CN219320520U - Light-emitting structural member, optical fiber assembly, laser interstitial thermotherapy system and laser interstitial thermotherapy system based on magnetic resonance interstitial - Google Patents

Abstract

The utility model provides a light-emitting structural member, an optical fiber assembly, a laser interstitial thermotherapy system and a laser interstitial thermotherapy system based on magnetic resonance interstice, wherein the light-emitting structural member is suitable for being connected to the far end of a transmission optical fiber, the light-emitting structural member comprises n reflecting surfaces, n is a natural number larger than 1, the n reflecting surfaces are sequentially arranged from the near end to the far end along the long axis of the light-emitting structural member, at least the 1 st to the n-1 st reflecting surfaces are reflecting surfaces with light transmittance, and the n reflecting surfaces enable light input from the near end of the light-emitting structural member to be emitted from the side direction of the light-emitting structural member.

Description

Light-emitting structural member, optical fiber assembly, laser interstitial thermotherapy system and laser interstitial thermotherapy system based on magnetic resonance interstitial

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a light-emitting structural member, an optical fiber assembly, a laser interstitial thermotherapy system and a laser interstitial thermotherapy system based on magnetic resonance interstitials.

Background

The laser interstitial thermotherapy is a therapeutic technology in which light is led into human body by optical fiber to make local biological tissue produce coagulation and necrosis after absorbing energy, and can attain the goal of removing in-situ tumor or focus by means of less invasion. This method has a number of advantages over conventional surgical resection: the operation time is short, the operation wound surface is small, a great deal of bleeding is rarely generated, the pain on a patient is small, the postoperative recovery effect is good, and the medicine has the characteristics of certain anti-inflammatory and bactericidal effects. Has good prospect in the treatment of various diseases, especially in the treatment research of tumors, and is currently used for treating tumors of many types, such as tumors of liver, brain, breast, retina and other parts.

In laser interstitial thermotherapy, in order to carry out conformal ablation on irregular focus tissues and reduce collateral damage on normal tissues, a lateral light-emitting optical fiber is adopted, the current lateral light-emitting optical fiber is realized through a reflecting structure, and because the inclination angle of the reflecting structure is too large, the angle of the reflecting structure relative to the axial direction is changed into total reflection, and the diameter of the reflecting structure is limited, so that the light-emitting area of a single reflecting structure is limited, the high-power laser is used for treatment, the energy density is too high, local tissue carbonization is easily caused, and the ablation effect is not expected; in the case of a cooling jacket outside the optical fiber, the cooling jacket may even be damaged, resulting in the cooling fluid flowing out and contacting the tissue, causing damage. At present, no optical fiber can realize the function of large-range lateral high-power light output in the axial direction of the optical fiber so as to meet the requirements.

Disclosure of Invention

In view of the foregoing, in a first aspect, the present utility model provides a light-emitting structure, which includes n reflecting surfaces, n is a natural number greater than 1, the n reflecting surfaces are sequentially disposed from a proximal end to a distal end along a long axis of the light-emitting structure, at least 1 st to n-1 st reflecting surfaces are reflecting surfaces having light transmittance, and the n reflecting surfaces change an outgoing direction of light rays after the light rays input from the proximal end of the light-emitting structure are reflected by the n reflecting surfaces. Further, the light emitting direction is changed, namely, the light is emitted from the side direction of the light emitting structural member after being input from the end face of the near end of the light emitting structural member. The light is transmitted from the near end to the far end of the light-emitting structural member after being input from the near end of the light-emitting structural member, and further, the light is transmitted from the near end to the far end of the light-emitting structural member along the long axis direction of the light-emitting structural member in the light-emitting structural member, it is to be noted that the long axis direction along the light-emitting structural member means that at least a part of the light is parallel to the long axis of the light-emitting structural member after being input from the near end of the light-emitting structural member, the 1 st to n-1 th reflecting surfaces have light transmittance, the light is refracted when passing through the reflecting surfaces, the transmission direction of the refracted light is offset to a certain extent compared with the light input from the near end, and the offset is also within the coverage range of 'the light is transmitted along the long axis direction of the light-emitting structural member'. In addition, in some embodiments, a portion of the light entering from the proximal end of the light emitting structure is not parallel to the long axis of the light emitting structure, but has an angle, and in the present utility model, the portion of the light should also fall within the coverage area of "light is transmitted along the long axis of the light emitting structure". In addition, the n reflecting surfaces are sequentially arranged from the near end to the far end along the long axis of the light emitting structure, that is, the positions of the intersection points of each reflecting surface and the long axis of the light emitting structure on the long axis are sequentially 1 to n, and other parts of the reflecting surfaces may not be sequentially arranged, for example, overlapping parts are formed.

In the preferred embodiment of the present utility model, the light-emitting structure is made of transparent and light-transmitting materials, and the light transmitted or reflected by the n reflecting surfaces can exit from the side of the light-emitting structure.

However, in some embodiments, the structural member body of the light-emitting structural member is provided with a lateral light-transmitting portion, and other parts except the lateral light-transmitting portion may be covered by an opaque structure, and the n reflecting surfaces enable light input from the proximal end of the light-emitting structural member to exit from the lateral light-transmitting portion of the light-emitting structural member.

Further, in still other embodiments, the lateral light-transmitting portions may be provided in plural numbers and arranged along the circumferential direction of the light-emitting structure, in which case the n reflecting surfaces are arranged in a desired arrangement in the circumferential direction with respect to the long axis of the light-emitting structure, so that the light rays exit from the multiple directions laterally after being transmitted and/or reflected by the n reflecting surfaces, and the light rays exiting from the multiple directions laterally exit from the preset multiple lateral light-transmitting portions.

In some embodiments, in the light emitting structure of the present utility model, the reflective surface disposed closest to the distal end is a total reflective surface.

In still other embodiments, the light-emitting structure of the present utility model further includes an opaque structure disposed on a distal side of the reflective surface disposed closest to the distal end, the opaque structure preventing light from exiting the distal end of the light-emitting member in the long axis direction.

In some embodiments, the angle between the reflecting surface and the long axis is greater than 0 degrees and less than 90 degrees. Preferably, the included angle between the reflecting surface and the long axis is more than or equal to 20 degrees and less than or equal to 70 degrees.

