CN219194993U

CN219194993U - Disposable biological reaction bag

Info

Publication number: CN219194993U
Application number: CN202223447050.3U
Authority: CN
Inventors: 陈宣陶; 陈佳; 高虎
Original assignee: Biotech Biotechnology Chengdu Co ltd
Current assignee: Biotech Biotechnology Chengdu Co ltd
Priority date: 2022-12-22
Filing date: 2022-12-22
Publication date: 2023-06-16
Anticipated expiration: 2032-12-22

Abstract

The utility model discloses a disposable biological reaction bag which comprises a bag body, an upper sealing cover, a lower sealing cover and a circular magnetic sheet, wherein the upper sealing cover is fixedly connected to the upper wall of the bag body. When the rotary liquid stirring device is used, the hanging ring is used for hanging and installing, so that the bag body filled with the culture liquid hangs down through dead weight, the external magnetic force is used for rotating and driving the circular magnetic sheet to rotate, the circular magnetic sheet drives the rotary rod to rotate, the auger blade on the outer wall of the rotary rod sucks liquid from the inside of the guide pipe through the liquid suction port and discharges the liquid from the liquid outlet, the effect of up-down circulation is realized, the guide pipe is driven to rotate through the transmission structure, the stirring bar is driven to stir the liquid in a rotating way, the bag body is unfolded to be cylindrical through the external supporting ring, the liquid stirring effect is good, and the mass transfer is uniform.

Description

Disposable biological reaction bag

Technical Field

The utility model relates to the technical field of medical appliances, in particular to a disposable biological reaction bag.

Background

Disposable bioreactor bags as used with the bioreactor system are pre-irradiation sterilized disposable bags for media and cell mixing. During the culture of research, development and commercial production operations, the disposable bioreactor bag plays a significant role, can provide a suitable environment for cell growth, and simultaneously minimizes the risk of cross contamination.

In order to improve the reaction speed and the culture effect, the conventional disposable biological reaction bags need to stir the liquid in the bags to achieve the mass transfer effect, most of the conventional disposable biological reaction stirring bags in the market are only internally provided with one or two groups of stirring blades driven by magnetic force to stir, and because the section of the interior of the bag body is abnormal, dead angles are very large during stirring, and the stirring effect of the bag body is not high due to the stirring of the stirring blades, so that the conventional disposable biological reaction bags are required to be further improved.

Disclosure of Invention

The utility model aims to solve the defects in the prior art and provides a disposable biological reaction bag.

In order to achieve the above purpose, the present utility model adopts the following technical scheme: the utility model provides a disposable biological reaction bag, includes the bag body, goes up sealed lid, lower sealed lid and circular magnetic sheet, go up sealed lid fixed connection at the bag body upper wall, go up sealed lid upper wall fixedly connected with rings, sealed lid fixed connection down is at the bag body lower wall, go up sealed lid, sealed lid down runs through bag body upper wall and lower wall respectively and all stretch into the bag body inside, circular magnetic sheet rotates and connects one side that sealed lid stretches into the bag body inside down, the bag body outer wall is provided with the bearing structure who is used for supporting the die cavity shape, circular magnetic sheet upper wall fixedly connected with bull stick, it is connected with the pipe to go up sealed lid lower wall rotation, the one end that the circular magnetic sheet was kept away from to the bull stick stretches into inside the pipe, the pipe is kept away from between the one end of last sealed lid and the circular magnetic sheet when the bag body is expanded completely forms the liquid suction mouth that supplies liquid to get into, the pipe outer wall is provided with outer stirring structure, be provided with between bull stick and the pipe through outside magnetic force rotation drive circular magnetic sheet drive upper and lower circulation structure, still be provided with between bull stick, pipe and the sealed lid.

As a further description of the above technical solution:

the support structure comprises three groups of outer support rings, the three groups of outer support rings are vertically distributed and sequentially fixedly connected to the outer wall of the bag body, and the overlooking section of each outer support ring is circular.

As a further description of the above technical solution:

the outer stirring structure comprises a plurality of groups of stirring strips, and the stirring strips are irregularly fixedly connected to the circumferential outer wall of the guide pipe.

