CN219440199U

CN219440199U - Oxygen bubble supply device

Info

Publication number: CN219440199U
Application number: CN202320139210.3U
Authority: CN
Inventors: 王越
Original assignee: Xinqing Medical Suzhou Co ltd
Current assignee: Xinqing Medical Suzhou Co ltd
Priority date: 2023-01-13
Filing date: 2023-01-13
Publication date: 2023-08-01
Anticipated expiration: 2033-01-13

Abstract

The utility model relates to an oxygen bubble supply device, which supplies oxygen bubbles which are oxygen micro-nano bubbles and/or oxygen nano bubbles, and comprises: an oxygen line assembly for delivering oxygen bubbles into the blood circuit; a bubble generator comprising a chamber for containing a gas-liquid mixture and a bubble cutting mechanism for generating mechanical shear forces for cutting the gas-liquid mixture to produce charged oxygen bubbles; the bubble generator is connected with the oxygen delivery pipeline component and is used for conveying generated oxygen bubbles to the oxygen delivery pipeline component. The oxygen bubble supply device has a simple and small whole structure, can simply and reliably manufacture and convey micron-level or even nano-level oxygen bubbles, can replace a hollow fiber membrane to be used as an oxygenation component, reduces the use of an anticoagulant, reduces the risk of bleeding, can reduce the contact area with blood, reduces the risk of coagulation and platelet activation, and can improve the safety as a whole.

Description

Oxygen bubble supply device

Technical Field

The utility model relates to the technical field of medical equipment, in particular to an oxygen bubble supply device.

Background

The extracorporeal membrane lung oxygenation technology (ECMO) is used for establishing an artificial lung outside a human body, mainly plays a part in replacing part of lung functions, supports the lung functions on the basis of not aggravating the primary diseases, enables organs to repair by themselves through the extracorporeal circulation function, and maintains oxygenation blood supply of organ tissues of the human body, so that vital signs are effectively maintained, and enough time is provided for subsequent treatment of damaged organs.

ECMO can provide gas exchange and systemic blood circulation. However, with ECMO technology, because of the relatively large area of contact with blood, there is still a need to use a certain amount of anticoagulant, resulting in a patient at risk of bleeding and thrombosis, and different sizes of ECMO are required for patients with different oxygen requirements. Meanwhile, when the device is used by adults, a 1/2 inch pipeline is usually matched, and the device is relatively traumatic. ECMO requires the use of hollow fiber membranes to effect oxygenation of blood and oxygen, however hollow fiber membranes are complex and expensive to manufacture.

Therefore, how to provide a blood oxygen supply device that is convenient to use and does not need a hollow fiber membrane is one of the technical problems that need to be solved in the art.

Disclosure of Invention

Based on the above-mentioned drawbacks in the prior art, the present utility model aims to provide an oxygen bubble supply device, which is safe in oxygen supply, convenient in use and wide in application scenario.

Therefore, the utility model provides the following technical scheme.

The utility model provides an oxygen bubble supply device, which supplies oxygen bubbles which are oxygen micro-nano bubbles and/or oxygen nano bubbles, and the oxygen bubble supply device comprises:

an oxygen line assembly for delivering the oxygen bubbles into the blood circuit;

a bubble generator comprising a chamber to contain a gas-liquid mixture and a bubble cutting mechanism to generate mechanical shear forces to cut the gas-liquid mixture to produce charged oxygen bubbles; the bubble generator is connected with the oxygen delivery pipeline component and used for conveying generated oxygen bubbles to the oxygen delivery pipeline component.

Preferably, the bubble cutting mechanism comprises a centrifugal mechanism, a multistage turbine mechanism or a homogenizing mechanism.

Preferably, a bubble filter is arranged between the oxygen therapy pipeline component and the bubble generator, and the bubble filter is used for filtering bubbles with the diameter larger than a preset value.

