CN219271106U - Pulse ablation catheter and pulse ablation device - Google Patents
Pulse ablation catheter and pulse ablation device Download PDFInfo
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- CN219271106U CN219271106U CN202222370179.2U CN202222370179U CN219271106U CN 219271106 U CN219271106 U CN 219271106U CN 202222370179 U CN202222370179 U CN 202222370179U CN 219271106 U CN219271106 U CN 219271106U
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Abstract
The embodiment of the application provides a pulse ablation catheter and a pulse ablation device. The pulse ablation catheter includes: an electrode assembly including a head electrode, a ring electrode; a catheter assembly comprising an inner tube, an outer tube; a support assembly comprising a balloon comprising at least an inflated state and a deflated state; wherein, the inner tube is connected with the head electrode and the outer tube; the saccule is connected with the head electrode and the outer tube; the ring electrode is at least partially disposed on the outer surface of the balloon. According to the embodiment of the application, the balloon is arranged, when the balloon is in the contracted state, the ring electrode and the balloon are attached to the inner tube, the overall cross-sectional area of the pulse ablation catheter is relatively small, the wound is small, and complications are correspondingly reduced. When the balloon is in an inflated state, the balloon is bent and arched towards one side far away from the inner tube to form a spherical netlike electric field, the electric field is more uniform in distribution and high in controllability, the coverage area is larger, the ring electrode can be in direct contact with target tissues, the ablation effect is improved, and the ablation time is shortened.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a pulse ablation catheter and a pulse ablation device.
Background
Arrhythmia is an important group of diseases in cardiovascular diseases, atrial fibrillation is a ubiquitous arrhythmia disease, the incidence rate is high, the harm is large, serious consequences such as cerebral apoplexy and arterial embolism of lower limbs are extremely easy to cause, and the treatment effect of the medicine is poor.
At present, the pulse ablation treatment technology of atrial fibrillation is increasingly paid attention to, and hopes are provided for radical treatment of atrial fibrillation. In treatment, the ablation energy selected is applied to cells of the tissue that cause the arrhythmia without affecting surrounding organs or tissues. However, by using the pulmonary vein electrical isolation ablation technique as an example, the point-to-point mode is adopted, and the tissue target cells are necrotized through ablation, so that the tissue electrical signal isolation is achieved, and the method is suitable for atrial fibrillation, atrial flutter and other arrhythmias formed by pulmonary veins or pulmonary veins. The limitation is that the area ablated per unit time is limited, resulting in longer time in the ablation treatment process, increasing the likelihood of damage to non-target tissue or the risk of tissue crusting, further increasing the likelihood of embolism.
In summary, the pulse ablation catheter in the related art has the technical problems that the ablation area is limited in unit time, and the operation time is long in the ablation process.
Disclosure of Invention
Aiming at the defects of the existing mode, the application provides a pulse ablation catheter and a pulse ablation device, which are used for solving at least one aspect of the technical problems that the pulse ablation catheter in the related technology has limited ablation area in unit time and the operation time in the ablation process is longer.
In a first aspect, embodiments of the present application provide a pulsed ablation catheter comprising:
an electrode assembly including a head electrode, a ring electrode;
a catheter assembly comprising an inner tube, an outer tube;
a support assembly comprising a balloon comprising at least an inflated state and a deflated state;
wherein, the first end of the inner tube is connected with the head electrode, and the second end of the inner tube is connected with the outer tube;
the first end of the balloon is connected with the first end of the head electrode, at least part of the head electrode is exposed, and the second end of the balloon is connected with the outer tube;
the ring electrode is at least partially arranged on the outer surface of the balloon;
when the balloon is in a contracted state, the ring electrode and the balloon are attached to the inner tube;
when the balloon is in an inflated state, the balloon is bent and arched towards the side far away from the inner tube, and a space exists between the ring electrode and the inner tube.
In some embodiments of the present application, the pulse ablation catheter further comprises a flexible conductive strip disposed on an inner surface of the balloon, a first end of the flexible conductive strip being electrically connected to the ring electrode and a second end of the flexible conductive strip being sleeved by the outer tube.
