CN219502681U - Reaction kettle for heparin sodium production - Google Patents

Abstract

The utility model relates to the technical field of heparin sodium production and discloses a reaction kettle for heparin sodium production, which comprises a kettle body, wherein a discharging component is fixedly connected to the bottom of the kettle body, the discharging component comprises a discharging pipe, a vibrating motor is fixedly connected to one side of the discharging pipe, a plate sleeve is fixedly connected to the bottom of the discharging pipe, a filtering component is sleeved inside the plate sleeve, the filtering component comprises a structural plate, a first through groove is formed in one end of the top of the structural plate in a penetrating manner, the reaction kettle is provided with a filtering device at the discharging end, the reaction kettle can directly filter a chyme intestinal mucosa when the chyme intestinal mucosa reaction is finished to discharge the chyme intestinal mucosa, a feeding pipe is not required to be opened when auxiliary materials such as protease, weak alkali liquor and the like are added, the feeding is not required to be carried out from the feeding pipe which can be plugged, steam and heat loss in the kettle can be prevented, meanwhile, the chyme intestinal mucosa mixture in the kettle is directly heated by an electric heating wire, and the heating speed is high.

Description

Reaction kettle for heparin sodium production

Technical Field

The utility model relates to the technical field of heparin sodium production, in particular to a reaction kettle for heparin sodium production.

Background

Heparin sodium is an acidic mucopolysaccharide sulfate substance produced by mast cells of animal connective tissue, is widely used in liver, lung and intestinal mucosa of mammals, is combined with protein to form a complex, has strong anticoagulation effect, is a first-choice medicine for preventing and treating thromboembolic diseases such as deep vein thrombosis, and needs to use a reaction kettle in the production process of heparin sodium for carrying out heating enzymolysis on the chymotrypsin intestinal mucosa scraped and stirred from small intestine.

The patent publication No. CN202322686U discloses a reaction kettle for heparin sodium production. The reaction kettle for heparin sodium production comprises an adsorption tank and a stirrer arranged on the adsorption tank, wherein the adsorption tank is formed by integrally connecting a cylindrical upper part and a conical lower part; the stirrer consists of stirring paddles, stirring rods and a motor; the agitator slant is installed on the lateral wall of adsorption tank, and the motor is in the adsorption tank outside, and the stirring rake that links to each other through puddler and motor is located in the conical lower part of adsorption tank, and this kind of reation kettle's advantage is: the agitator is installed rationally, and the puddler is difficult for bending deformation or rupture, and stirring effect is good, but traditional reation kettle discharge end does not have filtration, can not filter it when heparin sodium reaction is accomplished the ejection of compact, and heparin sodium needs to filter while hot, just can fully filter liquid, and easy cooling when carrying filtration equipment after the ejection of compact, can filter it again after need reheating.

Disclosure of Invention

In order to overcome the defects in the prior art, the utility model provides a reaction kettle for producing heparin sodium, which solves the problems in the prior art.

The utility model provides the following technical scheme: the reaction kettle for producing heparin sodium comprises a kettle body, wherein a discharging assembly is fixedly connected to the bottom of the kettle body and comprises a discharging pipe, a vibrating motor is fixedly connected to one side of the discharging pipe, a plate sleeve is fixedly connected to the bottom of the discharging pipe, and a filtering assembly is sleeved inside the plate sleeve;

the filter assembly comprises a structural plate, a first through groove is formed in one end of the top of the structural plate in a penetrating manner, a second through groove is formed in one end, far away from the first through groove, of the top of the structural plate in a penetrating manner, a conical filter screen is fixedly connected inside the second through groove, and filter cloth is glued to the top of the conical filter screen;

the limiting plate is fixedly connected to one end of the structural plate, and a holding groove is formed in the top of the structural plate in a penetrating mode at one end, far away from the limiting plate, of the structural plate.

Further, the cauldron body top fixedly connected with gear motor, gear motor bottom output shaft fixedly connected with puddler, the puddler is located the cauldron internal portion, cauldron body top one end fixedly connected with auxiliary material filling subassembly, the internal side fixedly connected with heating element of cauldron, gear motor work drives the puddler and rotates, can stir, mix the internal chyme intestinal mucosa of cauldron with auxiliary materials such as clear water and protease and weak alkali lye.