In some embodiments, in the light emitting structural member of the present utility model, n included angles between the n reflecting surfaces and the long axis are gradually reduced along a direction from the proximal end to the distal end of the long axis; in other embodiments, the n reflecting surfaces are at the same n angles to the long axis in a proximal to distal direction of the long axis; in other embodiments, at least one of the n reflecting surfaces forms a different angle with the long axis than the remaining n-1 angles along the direction from the proximal end to the distal end of the long axis.

In some embodiments, the reflectivity of the n reflecting surfaces increases gradually along the direction from the proximal end to the distal end of the long axis, and the reflectivity of the n reflecting surfaces and the intervals between the n reflecting surfaces are set so that the light intensity of the light emitted from the side of the light emitting structural member reflected by the n reflecting surfaces is substantially uniform along the long axis.

In some embodiments, the n reflecting surfaces are arranged in parallel, and by setting the included angle between the reflecting surfaces and the long axis and the intervals between the n reflecting surfaces, the light rays reflected by the n reflecting surfaces and emitted from the lateral direction of the light emitting structural member are basically perpendicular to the long axis.

In some embodiments, at least one of the 2 nd to nth reflecting surfaces is a concave surface along a direction from a proximal end to a distal end of the long axis, and the included angle between the nth reflecting surface and the long axis and the interval between the nth reflecting surfaces are set so that the light reflected by the concave surface and the light reflected by the rest reflecting surfaces are at least partially overlapped or adjacently distributed in a lateral direction of the light-emitting structural member.

In a second aspect, the present utility model provides an optical fiber, which includes a transmission optical fiber and a light emitting structural member provided in the first aspect, where a distal end of the transmission optical fiber is adjacent to a proximal end of the light emitting structural member, the light emitting structural member includes n reflecting surfaces, n is a natural number greater than 1, the n reflecting surfaces are sequentially disposed from the proximal end to the distal end along a long axis of the light emitting structural member, at least n-1 of the reflecting surfaces are reflecting surfaces having light transmittance, and the n reflecting surfaces change directions after light transmitted along an axis of the optical fiber leaves the distal end of the transmission optical fiber and enters the light emitting structural member through the n reflecting surfaces.

Further, the direction change by the n reflecting surfaces means that the light rays are emitted from the side direction of the light emitting structural member. The n reflecting surfaces are sequentially arranged from the near end to the far end along the long axis of the light emitting structure, that is, the positions of the intersection points of each reflecting surface and the long axis of the light emitting structure on the long axis are sequentially 1 to n, and other parts of the reflecting surfaces may not be sequentially arranged, for example, overlapping parts are formed.

Optionally, the transmission optical fiber is detachably connected with the light emergent structural member;

optionally, the transmission optical fiber is fixedly connected with the light emitting structural member.

When the light rays transmitted in the optical fiber pass through the n reflecting surfaces, light spots where the light rays intersect with the reflecting surfaces completely fall into the range of the reflecting surfaces.

In the optical fiber of the present utility model, the reflecting surface may be various structures capable of refracting and/or transmitting light, and the size, shape and structure of the reflecting surface are not limited, so long as the transmitted light passes through n reflecting surfaces, the light spot where the light intersects with the reflecting surface falls completely within the range of the reflecting surface, for example, the structure of the reflecting surface may be a plane, a convex surface, a concave surface or a cambered surface; the shape of the reflecting surface may be elliptical, rectangular, polygonal, circular, etc.

The reflectivity and/or the light transmittance of the n reflecting surfaces arranged in the light-emitting structural member are set according to the requirement, so that the light leaving the light-emitting structural member can realize expected emergent distribution. The exit profile depends on a number of factors, the reflection ratio of the reflecting surfaces, their angle to the long axis of the fiber, the structure of the reflecting surfaces, the spacing distance between the different reflecting surfaces, etc.

The desired distribution may be varied, i.e. the lateral exit light intensities may form different intensity spectra along the long axis, e.g.:

Uniform lateral light emission along the axial extension of the optical fiber;

locally enhancing the intensity of the lateral light emission;

the light increases less with tissue contact surface and the area of contact with the cooling jacket or nearby tissue increases significantly.

Optionally, the reflecting surface of the light emitting structural member closest to the far end is a total reflection structure.

Optionally, a light-tight structure is further disposed on a distal side of the reflecting surface disposed closest to the distal end in the light-emitting structure, and the light-tight structure can prevent light from exiting along the long axis of the optical fiber.

Optionally, in some embodiments, the reflective performance of the n reflective surfaces of the light-emitting structure sequentially increases from the proximal end to the distal end; preferably, the nth reflecting surface of the light emergent structural member is a total reflection structure.

Optionally, in some embodiments, by setting the reflectivity of the reflecting surface and the angle with the long axis, so that the light transmitted through the optical fiber can exit in a direction substantially perpendicular to the long axis of the optical fiber, uniform exit along the long axis is achieved, for example: when n=2, the reflectance of the 1 st reflecting surface is 50%, the light transmittance is 50%, and the reflectance of the 2 nd reflecting surface is 100%; when n=3, the reflectance of the 1 st reflecting surface is 30%, the light transmittance is 70%, the reflectance of the 2 nd reflecting surface is 50%, the light transmittance is 50%, and the reflectance of the 3 rd reflecting surface is 100%; when n=4, the 1 st reflection surface has a reflectance of 25%, a light transmittance of 75%, the 2 nd reflection surface has a reflectance of 33%, a light transmittance of 67%, the 3 rd reflection surface has a reflectance of 50%, a light transmittance of 50%, and the 4 th reflection surface has a reflectance of 100%. Various other choices of reflectivity and light transmittance of the n reflective surfaces are included within the scope of the present utility model.

Optionally, in some embodiments, the light-emitting structure is provided with an opaque structure at a distal end of the nth reflecting surface, and the opaque structure may prevent light from exiting from the distal end along the axis of the optical fiber along the long axis direction, in which case, the light transmittance of the nth reflecting surface is not required.

Optionally, in some embodiments, the light transmission performance of the n reflecting surfaces of the light emitting structural member disposed from the proximal end to the distal end sequentially decreases; further, the light transmittance of the nth reflecting surface of the light-emitting structural member is 0.

