CN219540078U - Dispersing device for producing anti-new crown drug intermediate - Google Patents

Abstract

The utility model discloses a dispersing device for producing an anti-new crown drug intermediate, which comprises a support frame and a stirring tank, wherein the stirring tank is fixed on the support frame, one end of the stirring tank is provided with a plurality of feed inlets, the other end of the stirring tank is provided with a discharge opening, the stirring device comprises a driving motor, a rotating shaft, a roll shaft, stirring sheets and a bearing seat, one end of the bearing seat is provided with a bearing, the other end of the bearing seat is fixedly connected with the bottom of the stirring tank, a plurality of notches are formed in the peripheral surface of the bearing seat, the driving motor is arranged at the top of the stirring tank, one end of the rotating shaft is connected with the output end of the driving motor, the other end of the rotating shaft is matched with the bearing of the bearing seat, the stirring sheets are fixed on the rotating shaft by bolts after being spliced, the roll shaft is fixed on the rotating shaft, and the peripheral surface of the roll shaft is provided with a plurality of waist-shaped notches. The stirring tank solves the problem that in the prior art, the connecting shaft and the stirring blade shake in the stirring tank in the stirring process due to the fact that the volume of the stirring tank is larger.

Description

Dispersing device for producing anti-new crown drug intermediate

Technical Field

The utility model relates to the technical field of chemical production equipment, in particular to a dispersing device for producing an anti-new crown drug intermediate.

Background

Diethyl glutamate is an intermediate material for preparing anti-new crown drugs, and belongs to an intermediate of the anti-new crown drugs. The diethyl glutamate is mainly prepared by condensation reaction, impurity extraction, acidification, washing and other procedures of amino acid ethyl ester, di-tert-butyl dicarbonate and NaOH aqueous solution, in the condensation reaction procedure, a tower reactor or a sleeve reactor with an intercooler is generally adopted for more accurate control of reaction temperature, during condensation reaction, the amino acid ethyl ester, the di-tert-butyl dicarbonate and the NaOH aqueous solution are respectively filled into the reactor, and then the heating reaction is carried out, however, when the amount of the amino acid ethyl ester, the di-tert-butyl dicarbonate and the NaOH aqueous solution is large, if stirring is not carried out, the reaction effect of the condensation reaction is affected.

At present, the tower reactor and the sleeve reactor are not provided with stirrers, the aqueous solution of the amino acid ethyl ester, the di-tert-butyl dicarbonate and the NaOH is filled into a special stirring tank, after being uniformly stirred by the stirring tank, the aqueous solution of the amino acid ethyl ester, the di-tert-butyl dicarbonate and the NaOH is pumped into the tower reactor or the sleeve reactor, in the stirring process, the capacity of the stirring tank is extremely large because the stirring tank is extremely large each time, the volume of the stirring tank is extremely large, in the stirring process, the stirring blades and the connecting shaft for connecting the stirring blades are usually suspended in the stirring tank, when the volume of the stirring tank is extremely large, the connecting shaft for connecting the stirring blades is extremely long, so that the connecting shaft and the stirring blades shake in the stirring tank in the stirring process, and in the continuous stirring process, if the stirring is not timely and not quickly performed, the di-tert-butyl dicarbonate is precipitated at the lowest end of the stirring tank, and finally the discharge port is blocked.

Disclosure of Invention

Aiming at the problems, the utility model provides a dispersing device for producing an anti-new crown drug intermediate with large stirring force.

The technical scheme for solving the technical problems is as follows:

the utility model provides a dispersion devices of production anti new crown medicine midbody, includes support frame, agitator tank, and the agitator tank is fixed on the support frame, and the one end of agitator tank is equipped with a plurality of feed inlets, and the other end of agitator tank is equipped with the discharge opening, still includes the agitating unit who stirs the material in the agitator tank, agitating unit includes driving motor, rotation axis, roller, stirring piece, bearing frame, and bearing frame one end is equipped with the bearing, and the bottom fixed connection of the other end and agitator tank is equipped with a plurality of breach on the global of bearing frame for the material flow direction discharge opening, driving motor arranges at the top of agitator tank, and driving motor is located the same end on the agitator tank with the feed inlet, and the one end and the output of driving motor of rotation axis are connected, and the other end and the bearing frame of rotation axis cooperate, and the stirring piece is two, utilizes the bolt fastening after the concatenation on the rotation axis, and the stirring piece is located the top of bearing frame, and the rotation axis runs through the roller to be fixed on the rotation axis, and the roller is located the top of stirring piece, the hollow design of roller, is equipped with a plurality of waist type breach on the global of roller.