In some embodiments of the present application, the flexible conductive tape includes a conductive core and an insulating layer surrounding the conductive core, the material of the conductive core includes at least one of copper, aluminum, tin, silver, and gold, and the material of the insulating layer includes polyimide.
In some embodiments of the present application, the balloon material comprises polyamide or thermoplastic polyurethane.
In some embodiments of the present application, the balloon and the head electrode are adhesively connected by a first adhesive layer, the first adhesive layer comprising an ultraviolet light curable adhesive;
alternatively, the balloon and the head electrode are welded.
In some embodiments of the present application, the balloon and the outer tube are adhesively connected by a second adhesive layer, the second adhesive layer comprising an ultraviolet light curable adhesive;
alternatively, the balloon and the outer tube are welded.
In some embodiments of the present application, the material of the ring electrode comprises an alloy of one or both of platinum and iridium.
In some embodiments of the present application, the orthographic projection profile of the ring electrode on the balloon includes regular and irregular patterns; the regular pattern includes a circle, a rectangle, a triangle, an ellipse, or a polygon, and the irregular pattern includes a zigzag shape, a concave shape, or a ring shape.
In some embodiments of the present application, the inner tube and the head electrode are adhesively connected by a third adhesive layer, and the third adhesive layer comprises an ultraviolet light curing adhesive.
In a second aspect, embodiments of the present application provide a pulse ablation device comprising: a pulsed ablation catheter as in any of the embodiments of the first aspect above.
The beneficial technical effects that technical scheme that this application embodiment provided brought include: according to the embodiment of the application, the balloon is arranged between the head electrode and the outer tube, the balloon supports the ring electrode and exposes at least part of the ring electrode, and the balloon at least comprises two states: a contracted state and an expanded state. When the sacculus is in a contracted state, the ring electrode and the sacculus are attached to the inner tube, at the moment, the overall cross-sectional area of the pulse ablation catheter is relatively small, and in the process of puncturing the skin or entering a target tissue area through a trachea, the electrode assembly and the support assembly enter the target tissue area along with the catheter assembly, so that the wound is small, and complications are correspondingly reduced. When the balloon is in an inflated state, the balloon is bent and arched towards the side far away from the inner tube, and a space exists between the ring electrode and the inner tube. The ring electrode and the head electrode jointly act to form a spherical netlike electric field, the electric field distribution is more uniform, the controllability is high, the coverage area is larger, at least part of the ring electrode exposed outside the balloon can be in direct contact with target tissues, pulse energy is directly transmitted to the target tissues, the ablation effect is improved, and the ablation time is shortened. Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings, in which:
fig. 1 is a schematic structural diagram of a pulse ablation catheter according to an embodiment of the present application;
FIG. 2 is a schematic illustration of another pulse ablation catheter according to an embodiment of the present application;
FIG. 3 is a schematic structural view of yet another pulse ablation catheter provided in an embodiment of the present application;
fig. 4 is a schematic structural view of still another pulse ablation catheter according to an embodiment of the present application.
In the figure:
1-ring electrode, 2-saccule, 3-flexible conductive band, 4-head electrode, 5-inner tube and 6-outer tube.
Detailed Description
Embodiments of the present application are described below with reference to the drawings in the present application. It should be understood that the embodiments described below with reference to the drawings are exemplary descriptions for explaining the technical solutions of the embodiments of the present application, and the technical solutions of the embodiments of the present application are not limited.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of other features, information, data, steps, operations, elements, components, and/or groups thereof, etc. that may be implemented as desired in the art. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. The term "and/or" as used herein refers to at least one of the items defined by the term.
For the purpose of making the objects, technical solutions and advantages of the present application more apparent, the embodiments of the present application will be described in further detail below with reference to the accompanying drawings.
The research finds that: the current pulmonary vein electrical isolation ablation is usually in a point-to-point mode, tissue target cells are necrotized through ablation, and then tissue electrical signal isolation is achieved, so that the method is suitable for arrhythmia such as atrial fibrillation, atrial flutter and the like formed by pulmonary veins or pulmonary veins. The limitations that exist are: the limited area ablated per unit time results in longer time during the ablation treatment, increasing the likelihood of damage to non-target tissue or the risk of tissue crusting, further increasing the likelihood of embolism. In summary, the pulse ablation catheter in the related art has the technical problems that the ablation area is limited in unit time, and the operation time is long in the ablation process.