Preferably, the oxygen therapy pipeline assembly comprises a first water tank, wherein one end of the first water tank is connected with the bubble generator, and the other end of the first water tank is used for being connected with the blood circuit; the first tank is used for containing a conveying solution.

Preferably, the transport solution is an electrolyte solution or a mixed solution including a liposome solution, a dextran solution, an albumin solution, and an electrolyte solution.

Preferably, the oxygen delivery pipeline assembly comprises a delivery pipeline, a first pressure sensor, a second pressure sensor and a hydraulic adjusting device, one end of the delivery pipeline is connected with the first water tank, the other end of the delivery pipeline is used for being connected with the blood circuit, a first control valve is arranged on the delivery pipeline, and the first pressure sensor and the second pressure sensor are respectively arranged at two ends of the delivery pipeline;

wherein the hydraulic pressure adjusting device is operable to adjust the hydraulic pressure in the delivery line when the hydraulic pressure difference between the first pressure sensor and the second pressure sensor is greater than a preset value.

Preferably, the hydraulic pressure adjusting device comprises a second water tank and a piston, the second water tank is communicated with the conveying pipeline, the piston is arranged above liquid in the second water tank, and the piston can move in the second water tank under the driving of external force so as to adjust the pressure of the liquid in the conveying pipeline.

Preferably, the hydraulic adjusting device comprises a piston rod and a linear driving mechanism, and the linear driving mechanism drives the piston rod to drive the piston to move; or alternatively

The second water tank comprises an air inlet and an air outlet, and the air pressure born by the piston can be regulated by controlling the air inlet rate of the air inlet and/or the air outlet rate of the air outlet so as to drive the piston to move.

Preferably, the oxygen delivery line assembly includes a dissolved oxygen detection device for detecting the oxygen concentration of the delivery solution in the first tank.

Preferably, the oxygen delivery pipeline assembly comprises a bubble size detection device and a return pipeline, wherein the bubble size detection device is arranged on the delivery pipeline and is positioned between the first control valve and the first water tank and used for detecting the diameter of bubbles in the delivery pipeline; one end of the return pipeline is connected with the conveying pipeline between the bubble size detection device and the first control valve, the other end of the return pipeline is connected with the bubble generator, and the return pipeline is provided with a second control valve and a driving pump;

when the bubble size detection device detects that the diameter of bubbles in the conveying pipeline is larger than a preset value, the first control valve is closed, the second control valve is opened, and the driving pump works to convey the bubbles in the conveying pipeline back to the bubble generator.

Preferably, the device further comprises a large bubble breaking device arranged at the bubble generator for breaking oxygen bubbles in the bubble generator when bubbles larger than a preset size exist.

The utility model has the following technical effects:

the utility model provides an oxygen bubble supply device, which can simply and reliably manufacture and convey micron-level or even nano-level oxygen bubbles, can be used for oxidizing hemoglobin in blood without generating air embolism, can replace a hollow fiber membrane as an oxygenation component, further can reduce the use of an anticoagulant, reduce the risk of bleeding, reduce the contact area with blood, reduce the risk of coagulation and platelet activation, and improve the safety as a whole, and has simple and small overall structure, convenient use and wide application fields.

Drawings

FIG. 1 is a schematic diagram showing an assembly structure of an oxygen bubble supply device and a blood circuit according to an embodiment of the present utility model;

fig. 2 is a schematic diagram illustrating an assembly structure of an oxygen bubble supply device and a blood circuit according to another embodiment of the present utility model.

Description of the reference numerals

100. An oxygen bubble supply device;

1. an oxygen delivery line assembly; 11. a first water tank; 121. a first pressure sensor; 122. a second pressure sensor; 131. a delivery line; 132. a return line; 141. a first control valve; 142. a second control valve; 151. a second water tank; 1511. an air inlet; 1512. an air outlet; 152. a piston; 153. a piston rod; 16. a dissolved oxygen detecting device; 17. a bubble size detecting device; 18. driving a pump;

2. a bubble generator;

3. a bubble filter;

4. a large bubble crushing device;

200. a blood circuit.