In some embodiments, when light exits the light structure from the side, reaching the tissue,

in the utility model, the light transmitted by the optical fiber can comprise ablation laser and indication light, and the indication light can be visible light, so that a user can confirm the availability of the optical fiber conveniently; the ablation laser may be a single wavelength or a mixture of wavelengths, for example 980nm laser, 1064nm laser, 980nm laser and 1064nm laser.

In the present utility model, the transmission fiber may include a core and a cladding, the core may be a single core or a composite of cores, made of glass materials and/or polymeric materials, including but not limited to silica, fluorozirconate, fluoroaluminate, sulfide, and sapphire glass; polymeric materials such as, but not limited to, polymethyl methacrylate; the cladding is formed of a material having a refractive index less than the refractive index of the core.

Optionally, the transmission fiber further comprises a protective layer; the cladding is encased in a protective layer configured to provide mechanical protection and support to the cladding and the core. The protective layer may be made of any suitable material such as, but not limited to, polyvinylchloride (PVC), polytetrafluoroethylene (PTFE), and the like.

In some embodiments, the optical fiber of the present utility model may further include a collimation portion for performing collimation adjustment on the optical fiber, a proximal end of the collimation portion being disposed adjacent to a distal end of the transmission optical fiber, a distal end of the collimation portion being disposed adjacent to a proximal end of the light-emitting structure, the collimation portion being configured such that, when the transmitted light passes through the n reflection surfaces, a light spot where the light intersects the reflection surfaces falls completely within a range of the reflection surfaces; i.e. the collimating section is such that the transmitted light rays are substantially parallel to the long axis of the optical fiber when outputted from the collimating section.

Alternatively, the collimating part may be a self-focusing lens.

In some embodiments of the present utility model, the n reflecting surfaces of the light-emitting structure have the same included angle with the optical fiber axis; further, the n reflecting surfaces have the same or different shapes.

In still other embodiments of the present utility model, the n reflecting surfaces of the light-emitting structure have different angles with the axis of the optical fiber; further, the n reflecting surfaces have the same or different shapes.

In some embodiments, the optical fiber of the present utility model further comprises a sleeve that may facilitate assembly or a unitary structure of the transmission optical fiber, the collimating portion, and the light extraction structure, preferably with a portion of the light extraction structure and/or the transmission optical fiber disposed within the sleeve.

In some embodiments, the optical fiber of the present utility model further comprises a reflective coating for preventing the transmitted light from exiting the portion where the reflective coating has been installed. The reflective coating may be disposed at any desired location, such as at a non-light-emitting portion of the light-emitting structure, corresponding to a sleeve of the non-light-emitting portion of the light-emitting structure.

In a second aspect, the present utility model provides an optical fiber assembly comprising a cooling jacket and the optical fiber described above. The cooling sleeve can be single-layer or double-layer, and a dividing structure is arranged between the optical fiber and the sleeve under the condition of single layer, so that a cavity between the optical fiber and the sleeve is divided into two parts, one part is used for cooling liquid to enter, heat is taken away from a light-emitting structural part at the far end, and then the cooling liquid flows out from the other part; under the condition of a double-layer cooling sleeve, a first cavity is formed between the optical fiber and the inner sleeve, a second cavity is formed between the inner sleeve and the outer sleeve, the first cavity and the second cavity are connected at the far end, cooling liquid enters from one cavity, takes away heat from a light emergent structural member reaching the far end, and flows out from the other cavity; various cooling jacket structures may be used as the assembly to construct the fiber optic assemblies of the present utility model.

In a third aspect, the present utility model provides a laser interstitial thermotherapy system comprising at least one optical fiber of the present utility model, a power supply, a laser, a controller, a user interface. The power supply is configured to deliver starting energy to the laser; the laser may comprise any suitable structure capable of providing laser energy for surgical use, including but not limited to CO ₂ A laser, an excimer laser, a semiconductor laser (e.g., a laser diode), or a fiber laser. The power supply is configured to convert the line voltage into a form suitable for laser operation and may include a linear power supply circuit and/or a switched mode voltage converter circuit. The controller communicates with the user interface and communicates one or more control signals to the power supply and/or the laser to perform various operations. For example, laser power level, pulse rate, pulse width, duty cycle, modulation, wavelength, operating voltage, etc. may be established directly or indirectly via a user interface and in communication with a power source and/or laser. The controller includes a memory unit, such as a non-volatile memory, configured to store calibration data, user preference data, treatment parameters, and the like. In an embodiment, the controller may be configured to implement diagnostic functions, built-in test functions, and power-on self-tests to identify any need to implement service and maintenance in order to replace consumables, etc., to ensure that the laser interstitial thermal therapy system performs the proper functions. Optical fiber and output device of laser And is configured to deliver laser energy to tissue.

In a fourth aspect, the present utility model provides a magnetic resonance-based laser interstitial hyperthermia system comprising the optical fiber of the present utility model, or the laser interstitial hyperthermia system. Part of the content of the magnetic resonance-based laser interstitial hyperthermia system can be referred to the present company's prior application 201810459539.1, the entire content of which is incorporated herein by reference; the laser interstitial thermotherapy system based on magnetic resonance of the present utility model may include:

magnetic resonance equipment, a workstation and the laser interstitial thermotherapy system according to the utility model;

the magnetic resonance apparatus may perform image acquisition preoperatively and/or intra-operatively;

the workstation may include a host, a display, and an input-output device, where the display is a touch screen, the display may also function as the input-output device; the workstation can receive preoperative and intraoperative medical image information of the magnetic resonance equipment and other imaging equipment (such as CT), establish a three-dimensional model, plan a treatment area, display intraoperative information, send control information to the laser interstitial hyperthermia system, calculate temperature, estimate ablation, confirm an ablation result and compare with a surgical plan.