In view of at least one of the above-mentioned technical problems or needs to be improved in the related art, the present application provides a pulse ablation catheter and a pulse ablation device. In this embodiment, by disposing the balloon 2 between the head electrode 4 and the outer tube 6, the balloon 2 supports the ring electrode 1 and exposes at least part of the ring electrode 1, and the balloon 2 includes at least two states: a contracted state and an expanded state. When the balloon 2 is in a contracted state, the ring electrode 1 and the balloon 2 are attached to the inner tube 5, at this time, the overall cross-sectional area of the pulse ablation catheter is relatively small, and in the process of puncturing the skin or entering the target tissue region through the trachea, the electrode assembly and the support assembly enter the target tissue region along with the catheter assembly, so that the wound is small, and complications are correspondingly reduced. When the balloon 2 is in the inflated state, the balloon 2 is curved and arched to the side away from the inner tube 5, and a space exists between the ring electrode 1 and the inner tube 5. The ring electrode 1 and the head electrode 4 jointly act to form a spherical netlike electric field, the electric field distribution is more uniform, the controllability is high, the coverage area is larger, at least part of the ring electrode 1 exposed outside the balloon 2 can be in direct contact with target tissues, pulse energy is directly transmitted to the target tissues, the ablation effect is improved, and the ablation time is shortened.
The following describes the technical solutions of the present application and how the technical solutions of the present application solve the above technical problems in detail with specific embodiments. It should be noted that the following embodiments may be referred to, or combined with each other, and the description will not be repeated for the same terms, similar features, similar implementation steps, and the like in different embodiments.
Fig. 1 is a schematic structural diagram of a pulse ablation catheter according to an embodiment of the present application.
In a first aspect, embodiments of the present application provide a pulsed ablation catheter comprising:
an electrode assembly including a head electrode 4, a ring electrode 1;
a catheter assembly comprising an inner tube 5, an outer tube 6;
a support assembly comprising a balloon 2, the balloon 2 comprising at least an inflated state and a deflated state;
wherein, the first end of the inner tube 5 is connected with the head electrode 4, and the second end of the inner tube 5 is connected with the outer tube 6;
the first end of the balloon 2 is connected with the first end of the head electrode 4 and at least part of the head electrode 4 is exposed, and the second end of the balloon 2 is connected with the outer tube 6;
the ring electrode 1 is at least partially arranged on the outer surface of the balloon 2;
when the balloon 2 is in a contracted state, the ring electrode 1 and the balloon 2 are attached to the inner tube 5;
when the balloon 2 is in the inflated state, the balloon 2 is curved and arched to the side away from the inner tube 5, and a space exists between the ring electrode 1 and the inner tube 5.
In the present embodiment, "first end" is defined as an end close to the head electrode 41, and "second end" is defined as an end far from the head electrode 41. The first end of the pulse ablation catheter in this embodiment pierces the skin or passes through the trachea to approach the target tissue region, and pulses are output through the head electrode 41 and the ring electrode 15 to form an electric field, which can be used for performing an electric ablation operation on the target tissue region.
Among them, the electric ablation operation is classified into irreversible electroporation and reversible electroporation according to the difference of electric field intensity. When the electric field intensity is greater than the electric field threshold of the target tissue, irreversible electroporation occurs, the cell membrane of the target cell generates an irreparable perforation, the target cell is damaged and dies due to the loss of homeostasis, thereby precisely destroying the target cell, and the adjacent normal cells are not affected. When the electric field intensity is smaller than the electric field threshold value of the target tissue, reversible electroporation occurs, the cell membrane of the target cell generates perforations which can be gradually repaired, the target cell continues the normal cell function and repairs the cell membrane formed by the phospholipid bilayer after a period of time, so that the medicine which cannot enter the target cell through the cell membrane can enter the target cell through electroporation and treat the target cell, and the subsequent target cell can still survive.