Further, auxiliary material filling subassembly includes the filling tube, the inside fixedly connected with backing ring of filling tube, the bottom fixedly connected with structure dish in the filling tube, the inside cover that runs through of structure dish is equipped with the connecting rod, connecting rod top fixedly connected with rubber slab, the outside equidistance that the connecting rod was kept away from at structure dish top is run through and is offered the structure groove, after pouring protease and weak base liquid into the filling tube, uses tools such as pole to promote the rubber slab to move down, makes protease and weak base liquid fall to the cauldron internal through the structure groove, after tools such as pull rod, internal pressure of cauldron or steam promote the rubber slab to move up and paste tightly in backing ring below, shutoff is carried out the filling tube.

Further, heating element includes the hot plate, the inside equidistance fixedly connected with electric heater strip of hot plate, it has the magnesia powder to fill between electric heater strip and the hot plate, and electric heater strip work can heat, and the magnesia powder plays insulating, heat conduction's effect, can absorb the temperature after the electric heater strip heats fast and conduct to the hot plate on, and can prevent the electric current conduction on the electric heater strip to the hot plate on.

Further, cauldron body one end fixedly connected with temperature controller, the detection end of temperature controller is located the internal portion of cauldron, the electric current output of temperature controller passes through the power cord and constitutes the electricity with the current input of magnesia powder to be connected, and the temperature controller can detect and show the internal temperature of cauldron, and operates the temperature controller and can control electric heater strip heating and heating temperature thereof.

Further, the second reservation groove has been run through at board cover top, the second reservation groove is located the unloading intraductal bottom, the first reservation groove has been run through to board cover bottom, the equal fixedly connected with sealing washer in bottom and the interior top in the board cover, the second reservation groove set up make things convenient for the intraductal chymal intestines mucosa of unloading etc. to fall to second through groove or first through inslot, the filtrate or the sticky outflow after the filtration under the convenient filtration of seting up of first reservation groove, the sealing washer be used for sealing between board cover and the structural slab.

Further, cauldron body top fixedly connected with inlet pipe, the inlet pipe top is provided with sealed lid, cauldron body one side fixedly connected with observation window opens sealed lid and can to the internal minced form intestines mucosa of filling of cauldron through the inlet pipe, closes sealed lid and can seal the inlet pipe, and the setting of observation window makes things convenient for personnel to observe the internal minced form intestines mucosa reaction condition of cauldron.

The utility model has the technical effects and advantages that:

1. according to the utility model, the second through groove and the filter cloth are arranged, after the reaction of the chyme intestinal mucosa is finished, the structural plate is pulled to enable the second through groove to move into the plate sleeve and to be opposite to the second through groove, the chyme intestinal mucosa mixture flowing out of the blanking pipe falls on the filter cloth, the filter cloth is filtered through the conical filter net and the filter cloth, filtered filtrate flows out of the first through groove, filtered sticky matters stay in the blanking pipe, the structural plate is pushed to enable the first through groove to move into the plate sleeve, sticky matters can flow out of the first through groove and the second through groove, in the filtering process, the vibration motor is turned on to generate vibration and be transmitted into the blanking pipe, the internal chyme intestinal mucosa mixture is vibrated, and the filtering efficiency of the chyme intestinal mucosa mixture is improved.

2. According to the utility model, the rubber plate, the baffle ring and the electric heating wire are arranged, the protease and the weak alkali solution are poured into the feeding pipe, tools such as the rod and the like are used for pushing the rubber plate to move downwards, the protease and the weak alkali solution fall into the kettle body through the plurality of structural grooves, the tools such as the rod and the like are pulled out after the addition is completed, the kettle body steam or pressure pushes the rubber plate to move upwards and cling to the lower part of the baffle ring to seal the rubber plate, loss of pressure or temperature in the kettle body when auxiliary materials are added can be prevented, the electric heating wire works to heat the chyme intestinal mucosa mixture in the kettle body through the magnesia powder and the heating plate, and compared with the traditional steam heating of steam, the heating speed is higher.

Drawings

Fig. 1 is a schematic diagram of the overall structure of the present utility model.

