CN219218009U

CN219218009U - Quick focusing device of gene sequencer

Info

Publication number: CN219218009U
Application number: CN202223161027.8U
Authority: CN
Inventors: 姜昕; 赵德志; 付国龙; 郭云涛; 朱云; 唐帅男
Original assignee: SHANGHAI GENOMEPILOT TECHNOLOGY Inc
Current assignee: SHANGHAI GENOMEPILOT TECHNOLOGY Inc
Priority date: 2022-11-28
Filing date: 2022-11-28
Publication date: 2023-06-20
Anticipated expiration: 2032-11-28

Abstract

The utility model provides a rapid focusing device of a gene sequencer, which comprises: a bottom plate; the two guide rods are fixed on one side of the top of the bottom plate, and a top plate is fixedly connected between the top ends of the two guide rods; the screw rod is rotationally connected to the bottom of the top plate, an adjusting block is connected to the outer surface of the bottom end of the screw rod in a threaded mode, a gene sequencing chip is fixedly connected to one side of the adjusting block, and the adjusting block is in sliding connection with the outer surfaces of the two guide rods. According to the rapid focusing device of the gene sequencer, the gene sequencing chip can be driven to move up and down through the up-and-down movement of the adjusting block, so that the distance between the gene sequencing chip and the objective lens is adjusted, a worker can conveniently control the distance between the objective lens and the gene sequencing chip, rapid focusing operation is formed, and the smoothness and stability of the up-and-down movement of the adjusting block are further improved through the arrangement of the two guide rods, and the follow-up focusing effect is improved.

Description

Quick focusing device of gene sequencer

Technical Field

The utility model relates to the technical field of optics, in particular to a rapid focusing device of a gene sequencer.

Background

The gene sequencer is a kind of instrument suitable for medical field, and is one new kind of gene detecting technology capable of analyzing and determining gene sequence from blood or human body appendages and predicting the possibility of various diseases, such as cancer, leukemia, etc.

Gene sequencing related products and techniques have evolved from laboratory studies to clinical use; second generation gene sequencing generally employs a gene chip that utilizes a hybridization sequencing method, i.e., a method of determining the nucleic acid sequence by hybridization with a set of nucleic acid probes of known sequence.

In the related art, before gene sequencing, focusing adjustment needs to be performed on an objective lens and a gene sequencing chip in an optical system, however, the gene sequencer in the prior art has certain defects in the focusing process, such as incapability of performing focusing adjustment rapidly and accurately, repeated operation and control are required, and the adjusted accuracy is not high and lacks corresponding focusing positioning performance.

Therefore, it is necessary to provide a rapid focusing device for a gene sequencer to solve the above technical problems.

Disclosure of Invention

The utility model provides a rapid focusing device of a gene sequencer, which solves the problem that the adjusted focusing position cannot be positioned so that the adjusted accuracy is not high.

In order to solve the technical problems, the rapid focusing device of the gene sequencer provided by the utility model comprises:

a bottom plate;

the two guide rods are fixed on one side of the top of the bottom plate, and a top plate is fixedly connected between the top ends of the two guide rods;

the screw rod is rotationally connected to the bottom of the top plate, an adjusting block is connected to the outer surface of the bottom end of the screw rod in a threaded manner, a gene sequencing chip is fixedly connected to one side of the adjusting block, and the adjusting block is in sliding connection with the outer surfaces of the two guide rods;

an objective lens fixed inside the top plate;

a dichroic mirror detachably mounted on top of the top plate;

and the detector is arranged on the other side of the top of the bottom plate.

Preferably, the top of roof fixedly connected with L type support, one side of L type support rotates and is connected with T type connecting block.

Preferably, the rotating end of the T-shaped connecting block is provided with two elastic clamping sleeves.

Preferably, the back of the dichroic mirror is fixedly connected with two U-shaped positioning frames, and two sides of the back of the dichroic mirror are respectively connected with two limiting plates through supporting rods in a rotating mode.

Preferably, the other side at the top of the bottom plate is fixedly connected with a supporting frame, and the top of the supporting frame is fixedly connected with a backing plate.

Preferably, four positioning holes are formed in the base plate, and four positioning rods are fixedly connected to the bottom of the detector.

Preferably, both sides of the bottom of the detector are rotatably connected with locking plates.

Compared with the related art, the rapid focusing device of the gene sequencer provided by the utility model has the following structure

The beneficial effects are that:

the utility model provides a rapid focusing device of a gene sequencer, which can drive an adjusting block to move up and down through the rotation of a screw rod, and can drive a gene sequencing chip to move up and down through the up and down movement of the adjusting block, so that the distance between the gene sequencing chip and an objective lens is adjusted, the distance between the objective lens and the gene sequencing chip is controlled by a worker conveniently, rapid focusing operation is formed, and the smoothness and stability of the up and down movement of the adjusting block are further improved through the arrangement of two guide rods, and the subsequent focusing effect is improved.