In one embodiment, the pulsed ablation catheter further comprises a handle, i.e., an operator's hand-held end. The handle maintains control of the first end of the pulsed ablation catheter as the first end of the pulsed ablation catheter approaches the target tissue region.
The handle is connected to an external source of pulsed energy and to a fluid generating device, the handle being capable of controlling whether the pulsed energy is released and the inflation and deflation of the balloon 2. The head electrode 4 is located at a first end of the pulse ablation catheter, the head electrode 4 being spaced from the handle. The first end of the outer tube 6 is connected with the balloon 2 with the ring electrode 1, the second end of the outer tube 6 is connected with the handle, and a wire connected with the ring electrode 1 is arranged in the catheter.
The material of the outer tube 6 comprises a medical polymer material, optionally the material of the outer tube 6 comprises at least one of polyethylene terephthalate T, thermoplastic polyurethane elastomer and polyurethane.
The first end of the pulse ablation catheter enters the body, adjacent to the target tissue area, and the outer tube 6 accommodates all internal wires and fluid circuits, and is connected to the balloon 2. The first end of the inner tube 5 is connected with the head electrode 4, the balloon 2 wraps the inner tube 5 and exposes at least part of the head electrode 4, and the second end of the inner tube 5 is sleeved at one end of the outer tube 6.
With the handle controlling the fluid generating device, the balloon 2 can achieve at least two states:
in the first state, the balloon 2 is in a contracted state. As shown in fig. 2, fig. 2 is a schematic structural diagram of another pulse ablation catheter according to an embodiment of the present application.
The balloon 2 has no gas or less gas, the balloon 2 is attached to the outer surface of the inner tube 5, no gap or less gap is formed between the balloon 2 and the inner tube 5, and the ring electrode 1 arranged on the surface of the balloon 2 is attached to the outer surface of the inner tube 5 along with the balloon 2, and no gap or less gap is formed between the ring electrode 1 and the inner tube 5. At this time, the cross-sectional area of the pulse ablation catheter is relatively small, so that the wound caused by puncturing the skin or passing through the trachea into the target tissue area is small, and complications are reduced correspondingly.
In the second state, the handle controls the fluid generating device to generate fluid. As shown in fig. 3, fig. 3 is a schematic structural diagram of yet another pulse ablation catheter according to an embodiment of the present application.
The fluid comprises gas, liquid or gas-liquid, part or all of the fluid is filled in the balloon 2, the material of the balloon 2 comprises an elastic material, the balloon 2 is elastically deformed after being filled with the fluid, the balloon 2 is bent and arched towards the side far away from the inner tube 5, a space exists between a part of area on the balloon 2 and the inner tube 5, and the balloon 2 forms an ellipsoid to contain the filled fluid.
It should be noted that, under the condition that the elastic deformation limit of the balloon 2 is not exceeded, changing the volume of the inflated fluid can affect the curvature of the ellipsoid obtained after the elastic deformation of the balloon 2, specifically, the size of the distance between the farthest point of the balloon 2 from the inner tube 5 and the inner tube 5.
Since the ring electrode 1 is provided on the surface of the balloon 2, a space is also created between the ring electrode 1 and the inner tube 5. The ring electrode 1 provided on the surface of the balloon 2 cooperates with the head electrode 4 provided at the first end of the inner tube 5 to form a spherical net-like electric field.
It will be appreciated that the spacing between the ring electrode 1 and the inner tube 5 is related to the curvature of the ellipsoid, i.e. the spacing between the ring electrode 1 and the inner tube 5 is positively related to the spacing between the furthest point of the balloon 2 and the inner tube 5. The volume of the filled fluid is changed, the distance between the furthest point of the saccule 2 and the inner tube 5 is different, the curvature of the ellipsoid is different, the distance between the ring electrode 1 and the inner tube 5 is also different, the size of the formed spherical netlike electric field is also different to a certain extent, and the spherical netlike electric field can be flexibly selected according to different target tissues.
Compared with the traditional needle electrode ablation, the needle electrode reaches the focus after being punctured by skin, is only suitable for superficial tissue ablation and can be accompanied with skin and tissue injury to a certain extent; meanwhile, the space electric field generated by the needle electrode is limited and not uniform enough, and the control of the ablation area and the intensity is relatively difficult; moreover, because needle electrodes have great limitations for ablation of pulmonary tissue with rib protection and relatively complex electrical characteristics, some lung cancer patients may relapse after pulse ablation therapy with needle electrodes.
