 6 also comprises a lifting driver connecting shaft 17, one end of the lifting driver connecting shaft 17 is connected with the output end of the lifting driver 6, the other end of the lifting driver connecting shaft 17 is fixedly connected with the lifting sleeve 7, after glycidol, special acyl chloride and an acid-binding agent are added into the tank 2, the tank 2 is placed on a bracket A, the tank 2 is moved to the lower part of the stirring device by the bracket A, then a proper stirrer 5 is selected (the proper means that the length of the stirring shaft 19 is suitable for the height of the tank 2, the length of the stirring blade 20 is suitable for the diameter of the tank body 2, the stirring blade can rotate in the tank body 2 and can not interfere with the inner wall of the tank body 2, then the stirrer 5 is connected to the connecting sleeve 18 of the stirrer 4, the lifting driver 6 is started, the lifting driver 6 controls the lifting driver connecting shaft 17 to stretch and retract, so that the lifting driver connecting shaft 17 drives the lifting sleeve 7 to slide on the guide shaft 3, the lifting sleeve 7 drives the stirrer 4 to lift, the stirrer 5 is kept in a suspended state in the tank body 2 and is not contacted with the bottom of the tank body 2, then the stirrer 4 is started again, the stirrer 4 drives the stirring shaft 19 to rotate, the stirring shaft 19 drives the stirring blade 20 to rotate, so that glycidyl pivalate in the tank body 2 is stirred, and in the process that the lifting driver 6 drives the lifting sleeve 7 to move up and down along the guide shaft 3, since one end of the connecting member 11 is fixedly connected with the connecting plate 8, the other end of the connecting member 11 is fixedly connected with the weight 9, the connecting member 11 is in a tensed state and rolls on the pulley 10 along with the up-and-down movement of the lifting sleeve 7, for example: when the lifting driver 6 drives the lifting sleeve 7 to move downwards along the guide shaft 3, the stirrer 4 moves along the lifting sleeve 7 in the same direction, at the moment, the connecting part 11 rolls on the pulley 10 so as to pull the balancing weight 9 to move upwards, and when the stirrer 5 meets the stirring condition (namely, the stirring blade 20 is suspended in the tank body 2 and does not interfere with the wall surface and the bottom of the tank body 2), the lifting driver 6 is closed at the moment, and the balancing weight 9 tightens the connecting part 11 so that the connecting part 11 drags the stirrer 4 and the stirrer 5, thereby preventing the stirrer 4 and the stirrer 5 from sliding downwards continuously; when the lifting driver 6 drives the lifting sleeve 7 to move upwards along the guide shaft 3, the stirrer 4 moves along the lifting sleeve 7 in the same direction, at the moment, the connecting part 11 rolls on the pulley 10 to pull the balancing weight 9 to move downwards, and when the stirrer 5 meets the stirring condition (namely, the stirring blade 20 is suspended in the tank 2 and does not interfere with the wall surface and the bottom of the tank 2), the lifting driver 6 is closed, at the moment, the stirrer 4 and the stirrer 5 slide downwards on the guide shaft 3 at any time due to the gravity of the stirrer 4 and the stirrer 5, but the connecting part 11 is pulled upwards to catch the stirrer 4 and the stirrer 5 due to the fact that the balancing weight 9 tightens the connecting part 11, so that the stirrer 4 and the stirrer 5 are prevented from sliding downwards. In this embodiment, the position of the stirrer 4 and the stirrer 5 on the guide shaft 3 is adjusted by the lifting driving mechanism, so that the stirrer 5 can extend into the tank 2 with different sizes for stirring, and the problem that stirring devices with different specifications are required to be designed in the tank with different sizes in the prior art is solved.

Preferably, the main body frame 1 is further provided with a limiting member 12.

The limiting component 12 is a steel bar, the limiting component 12 is in threaded fit with the main body frame 1, and when the balancing weight 9 moves downwards, the limiting component 12 limits the limiting position of the downward movement of the balancing weight 9, so that the wall stirrer 4 and the stirrer 5 are dragged too much by the connecting component 11 and collide with the main body frame 1 at the top.

Preferably, the stirring machine further comprises a righting mechanism, wherein the righting mechanism is positioned below the stirring machine 4 and is fixedly connected with the main body frame 1.

The righting mechanism comprises a bottom plate 13, a righting device 14, a left arm 15 and a right arm 16, wherein the bottom plate 13 is fixed on the main body frame 1, the righting device 14 is arranged on the bottom plate 13 in a telescopic mode, and the left arm 15 is matched with the right arm 16 so as to hold the tank body 2 stirred by the stirrer 4 tightly.