Further, still include first inlet pipe, second inlet pipe, third inlet pipe, first inlet pipe, second inlet pipe, third inlet pipe are connected with one of them feed inlet on the agitator tank respectively.

Further, the bottom of the stirring tank is conical.

Further, still include the top cap subassembly, be equipped with circular opening at the top of agitator tank, circular opening is located one side of driving motor, top cap subassembly and circular opening cooperation.

The dispersing device for producing the anti-new crown drug intermediate is mainly used for stirring raw materials of diethyl glutamate before condensation reaction, and conveying the stirred raw materials into a tower reactor or a sleeve reactor.

Drawings

FIG. 1 is a front view of a dispersion apparatus for producing an anti-neocrown drug intermediate of the present utility model;

FIG. 2 is a front view of a stirring device of a dispersion device for producing an anti-neocrown drug intermediate of the present utility model;

FIG. 3 is a perspective view of a stirred tank and a portion of a stirring device;

FIG. 4 is a front view of a mixing tank and a portion of a mixing device;

FIG. 5 is a perspective view of a portion of the stirring device;

fig. 6 is an enlarged view of a portion a in fig. 1;

fig. 7 is an enlarged view of a portion B in fig. 3.

The reference symbols in the drawings:

the stirring tank 2, the feed inlet 2a, the discharge outlet 2b, the driving motor 3, the rotating shaft 4, the roller shaft 5, the waist-shaped notch 5a, the stirring blade 6, the arc-shaped groove 6a, the bearing seat 7, the notch 7a, the bearing 7b, the first feed pipe 8, the second feed pipe 9, the third feed pipe 10, the round cover 11, the cross rod 12, the hinge part 13, the locking bolt 14, the locking bolt matching part 15, the clamping plate 16, the screw hole 16a, the base 17, the disc 18, the discharge pipe 19, the ladder frame 20,

Detailed Description

The utility model will be described in further detail with reference to the drawings and the detailed description. The anti-neocrown drug intermediate referred to in the following embodiments refers to diethyl glutamate.

As shown in fig. 1 to 7, the dispersing device for producing the anti-new crown drug intermediate comprises a supporting frame 1 and a stirring tank 2, wherein the stirring tank 2 is fixed on the supporting frame 1, one end of the stirring tank 2 is provided with a plurality of feed inlets 2a, the other end of the stirring tank 2 is provided with a discharge outlet 2b, and the dispersing device is characterized by further comprising a stirring device for stirring materials in the stirring tank 2, the dispersing device comprises a driving motor 3, a rotating shaft 4, a roll shaft 5, stirring sheets 6 and a bearing seat 7, one end of the bearing seat 7 is provided with a bearing, the other end of the bearing seat 7 is fixedly connected with the bottom of the stirring tank 2, a plurality of notches 7a are formed in the peripheral surface of the bearing seat 7 for the materials to flow to the discharge outlet 2b, the driving motor 3 is arranged at the top of the stirring tank 2, the driving motor 3 and the feed inlets 2a are positioned at the same end of the stirring tank 2, one end of the rotating shaft 4 is connected with the output end of the driving motor 3, the other end of the rotating shaft 4 is matched with the bearing of the bearing seat 7, the stirring sheets 6 are two sheets, after splicing are fixed on the rotating shaft 4 by bolts, the stirring sheets 6 are positioned above the bearing seat 7, the rotating shaft 4 penetrates through the roll shaft 5, the roll shaft 5 and is fixed on the roll shaft 5 and is positioned on the hollow waist 5, and the hollow waist 5 is designed on the roll shaft 5.