In the embodiment of the application, the spherical netlike electric field is formed by the combined action of the head electrode 4 and the ring electrode 1, so that the distribution of the spherical netlike electric field is more uniform, the controllability is high, the coverage range is larger, and the ablation effect is improved. The pulse ablation catheter in the embodiment of the application punctures or enters a target tissue area through a trachea in a state that a head end tube is attached to an inner tube 5, and melts deep focus tissues under the action of a high-voltage pulse electric field, so that focus cell tissues are necrotized, and the ablation depth is improved; by changing the volume of the filled fluid, the balloon 2 is elastically deformed to form an ellipsoid, the ring electrode 1 and the head electrode 4 form electrodes in spherical net distribution, the electric field distribution is more uniform and high in controllability, and at least part of the ring electrode 1 exposed on the surface of the balloon 2 is in direct contact with target tissues, so that the ablation effect is improved; the area of the wound is reduced or avoided, and the complications after the operation are correspondingly reduced.
As shown in fig. 4, fig. 4 is a schematic structural view of still another pulse ablation catheter according to an embodiment of the present application.
In some embodiments of the present application, the pulse ablation catheter further comprises a flexible conductive strip 3, the flexible conductive strip 3 is disposed on the inner surface of the balloon 2, a first end of the flexible conductive strip 3 is electrically connected with the ring electrode 1, and a second end is sleeved with the outer tube 6.
In this embodiment, the flexible conductive tape 3 is disposed on the inner surface of the balloon 2 and is attached to the inner surface of the balloon 2. The number of ring electrodes 1 includes a plurality.
In one embodiment, at least part of the flexible conductive strip 3 has a first end electrically connected to one of the ring electrodes 1 and a second end sleeved by the outer tube 6 and extending towards the handle side for connection to a power source.
In another embodiment, at least one end of at least part of the flexible conductive strip 3 is electrically connected to one ring electrode 1, the other end of the flexible conductive strip 3 is electrically connected to the other ring electrode 1, the two ring electrodes 1 are connected in series, and at least one flexible conductive strip 3 on the serial branch is connected to the ring electrode 1 and the power supply respectively at two ends as in the above embodiment.
In yet another embodiment, the material of the flexible conductive strip 3 comprises an elastic material. When the balloon 2 is in a contracted state, the flexible conductive tape 3 is attached to the inner surface of the balloon 2; when fluid is filled into the balloon 2, the balloon 2 deforms gradually to expand, the flexible conductive strip 3 also stretches and deforms along with the balloon 2, and extends in the length direction, so that the situation that the flexible conductive strip 3 breaks due to excessive deformation is avoided, the power supply of the head electrode 4 on the corresponding branch is lost, and a complete electric field cannot be formed.
In yet another embodiment, the material of the flexible conductive strip 3 comprises a flexible material. When the balloon 2 is in a contracted state, one section of the flexible conductive strip 3 is attached to the inner surface of the balloon 2, and the other section of the flexible conductive strip 3 is bent in the outer tube 6 for a plurality of times, namely, the flexible conductive strip 3 leaves a margin in the length direction; when the balloon 2 is filled with fluid, the balloon 2 is gradually deformed and expanded, and the flexible conductive strip 3 pulls the bent portion of the outer tube 6 to extend out of the outer tube 6, i.e., the length of the portion of the flexible conductive strip 3 located outside the outer tube 6 becomes longer. Thereby avoiding that the flexible conductive strip 3 is broken due to excessive deformation, and the head electrode 4 on the corresponding branch loses power supply and cannot form a complete electric field.
In some embodiments of the present application, the flexible conductive tape 3 comprises a conductive cell and an insulating layer surrounding the conductive cell, the material of the conductive cell comprising at least one of copper, aluminum, tin, silver, and gold, and the material of the insulating layer comprising polyimide.