Detailed Description

In order to make the technical scheme and the beneficial effects of the utility model more obvious and understandable, the following detailed description is given by way of example. Unless defined otherwise, technical and scientific terms used herein have the same meaning as technical and scientific terms in the technical field to which this application belongs.

In the description of the present utility model, unless explicitly defined otherwise, terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "height", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., refer to an orientation or positional relationship based on that shown in the drawings, and are merely for convenience of simplifying the description of the present utility model, and do not indicate that the apparatus or element referred to must have a specific orientation, be constructed and operated in a specific orientation, i.e., are not to be construed as limiting the present utility model.

In the present utility model, the terms "first", "second" are used for descriptive purposes only and are not to be construed as relative importance of the features indicated or the number of technical features indicated. Thus, a feature defining "first", "second" may explicitly include at least one such feature. In the description of the present utility model, "plurality" means at least two; "plurality" means at least one; unless otherwise specifically defined.

In the present utility model, the terms "mounted," "connected," "secured," "disposed," and the like are to be construed broadly, unless otherwise specifically limited. For example, "connected" may be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, or can be communicated between two elements or the interaction relationship between the two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present utility model, unless explicitly defined otherwise, a first feature "on", "above", "over" and "above", "below" or "under" a second feature may be that the first feature and the second feature are in direct contact, or that the first feature and the second feature are in indirect contact via an intermediary. Moreover, a first feature "above," "over" and "on" a second feature may be that the first feature is directly above or obliquely above the second feature, or simply indicates that the level of the first feature is higher than the level of the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the level of the first feature is less than the level of the second feature.

The oxygen bubble supply device of the present utility model is described in detail below with reference to fig. 1 to 2.

In the present embodiment, as shown in fig. 1 and 2, the oxygen bubbles supplied by the oxygen bubble supply device 100 are oxygen micro-nano bubbles and/or oxygen nano bubbles, and the oxygen bubble supply device 100 includes an oxygen transfer line assembly 1 and a bubble generator 2, and the oxygen transfer line assembly 1 is used for transferring oxygen bubbles into the blood circuit 200. The bubble generator 2 comprises a chamber for containing a gas-liquid mixture and a bubble cutting mechanism for generating mechanical shearing force for cutting the gas-liquid mixture to generate oxygen micro-nano bubbles and/or oxygen nano bubbles, wherein the shape of the oxygen bubbles with the size is maintained by self-charged charges on the bubbles, the charging property of the micro-nano bubbles is related to the structure of a water sub-group at a gas-liquid interface, pure water at the gas-liquid interface is composed of water molecules and a small amount of H & lt+ & gt and OH & lt- & gt generated by ionization, and the gas-liquid interface formed by the micro-nano bubbles in the water has the characteristic of being easy to accept H & lt+ & gt and OH & lt- & gt, and cations are usually easier to leave the gas-liquid interface than anions to enable the interface to be negatively charged. The already charged surface tends to adsorb counter ions (especially high valence counter ions) in the medium, thereby forming a stable electric double layer. In the definition in the art, oxygen micro-nano bubbles refer to oxygen bubbles having a diameter of between tens of micrometers and hundreds of nanometers, and oxygen nano bubbles refer to oxygen bubbles having a diameter of less than 100 nanometers. Thus, the oxygen microbubbles and/or oxygen nanobubbles formed by the cleavage can form charged oxygen bubbles. The bubble generator 2 is connected to the oxygen line assembly 1 for delivering generated oxygen bubbles to the oxygen line assembly 1 and then delivering the oxygen bubbles to the blood circuit 200 through the oxygen line assembly 1.

It should be understood that the blood circuit 200 may be a blood circuit in a blood circulation device, or may be a test circuit with blood. Taking a blood circuit in a blood circulation device as an example, the blood circuit is used for being connected with a blood vessel of a human body, and comprises a circuit inlet and a circuit outlet, when the blood circuit is connected with the human body, venous blood of the human body can enter the circuit inlet, hemoglobin and transported micro-oxygen bubbles in the circuit are oxygenated, and the oxygenated blood is transported to the human body through the circuit outlet. It will be appreciated that the test circuit with blood may also have a circuit inlet and a circuit outlet to enable an oxygenation efficiency test.

