CN219416929U - Cover plate for slide sample processing and slide sample processing device - Google Patents

Abstract

The utility model provides a cover plate for slide sample treatment and a slide sample treatment device, wherein the cover plate comprises a slide plane (8) and a reagent sample adding inclined plane (5) which is obliquely connected with the top edge of the slide plane (8), a longitudinal limiting piece (7) is arranged at the bottom end of the slide plane (8), side walls (6) which are bilaterally symmetrical are arranged at the two sides of the slide plane (8), and the side walls (6) comprise slide binding surfaces (601) which are parallel to the slide plane and are higher than the slide plane; the two sides of the reagent sample adding inclined plane are provided with side plates (1) for transverse limiting of the slide, and two sides of one end of the reagent sample adding inclined plane (5) connected with the slide plane (8) are symmetrically provided with inclined reagent drainage surfaces (2). According to the utility model, the reagent drainage surface is arranged on the cover plate, so that the detection reagent is drained to the capillary cavity between the glass slide and the cover plate, and the detection reagent can uniformly cover the sample.

Description

Cover plate for slide sample processing and slide sample processing device

Technical Field

The utility model relates to the technical field of experimental instruments, in particular to a cover plate for slide sample treatment and a slide sample treatment device.

Background

The detection of slide samples may undergo several or even tens of steps depending on the type of detection and the means. The complex detection method requires more detection time and detection steps, the time of exposing the slide in the air is prolonged, and the experimental environment and the manual operation can have great influence on the detection result of the sample.

The slide is exposed to air and the detection reagent covered on the sample is volatile, resulting in a dry plate, and is also susceptible to airborne drift. In the process of detecting reagent dripping, dosage is not easy to control, and reagent coverage problem can exist. The original liquid on the glass slide needs to be removed in the sample processing process, and the process has large human error, which may cause excessive waste liquid residue to affect the next experiment, or damage the sample in the wiping process and dry the sample caused by wiping. Although some of the problems can be solved using a cover slip, there is a need for a device that solves the above problems due to the disadvantage of the cover slip being easily broken and easily moved.

The prior art is as disclosed in Chinese patent publication No. CN106226141A for a slide cover plate for slide specimen treatment and a use method thereof, wherein the slide cover plate consists of a capillary plane, a positioning block, a sample adding groove and a diversion port, a capillary gap is formed between a slide and the capillary plane, the slide is limited by different positioning blocks, and waste liquid is discharged through the diversion port. The Chinese patent publication No. CN216718451U discloses a glass slide cover plate, an immunohistochemical staining combination and a specimen processing device, wherein the glass slide cover plate comprises a bottom plate, a support frame and a lug provided with a glass slide supporting hook, and the bottom plate consists of a capillary plate and a liquid inlet sloping plate. The scheme can overcome the defects that the cover glass is easy to break and move to a certain extent, but still has the problems of uneven reagent coverage and excessively complex cover plate device.

Disclosure of Invention

In order to overcome the above-mentioned drawbacks in the prior art, a first aspect of the present utility model proposes a cover plate for slide sample treatment, comprising a slide plane and a reagent sample loading inclined plane obliquely connected to the top edge of the slide plane, wherein the bottom end of the slide plane is provided with a longitudinal limiting member, two sides of the slide plane are provided with side walls which are bilaterally symmetrical, and the side walls comprise a slide fitting surface parallel to the slide plane and higher than the slide plane; the both sides on reagent application of sample inclined plane are provided with the curb plate for the horizontal spacing of slide, and reagent application of sample inclined plane and the continuous one end bilateral symmetry of slide plane are provided with the reagent drainage face of slope, effectively infiltrate the sample, avoid the uneven error that leads to of reagent coverage, also can have better mobility at clearance waste liquid in-process simultaneously, avoid the waste liquid to remain the influence to final testing result.

Further, a waste liquid drainage groove is formed in the longitudinal limiting piece and used for discharging waste liquid, and meanwhile, the limiting function is achieved, and the setting of the limiting device is reduced.