In this embodiment, the conductive core is made of an alloy composed of one or more of copper, aluminum, tin, silver and gold. The conductivity of the material is relatively low, and the loss in the process of transmitting signals is less. The material of the insulating layer comprises Polyimide (PI), and the Polyimide has better insulating property and high affinity with target tissues, and does not generate rejection reaction.
Optionally, the preparation method of the conductive cell comprises a gold deposition method, the gold deposition process adopts a chemical deposition method, a plating layer is generated by a chemical oxidation-reduction reaction method, and the thickness is generally thicker, which is one of the chemical nickel Jin Jinceng deposition methods, so that a thicker gold layer can be achieved.
The gold deposition process deposits a nickel-gold coating with stable color, good brightness, smooth coating and good weldability on the surface of the printed circuit. The method can be basically divided into four stages: pretreatment (degreasing, microetching, activating and post-leaching), nickel and gold deposition, and post-treatment (waste Jin Shuixi, deionized water washing and drying). The thickness of the deposited gold is between 0.025 and 0.1 um.
Gold is applied to surface treatment of a circuit board, and is generally applied to a key board, a gold finger board and the like because of high conductivity, good oxidation resistance and long service life.
In some embodiments of the present application, the material of balloon 2 comprises polyamide or thermoplastic polyurethane.
In this embodiment, the material of the balloon 2 is Polyamide (PA) or Thermoplastic Polyurethane (TPU), and PA has flexibility, bending resistance, toughness, chemical resistance, and abrasion resistance, and is not easily broken. No substances harmful to the human body are released, and thus no inflammation of the skin or tissue is caused.
The TPU has better transparency, high strength and tearing property, chemical resistance and wear resistance; has wide hardness range, smooth surface, antifungal and microorganism resistance and high water resistance.
In some embodiments of the present application, the balloon 2 and the head electrode 4 are adhesively connected by a first adhesive layer, wherein the first adhesive layer comprises ultraviolet light curing glue;
alternatively, the balloon 2 and the head electrode 4 are fusion-connected.
In one embodiment, the balloon 2 is in viscous connection with the head electrode 4, and the ultraviolet light curing adhesive has the characteristics of long storage period, no solvent, high curing speed, good transparency, good heat resistance and chemical resistance and the like, and is applied to the fields of medical care, electronic components, daily life and the like.
Specifically: an Ultraviolet (UV) curing glue is coated on one side surface of the balloon 2 facing the head electrode 4 or one side surface of the head electrode 4 facing the balloon 2, the head electrode 4 or the balloon 2 is attached to the glue, and the UV curing glue is irradiated by Ultraviolet light.
Under the irradiation of ultraviolet light with proper wavelength and light intensity, the photoinitiator in the adhesive is quickly decomposed into free radicals or cations, and then unsaturated bond polymerization is initiated, so that the material is solidified.
In another embodiment, the welding connection between the balloon 2 and the head electrode 4 is achieved by heating one of the balloon 2 and the head electrode 4 by a laser or other heating device to make the connection become molten, placing the other into the connection in the molten state, cooling and solidifying the connection, and completing the welding connection between the balloon 2 and the head electrode 4.
In some embodiments of the present application, the balloon 2 and the outer tube 6 are adhesively connected by a second adhesive layer, wherein the second adhesive layer comprises an ultraviolet light curing adhesive;
alternatively, the balloon 2 and the outer tube 6 are welded.
In one embodiment, the balloon 2 is in viscous connection with the outer tube 6, and the ultraviolet light curing adhesive has the characteristics of long storage period, no solvent, high curing speed, good transparency, good heat resistance and chemical resistance and the like, and is applied to the fields of medical sanitation, electronic components, daily life and the like.
Specifically: an Ultraviolet (UV) curing glue is coated on the surface of the balloon 2 facing the outer tube 6 or the surface of the outer tube 6 facing the balloon 2, the outer tube 6 or the balloon 2 is attached to the glue, and the UV curing glue is irradiated by UV light.
Under the irradiation of ultraviolet light with proper wavelength and light intensity, the photoinitiator in the adhesive is quickly decomposed into free radicals or cations, and then unsaturated bond polymerization is initiated, so that the material is solidified.