Drawings

FIG. 1 is a schematic diagram of a first embodiment of a rapid focusing device of a gene sequencer according to the present utility model;

FIG. 2 is a rear view of the rapid focusing device of the gene sequencer shown in FIG. 1;

FIG. 3 is a schematic diagram of a combination of the objective lens and dichroic mirror shown in FIG. 1;

FIG. 4 is an enlarged schematic view of portion A shown in FIG. 3;

fig. 5 is a schematic structural diagram of a second embodiment of a rapid focusing device of a gene sequencer.

Reference numerals in the drawings: 1. a bottom plate; 2. a guide rod; 3. a top plate; 4. a screw rod; 5. an adjusting block; 6. a gene sequencing chip; 7. an objective lens; 8. a dichroic mirror; 9. a detector; 10. an L-shaped bracket; 11. a T-shaped connecting block; 12. a U-shaped positioning frame; 13. a limiting plate; 14. a support frame; 15. a backing plate; 16. and a locking plate.

Detailed Description

The utility model will be further described with reference to the drawings and embodiments.

First embodiment

Referring to fig. 1, fig. 2, fig. 3, and fig. 4 in combination, fig. 1 is a schematic structural diagram of a first embodiment of a rapid focusing device of a gene sequencer according to the present utility model; FIG. 2 is a rear view of the rapid focusing device of the gene sequencer shown in FIG. 1; FIG. 3 is a schematic diagram of a combination of the objective lens and dichroic mirror shown in FIG. 1; fig. 4 is an enlarged schematic view of a portion a shown in fig. 3. The quick focusing device of the gene sequencer comprises:

a base plate 1;

the two guide rods 2 are fixed on one side of the top of the bottom plate 1, and a top plate 3 is fixedly connected between the top ends of the two guide rods 2;

the screw rod 4 is rotationally connected to the bottom of the top plate 3, the outer surface of the bottom end of the screw rod 4 is in threaded connection with an adjusting block 5, one side of the adjusting block 5 is fixedly connected with a gene sequencing chip 6, and the adjusting block 5 is in sliding connection with the outer surfaces of the two guide rods 2;

an objective lens 7, the objective lens 7 being fixed inside the top plate 3;

a dichroic mirror 8, the dichroic mirror 8 being detachably mounted on top of the top plate 3;

a detector 9, the detector 9 being mounted on the other side of the top of the base plate 1;

the adjusting block 5 can be driven to move up and down through the rotation of the screw rod 4, and the gene sequencing chip 6 can be driven to move up and down through the up and down movement of the adjusting block 5, so that the distance between the gene sequencing chip 6 and the objective lens 7 is adjusted, and further, the distance between the objective lens 7 and the gene sequencing chip 6 is controlled by a worker conveniently, so that rapid focusing work is formed;

by the arrangement of the two guide rods 2, the smoothness and stability of the up-and-down movement of the regulating block 5 are further improved, and the follow-up focusing effect is improved;

the detection light emitted by the detector 9 is reflected to the objective lens 7 through the dichroic mirror 8, the objective lens 7 converges and irradiates the detection light on the gene sequencing chip 6, the gene sequencing chip 6 reflects feedback light, the feedback light converges and irradiates the dichroic mirror 8 through the objective lens 7, the feedback light is reflected by the dichroic mirror 8 and then irradiates the detector 9, and the detector 9 collects the feedback light, so that whether the relative distance between the objective lens 7 and the gene sequencing chip 6 is proper or not is analyzed;

generally, the focal point of the objective lens 7 is just focused on the gene sequencing chip 6.

The top of the top plate 3 is fixedly connected with an L-shaped bracket 10, and one side of the L-shaped bracket 10 is rotatably connected with a T-shaped connecting block 11.

The rotating end of the T-shaped connecting block 11 is provided with two elastic clamping sleeves;

through the setting of elastic clamping sleeve, be convenient for improve the resistance when its T type connecting block 11 is adjusted, and then improve the stability after the angle modulation of T type connecting block 11.

The back of the dichroic mirror 8 is fixedly connected with two U-shaped positioning frames 12, and two sides of the back of the dichroic mirror 8 are respectively connected with two limiting plates 13 through supporting rods in a rotating way;

through the setting of two U type locating frames 12 for four corners to T type connecting block 11 fix a position the chucking, guarantee the locality of its dichroscope 8 installation in-process, through the rotation of two limiting plates 13 moreover, can rotate to T type connecting block 11 on, form the chucking with T type connecting block 11, guarantee the stability of its dichroscope 8 installation, have good dismouting function.