FIG. 2 is a schematic diagram of the internal structure of the kettle body of the present utility model.

Fig. 3 is a schematic structural view of a discharging assembly of the present utility model.

Fig. 4 is a schematic view of the internal structure of the discharge assembly and the filter assembly of the present utility model.

Fig. 5 is a schematic view of the internal structure of the auxiliary material filling assembly according to the present utility model.

The reference numerals are: 1. a kettle body; 2. a discharge assembly; 3. an auxiliary material filling component; 4. a speed reducing motor; 5. a heating assembly; 6. a stirring rod; 7. a temperature controller; 8. a feed pipe; 9. sealing cover; 10. a heating plate; 11. an electric heating wire; 12. magnesium oxide powder; 13. discharging pipes; 14. a plate sleeve; 15. a vibration motor; 16. a filter assembly; 17. a structural panel; 18. a first through groove; 19. a second through slot; 20. a filter cloth; 21. a limiting plate; 22. a holding groove; 23. a seal ring; 24. a first reserved slot; 25. a second reserve tank; 26. a conical filter screen; 27. a feeding tube; 28. a structural tray; 29. a structural groove; 30. a connecting rod; 31. a rubber plate; 32. a baffle ring; 33. and an observation window.

Description of the embodiments

The embodiments of the present utility model will be described more fully hereinafter with reference to the accompanying drawings, in which the embodiments of the present utility model are shown by way of illustration only, and the utility model is not limited to the embodiments of the present utility model, but other embodiments of the present utility model will be apparent to those skilled in the art without making any inventive effort.

Referring to fig. 1-5, the utility model provides a reaction kettle for heparin sodium production, which comprises a kettle body 1, wherein a discharging component 2 is fixedly connected to the bottom of the kettle body 1, the discharging component 2 comprises a discharging pipe 13, a vibrating motor 15 is fixedly connected to one side of the discharging pipe 13, a plate sleeve 14 is fixedly connected to the bottom of the discharging pipe 13, and a filtering component 16 is sleeved in the plate sleeve 14;

the filter assembly 16 comprises a structural plate 17, a first through groove 18 is formed in one end of the top of the structural plate 17 in a penetrating manner, a second through groove 19 is formed in one end, far away from the first through groove 18, of the top of the structural plate 17 in a penetrating manner, a conical filter screen 26 is fixedly connected inside the second through groove 19, and filter cloth 20 is glued to the top of the conical filter screen 26;

one end of the structural plate 17 is fixedly connected with a limiting plate 21, and one end, far away from the limiting plate 21, of the top of the structural plate 17 is provided with a holding groove 22 in a penetrating mode.

Wherein, cauldron body 1 top fixedly connected with gear motor 4, gear motor 4 bottom output shaft fixedly connected with puddler 6, puddler 6 are located the internal portion of cauldron, and gear motor 4 work drives puddler 6 and rotates, can stir, mix the interior chyme intestinal mucosa of cauldron body 1 with auxiliary material such as clear water and protease and weak alkali lye, and cauldron body 1 top one end fixedly connected with auxiliary material filling subassembly 3, the inboard fixedly connected with heating element 5 of cauldron body 1.

Wherein, auxiliary material filling subassembly 3 includes filling tube 27, filling tube 27's setting is convenient to pour protease and weak base liquid into its inside, filling tube 27 inside fixedly connected with baffle ring 32, the inside fixedly connected with structure dish 28 in filling tube 27, the inside cover that runs through of structure dish 28 is equipped with connecting rod 30, connecting rod 30 cover is in structure dish 28, can reciprocate, connecting rod 30 top fixedly connected with rubber slab 31, rubber slab 31 moves up and pastes tightly in baffle ring 32 below in cauldron body 1 internal pressure or steam promotion, can block up filling tube 27, structure groove 29 has been offered in the equidistance penetration outside that connecting rod 30 was kept away from at structure dish 28 top, the protease and the weak base liquid of conveniently pouring in filling tube 27 fall to cauldron body 1 in the seting up of structure groove 29.