As a further description of the above technical solution:

the upper-lower circulation structure comprises an auger blade and a liquid outlet hole, the liquid outlet hole is formed in the outer wall of the guide pipe and close to one end of the upper sealing cover, the auger blade is fixedly connected to the outer wall of the rotating rod, the auger blade is composed of a framework and a rubber lining layer, the framework is fixedly connected to the outer wall of the rotating rod in a spiral mode, the rubber lining layer is coated on the outer wall of the framework, and the upper end level of the auger blade is higher than the liquid outlet hole.

As a further description of the above technical solution:

the transmission structure comprises a rotating shaft, a first gear, a second gear and a toothed ring, wherein the rotating shaft is fixedly connected to the lower wall of the upper sealing cover and located inside the guide pipe, the first gear, the second gear and the toothed ring are respectively and fixedly connected to one end of the rotating shaft, which is far away from the upper sealing cover, one end of the rotating rod, which is far away from the circular magnetic sheet, and the inner side wall of the guide pipe, multiple groups of teeth are arranged on the inner side wall of the toothed ring, and the first gear is meshed with the second gear and the toothed ring simultaneously.

As a further description of the above technical solution:

the outer wall of the rotating rod is positioned at one end close to the circular magnetic sheet and is rotationally connected with a supporting frame, and the supporting frame is fixedly connected with the inner side wall of the guide pipe.

The utility model has the following beneficial effects:

compared with the prior art, this disposable biological reaction bag hangs the installation through rings during the use for the bag body that is equipped with the culture solution hangs down through the dead weight, and outside magnetic force rotary drive drives the rotary disk piece and rotates, and the rotary disk piece drives the bull stick rotation, and the auger blade of bull stick outer wall is followed the imbibition mouth and is followed the pipe inside with liquid and is inhaled and follow the liquid outlet discharge, realizes upper and lower endless effect, and the pipe passes through the transmission structure transmission rotation, drives the stirring strip and carries out rotatory stirring to liquid, and the bag body struts through outer the ring and is cylindrically, and liquid stirring is effectual, and mass transfer is even.

Drawings

FIG. 1 is a schematic view of the overall structure of a disposable bioreactor bag according to the present utility model;

FIG. 2 is a partial sectional view of the lower end of the guide tube and the rotating rod of the disposable bioreactor bag according to the present utility model;

FIG. 3 is a schematic view of a top-down structure of a support frame of a disposable bioreactor bag according to the present utility model;

fig. 4 is a partial cross-sectional view of a catheter, an upper sealing cover, a rotating rod and a transmission structure of a disposable bioreactor bag according to the present utility model.

Legend description:

1. a bag body; 2. an outer support ring; 3. an upper sealing cover; 4. a lower sealing cover; 5. a conduit; 6. stirring strips; 7. a liquid outlet hole; 8. a circular magnetic sheet; 9. a rotating rod; 10. a hanging ring; 11. a skeleton; 12. a lining adhesive layer; 13. a support frame; 14. a rotating shaft; 15. a first gear; 16. a toothed ring; 17. and a second gear.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1 to 4, the present utility model provides a disposable bioreactor bag: the bag comprises a bag body 1, an upper sealing cover 3, a lower sealing cover 4 and a circular magnetic sheet 8, wherein the upper sealing cover 3 is fixedly connected to the upper wall of the bag body 1, the upper wall of the upper sealing cover 3 is fixedly connected with a hanging ring 10, and the bag body 1 is hung through the hanging ring 10, so that the bag body 1 can hang down through the dead weight, and can be unfolded;

the lower sealing cover 4 is fixedly connected to the lower wall of the bag body 1, the upper sealing cover 3 and the lower sealing cover 4 respectively penetrate through the upper wall and the lower wall of the bag body 1 and extend into the bag body 1, the circular magnetic sheet 8 is rotatably connected to one side of the lower sealing cover 4 extending into the bag body 1, the outer wall of the bag body 1 is provided with a supporting structure for supporting the shape of a cavity, the supporting structure comprises three groups of outer supporting rings 2, the three groups of outer supporting rings 2 are sequentially and fixedly connected to the outer wall of the bag body 1 in an up-down distribution manner, the overlooking section of the outer supporting rings 2 is circular, the bag body 1 is supported by the circular outer supporting rings 2, and the dead angle positions of liquid stirring and up-down circulation can be reduced;