In this embodiment, the righting mechanism further comprises an air cylinder 21, a jacking device driving shaft 22, a screw rod handle 23, a groove plate 24, a screw rod sleeve 25 and a screw rod 30, the left arm 15 comprises a first short arm 26 and a first long arm 27, the right arm 16 comprises a second short arm 28 and a second long arm 29, the air cylinder 21 is fixed on the bottom plate 13 and is positioned at the middle position of the groove plate 24, one end of the jacking device driving shaft 22 is connected with the output end of the air cylinder 21, the other end of the jacking device driving shaft 22 is fixedly connected with the jacking device 14, the groove plate 24 is arranged on the bottom plate 13, the screw rod sleeve 25 is sleeved on the screw rod 30, the screw rod 30 is in threaded fit with the screw rod sleeve 25, the screw rod sleeve 25 and the screw rod 30 are arranged in the groove of the groove plate 24, the screw rod handle 23 is connected with the screw rod 30, one end of the first long arm 27 is connected with one end of the groove plate 24, the other end of the first long arm 27 is connected with the first short arm 26, one end of the second long arm 29 is connected with the other end of the groove plate 24, the other end of the second long arm 29 is connected with the second short arm 28, when the glycidyl pivalate in the tank body 2 is stirred, the tank body 2 is moved between the left arm 15 and the right arm 16 by the bracket A, then the screw rod 30 is rotated to lengthen or shorten the screw rod 30, so that the included angle between the left arm 15 and the right arm 16 is adapted to the size of the tank body 2, the tank body 2 is held by the left arm 15 and the right arm 16, meanwhile, the cylinder 21 is started, the cylinder 21 controls the ejector driving shaft 22 to extend or retract, so that the ejector driving shaft 22 drives the ejector 14 to push the tank body 2 or keep away from the tank body 2, when the ejector 14 pushes the outer wall surface of the tank body 2, and at the moment, the ejector 14 is matched with the left arm 15 and the right arm 16 to straighten the tank body 2, so as to prevent the stirrer 4 from driving the stirrer 5 to stir the glycidyl pivalate in the tank body 2, the tank 2 is rocked.

Finally, it should be explained that: the above embodiments are merely illustrative of the preferred embodiments of the present utility model, and not limiting the scope of the present utility model; although the utility model has been described in detail with reference to the foregoing embodiments, it will be appreciated by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the corresponding technical solutions.

Claims

1. The stirring device for preparing the anti-tuberculosis new drug intermediate comprises a main body frame (1) and a tank body (2), wherein a guide shaft (3) is arranged on the main body frame (1), and is characterized by further comprising a stirrer (4), a stirrer (5), a lifting mechanism for driving the stirrer (4) to lift along the guide shaft (3) and a stirrer counterweight device, one end of the stirrer (5) is connected with the output end of the stirrer (4), the other end of the stirrer (5) stretches into the tank body (2), the lifting mechanism comprises a lifting driver (6), a lifting sleeve (7) and a connecting plate (8), the lifting driver (6) is arranged on the main body frame (1), the lifting sleeve (7) is in sliding fit with the guide shaft (3), one end of the connecting plate (8) is fixedly connected with the stirrer (4), the other end of the connecting plate is matched with the lifting driver (6), the stirrer counterweight device comprises a balancing weight (9), a pulley (10) and a connecting part (11), the pulley (10) is fixedly arranged on the main body frame (1), the connecting part (11) is in sliding fit with the pulley (10), one end of the connecting part (11) is fixedly connected with the connecting plate (4) on one side of the main body frame (1), the balancing weight (9) is located the opposite side of main part frame (1), and lift driver (6) drive lift cover (7) are along guiding axle (3) axial end slip, and mixer (4) follow lift cover (7) to the same direction motion, and connecting piece (11) are slided on pulley (10), and balancing weight (9) are to the opposite direction motion of mixer (4) motion.

2. The stirring device for preparing the intermediate of the antitubercular new medicine according to claim 1, characterized in that the main body frame (1) is also provided with a limiting component (12).

3. The stirring device for preparing the anti-tuberculosis new drug intermediate according to claim 1, further comprising a righting mechanism, wherein the righting mechanism is positioned below the stirring machine (4) and is fixedly connected with the main body frame (1).

4. A stirring device for preparing an anti-tuberculosis new drug intermediate according to claim 3, characterized in that the righting mechanism comprises a bottom plate (13), a jacking device (14), a left arm (15) and a right arm (16), wherein the bottom plate (13) is fixed on the main body frame (1), the jacking device (14) is arranged on the bottom plate (13) in a telescopic way, and the left arm (15) is matched with the right arm (16) so as to hold the tank (2) stirred by the stirrer (4).