Wherein, heating element 5 includes hot plate 10, and the inside equidistance fixedly connected with electric heater strip 11 of hot plate 10, electric heater strip 11 work can heat, and it has magnesia powder 12 to fill between electric heater strip 11 and the hot plate 10, and magnesia powder 12 plays insulating, heat conduction's effect, can absorb the temperature after electric heater strip 11 heats fast and conduct to hot plate 10 on, and can prevent that electric current on the electric heater strip 11 from conducting to hot plate 10 on.

Wherein, cauldron body 1 one end fixedly connected with temperature controller 7, the detection end of temperature controller 7 is located the internal portion of cauldron, and the electric current output of temperature controller 7 constitutes the electricity through the electric wire and is connected with the electric current input of magnesia powder 12, and temperature controller 7 can detect and show the internal temperature of cauldron, and the operation temperature controller 7 can control electric heater strip 11 heating and heating temperature thereof.

Wherein, the second reservation groove 25 has been run through at board cover 14 top, the second reservation groove 25 is located the unloading intraductal bottom of 13, the seting up of second reservation groove 25 makes things convenient for the chyme intestinal mucosa etc. in the unloading intraductal to fall to in second through groove 19 or the first through groove 18, the board cover 14 bottom has run through and has been setted up first reservation groove 24, the seting up of first reservation groove 24 makes things convenient for filtrate under the filtration or the thick outflow after the filtration, the equal fixedly connected with sealing washer 23 of bottom and interior top in board cover 14, sealing washer 23 be used for sealing between board cover 14 and the structural slab 17.

Wherein, cauldron body 1 top fixedly connected with inlet pipe 8, inlet pipe 8 top is provided with sealed lid 9, opens sealed lid 9 and can annotate the chyme intestinal mucosa in the cauldron body 1 through inlet pipe 8, closes sealed lid 9 and can seal up inlet pipe 8, cauldron body 1 one side fixedly connected with observation window 33, and the setting of observation window 33 makes things convenient for personnel to observe the internal chyme intestinal mucosa reaction condition of cauldron body 1.

The working principle of the utility model is as follows: the device is connected with an external power supply by using a power line, a sealing cover 9 is opened to pour the minced-shaped intestinal mucosa into a kettle body 1 through a feed pipe 8, after a certain amount of clear water is added, a reducing motor 4 is opened to drive a stirring rod 6 to rotate, the minced-shaped intestinal mucosa and the clear water are stirred and mixed, when protease and weak alkali liquor are required to be added, the minced-shaped intestinal mucosa and the clear water are poured into a feed pipe 27, a rubber plate 31 is pushed to move downwards by using tools such as rods and the like, the protease and the weak alkali liquor enter the feed pipe 27 and then fall into the kettle body 1 through a plurality of structural grooves 29, the tools such as rods and the like are pulled out after the addition, steam or pressure in the kettle body 1 pushes the rubber plate 31 to move upwards and cling to the lower part of a baffle ring 32, the kettle body is plugged, loss of pressure or temperature in the kettle body 1 can be prevented when auxiliary materials are added, a set value of the temperature controller 7 is set to control an electric heating wire 11 to heat, magnesium oxide powder 12 can quickly absorb the temperature of the electric heating wire 11 after heating and is conducted onto a heating plate 10, heating the chyme intestinal mucosa mixture in the kettle body 1 to enable the chyme intestinal mucosa mixture to react in a constant temperature environment, holding the structural plate 17 through the holding groove 22 after the reaction is finished, pulling the structural plate 17 to enable the second through groove 19 to move into the plate sleeve 14 and to be opposite to the second reserved groove 25, enabling the chyme intestinal mucosa mixture after the reaction in the kettle body 1 to fall on the filter cloth 20, filtering the chyme intestinal mucosa mixture through the conical filter screen 26 and the filter cloth 20, enabling filtered filtrate to flow out through the first reserved groove 24 at the bottom of the plate sleeve 14, opening the vibrating motor 15 to generate vibration and conducting the vibration into the blanking pipe 13 during the filtering process to vibrate the internal chyme intestinal mucosa mixture, improving the filtering efficiency of the chyme intestinal mucosa mixture, holding the structural plate 17 again through the holding groove 22 after the filtering is finished, enabling the first through groove 18 to move into the plate sleeve 14 and to be opposite to the second reserved groove 25, the filtered dope may flow out through the first through-groove 18 and the first pre-groove 24.