The working principle of the rapid focusing device of the gene sequencer provided by the utility model is as follows:

through manual rotatory regulation to lead screw 4, through the rotation of lead screw 4, can drive regulating block 5 up-and-down motion, through regulating block 5 up-and-down motion, can drive gene sequencing chip 6 up-and-down motion, thereby adjust the distance between gene sequencing chip 6 and objective 7, the probe light that follows the detector 9 and send out reflects to on objective 7 through dichroic mirror 8, objective 7 is with this probe light collection illumination on gene sequencing chip 6, gene sequencing chip 6 reflects out feedback light, this feedback light is with gathering illumination to dichroic mirror 8 through objective 7, it is in detector 9 department after this dichroic mirror 8 reflection, be gathered by detector 9, thereby be in suitable relative distance between analysis objective 7 and the gene sequencing chip 6.

Second embodiment

Referring to fig. 5 in combination, a second embodiment of the present application provides another rapid focusing device for a gene sequencer based on the rapid focusing device for a gene sequencer provided in the first embodiment of the present application. The second embodiment is merely a preferred manner of the first embodiment, and implementation of the second embodiment does not affect the implementation of the first embodiment alone.

Specifically, the quick focusing device of the gene sequencer provided in the second embodiment of the present application is different in that the other side of the top of the bottom plate 1 is fixedly connected with a supporting frame 14, and the top of the supporting frame 14 is fixedly connected with a backing plate 15.

Four positioning holes are formed in the base plate 15, and four positioning rods are fixedly connected to the bottom of the detector 9;

through the seting of locating hole, the insertion of locating lever of being convenient for, and then guarantee its detector 9 and be located the locatability at backing plate 15 top, avoid appearing the removal of controlling from front to back.

Both sides of the bottom of the detector 9 are rotatably connected with locking plates 16;

through the rotation of locking plate 16, can rotate to the bottom of backing plate 15, lock through locking plate 16, guarantee its detector 9 and be located the stability at backing plate 15 top for detector 9 has good dismantled and assembled function.

The foregoing is only illustrative of the present utility model and is not to be construed as limiting the scope of the utility model, and all equivalent structures or equivalent flow modifications which may be made by the teachings of the present utility model and the accompanying drawings or which may be directly or indirectly employed in other related art are within the scope of the utility model.

Claims

1. Quick focusing device of gene sequencer, its characterized in that includes:

a bottom plate (1);

the two guide rods (2), the two guide rods (2) are fixed on one side of the top of the bottom plate (1), and a top plate (3) is fixedly connected between the top ends of the two guide rods (2);

the screw rod (4) is rotationally connected to the bottom of the top plate (3), an adjusting block (5) is connected to the outer surface of the bottom end of the screw rod (4) in a threaded mode, a gene sequencing chip (6) is fixedly connected to one side of the adjusting block (5), and the adjusting block (5) is connected with the outer surfaces of the two guide rods (2) in a sliding mode;

an objective lens (7), wherein the objective lens (7) is fixed inside the top plate (3);

a dichroic mirror (8), the dichroic mirror (8) being detachably mounted on top of the top plate (3);

and the detector (9) is arranged on the other side of the top of the bottom plate (1).

2. The rapid focusing device of the gene sequencer according to claim 1, wherein an L-shaped bracket (10) is fixedly connected to the top of the top plate (3), and a T-shaped connecting block (11) is rotatably connected to one side of the L-shaped bracket (10).

3. The rapid focusing device of the gene sequencer according to claim 2, wherein the rotating end of the T-shaped connecting block (11) is provided with two elastic clamping sleeves.

4. The rapid focusing device of the gene sequencer according to claim 2, wherein the back of the dichroic mirror (8) is fixedly connected with two U-shaped positioning frames (12), and two limiting plates (13) are rotatably connected to two sides of the back of the dichroic mirror (8) through supporting rods.

5. The rapid focusing device of the gene sequencer according to claim 1, wherein a supporting frame (14) is fixedly connected to the other side of the top of the bottom plate (1), and a backing plate (15) is fixedly connected to the top of the supporting frame (14).

6. The rapid focusing device of the gene sequencer according to claim 5, wherein four positioning holes are formed in the base plate (15), and four positioning rods are fixedly connected to the bottom of the detector (9).

7. The rapid focusing device of the gene sequencer according to claim 6, wherein the locking plates (16) are rotatably connected to both sides of the bottom of the detector (9).