The utility model has at least the following advantages:

1. compared with the light-emitting structural member in the related art, the light-emitting structural member provided by the utility model has the advantages that the side light-emitting structural member is greatly improved in the aspect of side light emission, in the related art, the side light-emitting optical fiber realizes side light emission through one reflecting structure, but the side light-emitting area of a single reflecting structure is limited by the internal space of the light-emitting structural member, and the axial large-range side light emission cannot be realized. If the lateral light emitting range is increased by increasing the inclination angle of the single reflecting structure, the risk that the light cannot be emitted according to the expected direction at all may occur, specifically: because the refractive index of the inside of the optical structural member is different from that of the shell of the optical structural member, when the inclination angle of the reflecting structure is overlarge, the input light is possibly changed into total reflection when passing through the reflecting structure, so that the light oscillates in the inside of the optical structural member and is emitted from one corner of the far end of the optical structural member in a concentrated way, and the deviation from the expectation of lateral large-range emission is avoided; in addition, since the diameter of the scattering head of the optical core is small (about 1 mm), a single reflecting surface with a particularly large inclination angle cannot be processed in a small space in terms of processing technology, so that the angle of the reflecting structure relative to the axial direction is greatly limited, and the limitation of the diameter (less than 1 mm) of the optical structure leads to the limited light emitting area of the single reflecting structure, so that the energy density is too high when high-power laser is used for treatment, local tissue carbonization is easily caused, and the ablation effect is not expected; in the case of a cooling jacket outside the optical fiber, the cooling jacket may even be damaged, resulting in the cooling fluid flowing out and contacting the tissue, causing damage.

According to the utility model, the light-emitting structural member is connected to the far end of the transmission optical fiber, and n reflecting surfaces which are sequentially arranged from the near end to the far end along the long axis of the light-emitting structural member are utilized, wherein at least 1 st to n-1 st reflecting surfaces are reflecting surfaces with light transmittance, and light input from the near end of the light-emitting structural member is emitted from the side direction of the light-emitting structural member through the action of the n reflecting surfaces, so that the function that the optical fiber can emit light in a large-range lateral direction in the axial direction of the optical fiber is realized. In addition, the reflection performance of the n reflection surfaces disposed in the light-emitting structural member may be set according to requirements, so that the light leaving the light-emitting structural member can achieve a desired exit distribution, for example: uniform lateral light emission along the axial extension of the optical fiber; or locally enhancing the intensity of the lateral light emission; alternatively, the light has less increase in contact surface with tissue and significantly increased contact area with or near the cooling jacket. Furthermore, due to the arrangement of the n reflecting surfaces, the light intensity of the lateral emergent light of the optical fiber can be reduced due to the fact that the lateral emergent range is enlarged, the power density of the laser irradiated to the tissue or the cooling sleeve is reduced under the condition that the overall output high-power laser is kept, and the possibility of tissue carbonization and penetration of the cooling sleeve is reduced.

2. The optical fiber can be customized according to the medical image data.

In order to make the above objects, features and advantages of the present utility model more comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of a light-emitting structure according to an embodiment of the present utility model;

FIG. 2 is a schematic view of a light-emitting structure according to another embodiment of the present utility model;

FIG. 3 is a schematic illustration of an optical fiber according to one embodiment of the present utility model;

FIG. 4 is a side view of the optical fiber of FIG. 3 at an angle;

FIG. 5 is a schematic view of an optical fiber according to yet another embodiment of the present utility model;

FIG. 6 is a side view of the optical fiber of FIG. 5 at an angle;

FIG. 7 is a schematic view of a fiber optic structure according to yet another embodiment of the present utility model;

FIG. 8 is a schematic view of an optical fiber light emitting structure according to another embodiment of the present utility model;

FIG. 9 is a schematic view of an optical fiber light emitting structure according to another embodiment of the present utility model;

FIG. 10 is a schematic view of an optical fiber light emitting structure according to another embodiment of the present utility model;

FIG. 11 is a schematic illustration of an optical fiber assembly in use according to one embodiment of the present utility model;

FIG. 12 is a schematic view of an optical fiber according to one embodiment of the present utility model;

FIG. 13 is a schematic view of an optical fiber according to another embodiment of the present utility model;

FIG. 14 is a schematic view of an optical fiber according to yet another embodiment of the present utility model;

FIG. 15 is a schematic view of an optical fiber according to another embodiment of the present utility model;

FIG. 16 is a schematic view of an optical fiber according to yet another embodiment of the present utility model;

FIG. 17 is a schematic view of an optical fiber according to another embodiment of the present utility model;

FIG. 18 is a schematic diagram of a laser interstitial thermal therapy system according to an embodiment of the present utility model;

icon:

00-laser interstitial thermotherapy system; 50-transmission fiber; 60-a light emergent structural member; 601-1 st reflecting surface 601; 602-2 nd reflecting surface; 603-3 rd reflecting surface; 604-4 th reflecting surface; 605-light absorbing structure; 70-collimation portion; 80-sleeve; 90-cooling jacket; 10-optical fiber; 11-a power supply; 12-a controller; 13-a light source module; 14-a user interface; 15-memory cell.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

The present utility model relates to the use of a proximal and a distal end to describe the assembly, meaning that the proximal end of the assembly is the end that is farther from the tissue to be treated during use and the distal end of the assembly is the end that is closer to the tissue to be treated during use.

Referring to fig. 1, there is shown a side view of an light-emitting structure 60 of one example of the present utility model, in which a 1 st reflective surface 601, a 2 nd reflective surface 602, and a 3 rd reflective surface 603 are provided; an included angle with a long axis (shown by a dotted line), wherein, the angle 1 is more than the angle 2, and the angle 2 is more than the angle 3; the number of reflective surfaces and the angle of inclination are exemplary, and the number of reflective surfaces may be selected from other choices, such as 2, 4, 5, 6, etc., and the angle of inclination of the different reflective surfaces may be the same, and the proximal end of the light exit structure 60 may be flush for connection to the distal end of the transmission fiber. The material of the light-emitting structure may be any suitable material, such as quartz glass, a structure formed by curing gel, etc.

In the light-emitting structural member, the included angle between the reflecting surface and the long axis is more than 0 degrees and less than 90 degrees. In some embodiments, the included angle is preferably greater than 20 degrees and less than 70 degrees, such as in the example of fig. 1, < 1 is 60 degrees, < 2 is 45 degrees, and < 3 is 30 degrees. In still other embodiments, the included angle is further preferably greater than 40 degrees and less than 50 degrees. The smaller the included angle is, the more light rays are totally reflected, the less light rays can be emitted radially through refraction, the closer the included angle is to 90 degrees, the larger the proportion of optical fibers returned to the laser is, and the larger damage to the laser is caused.