The last points to be described are: first, in the description of the present utility model, it should be noted that, unless otherwise specified and defined, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be mechanical or electrical, or may be a direct connection between two elements, and "upper," "lower," "left," "right," etc. are merely used to indicate relative positional relationships, which may be changed when the absolute position of the object being described is changed;

secondly: in the drawings of the disclosed embodiments, only the structures related to the embodiments of the present disclosure are referred to, and other structures can refer to the common design, so that the same embodiment and different embodiments of the present disclosure can be combined with each other under the condition of no conflict;

finally: the foregoing description of the preferred embodiments of the utility model is not intended to limit the utility model to the precise form disclosed, and any such modifications, equivalents, and alternatives falling within the spirit and principles of the utility model are intended to be included within the scope of the utility model.

Claims (7)

1. The utility model provides a reation kettle that heparin sodium production was used, includes the cauldron body (1), its characterized in that: the device is characterized in that a discharging assembly (2) is fixedly connected to the bottom of the kettle body (1), the discharging assembly (2) comprises a discharging pipe (13), a vibrating motor (15) is fixedly connected to one side of the discharging pipe (13), a plate sleeve (14) is fixedly connected to the bottom of the discharging pipe (13), and a filtering assembly (16) is sleeved inside the plate sleeve (14);

the filter assembly (16) comprises a structural plate (17), a first through groove (18) is formed in one end of the top of the structural plate (17) in a penetrating mode, a second through groove (19) is formed in one end, far away from the first through groove (18), of the top of the structural plate (17) in a penetrating mode, a conical filter screen (26) is fixedly connected inside the second through groove (19), and filter cloth (20) is glued to the top of the conical filter screen (26);

one end of the structural plate (17) is fixedly connected with a limiting plate (21), and one end, far away from the limiting plate (21), of the top of the structural plate (17) is provided with a holding groove (22) in a penetrating mode.

2. The reaction kettle for heparin sodium production according to claim 1, wherein: the novel kettle comprises a kettle body (1), wherein a gear motor (4) is fixedly connected to the top of the kettle body (1), a stirring rod (6) is fixedly connected to an output shaft at the bottom of the gear motor (4), the stirring rod (6) is positioned inside the kettle body (1), an auxiliary material filling assembly (3) is fixedly connected to one end of the top of the kettle body (1), and a heating assembly (5) is fixedly connected to the inner side of the kettle body (1).

3. The reaction kettle for heparin sodium production according to claim 2, wherein: auxiliary material filling subassembly (3) are including filling tube (27), inside fixedly connected with baffle ring (32) of filling tube (27), in filling tube (27) bottom fixedly connected with structure dish (28), inside the penetrating sleeve of structure dish (28) is equipped with connecting rod (30), connecting rod (30) top fixedly connected with rubber slab (31), structure groove (29) have been seted up in outside equidistance that connecting rod (30) were kept away from at structure dish (28) top.

4. The reaction kettle for heparin sodium production according to claim 2, wherein: the heating assembly (5) comprises a heating plate (10), electric heating wires (11) are fixedly connected to the inside of the heating plate (10) at equal intervals, and magnesia powder (12) is filled between the electric heating wires (11) and the heating plate (10).

5. The reaction kettle for heparin sodium production according to claim 4, wherein: one end of the kettle body (1) is fixedly connected with a temperature controller (7), a detection end of the temperature controller (7) is positioned inside the kettle body (1), and a current output end of the temperature controller (7) is electrically connected with a current input end of the magnesia powder (12) through a power line.

6. The reaction kettle for heparin sodium production according to claim 1, wherein: the second reservation groove (25) has been run through at board cover (14) top, second reservation groove (25) are located the unloading intraductal bottom of pipe (13), first reservation groove (24) has been run through to board cover (14) bottom, bottom and interior top all fixedly connected with sealing washer (23) in board cover (14).

7. The reaction kettle for heparin sodium production according to claim 1, wherein: the novel kettle is characterized in that a feeding pipe (8) is fixedly connected to the top of the kettle body (1), a sealing cover (9) is arranged at the top of the feeding pipe (8), and an observation window (33) is fixedly connected to one side of the kettle body (1).