Through adopting above-mentioned scheme, can simply reliably make and carry micron level even nanometer level oxygen bubble, the oxygen bubble of this size level can with the hemoglobin oxygenation in the blood, and can not produce the air lock, consequently can replace hollow fiber membrane as oxygenation parts, further, can reduce the use of anticoagulant, reduce the risk of hemorrhage, can also reduce the area of contact with blood, reduce the risk of coagulation and platelet activation, the whole security that can improve, and oxygen bubble supply device overall structure is simple small and exquisite, convenient to use, applicable occasion is many.

In one embodiment, the bubble cutting mechanism comprises a centrifugal mechanism, a multi-stage turbine mechanism, or a homogenizing mechanism.

Wherein, the liquid crystal display device comprises a liquid crystal display device,

the centrifugal mechanism comprises a sound wave processor and a centrifugal instrument, wherein the sound wave processor is used for enabling the mixture of liquid and gas to generate tiny gas microbubbles, and then the centrifugal instrument is used for generating centrifugal force to shear the gas-liquid mixture to form the oxygen bubbles.

The multi-stage turbine mechanism is used for enabling the liquid to generate vortex, the vortex absorbs air to be rubbed into fine microbubbles, then nanoscale bubbles are generated through magnetic resonance and released into the liquid, and the oxygen bubbles are formed.

The homogenizing mechanism is used for placing the gas-liquid mixture into the homogenizer for mixing and stirring, kneading the gas and the liquid into bubbles under the action of shearing force, and shearing the bubbles into the oxygen bubbles through shearing for a plurality of times.

In one embodiment, as shown in fig. 1 and 2, a bubble filter 3 is disposed between the oxygen therapy line assembly 1 and the bubble generator 2, and the bubble filter 3 is used for filtering bubbles with a diameter greater than a preset value. In the process of generating bubbles, the bubble generator 2 also generates bubbles with larger diameters, which are harmful to human bodies, and the harmful bubbles are filtered out by the bubble filter 3, so that the use safety of the oxygen bubble supply device is improved. The bubble filter 3 can be constructed as a standard hydrophobic filter membrane of the respective diameter or as another construction which can serve to filter bubbles of the respective diameter.

In one embodiment, as shown in fig. 1 and 2, the oxygen therapy line assembly 1 includes a first water tank 11, one end of which is connected to the bubble generator 2, and the other end of which is connected to the blood circuit 200; the first tank 11 is used for containing the transport solution. By defining the volume of the first water tank 11 to act as a buffer for oxygen bubbles generated by the bubble generator 2, the stability of delivery throughout the oxygen delivery line assembly 1 is stabilized.

Further, the transport solution is an electrolyte solution, or a mixed solution including a liposome solution, a dextran solution, an albumin solution, and an electrolyte solution. The oxygen bubbles generated by the bubble generator 2 are negatively charged, and the mixed solution can be prepared to have a certain negative charge, so that the transportation of the oxygen bubbles can be accelerated.