Referring to fig. 2, there is shown a side view of a light-exiting structure 60 of yet another example of the present utility model, wherein a 1 st reflective surface 601, a 2 nd reflective surface 602, and a 3 rd reflective surface 603 are provided; the included angles of the 3 reflecting surfaces and the long axis are the same, namely the three reflecting surfaces are arranged in parallel; the first reflecting surface 601 is connected with the distal end of the transmission optical fiber, and the distal end of the transmission optical fiber is provided with an inclined surface structure matched with the distal end of the transmission optical fiber, so that compared with a flush structure, the specular reflection of light in the light transmission direction can be reduced, and the damage of laser returned to the laser is reduced; it will be appreciated that the first reflective surface 601 may not be provided, i.e. only the 2 nd reflective surface 602 and the 3 rd reflective surface 603 may be included.

In the light extraction structure, in a proximal to distal direction along the long axis, in some embodiments, the n reflecting surfaces taper off of the long axis, such as in the example of fig. 1; in still other embodiments, the n reflecting surfaces are at the same n angles to the long axis, such as the example of fig. 2; in some other embodiments, at least one of the n angles of the n reflecting surfaces to the long axis is different from the remaining n-1 angles, for example, when n is 3, angle 1 is 50 degrees, angle 2 is 30 degrees, and angle 3 is 50 degrees.

Referring to fig. 3-4, there is shown a schematic diagram of one example of an optical fiber of the present utility model, the optical fiber comprising: transmission fiber 50 and light extraction structure 60, wherein: the transmission optical fiber comprises a fiber core, a cladding and a protective layer; the light-emitting structure 60 is provided with a 1 st reflecting surface 601, a 2 nd reflecting surface 602, and a 3 rd reflecting surface 603. This configuration is merely exemplary, and the axial length of the delivery fiber is much greater than the axial length of the treatment tip, omitting the proximal homostructure;

in some examples on this basis, the 1 st reflective surface 601 has a reflectivity less than the 2 nd reflective surface 602, and the 2 nd reflective surface 602 has a reflectivity less than the 3 rd reflective surface 603;

in some examples based on this, the 1 st reflective surface 601 has a light transmittance that is greater than the 2 nd reflective surface 602, and the 2 nd reflective surface 602 has a light transmittance that is greater than the 3 rd reflective surface 603;

Based on another example of the foregoing, the 1 st reflecting surface has a reflectance of 30%, the light transmittance of 70%, the 2 nd reflecting surface has a reflectance of 50%, the light transmittance of 50%, and the 3 rd reflecting surface has a reflectance of 100%; so that the intensity of the light exiting laterally along the long axis of the fiber reaches the desired distribution, i.e., the intensity distribution of the light illuminated area is substantially uniform along the long axis.

The 1 st reflecting surface 601, the 2 nd reflecting surface 602, and the 3 rd reflecting surface 603 have different angles with the long axis L-L, refer to fig. 1 again. Both the distal end of the transmission fiber 50 and the proximal end of the light extraction structure 60 are perpendicular to the plane of the long axis L-L.

Referring to fig. 5 and 6, there is shown a schematic diagram of yet another example of an optical fiber of the present utility model, the optical fiber comprising: transmission fiber 50 and light extraction structure 60, wherein: the transmission optical fiber comprises a fiber core, a cladding and a protective layer; the light-emitting structural member 60 is provided with a 1 st reflecting surface 601 and a 2 nd reflecting surface 602; this configuration is merely exemplary, and the axial length of the delivery fiber is much greater than the axial length of the treatment tip, omitting the proximal homostructure; the 1 st reflecting surface 601 is disposed parallel to the 2 nd reflecting surface 602, the 1 st reflecting surface has a reflectance of 50%, the light transmittance of 50%, and the 2 nd reflecting surface has a reflectance of 100%.

The distal end face of the transmission fiber 50 and the proximal end face of the light exit structure 60 are inclined planes that are parallel and adjacently disposed, i.e., have the same included angle with the long axis L-L. It will be appreciated that the proximal end of the light extraction structure 60 may also be provided with a reflective surface to further increase the light extraction range.

Referring to fig. 7, there is shown a schematic view of yet another example of the optical fiber of the present utility model, wherein the transmission fiber is not shown, only the light exit structure 60 is shown, the light exit structure 60 is provided with 4 reflecting surfaces: a 1 st reflecting surface 601, a 2 nd reflecting surface 602; a 3 rd reflecting surface 603, a 4 th reflecting surface 604; the 4 reflecting surfaces are arranged in parallel, and the emergent directions of the light rays are basically vertical to the long axis of the optical fiber through the arrangement of angles and intervals;

further, by setting the light transmittance and reflectance of the 4 reflecting surfaces, the light intensity of the outgoing light rays along the long axis of the optical fiber is made substantially the same, for example, the intensity difference is not more than 20%, preferably not more than 10%, and most preferably not more than 5%.

Referring to fig. 8, there is shown a schematic view of yet another example of the optical fiber of the present utility model, wherein the transmission fiber is not shown, only the light exit structure 60 is shown, the light exit structure 60 is provided with 2 reflecting surfaces: a 1 st reflecting surface 601, a 2 nd reflecting surface 602; the 1 st reflecting surface 601 is a plane, the 2 nd reflecting surface 602 is a concave surface, by setting the interval distance and the inclination degree of the 2 nd reflecting surfaces, the light rays emitted by the 2 nd reflecting surface 602 are overlapped with a part of the light rays emitted by the 1 st reflecting surface 601, so that the local lateral emergent light intensity increase (shown by a bold line) on the ablation tissue parallel to the long axis of the optical fiber is realized, and the tissue region with treatment (such as ablation) is suitable for treatment (such as ablation) illustration), wherein the shaded part shows a schematic diagram of ideal ablation results.

Referring to fig. 9, there is shown a schematic diagram of yet another example of the optical fiber of the present utility model, wherein the transmission fiber is not shown, only the light exit structure 60 is shown, the light exit structure 60 is provided with 2 reflecting surfaces: a 1 st reflecting surface 601, a 2 nd reflecting surface 602; the 1 st reflecting surface 601 is a first concave surface, the 2 nd reflecting surface 602 is a second concave surface, and by setting the interval distance and the inclination degree of the 2 nd reflecting surfaces, the light rays emitted by the 2 nd reflecting surface 602 are distributed adjacently to the light rays emitted by the 1 st reflecting surface 601, and the intensity of the light rays emitted by the 2 nd reflecting surface 602 is larger than that of the light rays emitted by the 1 st reflecting surface 601 due to stronger convergence effect of the 2 nd reflecting surface 602, and the thickened lines are used for illustration.

