CN219272694U - Device for removing organic impurities from crude drug intermediate - Google Patents
Device for removing organic impurities from crude drug intermediate Download PDFInfo
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- CN219272694U CN219272694U CN202320150689.0U CN202320150689U CN219272694U CN 219272694 U CN219272694 U CN 219272694U CN 202320150689 U CN202320150689 U CN 202320150689U CN 219272694 U CN219272694 U CN 219272694U
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- Prior art keywords
- control valve
- extraction tank
- liquid
- crude drug
- phase control
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- 239000012535 impurity Substances 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 title claims abstract description 34
- 229940079593 drug Drugs 0.000 title claims abstract description 31
- 238000000605 extraction Methods 0.000 claims abstract description 39
- 239000012074 organic phase Substances 0.000 claims abstract description 24
- 239000012071 phase Substances 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 239000011521 glass Substances 0.000 claims abstract description 13
- 238000004090 dissolution Methods 0.000 claims abstract description 11
- 238000000926 separation method Methods 0.000 claims abstract description 7
- 239000008346 aqueous phase Substances 0.000 claims description 11
- 230000007704 transition Effects 0.000 claims description 7
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 229940088679 drug related substance Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 238000000746 purification Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000005587 bubbling Effects 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000011265 semifinished product Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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Abstract
The utility model relates to a device for removing organic impurities from crude drug intermediates, which belongs to the technical field of organic chemical devices and crude drug purification and is formed by combining a dissolution adjusting kettle, a head tank, a liquid separation extraction tank, a sight glass, an inclined tube, a control valve, a vacuum tube and the like. Its innovation point includes 3 aspects: 1, the control valves related to the extraction tank are intensively arranged to the same or similar height, so that the safe operation is facilitated; 2 is that a inclined tube is arranged below the sight glass, so that impurities can be removed more easily; 3, using vacuum as power to fully and uniformly mix the organic phase and the water phase in the extraction tank; the device for removing the organic impurities from the crude drug intermediate disclosed by the technical scheme of the utility model can effectively remove the organic impurities in the production process of the crude drug, and has the characteristics of simple structure, small occupied space and convenience in operation.
Description
Technical Field
The utility model relates to the technical scheme, an organic chemical device and the technical field of crude drug purification, in particular to a device for removing organic impurities from crude drug intermediates.
Background
The quality of the raw material medicine is the main support of the chemical pharmaceutical industry, and the quality of the raw material medicine determines the quality of the preparation, so the quality standard requirement is very strict, and strict national pharmacopoeia standards and quality control methods are formulated for the raw material medicine widely applied in all countries around the world.
The impurity removal step in the production process of the bulk drug is one of the common procedures in the pharmaceutical chemical synthesis, and is widely applied in the pharmaceutical chemical field. In the production of bulk drugs, most semi-finished products are required to be refined and purified so as to effectively remove mechanical impurities and organic impurities, thereby obtaining the bulk drugs with higher purity.
Extraction is a common impurity removing process in the production process of bulk drugs, and is one of paths for removing organic impurities which are sought by pharmacy people all the time, and continuous improvement and innovation of an extraction device are adopted to achieve better impurity removing effect.
Disclosure of Invention
The technical scheme of the utility model discloses a device for removing organic impurities from crude drug intermediates, which is an improved liquid-separating extraction combined device, and not only can effectively remove the organic impurities in crude drug semi-finished products, but also has the advantages of simple structure, safe and convenient operation.
The utility model relates to a device for removing organic impurities from crude drug intermediates, which comprises: the device is characterized in that the upper part of the dissolution regulating kettle is connected with the high-level tank, the bottom of the dissolution regulating kettle is connected with the top of the liquid-separating extracting tank through a pipeline, the bottom of the liquid-separating extracting tank is connected with the sight glass, the water-phase control valve is arranged right below the sight glass, the organic phase control valve and the water-phase control valve are connected through the inclined pipe, the top of the liquid-separating extracting tank is connected with the vacuum pipe, the vacuum control valve is arranged at one side position below the liquid-separating extracting tank, the top of the liquid-separating extracting tank is also connected with the blow-down pipe, and the blow-down control valve is arranged at one side position of the liquid-separating extracting tank.
Preferably, the device for removing organic impurities from the crude drug intermediate is characterized in that an inclined tube communicated between the organic phase control valve and the water phase control valve forms an angle of 30-75 degrees with a horizontal line, and the inclined tube is 30-50 cm long. The purpose of this design is to ensure that the aqueous phase residue in the pipeline cannot flow into the organic phase.
Preferably, the device for removing organic impurities from the crude drug intermediate according to the technical scheme of the utility model is characterized in that the emptying control valve, the vacuum control valve, the organic phase control valve and the water phase control valve are positioned at the same or similar horizontal height positions. The purpose of this design is to provide safe operation and to reduce labor intensity.