In this embodiment, the aqueous solution of amino acid ethyl ester, di-t-butyl dicarbonate and NaOH enters the stirring tank 2 from the feed inlet 2a, the stirring device is started to work before entering the stirring tank 2, the driving motor 3 rotates when the stirring device works, the driving motor 3 drives the rotating shaft 4 to rotate, thereby the rotating shaft 4 drives the roll shaft 5 and the stirring blade 6 to rotate, and during rotation, since one end of the rotating shaft 4 is fixedly connected with the output end of the driving motor 3 and the other end of the rotating shaft 4 is inserted into the inner ring of the bearing 7b of the bearing seat 7, the two ends of the rotating shaft 4 have supporting points, the rotating shaft 4 does not shake when the stirring tank 2 rotates even if the length of the rotating shaft 4 is designed to be too long when facing the stirring tank 2 with higher height, and the weight of the lower end part of the rotating shaft 4 is increased by arranging the roll shaft 5, and the problem that the rotating shaft 4 shakes is further avoided while the stirring is accelerated.

In this embodiment, the hollow design of the roll shaft 5 is to provide a waist-shaped notch 5a on the circumferential surface of the roll shaft 5 to facilitate the roll shaft 5 to provide better stirring force, and protect the driving motor 3 on the premise of increasing the weight of the rotating shaft 4 to avoid low stirring efficiency and uneven stirring of materials caused by too slow speed when the driving motor 3 drives the rotating shaft 4 and the roll shaft 5 to rotate; in this embodiment, the plurality of notches 7a at the lower end of the bearing seat 7 are mainly used for making the material flow to the discharge opening 2b, when the amino acid ethyl ester, di-tert-butyl dicarbonate and NaOH aqueous solution are added into the stirring tank 2, they are rapidly collected at the discharge opening 2b due to gravity, as the amount of the amino acid ethyl ester, di-tert-butyl dicarbonate and NaOH aqueous solution added continuously increases, some di-tert-butyl dicarbonate is precipitated at the bottom of the stirring tank 2, so that the discharge opening 2b is not blocked, the stirring sheet 6 is arranged above the bearing seat 7, the discharge opening 2b is just below the bearing seat 7, and when the rotating shaft 4 rotates, the stirring sheet 6 is driven by the rotating shaft 4 to rotate, so that the stirring sheet 6 continuously agitates the material at the discharge opening 2b, thereby avoiding the precipitation of the material at the bottom of the stirring tank 2, and further solving the problem that the material precipitation is blocked, the stirred material enters the discharge pipe 19 from the discharge opening 2b, and the discharge pipe 19 is communicated with the tower reactor or the sleeve reactor for condensation reaction, and the valve (the valve is opened in the sleeve reactor) is not shown in the figure).

In this embodiment, since the volume of the agitation tank 2 is generally large, the ladder frame 20 is provided on the supporting frame 1 for the convenience of maintenance and cleaning in the following.

Preferably, the stirring tank further comprises a first feeding pipe 8, a second feeding pipe 9 and a third feeding pipe 10, wherein the first feeding pipe 8, the second feeding pipe 9 and the third feeding pipe 10 are respectively connected with one of the feed inlets 2a on the stirring tank 2.

In the present embodiment, the first feed pipe 8 is an amino acid ethyl ester feed pipe, the second feed pipe 9 is a di-tert-butyl dicarbonate feed pipe, the third feed pipe 10 is a NaOH aqueous solution feed pipe, and the amino acid ethyl ester, di-tert-butyl dicarbonate and NaOH aqueous solution are fed into the stirring tank 2 through the first feed pipe 8, the second feed pipe 9 and the third feed pipe 10, respectively, so as to perform stirring before the condensation reaction.

Preferably, the stirring tank further comprises a top cover assembly, a circular opening is formed in the top of the stirring tank 2, the circular opening is located on one side of the driving motor 3, and the top cover assembly is matched with the circular opening.