Referring to fig. 10, there is shown a schematic view of yet another example of the optical fiber of the present utility model, in which the transmission fiber is not shown, only the light-exiting structure 60 is shown, the light-exiting structure 60 is provided with 2 parallel-arranged planar-structured reflecting surfaces, and the angles between the reflecting surfaces and the long axes are different from those of fig. 7: a 1 st reflecting surface 601, a 2 nd reflecting surface 602; the figure also shows the positions L1 and L2 where the light leaves the light-emitting structure through the reflecting surface, the distance L3 along the axial direction of the optical fiber when reaching the tissue only through the 1 st reflecting surface 601, after using the 1 st reflecting surface 601 and the 2 nd reflecting surface 602, the distance along the axial direction of the optical fiber when reaching the tissue is increased by L2 compared with the distance L2 along the axial direction of the optical fiber when only using the 1 st reflecting surface 601, and since L2 is equivalent to L1, compared with the case of reflecting by only using a single reflecting surface, the intensity of the optical fiber in the embodiment when exiting through the surface of the light-emitting structure is reduced by 50% under the condition of using the treatment laser with the same light intensity; meanwhile, as L2 is smaller than L3, the increased ablation range is limited, the light intensity is reduced less under the condition that the output power of a single optical fiber is fixed, and the same effect can be achieved by only increasing a small amount of ablation time while reducing the carbonization risk of tissues close to a light-emitting structural member.

Referring to fig. 11, there is shown a schematic view of an example of an optical fiber assembly of the present utility model, in which the transmission fiber of the optical fiber is not shown, only the light exit structure 60 of the optical fiber is shown, and the cooling jacket 90, the light exit structure 60 is provided with 2 parallel-arranged planar structured reflective surfaces: a 1 st reflecting surface 601, a 2 nd reflecting surface 602; the distance L1 and L2 along the long axis of the optical fiber from the intersection of the light ray and the cooling jacket after leaving the side of the light-emitting structure through the reflecting surface are also shown, the distance L1 along the long axis of the optical fiber from the position where the light ray reaches the cooling jacket through the 1 st reflecting surface 601 is only, the distance L3 along the long axis of the optical fiber when reaching the tissue is the distance L1 along the long axis of the optical fiber, and the distance L2 along the axial direction of the optical fiber when reaching the cooling jacket or the tissue is increased compared with the distance L2 along the axial direction of the optical fiber when only using the 1 st reflecting surface 601 after using the 1 st reflecting surface 601, because L2 is approximately equivalent to L1, the intensity of the light when passing through the cooling jacket is reduced by about 50% when using the same intensity of therapeutic laser compared with the case where only using a single reflecting surface is used; meanwhile, as L2 is smaller than L3, the increased ablation range is limited, the light intensity is reduced less under the condition of certain output power, and the same effect can be achieved by only increasing a small amount of ablation time while reducing the cooling sleeve penetrating through the adjacent light-emitting structural member. The cooling jacket may be single-layered or double-layered, for example, in the case of a single layer, a split structure is provided between the optical fiber and the jacket, such that the cavity between the optical fiber and the jacket is divided into two parts, one part being used for the entry of the cooling fluid, the removal of heat from the light-exiting structure reaching the distal end, and the outflow from the other part; for example, in the case of a double-layer cooling jacket, a first cavity is formed between the optical fiber and the inner jacket, a second cavity is formed between the inner jacket and the outer jacket, the first cavity and the second cavity are connected at the far end, and cooling liquid enters from one cavity, takes away heat from a light-emitting structural member reaching the far end, and flows out from the other cavity; it will be appreciated that a variety of suitable cooling jacket structures may be provided as an assembly to construct the fiber optic assemblies of the present utility model.

The optical fiber of the present utility model may further include a collimating part, referring to fig. 12, which is a schematic view showing one example of the optical fiber assembly of the present utility model, the optical fiber including: transmission fiber 50, self-focusing lens 70, and light extraction structure 60, wherein: the transmission fiber 50 includes a core, a cladding, and a protective layer; the light-emitting structure 60 is provided with a 1 st reflecting surface 601, a 2 nd reflecting surface 602, and a 3 rd reflecting surface 603. This configuration is merely exemplary, and the axial length of the delivery fiber is much greater than the axial length of the treatment tip, omitting the proximal homostructure;

the 1 st reflective surface 601 has a smaller reflectance than the 2 nd reflective surface 602, and the 2 nd reflective surface 602 has a smaller reflectance than the 3 rd reflective surface 603;

the 1 st reflecting surface 601 has a light transmittance larger than that of the 2 nd reflecting surface 602, and the 2 nd reflecting surface 602 has a light transmittance larger than that of the 3 rd reflecting surface 603;

in one example, the 1 st reflective surface has a reflectance of 30%, a light transmittance of 70%, the 2 nd reflective surface has a reflectance of 50%, a light transmittance of 50%, and the 3 rd reflective surface has a reflectance of 100%;

the 1 st reflecting surface 601, the 2 nd reflecting surface 602, and the 3 rd reflecting surface 603 have the same angle with the long axis L-L. The distal end of the transmission fiber 50, the connection surface of the self-focusing lens 70 and the light extraction structure 60 are all perpendicular to the long axis L-L.

The distal end of the 3 rd reflecting surface 603 is further provided with a light absorbing structure 605 (not shown) to prevent the optical fiber from exiting along the long axis of the optical fiber.

The laser light emitted from the distal end of the transmission fiber 50 passes through the self-focusing lens 70 to become substantially parallel to the long axis of the fiber, so that the laser light, after exiting the self-focusing lens 70, falls within the range of the reflection surfaces when intersecting the 3 reflection surfaces.

The present utility model does not limit the shape and the size of the reflecting surface of the light-emitting structure, and referring to fig. 12 and 13, in one example, the light-emitting structure 60 has a rectangular structure, in which 3 reflecting surfaces having a rectangular shape are provided, a 1 st reflecting surface 601, a 2 nd reflecting surface 602, and a 3 rd reflecting surface 603; the laser light enters the self-focusing lens 70 through the transmission fiber 50 and then exits through 3 reflecting surfaces. Referring to fig. 14, a light extraction structure 60 is shown having a horseshoe cross-section.