Preferably, the device for removing organic impurities from the crude drug intermediate according to the technical scheme of the utility model is characterized in that the blow-down pipe is inserted into the bottom of the liquid-separating extraction tank from the top of the liquid-separating extraction tank. The purpose of this design is, when remixing, vacuum is power, and air gets into from the liquid extraction jar bottom to bubbling form drives the material and mixes.
The device for removing the organic impurities from the crude drug intermediate has the obvious beneficial effects that 1 the inclined tube communicated between the organic phase control valve and the aqueous phase control valve can ensure that the aqueous phase can not enter the organic phase, and the extraction effect is ensured; 2, the control valves are at the same or similar height, thereby being beneficial to safe operation and reducing the labor intensity of staff; 3 the blow-down pipe is inserted into the bottom of the liquid separation extraction tank, so that the air can be ensured to be in a bubbling mode to promote the mixing of materials, and the extraction effect is further improved.
The device for removing the organic impurities from the bulk drug intermediate has the advantages of simple structure, small occupied space and convenience in operation.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings for a person having ordinary skill in the art.
Fig. 1 is a schematic plan view of an apparatus for removing organic impurities from an intermediate of a crude drug according to an embodiment of the present utility model.
In fig. 1: dissolution adjusting kettle 01, high-level tank 011, bottom valve 012, liquid-separating extraction tank 02, mixed liquid inlet 021, vacuum control valve 022, sight glass 023, vent control valve 024, water phase control valve 025, inclined tube 026, organic phase control valve 027, transition layer control valve 028, vacuum tube 029, and vent tube 030.
Description of the embodiments
For the purpose of making the objects, technical solutions and advantages of the present utility model more apparent, an embodiment of the present utility model will be further described with reference to fig. 1.
Referring to fig. 1, an apparatus for removing organic impurities from an intermediate of a crude drug according to an embodiment of the present utility model includes a dissolution adjusting tank 01, an overhead tank 011, a bottom valve 012, a liquid-separating extraction tank 02, a mixed liquid inlet 021, a vacuum control valve 022, a sight glass 023, a vent control valve 024, an aqueous phase control valve 025, a chute 026, an organic phase control valve 027, a transition layer control valve 028, a vacuum tube 029, and a vent tube 030.
The device for removing organic impurities from an intermediate of a bulk drug according to the embodiment of the present utility model is characterized in that an elevated tank 012 is connected and arranged on the dissolution adjusting kettle 01, the bottom of the dissolution adjusting kettle is connected with the top of a liquid-separating extraction tank 02 through a bottom valve 012 and a pipeline, a sight glass 023 is connected to the bottom of the liquid-separating extraction tank 02, a water-phase control valve 025 is arranged under the sight glass, an organic phase control valve 027 and a transition layer control valve 028 are arranged under the sight glass, the organic phase control valve and the water-phase control valve are connected by an inclined tube 026, a vacuum tube 029 is connected to the top of the liquid-separating extraction tank, a vacuum control valve 022 is arranged at one side of the bottom of the liquid-separating extraction tank, a blow-down tube 030 is also connected to the top of the liquid-separating extraction tank, and the blow-down control valve 024 is arranged at one side of the liquid-separating extraction tank. The purpose of the design is that in the dissolution adjusting kettle, the solvent and the materials used as the extractant can be fully and evenly mixed and the PH value and the concentration can be moderately adjusted, and in the liquid-separating extracting tank, the repeated mixing extraction is carried out by taking vacuum as power, so that the organic phase and the water phase can be clearly layered and separated to the greatest extent.
Further, the device for removing organic impurities from an intermediate of a bulk drug according to the embodiment of the present utility model is characterized in that an inclined tube communicating between the organic phase control valve and the aqueous phase control valve forms an angle of 30 ° to 75 ° with a horizontal line, and the inclined tube is 30 cm to 50cm long. The purpose of this design is to ensure that the aqueous phase residue in the pipeline cannot flow into the organic phase.