Further, the tip of the reagent loading ramp is recessed inwardly to form a slide label viewing slot. One end of the reagent sample adding inclined plane is provided with a slide label observation groove, which is favorable for information scanning of slides, avoids adding wrong reagent in the multi-sample detection process, and reduces human error.

Further, the glass slide joint surface of the side wall is 0.01-0.5mm higher than the glass slide plane, so that a capillary cavity is formed between the glass slide plane and the glass slide, and a detection reagent can be actively sucked into a broken sample, so that the sample is prevented from being damaged due to direct dripping or spraying of the reagent above the sample.

Further, the side plate also comprises a wedge-shaped supporting edge parallel to the reagent loading inclined plane, so that the cover plate can be fixed on the slide bracket,

a second aspect of the present utility model provides a slide sample processing apparatus comprising a slide, a slide holder provided with a plurality of slots for receiving the cover plate, and a cover plate according to the first aspect of the present utility model.

The utility model provides a cover plate for slide sample treatment and a bracket comprising the cover plate, wherein the transverse and longitudinal positions of a slide are limited by a reagent sample adding inclined plane and a waste liquid draining groove, so that a limiting device is simplified, and the effect of fixing the slide is achieved. Compared with the prior art, the detection reagent is uniformly covered, and detection errors caused by insufficient sample reaction due to uneven coverage of the detection reagent are avoided. One end of the slide cover plate is provided with a waste liquid drainage groove to conveniently drain waste liquid, reduce reagent residue and avoid errors caused by insufficient reaction of the reagent in the next step due to residual reagent. One end of the reagent sample adding inclined plane is provided with a slide label observation groove, so that the loss and error caused by adding wrong reagent can be avoided in the process of simultaneously detecting a plurality of groups of samples. The reagent sample adding inclined plane and the side plate form a wedge-shaped supporting edge, the cover plate can be fixed on a specific bracket, and the problem of insufficient space caused by flat slide is reduced when a plurality of groups of samples are detected simultaneously.

Drawings

The accompanying drawings illustrate embodiments and, together with the description, serve to explain the principles of the present application. The elements of the drawings are not necessarily to scale relative to each other. Like reference numerals designate corresponding similar parts.

FIG. 1 is a schematic view of a cover plate for slide sample processing according to an embodiment of the present utility model;

fig. 2 is a schematic view of a slide sample processing apparatus according to another embodiment of the present utility model.

Reference numerals in the drawings: the device comprises a 1-side plate, a 2-reagent drainage surface, a 3-slide label observation groove, a 4-wedge-shaped supporting edge, a 5-reagent sample adding inclined plane, a 6-side wall, a 601-slide binding surface, a 7-longitudinal limiting piece, an 8-slide plane, a 101-bracket, a 102-cover plate and a 103-slide.

Detailed Description

The following describes examples of the present application to better understand the present application, and many of the intended advantages of other embodiments and embodiments can be appreciated from the detailed description that follows. It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising" does not exclude the presence of additional identical elements in a process, method, article, or apparatus that comprises an element. Components of embodiments may be positioned in a number of different orientations, and so directional terminology, such as "top," "bottom," "left," "right," "up," "down," etc., is used with reference to the orientation of the figures to describe some embodiments. It is to be understood that the directional terminology is used for purposes of illustration and not limitation.

FIG. 1 is a schematic view of a cover plate for slide sample treatment, the cover plate comprises a slide plane 8, the slide plane 8 and a reagent sample adding inclined plane 5 obliquely connected with the top edge of the slide plane 8, a longitudinal limiting piece 7 is arranged at the bottom end of the slide plane 8, side walls 6 which are bilaterally symmetrical are arranged at two sides of the slide plane, and the side walls 6 comprise a slide attaching surface 601 which is parallel to the slide plane 8 and higher than the slide plane 8; two sides of the reagent sample adding inclined plane are provided with side plates 1 for transverse limit of the slide. The side plate 1 also comprises a wedge-shaped supporting edge 4 parallel to the reagent sample adding inclined plane 5, and batch experiments are carried out by placing the wedge-shaped supporting edge 4 in a corresponding bracket.

The longitudinal limiting member 7 in this embodiment is provided with a waste liquid draining groove. The end of the longitudinal limiting piece 7 connected with the slide plane 8 gradually reduces the cross-sectional area along the direction of the waste liquid draining groove to form two bevel edges, and the bevel edges are used for keeping the slide sample moist by capillary siphoning and draining the reagent to the waste liquid draining groove. The side plate 1 is higher than the side wall 6, and the thickness of the slide is reserved for limiting the transverse position of the slide, so that the slide is prevented from sliding in the process of adding the detection reagent. The reagent sample adding inclined plane and the waste liquid draining groove limit the transverse and longitudinal positions of the slide, so that the limiting device is simplified, and the slide is fixed. Meanwhile, the waste liquid drainage groove is arranged at the lower end of the slide plane, so that the position limiting effect is achieved, the sample is conveniently cleaned and discharged, the waste liquid residue is reduced, and the error caused by insufficient reaction of the next reagent due to the waste liquid residue is avoided.

In another preferred embodiment, the top end of the reagent loading inclined plane 5 is inwards sunken to form a slide label observing groove 3, and samples are identified through the slide label observing groove 3 when multiple sample detection is carried out simultaneously, so that the error of loading of detection reagents is avoided.

In another preferred embodiment, the reagent drainage surface 2 is symmetrically arranged at two sides of one end of the reagent sample adding inclined surface connected with the slide plane, so that the detection reagent is drained into the capillary cavity, and the sample is completely infiltrated. Compared with the prior art, the cover plate provided with the reagent drainage inclined plane 2 can better drain the reagent into the capillary cavity, so that the detection reagent is covered more uniformly, and detection errors caused by insufficient sample reaction due to uneven detection reagent coverage are avoided.

The cover plate provided by the utility model can be singly used, and can be assembled with a specific bracket for batch experiments. In another preferred embodiment, fig. 2 is a schematic view of a slide sample processing apparatus according to another embodiment of the present utility model, where the slide sample processing apparatus includes a slide 103, a bracket 101, and a cover plate 102, the bracket 101 is provided with a plurality of cover plate slots, and the cover plate 102 and the slide 103 are assembled into a slide assembly, and the slide assembly can be fixed to the bracket by a slot structure of the bracket.

The foregoing is a preferred embodiment of the present application, and it will be apparent to those skilled in the art that various modifications and variations can be made to the embodiment of the present application without departing from the spirit and scope of the application. In this manner, the present application is also intended to cover such modifications and changes as fall within the scope of the claims of the application and the equivalents thereof.

Claims (6)

1. A cover plate for slide sample treatment, which is characterized by comprising a slide plane (8) and a reagent sample adding inclined plane (5) obliquely connected with the top edge of the slide plane (8), wherein a longitudinal limiting piece (7) is arranged at the bottom end of the slide plane (8), side walls (6) which are bilaterally symmetrical are arranged on two sides of the slide plane (8), and the side walls (6) comprise a slide attaching surface (601) which is parallel to the slide plane and higher than the slide plane; the reagent sample adding inclined plane is characterized in that two sides of the reagent sample adding inclined plane are provided with side plates (1) for transverse limiting of a slide, and inclined reagent drainage surfaces (2) are symmetrically arranged at two sides of one end, connected with a slide plane (8), of the reagent sample adding inclined plane (5).

2. Cover plate for slide sample processing according to claim 1, characterized in that the longitudinal limit piece (7) is provided with a waste liquid drain groove.

3. Cover plate for slide sample processing according to claim 1, characterized in that the top end of the reagent loading ramp (5) is recessed inwards forming a slide label viewing slot (3).

4. Cover plate for slide sample processing according to claim 1, characterized in that the slide engaging surface (601) of the side wall (6) is 0.01-0.5mm above the slide plane (8) such that a capillary cavity is formed between the slide plane (8) and the slide.

5. Cover plate for slide sample processing according to claim 1, characterized in that the side plate (1) further comprises a wedge-shaped support edge (4) parallel to the reagent loading ramp (5).

6. A slide sample processing apparatus comprising a slide (103), a slide holder (101) and a cover plate (102) according to any one of claims 1-5, the slide holder (101) being provided with a plurality of slots for receiving the cover plate (102).