The treatment fiber of the present utility model in combination with any of the above embodiments may further comprise a sleeve, one specific example of which is shown with reference to fig. 14 and 15, the sleeve 80 may facilitate the assembly or unitary construction of the transmission fiber 50, the self-focusing lens 70, and the light extraction structure 60. The whole structure of the light-emitting structural member is a cylinder with part of the structure removed, the cross section is U-shaped, the shape of the 1 st reflecting surface 601, the 2 nd reflecting surface 602 and the 3 rd reflecting surface 603 is similar to the U-shape, the light-emitting part is a plane, the light rays emitted in parallel are prevented from changing directions again due to the emergent interface, and the parallelism of the side emergent light rays is maintained.

In the manufacturing process, firstly, the sleeve 80 is manufactured, then the light emergent structural member 60 is placed in the sleeve 80 so that the distal end of the light emergent structural member 60 is abutted with the sleeve 80, then the self-focusing lens 70 is placed in the sleeve 80 so that the distal end of the self-focusing lens 70 is abutted with the proximal end of the light emergent structural member 60, and then the distal end of the transmission optical fiber 50 is abutted with the proximal end of the self-focusing lens 70, and the central axes are aligned; the outer diameters of the transmission fiber 50, the light extraction structure 60, and the self-focusing lens 70 may be less than or equal to the inner diameter of the sleeve 80; when the outer diameter of the transmission fiber 50 is smaller than the sleeve 80 and the distal end of the transmission fiber is disposed in the sleeve 80, a clamping structure (not shown) may also be provided to abut the transmission fiber with the self-focusing lens 70 and fix the transmission fiber relative to the sleeve 80 with the central axis aligned; further, the distal end of the self-focusing lens 70 and the proximal end of the light extraction structure 60 may be bonded by an adhesive, and the distal end of the transmission fiber 50 and the proximal end of the self-focusing lens 70 may be bonded by an adhesive.

In embodiments of the present utility model, the connection of the distal end of the transmission fiber to the collimating part or the light exit structure may be fixed, e.g. by adhesive connection, fusion bonding, etc., or may be detachable, e.g. by plugging, etc.

Based on any of the above embodiments, the optical fiber of the present utility model may further include a reflective coating.

Referring to fig. 16, there is shown a side view and a cross-sectional view of a distal portion of an optical fiber according to an embodiment of the present utility model, with a reflective coating disposed on an outer surface of the light-exiting structure 60 or an inner surface of the sleeve 80, and showing an angular range, e.g., 60 degrees, in the cross-sectional view that allows light to exit.

Referring to fig. 17, there is shown a side view and a cross-sectional view of a distal portion of an optical fiber according to one embodiment of the present utility model, with a reflective coating disposed on an outer surface of the sleeve 80, and in which the angular range, e.g., 90 degrees, that allows light to exit is shown.

It will be appreciated that the angular extent of the exit may be determined as desired, for example 120 degrees, 150 degrees, 180 degrees, etc.

Referring to fig. 18, there is shown a schematic diagram of a laser interstitial thermal treatment system according to the present utility model, the system comprising: at least one optical fiber 10, a power supply 11, a controller 12, a light source module 13, a user interface 14 of the present utility model. The power supply 11 is configured to deliver energy to the light source module 13. The light source module 13 may include one or more lasers, which are any suitable structure capable of providing laser energy for surgical use, including but not limited to CO ₂ Laser, excimer laser, and semiconductorA laser (e.g., a laser diode) or a fiber laser. The power supply 11 is configured to convert the line voltage into a form suitable for operation of the light source module 13 and may include a linear power supply circuit and/or a switched mode voltage converter circuit. The controller 13 communicates with the user interface 14 and transmits one or more control signals to the power supply 11 and/or the laser 14 to facilitate operation of the laser interstitial thermal therapy system 00. For example, laser power level, pulse rate, pulse width, duty cycle, modulation, wavelength, operating voltage, etc. may be established directly or indirectly via the user interface 14 and in communication with the power source 11 and/or the laser 14. The controller 13 includes a storage unit 15 (e.g., a non-volatile memory), the storage unit 15 being configured to store calibration data, user preference data, treatment parameters, and the like. The controller 13 may be configured to implement a diagnostic function, a built-in test (BI T) function, and a power-on self test (POST) to identify any need to implement overhaul and maintenance in order to replace consumables or the like, thereby ensuring that the laser interstitial thermal therapy system 00 performs the proper function. The optical fiber 10 is in operative communication with an output device 16 of the light source module 13 and is configured to deliver laser energy to tissue.

The light source module 13 includes one or more sets of lasers that can generate laser light of any wavelength suitable for treatment. In the case where the light source module 13 includes two or more groups of lasers, the treatment lasers of each group may be the same or different, and the lasers generated by the two or more groups of lasers may be integrated at the beam combiner; in some examples, two lasers producing lasers of the same wavelength are included, and in other examples, two lasers producing lasers of different wavelengths, e.g., one of the lasers may produce laser light of 980nm wavelength and the other laser may produce laser light of 1064nm wavelength; in the use process, the regulation and control can be performed by controlling the lasers according to the needs, for example, the light power, the light emitting time and the light emitting mode of each laser can be respectively regulated and controlled at the same time; the combined use modes of the two lasers can be various, and can be synchronous or asynchronous, alternate and the like; for example, a first laser that produces 980nm wavelength laser light is controlled to operate for a first period of time, and a second laser that produces 1064nm wavelength laser light is controlled to operate for a second, subsequent period of time; alternatively, the first laser producing 980nm wavelength laser light and the second laser producing 1064nm wavelength laser light may be controlled to operate simultaneously in the first phase, and then the first laser is turned off, with only the second laser continuing to operate for the second period of time.

The laser interstitial thermotherapy system of the present utility model may further comprise a cooling circulation device comprising a peristaltic pump, a cooling fluid and a cooling jacket, the cooling jacket being used in combination with the optical fibers, i.e. each optical fiber may be used together with a corresponding cooling jacket, the peristaltic pump may simultaneously pump the cooling fluid to two or more cooling jackets, the cooling fluid may be any fluid suitable for cooling, preferably including double distilled water, medical saline, etc.;

the cooling circulation device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, the cooling jacket being broken, etc.