In another embodiment, the welding connection between the balloon 2 and the outer tube 6 is achieved by heating one of the balloon 2 and the outer tube 6 with a laser or other heating device to change the junction into a molten state, placing the other into the molten state junction, and cooling and solidifying the junction to complete the welding connection between the balloon 2 and the outer tube 6.
In some embodiments of the present application, the material of the ring electrode 1 includes an alloy of one or both of platinum and iridium.
In a specific embodiment, the material of the ring electrode 1 comprises a platinum iridium (PtIr) alloy.
Alternatively, the material of the ring electrode 1 includes platinum iridium alloy 10 and platinum iridium alloy 5, which refer to alloys having iridium content of 10% and 5% in the alloy, respectively. The platinum iridium alloy 10 and the platinum iridium alloy 5 are classical potentiometer winding materials, and are hard in texture and good in high temperature resistance and corrosion resistance.
In some embodiments of the present application, the orthographic projection profile of the ring electrode 1 on the balloon 2 includes regular patterns and irregular patterns; the regular pattern includes a circle, a rectangle, a triangle, an ellipse, or a polygon, and the irregular pattern includes a zigzag shape, a concave shape, or a ring shape.
In a specific embodiment, the orthographic projection profile of the at least one ring electrode 1 on the balloon 2 is circular. The circular electrode has no sharp edges and corners, the risk of damage to target tissues due to friction is reduced, the electric field coverage area generated by the circular electrode is large, and the ablation effect is good.
In some embodiments of the present application, the inner tube 5 and the head electrode 4 are adhesively connected by a third adhesive layer, and the third adhesive layer comprises ultraviolet light curing glue.
In one embodiment, the inner tube 5 is in viscous connection with the head electrode 4, and the ultraviolet light curing adhesive has the characteristics of long storage period, no solvent, high curing speed, good transparency, good heat resistance and chemical resistance and the like, and is applied to the fields of medical sanitation, electronic components, daily life and the like.
Specifically: and coating Ultraviolet (UV) curing glue on one side surface of the inner tube 5 facing the head electrode 4 or one side surface of the head electrode 4 facing the inner tube 5, attaching the head electrode 4 or the inner tube 5 to the glued part, and irradiating the UV curing glue with Ultraviolet light.
Based on the same conception, in a second aspect, embodiments of the present application provide a pulse ablation device comprising: a pulsed ablation catheter as in any of the embodiments of the first aspect above.
Compared with the prior art, the method and the device can realize at least the following beneficial effects: in this embodiment, by disposing the balloon 2 between the head electrode 4 and the outer tube 6, the balloon 2 supports the ring electrode 1 and exposes at least part of the ring electrode 1, and the balloon 2 includes at least two states: a contracted state and an expanded state. When the balloon 2 is in a contracted state, the ring electrode 1 and the balloon 2 are attached to the inner tube 5, at this time, the overall cross-sectional area of the pulse ablation catheter is relatively small, and in the process of puncturing the skin or entering the target tissue region through the trachea, the electrode assembly and the support assembly enter the target tissue region along with the catheter assembly, so that the wound is small, and complications are correspondingly reduced. When the balloon 2 is in the inflated state, the balloon 2 is curved and arched to the side away from the inner tube 5, and a space exists between the ring electrode 1 and the inner tube 5. The ring electrode 1 and the head electrode 4 jointly act to form a spherical netlike electric field, the electric field distribution is more uniform, the controllability is high, the coverage area is larger, at least part of the ring electrode 1 exposed outside the balloon 2 can be in direct contact with target tissues, pulse energy is directly transmitted to the target tissues, the ablation effect is improved, and the ablation time is shortened.
Those of skill in the art will appreciate that the various operations, methods, steps in the flow, actions, schemes, and alternatives discussed in the present application may be alternated, altered, combined, or eliminated. Further, other steps, means, or steps in a process having various operations, methods, or procedures discussed in this application may be alternated, altered, rearranged, split, combined, or eliminated. Further, steps, measures, schemes in the prior art with various operations, methods, flows disclosed in the present application may also be alternated, altered, rearranged, decomposed, combined, or deleted.