In this embodiment, the top cap subassembly includes dome 11, horizontal pole 12, articulated elements 13, locking bolt 14, locking bolt mating elements 15, dome 11 is used for sealing the circular opening at the top of agitator tank 2, the middle part and the dome 11 fixed connection of horizontal pole 12, therefore, articulated elements 13 are fixed on agitator tank 2, locking bolt mating elements 15 are fixed on agitator tank 2, horizontal pole 12 one end articulates with articulated elements 13, the other end passes through locking bolt 14 and locking bolt mating elements 15 cooperation, when needs to cover dome 11, screw locking bolt 14, make locking bolt 14 continuously screw into the screw in locking bolt mating elements 15, thereby make horizontal pole 12 compress tightly dome 11, so need set up circular opening at the top of agitator tank 2, because there is not other observation hole on the global of agitator tank 2, also inconvenient set up on the global of agitator tank 2, so, whether for subsequent cleaning the agitator tank, still monitor the stirring process, all need set up a circular opening, then set up circular opening at the top of agitator tank 2, but, because the di-tert-butyl dicarbonate is the top cap is the dangerous chemical, do not cause the environmental protection to the top cap subassembly, but, the top cap is not sealed with the top cap 2, on the other side, the other amino acid is prevented from getting into the environment, the top cap subassembly is not influenced by the top cap, on the other side, the top cap is sealed, the top cap is difficult to get into the solution, the top cap is sealed, the solution is difficult to get into the environment, and the solution is difficult to get into the top cap, and the solution is difficult to get into the solution, and has no acid, and has to the effect, and has the effect.

In this embodiment, the stirring tank 2 is further provided with a locking and fixing assembly for fixing the stirring tank 2 on the supporting frame, the locking and fixing assembly comprises a clamping plate 16, a base 17 and a disc 18, the base 17 is fixed on the supporting frame 1 through bolts, one end of the clamping plate 16 is provided with a plurality of screw holes 16a, the bolts penetrate through the screw holes 16a to fix the clamping plate 16 on the disc 18, the disc 18 is fixedly connected with the base 17, the other end of the clamping plate 16 is in contact with the peripheral surface of the stirring tank 2, and a plurality of groups of locking and fixing assemblies are arranged on the supporting frame 1 so as to lock the stirring tank 2 on the supporting frame 1 in a suspending manner.

Finally, it should be explained that: the above embodiments are merely illustrative of the preferred embodiments of the present utility model, and not limiting the scope of the present utility model; although the utility model has been described in detail with reference to the foregoing embodiments, it will be appreciated by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the corresponding technical solutions.

Claims (4)

1. The dispersing device for producing the anti-new crown drug intermediate comprises a supporting frame (1) and a stirring tank (2), wherein the stirring tank (2) is fixed on the supporting frame (1), one end of the stirring tank (2) is provided with a plurality of feeding holes (2 a), and the other end of the stirring tank (2) is provided with a discharging hole (2 b), and the dispersing device is characterized by further comprising a stirring device for stirring materials in the stirring tank (2), the dispersing device comprises a driving motor (3), a rotating shaft (4), a roller shaft (5), stirring sheets (6) and a bearing seat (7), one end of the bearing seat (7) is provided with a bearing, the other end of the bearing seat is fixedly connected with the bottom of the stirring tank (2), a plurality of notches (7 a) are formed in the peripheral surface of the bearing seat (7) for the materials to flow to the discharging hole (2 b), the driving motor (3) is arranged at the top of the stirring tank (2), one end of the driving motor (3) is positioned on the stirring tank (2), one end of the rotating shaft (4) is connected with the output end of the driving motor (3), the other end of the rotating shaft (4) is matched with the bearing seat (7), the bearing seat (6) is fixedly connected with the stirring sheets (6) by utilizing the bearing seat (6) which are fixedly connected with the stirring sheets (5) on the rotating shaft (5), the roll shaft (5) is fixed on the rotating shaft (4), the roll shaft (5) is positioned above the stirring piece (6), the roll shaft (5) is in a hollow design, and a plurality of waist-shaped notches (5 a) are formed in the peripheral surface of the roll shaft (5).

2. The dispersing device for producing anti-neocrown drug intermediates according to claim 1, further comprising a first feeding pipe (8), a second feeding pipe (9) and a third feeding pipe (10), wherein the first feeding pipe (8), the second feeding pipe (9) and the third feeding pipe (10) are respectively connected with one of the feeding ports (2 a) on the stirring tank (2).

3. The dispersion apparatus for producing an anti-neocrown pharmaceutical intermediate according to claim 1, wherein the bottom of the agitation tank (2) is tapered.

4. The dispersing device for producing an anti-neocrown drug intermediate according to claim 1, further comprising a cap assembly provided with a circular opening at the top of the stirring tank (2), the circular opening being located at one side of the driving motor (3), the cap assembly being fitted with the circular opening.