Referring to fig. 11, which is a schematic diagram illustrating a magnetic resonance-based laser interstitial thermotherapy system of the present utility model, a part of the content of the magnetic resonance-based laser interstitial thermotherapy system may be referred to the present company's prior application 201810459539.1, the entire contents of which are incorporated herein by reference; the laser interstitial thermotherapy system based on magnetic resonance of the present utility model comprises:

magnetic resonance equipment, a workstation and the laser interstitial thermotherapy system according to the utility model;

the magnetic resonance device can perform image acquisition before and during operation;

The workstation comprises a host, a display and an input/output device, and the display can also be used as the input/output device when the display is a touch screen; the workstation can receive preoperative and intraoperative medical image information of the magnetic resonance device and other imaging devices (such as CT), build a three-dimensional model, plan a treatment area, display intraoperative information, send control information to the laser interstitial hyperthermia system, calculate temperature and predict ablation.

It will be clear to those skilled in the art that, for convenience and brevity of description, specific working procedures of the above-described system and apparatus may refer to corresponding procedures in the foregoing method embodiments, which are not described herein again.

In addition, in the description of embodiments of the present utility model, unless explicitly stated and limited otherwise, the term "coupled" is to be interpreted broadly, as for example, whether fixedly coupled, detachably coupled, or integrally coupled; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Finally, it should be noted that: the above examples are only specific embodiments of the present utility model, and are not intended to limit the scope of the present utility model, but it should be understood by those skilled in the art that the present utility model is not limited thereto, and that the present utility model is described in detail with reference to the foregoing examples: any person skilled in the art may modify or easily conceive of the technical solution described in the foregoing embodiments, or perform equivalent substitution of some of the technical features, while remaining within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model, and are intended to be included in the scope of the present utility model. Therefore, the protection scope of the present utility model shall be subject to the protection scope of the claims.

Claims (19)

1. The utility model provides a light-emitting structure, its characterized in that is suitable for being connected in the distal end of transmission optic fibre, light-emitting structure contains n reflecting surface, and n is greater than 1's natural number, n reflecting surface sets gradually from the near-end to the distal end along the major axis of light-emitting structure, wherein 1 st through n-1 st reflecting surface is the reflecting surface that has the light transmissivity, n reflecting surface makes the light of the near-end input of light-emitting structure follow the side direction outgoing of light-emitting structure.

2. The light-emitting structure according to claim 1, wherein the reflecting surface disposed closest to the distal end is a total reflecting surface.

3. The light-emitting structure according to claim 1, further comprising an opaque structure provided on a distal side of the reflecting surface provided closest to the distal end, the opaque structure for preventing the light from exiting from the distal end of the light-emitting structure in the long axis direction.

4. The light-emitting structure according to claim 1, wherein the angle between the reflecting surface and the long axis is greater than 0 degrees and less than 90 degrees.

5. The light-emitting structure according to claim 4, wherein an angle between the reflecting surface and the long axis is 20 degrees or more and 70 degrees or less.

6. The light-emitting structure according to claim 1, wherein n angles between the n reflecting surfaces and the long axis are gradually reduced along a direction from a proximal end to a distal end of the long axis; or, along the direction from the near end to the far end of the long axis, n included angles between the n reflecting surfaces and the long axis are the same; or, in the direction from the near end to the far end of the long axis, at least one included angle of the n reflecting surfaces and the n included angles of the long axis are different from the other n-1 included angles.

7. The light-emitting structure according to claim 1, wherein the n reflecting surfaces have progressively increasing reflectivities along the direction from the proximal end to the distal end of the long axis, and the reflectivities of the n reflecting surfaces and the intervals between the n reflecting surfaces are set so that the light intensity of the light reflected by the n reflecting surfaces and emitted from the lateral direction of the light-emitting structure is substantially uniform in the distribution along the long axis direction.

8. The light-emitting structure according to claim 1, wherein the n reflecting surfaces are arranged in parallel, and the angle between the reflecting surfaces and the long axis and the interval between the n reflecting surfaces are set so that the light rays reflected by the n reflecting surfaces and emitted from the side direction of the light-emitting structure are substantially perpendicular to the long axis.

9. The light-emitting structure according to claim 1, wherein at least one of the 2 nd to nth reflecting surfaces is a concave surface along a direction from a proximal end to a distal end of the long axis, and the angles between the nth reflecting surfaces and the long axis and the intervals between the nth reflecting surfaces are set so that light rays reflected by the concave surface and light rays reflected by the remaining reflecting surfaces are at least partially overlapped or adjacently distributed in a lateral direction of the light-emitting structure.

10. An optical fiber comprising a transmission fiber and the light extraction structure of any one of claims 1-9, the distal end of the transmission fiber being contiguous with the proximal end of the light extraction structure.

11. The fiber of claim 10, wherein the transmission fiber is removably connected to the light extraction structure.

12. The optical fiber according to claim 10, wherein the angles between the n reflecting surfaces and the long axis of the light-emitting structural member, the intervals between the n reflecting surfaces and the reflectivity of the n reflecting surfaces are set so that n parts of light rays leaving the light-emitting structural member laterally through the n reflecting surfaces can form a specific intensity distribution along the axis, namely, the lateral light-emitting intensity can form different intensity spectrums along the long axis.

13. The optical fiber of claim 10, wherein when the light transmitted through the transmission optical fiber passes through the n reflecting surfaces, a spot boundary at which the light intersects the reflecting surfaces falls entirely within the range of the reflecting surfaces.

14. The optical fiber of claim 10, further comprising a collimation portion for collimation adjustment of the light, a proximal end of the collimation portion being disposed adjacent to a distal end of the transmission fiber, a distal end of the collimation portion being disposed adjacent to a proximal end of the light extraction structure.

15. The optical fiber of claim 10, further comprising a reflective coating for preventing the transmitted light from exiting a portion where the reflective coating has been installed.

16. The optical fiber of claim 10, further comprising a sleeve in which the light extraction structure and/or a portion of the transmission fiber is disposed.

17. An optical fiber assembly comprising a cooling jacket and the optical fiber of any of claims 10 to 16.

18. A laser interstitial thermotherapy system comprising the optical fiber of any one of claims 10 to 16 or the optical fiber assembly of claim 17.

19. A magnetic resonance interstitial thermotherapy system based on laser, characterized by comprising the optical fiber of any one of claims 10 to 16 or the optical fiber assembly of claim 17.

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