In one embodiment, as shown in fig. 1, the oxygen delivery line assembly 1 includes a delivery line 131, a first pressure sensor 121, a second pressure sensor 122, and a hydraulic adjustment device. One end of the delivery pipeline 131 is connected with the first water tank 11, the other end of the delivery pipeline 131 is connected with the blood circuit 200, a first control valve 141 is arranged on the delivery pipeline 131, and the first pressure sensor 121 and the second pressure sensor 122 are respectively arranged at two ends of the delivery pipeline 131; wherein the hydraulic pressure adjusting means is operable to adjust the hydraulic pressure in the delivery line when the hydraulic pressure difference between the first pressure sensor 121 and the second pressure sensor 122 is greater than a preset value. It can be understood that the oxygen bubble concentration or the change of the conveying speed in the first water tank 11 affects the oxygen bubble input efficiency in the conveying pipeline 131, and the conveying speed of the conveying pipeline 131 into the blood circuit 200 or the hydraulic pressure in the blood circuit 200 affects the oxygen bubble output efficiency of the conveying pipeline 131, and even the phenomenon that the blood in the blood circuit 200 permeates into the conveying pipeline 131 occurs, so that the pressure difference at two ends of the conveying pipeline 131 can be accurately controlled by arranging the first pressure sensor 121, the second pressure sensor 122 and the hydraulic pressure adjusting device, so as to ensure effective and safe oxygen bubble conveying.

It should be appreciated that the first pressure sensor 121 is configured to detect the hydraulic pressure of the fluid in the first reservoir 11 applied to the inlet end of the delivery line 131 and the second pressure sensor 122 is configured to detect the hydraulic pressure of the fluid in the blood circuit 200 applied to the outlet end of the delivery line 131.

Further, as shown in fig. 1 and 2, the hydraulic pressure adjusting device includes a second water tank 151 and a piston 152. The second water tank 151 is in communication with the delivery pipe 131, and the piston 152 is disposed above the liquid in the second water tank 151, and the piston 152 is movable in the second water tank 151 under the driving of an external force to adjust the liquid pressure in the delivery pipe. When the pressure difference between the two ends of the conveying pipeline 131 is greater than the preset value, the piston 152 is driven by the external force to move, so that the liquid in the conveying pipeline 131 flows to the second water tank 151 or the liquid in the second water tank 151 flows to the conveying pipeline 131, and finally the hydraulic pressure difference between the two ends of the conveying pipeline 131 is not greater than the preset value.

Further, as shown in fig. 1, in an embodiment, the hydraulic adjusting device includes a piston rod 153 and a linear driving mechanism, the linear driving mechanism drives the piston rod 153 to move, and the linear driving mechanism applies a mechanical driving force to the piston rod 153 to finally drive the piston 152 to move, so that the driving is stable and quick.

In yet another embodiment, as shown in fig. 2, the second water tank 151 includes an air inlet 1511 and an air outlet 1512, and the air pressure to which the piston 152 is subjected can be adjusted by controlling the air inlet rate of the air inlet 1511 and/or the air outlet rate of the air outlet 1512 to drive the piston 152 to move. By varying the air pressure in the space above the piston 152, the piston 152 is moved and the control is more accurate and reliable.

In one embodiment, as shown in fig. 1, the oxygen delivery line assembly 1 includes a dissolved oxygen detecting device 16 for detecting the oxygen concentration of the solution delivered in the first water tank 11, so that the bubble generator 2 can adjust its own bubble generation efficiency according to the oxygen concentration in the first water tank 11, so that the oxygen concentration in the oxygen delivery line assembly 1 is substantially maintained within a range value, and thus oxygen can be stably, safely and effectively supplied.

In one embodiment, as shown in fig. 1, the oxygen delivery pipeline assembly 1 includes a bubble size detection device 17 and a return pipeline 132, wherein the bubble size detection device 17 is disposed on the delivery pipeline 131 and is located between the first control valve 141 and the first water tank 11, so as to detect the diameter of bubbles in the delivery pipeline 131; one end of the return line 132 is connected to the delivery line 131 between the bubble size detection device 17 and the first control valve 141, and the other end is connected to the bubble generator 2, and the return line 132 is provided with the second control valve 142 and the drive pump 18. When the bubble size detecting device 17 detects that the diameter of the bubble in the conveying pipeline 131 is greater than a preset value, the first control valve 141 may be closed, the second control valve 142 may be opened, the driving pump 18 is operated to convey the bubble in the conveying pipeline 131 back into the bubble generator 2, and when the bubble size detecting device 17 detects that the diameter of the bubble in the conveying pipeline 131 accords with the preset value, the second control valve 142 may be closed, the first control valve 141 may be opened, and the conveying pipeline 131 conveys the oxygen bubble to the blood circuit 200 again, so as to ensure the safety of oxygen bubble supply. Alternatively, the drive pump 18 is a peristaltic pump. It will be appreciated that the oxygen line assembly 1 has a control unit to control the various actions of the first control valve 141, the second control valve 142 and the drive pump 18.