In the description of the present application, the directions or positional relationships indicated by the words "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., are based on the exemplary directions or positional relationships shown in the drawings, are for convenience of description or simplifying the description of the embodiments of the present application, and do not indicate or imply that the apparatus or components referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.
The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.
In the description of the present specification, a particular feature, structure, material, or characteristic may be combined in any suitable manner in one or more embodiments or examples.
It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the order in which the steps are performed is not limited to the order indicated by the arrows. In some implementations of embodiments of the present application, the steps in each flow may be performed in other orders as desired, unless explicitly stated herein. Moreover, some or all of the steps in the flowcharts may include multiple sub-steps or multiple stages based on the actual implementation scenario. Some or all of the sub-steps or stages may be executed at the same time, or may be executed at different times, where the execution sequence of the sub-steps or stages may be flexibly configured according to the requirements, which is not limited by the embodiment of the present application.
The foregoing is only a part of the embodiments of the present application, and it should be noted that, for those skilled in the art, other similar implementation means based on the technical ideas of the present application are adopted without departing from the technical ideas of the solutions of the present application, and also belong to the protection scope of the embodiments of the present application.
Claims (9)
1. A pulse ablation catheter, comprising:
an electrode assembly including a head electrode, a ring electrode;
a catheter assembly comprising an inner tube, an outer tube;
a support assembly comprising a balloon, the balloon comprising at least an inflated state and a deflated state;
wherein a first end of the inner tube is connected with the head electrode, and a second end of the inner tube is connected with the outer tube;
the first end of the balloon is connected with the first end of the head electrode, at least part of the head electrode is exposed, and the second end of the balloon is connected with the outer tube;
the ring electrode is at least partially arranged on the outer surface of the balloon;
when the balloon is in a contracted state, the ring electrode and the balloon are attached to the inner tube;
when the balloon is in an inflated state, the balloon is bent and arched towards the side far away from the inner tube, and a space exists between the ring electrode and the inner tube.
2. The pulse ablation catheter of claim 1, further comprising a flexible conductive strip disposed on an inner surface of the balloon, the flexible conductive strip having a first end electrically connected to the ring electrode and a second end sleeved by the outer tube.
3. The pulse ablation catheter of claim 2, wherein the flexible conductive strip comprises a conductive core and an insulating layer surrounding the conductive core.
4. The pulse ablation catheter of claim 1, wherein the balloon material comprises polyamide or thermoplastic polyurethane.
5. The pulse ablation catheter of claim 1, wherein the balloon is adhesively connected to the head electrode by a first adhesive layer comprising an ultraviolet curable adhesive;
alternatively, the balloon and the head electrode are in fusion connection.
6. The pulse ablation catheter of claim 1, wherein the balloon is adhesively connected to the outer tube by a second adhesive layer, the second adhesive layer comprising an ultraviolet curable glue;
or the balloon and the outer tube are in fusion connection.
7. The pulsed ablation catheter of claim 1, wherein an orthographic projection profile of the ring electrode on the balloon comprises a regular pattern and an irregular pattern; the regular pattern includes a circle, triangle, ellipse, or polygon, and the irregular pattern includes a zigzag, a concave, or a ring.
8. The pulse ablation catheter of claim 1, wherein the inner tube and the head electrode are adhesively connected by a third adhesive layer, the third adhesive layer comprising an ultraviolet curable glue.
9. A pulse ablation device, comprising: the pulsed ablation catheter of any of claims 1-8.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222370179.2U CN219271106U (en) | 2022-09-06 | 2022-09-06 | Pulse ablation catheter and pulse ablation device |
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| CN202222370179.2U CN219271106U (en) | 2022-09-06 | 2022-09-06 | Pulse ablation catheter and pulse ablation device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117297757A (en) * | 2023-11-27 | 2023-12-29 | 中国科学院深圳先进技术研究院 | Multichannel balloon electrode and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117297757A (en) * | 2023-11-27 | 2023-12-29 | 中国科学院深圳先进技术研究院 | Multichannel balloon electrode and preparation method and application thereof |
| CN117297757B (en) * | 2023-11-27 | 2024-03-15 | 中国科学院深圳先进技术研究院 | Multichannel balloon electrode and preparation method and application thereof |
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