the upper wall of the circular magnetic sheet 8 is fixedly connected with a rotating rod 9, the lower wall of the upper sealing cover 3 is rotationally connected with a guide pipe 5, one end, close to the circular magnetic sheet 8, of the outer wall of the rotating rod 9 is rotationally connected with a supporting frame 13, and the supporting frame 13 is fixedly connected with the inner side wall of the guide pipe 5. One end of the rotating rod 9 far away from the circular magnetic sheet 8 stretches into the guide pipe 5, a liquid suction port for liquid to enter is formed between one end of the guide pipe 5 far away from the upper sealing cover 3 and the circular magnetic sheet 8 when the bag body 1 is completely unfolded, an outer stirring structure is arranged on the outer wall of the guide pipe 5, the outer stirring structure comprises a plurality of groups of stirring strips 6, the plurality of groups of stirring strips 6 are fixedly connected to the circumferential outer wall of the guide pipe 5 in an irregular shape, when the guide pipe 5 is driven by a transmission structure, the rotating motion opposite to the rotating direction of the rotating rod 9 is carried out, so that the plurality of groups of stirring strips 6 are driven to stir liquid, the plurality of groups of stirring strips 6 are irregularly distributed, the flowing direction of the liquid is changeable during stirring, and the stirring effect is good;

the upper and lower circulating structures driven by the circular magnetic sheet 8 are arranged between the rotating rod 9 and the guide pipe 5 through external magnetic force rotation, the upper and lower circulating structures comprise auger blades and a liquid outlet 7, the liquid outlet 7 is arranged on the outer wall of the guide pipe 5 and is close to one end of the upper sealing cover 3, the auger blades are fixedly connected to the outer wall of the rotating rod 9, each auger blade consists of a framework 11 and a lining rubber layer 12, the framework 11 is fixedly connected to the outer wall of the rotating rod 9 in a spiral mode, the lining rubber layer 12 is coated on the outer wall of the framework 11, the upper end of each auger blade is higher than the liquid outlet 7 in horizontal height, the rotating rod 9 is driven by external magnetic force to rotate through magnetic attraction with the circular magnetic sheet 8, so that the auger blades are driven to rotate, the outer wall of each auger blade is in sliding contact with the inner side wall of the guide pipe 5, liquid entering from a liquid suction port is driven to move upwards when the auger blades rotate, suction force is continuously formed at the liquid suction port, the absorbed liquid is finally discharged from the liquid outlet 7, the effect of circulating bottom liquid to the upper part is achieved, and the mass transfer effect is enhanced;

still be provided with the transmission structure who is used for the transmission between bull stick 9, pipe 5 and the upper seal lid 3, transmission structure includes pivot 14, first gear 15, second gear 17 and ring gear 16, pivot 14 fixed connection just is located pipe 5 inside at upper seal lid 3 lower wall, first gear 15, second gear 17 and ring gear 16 are fixed connection respectively in pivot 14 keep away from the one end of upper seal lid 3, the bull stick 9 is kept away from the one end of circle magnetic sheet 8 and pipe 5 inside wall, ring gear 16 inside wall is provided with the multiunit tooth, first gear 15 meshes with second gear 17 and ring gear 16 simultaneously, when outside magnetic force drive drives bull stick 9 rotatory, second gear 17 drives the first gear 15 of meshing with it and makes reverse rotation, first gear 15 drives pipe 5 rotation through the meshing with ring gear 16, thereby make pipe 5 can drive stirring strip 6 and stir.

Working principle: the bag body 1 is hung through the hanging ring 10, the bag body 1 can hang down through the dead weight, the bag body 1 is supported through the annular outer supporting ring 2, the dead angle position of stirring and up-down circulation of liquid can be reduced, external magnetic force driving drives the rotating rod 9 to rotate through magnetic attraction with the circular magnetic sheet 8, thereby driving the auger blade to rotate, the outer wall of the auger blade is in sliding contact with the inner wall of the guide pipe 5, when the auger blade rotates, the liquid entering from the liquid suction port is driven to move upwards, suction force is continuously formed at the liquid suction port, the adsorbed liquid is finally discharged from the liquid outlet 7, the effect of circulating bottom liquid to the upper part is completed, the mass transfer effect is enhanced, when external magnetic force driving drives the rotating rod 9 to rotate, the first gear 15 meshed with the first gear 15 is driven to rotate reversely, the first gear 15 drives the guide pipe 5 to rotate through meshing with the toothed ring 16, thereby enabling the guide pipe 5 to drive the stirring strips 6 to stir, the liquid flowing directions of a plurality of groups of stirring strips 6 are irregularly distributed, and the stirring effect is good.

Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present utility model, and although the present utility model has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present utility model.

Claims

1. The utility model provides a disposable biological reaction bag, includes bag body (1), goes up sealed lid (3), sealed lid (4) and circle magnetic sheet (8) down, its characterized in that: the upper sealing cover (3) is fixedly connected with the upper wall of the bag body (1), the upper wall of the upper sealing cover (3) is fixedly connected with a hanging ring (10), the lower sealing cover (4) is fixedly connected with the lower wall of the bag body (1), the upper sealing cover (3) and the lower sealing cover (4) respectively penetrate through the upper wall and the lower wall of the bag body (1) and extend into the bag body (1), the circular magnetic sheet (8) is rotationally connected with one side of the lower sealing cover (4) extending into the bag body (1), the outer wall of the bag body (1) is provided with a supporting structure for supporting the shape of a cavity, the upper wall of the circular magnetic sheet (8) is fixedly connected with a rotating rod (9), the utility model discloses a sealed container, including sealed lid, sealing lid, pipe (5) are connected with in the rotation of upper seal lid (3) lower wall, the one end that circle magnetic sheet (8) was kept away from to bull stick (9) stretches into inside pipe (5), form the imbibition mouth that supplies the liquid to get into between one end that upper seal lid (3) was kept away from to pipe (5) and circle magnetic sheet (8) when bag body (1) was expanded completely, pipe (5) outer wall is provided with outer stirring structure, be provided with the upper and lower circulation structure that drives through outside magnetic force rotation drive circle magnetic sheet (8) between bull stick (9) and pipe (5), bull stick (9), A transmission structure for transmission is also arranged between the guide pipe (5) and the upper sealing cover (3).

2. A disposable bioreactor bag according to claim 1, wherein: the support structure comprises three groups of outer supporting rings (2), the three groups of outer supporting rings (2) are vertically distributed and sequentially fixedly connected to the outer wall of the bag body (1), and the overlooking section of each outer supporting ring (2) is circular.

3. A disposable bioreactor bag according to claim 2, wherein: the outer stirring structure comprises a plurality of groups of stirring strips (6), and the stirring strips (6) are fixedly connected to the circumferential outer wall of the guide pipe (5) in an irregular shape.

4. A disposable bioreactor bag according to claim 3, wherein: the upper-lower circulation structure comprises auger blades and a liquid outlet hole (7), wherein the liquid outlet hole (7) is formed in the outer wall of the guide pipe (5) and close to one end of the upper sealing cover (3), the auger blades are fixedly connected to the outer wall of the rotating rod (9), each auger blade consists of a framework (11) and a rubber lining layer (12), the framework (11) is spirally fixedly connected to the outer wall of the rotating rod (9), the rubber lining layer (12) is coated on the outer wall of the framework (11), and the upper end level of each auger blade is higher than that of the liquid outlet hole (7).

5. The disposable bioreactor bag of claim 4, wherein: the transmission structure comprises a rotating shaft (14), a first gear (15), a second gear (17) and a toothed ring (16), wherein the rotating shaft (14) is fixedly connected to the lower wall of an upper sealing cover (3) and located inside a guide pipe (5), the first gear (15), the second gear (17) and the toothed ring (16) are respectively and fixedly connected to one end, far away from the upper sealing cover (3), of the rotating shaft (14), one end, far away from the circular magnetic sheet (8), of a rotating rod (9) and the inner side wall of the guide pipe (5), multiple groups of teeth are arranged on the inner side wall of the toothed ring (16), and the first gear (15) is meshed with the second gear (17) and the toothed ring (16) simultaneously.

6. A disposable bioreactor bag according to claim 5, wherein: the outer wall of the rotating rod (9) is positioned at one end close to the circular magnetic sheet (8) and is rotationally connected with a supporting frame (13), and the supporting frame (13) is fixedly connected with the inner side wall of the guide pipe (5).