Further, as shown in fig. 1, the apparatus further comprises a large bubble breaking device 4 disposed at the bubble generator 2, and configured to break up the oxygen bubbles in the bubble generator 2 when detecting that bubbles larger than a predetermined size exist (e.g. detecting by using a bubble size detector), so as to break up and reuse the large oxygen bubbles returned into the bubble generator 2, thereby preventing the large bubbles from entering the blood circuit to generate adverse effects. Wherein the large bubble breaking means 4 include, but are not limited to, ultrasound means or magnetic resonance means.

It should be understood that the above examples are illustrative and are not intended to encompass all possible implementations encompassed by the claims. Various modifications and changes may be made in the above embodiments without departing from the scope of the disclosure. Likewise, the individual features of the above embodiments can also be combined arbitrarily to form further embodiments of the utility model which may not be explicitly described. Therefore, the above examples merely represent several embodiments of the present utility model and do not limit the scope of protection of the patent of the present utility model.

Claims

1. An oxygen bubble supply device which supplies oxygen bubbles that are oxygen micro-nano bubbles and/or oxygen nano bubbles, characterized in that the oxygen bubble supply device comprises:

2. The oxygen bubble supply apparatus of claim 1, wherein the bubble cutting mechanism comprises a centrifugal mechanism, a multi-stage turbine mechanism, or a homogenizing mechanism.

3. The oxygen bubble supply apparatus according to claim 1, wherein a bubble filter is provided between the oxygen therapy line assembly and the bubble generator, the bubble filter being configured to filter bubbles having a diameter greater than a preset value.

4. The oxygen bubble supply apparatus of claim 1, wherein the oxygen delivery line assembly comprises a first water tank having one end connected to the bubble generator and the other end connected to the blood circuit; the first tank is used for containing a conveying solution.

5. The oxygen bubble supply apparatus according to claim 4, wherein the oxygen therapy line assembly comprises a delivery line, a first pressure sensor, a second pressure sensor and a hydraulic pressure adjusting device, one end of the delivery line is connected with the first water tank, the other end of the delivery line is connected with the blood circuit, a first control valve is arranged on the delivery line, and the first pressure sensor and the second pressure sensor are respectively arranged at two ends of the delivery line;

6. The oxygen bubble supply apparatus according to claim 5, wherein the hydraulic pressure adjusting means includes a second water tank that communicates with the delivery pipe, and a piston that is provided above the liquid in the second water tank, the piston being movable in the second water tank under an external force to adjust the liquid pressure in the delivery pipe.

7. The oxygen bubble supply apparatus according to claim 6, wherein the hydraulic pressure adjusting means includes a piston rod and a linear driving mechanism that drives the piston rod to move the piston; or alternatively

8. The oxygen bubble supply apparatus according to claim 4, wherein the oxygen delivery line assembly comprises a dissolved oxygen detection device for detecting the oxygen concentration of the delivery solution in the first water tank.

9. The oxygen bubble supply apparatus of claim 5, wherein the oxygen delivery line assembly includes a bubble size detection means disposed on the delivery line between the first control valve and the first water tank for detecting a diameter of a bubble in the delivery line; one end of the return pipeline is connected with the conveying pipeline between the bubble size detection device and the first control valve, the other end of the return pipeline is connected with the bubble generator, and the return pipeline is provided with a second control valve and a driving pump;

10. The oxygen bubble supply apparatus according to claim 9, further comprising a large bubble breaking device provided at the bubble generator for breaking oxygen bubbles in the bubble generator when bubbles larger than a preset size are present.