Further, the device for removing organic impurities from an intermediate of a crude drug according to the embodiment of the present utility model comprises the following detailed operation procedures: firstly, putting materials to be extracted and purified and a proper solvent into a dissolution adjusting kettle 01, starting stirring to uniformly mix the materials, and adjusting the PH value by means of an overhead tank 011; after a certain time, the over-vacuum control valve 022 is opened, and the mixed material is transferred into the liquid-separating extraction tank 02 through the bottom valve 012 and the mixed liquid inlet 021 by means of vacuum; when the layering effect is not ideal, opening a vent control valve 024, allowing air to enter from the bottom of the liquid separation extraction tank through a vent pipe 030 by means of vacuum, and remixing the materials in a bubbling mode; when insufficient amounts of solvent are found, in the same manner, vent control valve 024 is opened, allowing solvent to enter from the bottom of the liquid separation extraction tank via vent pipe 030 by means of vacuum for further extraction; when the layering is clear, standing for a period of time, opening an aqueous phase control valve 025, and discharging and transferring the aqueous phase to another process; when the organic phase is found from the sight glass 023, the water phase control valve is closed, the transition layer control valve 028 is opened, the oil-water phase transition layer is discharged, and the flow goes to the next working procedure for further treatment; then, closing the transition layer control valve, opening the organic phase control valve 027, and transferring the organic phase to another process for further treatment; the organic impurities in the crude drug semi-finished product can be removed by repeating the operation for 1 to 3 times.
Further, the device for removing organic impurities from an intermediate of a crude drug according to the embodiment of the present utility model is characterized in that the emptying control valve, the vacuum control valve, the organic phase control valve and the aqueous phase control valve are located at the same or similar level positions. The purpose of this design is to provide safe operation and to reduce labor intensity.
Further, the device for removing organic impurities from an intermediate of a crude drug according to the embodiment of the present utility model is characterized in that the blow-down pipe is inserted from the top of the liquid extraction tank to the bottom of the liquid separation extraction tank. The purpose of this design is, when remixing, vacuum is power, and air gets into from the liquid extraction jar bottom to bubbling form drives the material and mixes.
The device for removing the organic impurities from the crude drug intermediate has the obvious beneficial effects that the device comprises 3 aspects, namely, 1, the inclined tube communicated between the organic phase control valve and the water phase control valve can ensure that the water phase can not enter the organic phase, and the extraction effect is ensured; 2, the control valves are at the same or similar height, thereby being beneficial to safe operation and reducing the labor intensity of staff; 3 the blow-down pipe is inserted into the bottom of the liquid separation extraction tank, so that the air can be ensured to be in a bubbling mode to promote the mixing of materials, and the extraction effect is further improved.
The device for removing the organic impurities from the crude drug intermediate has the advantages of being simple in structure, small in occupied space and convenient to operate.
The generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the utility model. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model. The scope of the present utility model is to be accorded the widest scope consistent with the principles and novel features described herein.
Claims (4)
1. An apparatus for removing organic impurities from a drug substance intermediate comprising: the device is characterized in that the upper part of the dissolution adjusting kettle is connected with the high-level tank, the bottom of the dissolution adjusting kettle is connected with the top of the liquid-separating extraction tank through a pipeline, the bottom of the liquid-separating extraction tank is connected with the sight glass, the water-phase control valve is arranged under the sight glass, the organic phase control valve and the transition layer control valve are arranged under the sight glass, the organic phase control valve and the water-phase control valve are connected through the inclined pipe, the top of the liquid-separating extraction tank is connected with the vacuum pipe, the vacuum control valve is arranged at one side position under the liquid-separating extraction tank, the top of the liquid-separating extraction tank is also connected with the vacuum pipe, and the vacuum control valve is arranged at one side position of the liquid-separating extraction tank.
2. The device for removing organic impurities from an intermediate of a crude drug according to claim 1, wherein the inclined tube communicated between the organic phase control valve and the aqueous phase control valve forms an angle of 30-75 degrees with a horizontal line, and the inclined tube is 30-50 cm long.
3. The device for removing organic impurities from an intermediate of a pharmaceutical composition according to claim 1, wherein the vent control valve, the vacuum control valve, the organic phase control valve, and the aqueous phase control valve are positioned at the same or similar level.
4. The apparatus for removing organic impurities from a drug substance intermediate according to claim 1, wherein said blow-down tube is inserted from the top of the liquid extraction tank to the bottom of the liquid separation extraction tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320150689.0U CN219272694U (en) | 2023-02-08 | 2023-02-08 | Device for removing organic impurities from crude drug intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320150689.0U CN219272694U (en) | 2023-02-08 | 2023-02-08 | Device for removing organic impurities from crude drug intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219272694U true CN219272694U (en) | 2023-06-30 |
Family
ID=86914365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320150689.0U Active CN219272694U (en) | 2023-02-08 | 2023-02-08 | Device for removing organic impurities from crude drug intermediate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219272694U (en) |
-
2023
- 2023-02-08 CN CN202320150689.0U patent/CN219272694U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 461500 eastern part of Wei Wu Road, Changge, Xuchang, Henan Patentee after: Xintiandi Pharmaceutical Co.,Ltd. Address before: 461500 eastern part of Wei Wu Road, Changge, Xuchang, Henan Patentee before: HENAN NEWLAND PHARMACEUTICAL Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |