CN219185636U - Optical stimulation system - Google Patents

Abstract

The present application relates to a light stimulation system. The optical stimulation system includes: the monitoring assembly, the transmitting coil and the optical stimulus cornea shaping mirror; the optical stimulation cornea shaping mirror comprises a flexible substrate, an induction coil, an optical stimulation component and a driving component; the induction coil, the light stimulation component and the driving component are arranged on the flexible substrate, and the driving component is respectively connected with the induction coil and the light stimulation component; the monitoring component is connected with the transmitting coil and is used for collecting eye movement parameters of organisms and controlling the transmitting coil to transmit energy to the induction coil. Thereby realizing the optical stimulation to the photoreceptor cells of organisms, promoting the restoration of the photoreceptor cells and achieving the vision restoration effect; in addition, the photo-stimulated cornea shaping lens is used as a photo-stimulated device, can be worn on the cornea of an eyeball, can be worn and taken down at any time, is convenient to use, and cannot influence daily activities of organisms.

Description

Optical stimulation system

Technical Field

The application relates to the technical field of medical instruments, in particular to a light stimulation system.

Background

Retinal degenerative diseases are an important social and medical problem, and complete, severe or partial vision loss may ultimately lead to blindness due to degeneration of the visual cells. Among the most common are age-related macular degeneration and retinitis pigmentosa. Although the death of the photosensitive cells at the lesion is almost completely lost, the survival rate of the retinal nerve cells (inner nuclear layer and ganglion cell layer) is high. Thus, the introduction of light-sensitive proteins (optogenetic tools) in artificial form (optogenetics) into these non-photosensitive neural cells can transform them into photosensitive neural cells, i.e. photoreceptor cells, which are able to react to light. The energy metabolism of mitochondria of the photoreceptor cells is regulated and controlled by the artificial light stimulation of the light stimulation device, so that the repair of the photoreceptor cells can be promoted, and the vision recovery is facilitated.

However, the conventional optical stimulation device is mainly an active system implanted in a living body, and is heavy and easily affects daily activities of the living body, thereby affecting daily behaviors of the living body.

Disclosure of Invention

In view of the above, it is necessary to provide a light stimulation system capable of avoiding the problem of affecting daily activities of living bodies.

In a first aspect, the present application provides a light stimulation system comprising: the monitoring assembly, the transmitting coil and the optical stimulus cornea shaping mirror; wherein,,

the optical stimulation cornea shaping mirror comprises a flexible substrate, an induction coil, an optical stimulation component and a driving component; the induction coil, the light stimulation component and the driving component are arranged on the flexible substrate, and the driving component is respectively connected with the induction coil and the light stimulation component;

the monitoring component is connected with the transmitting coil and used for collecting an eye electric signal of a living body and controlling the transmitting coil to transmit energy to the induction coil so that the induction coil generates resonance current, and the driving component drives the optical stimulation component to generate an optical signal according to the resonance current.

In one embodiment, the monitoring assembly includes at least two bioelectric sensors, each of the bioelectric sensors configured to acquire a bioelectric signal of a location around an eye of an organism to form the bioelectric signal.

In one embodiment, the monitoring assembly comprises four bioelectric sensors, wherein one bioelectric sensor is used for acquiring a bioelectric signal at a canthus position outside a first eye ball of an organism, another bioelectric sensor is used for acquiring a bioelectric signal at a periocular position right below a pupil of the first eye ball, yet another bioelectric sensor is used for acquiring a bioelectric signal at a frontal area position on a sagittal plane of a midline, and yet another bioelectric sensor is used for acquiring a bioelectric signal at an eyebrow position right above a second eye ball.

In one embodiment, the bioelectric sensor comprises a dry electrode.

In one embodiment, the light stimulation assembly comprises a light emitting diode array comprising a plurality of light emitting diodes.

In one embodiment, the light emitting diodes in the light emitting diode array are arranged at equal intervals.

In one embodiment, the photo-stimulated cornea shaping lens further comprises a first cornea shaping layer and a second cornea shaping layer, wherein the first cornea shaping layer and the second cornea shaping layer are respectively positioned on two opposite sides of the flexible substrate.

In one embodiment, the first shaping layer, the flexible substrate and the second shaping layer are concave structures with concave middle portions.

In one embodiment, the induction coil is disposed at an edge of the flexible substrate and around the light stimulation assembly.

In one embodiment, the flexible substrate comprises a flexible circuit board.

According to the optical stimulation system, the transmitting coil is controlled to transmit energy to the induction coil, so that the induction coil generates resonant current, the driving assembly is powered, and the driving assembly drives the optical stimulation assembly to generate optical signals, so that optical stimulation is carried out on photoreceptor cells of organisms, the restoration of the photoreceptor cells is promoted, the vision restoration effect is achieved, and further the daily activities of the organisms are not affected in the optical stimulation process. And above-mentioned in-process light stimulative cornea plastic mirror need not to use the battery, realizes the light stimulative process through wireless power supply's mode, has effectively avoided the battery regularly to change or the great problem of the degree of difficulty of charging, and in addition, this embodiment adopts light stimulative cornea plastic mirror as light stimulative device, can wear on eyeball cornea, can wear at any time and take off, and it is comparatively convenient to use, can not cause the influence to the daily activity of organism.

Drawings

FIG. 1 is a schematic diagram of a specific localization expression process of a light sensitive protein;

FIG. 2 is a schematic diagram of a light stimulation system in one embodiment;

FIG. 3 is a schematic illustration of light stimulation of a light stimulated keratoplasty lens in accordance with one embodiment;

FIG. 4 is a schematic diagram of a light stimulation system according to another embodiment;

FIG. 5 is a schematic diagram of a distribution of bio-sensor locations in one embodiment;

fig. 6 is a schematic diagram of the structure of a photo-stimulated cornea shaping lens in one embodiment.

Reference numerals illustrate:

11-eyeball, 111-retina, 2-light stimulation cornea shaping lens, 21-flexible substrate, 22-induction coil, 23-light stimulation component, 231-light emitting diode, 24-driving component, 25-first cornea shaping layer, 26-second cornea shaping layer, 31-photoreceptor cell, 311-ion, 312-ion channel, 313-cell membrane, 41-emitting coil, 42-monitoring component, 421-bioelectric sensor, 43-eye shade, 51-first eyeball, 52-second eyeball.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

It will be understood that the terms "first," "second," and the like, as used herein, may be used to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish one element from another element.

It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or be connected to the other element through intervening elements. Further, "connection" in the following embodiments should be understood as "electrical connection", "communication connection", and the like if there is transmission of electrical signals or data between objects to be connected.

As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," and/or the like, specify the presence of stated features, integers, steps, operations, elements, components, or groups thereof, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or groups thereof. Also, the term "and/or" as used in this specification includes any and all combinations of the associated listed items.

The photosensitive cells (rods and cones) in the retina are special nerve epithelial cells, contain natural photosensitive pigment protein rhodopsin and can conduct visual light. Rhodopsin proteins in cells are capable of absorbing photons, triggering a change in cell membrane potential, converting light (visible electromagnetic radiation) into a signal capable of stimulating biological processes. Signals are transmitted from photoreceptor cells to adjacent neurons through synapses, undergo a complex series of processes and are transmitted to the brain.

As described in the background, retinal degenerative diseases are an important social and medical problem, and complete, severe or partial vision loss may eventually lead to blindness due to degeneration of visual cells. Among the most common are age-related macular degeneration and retinitis pigmentosa. Although the death of the photosensitive cells at the lesion is almost completely lost, the survival rate of the retinal nerve cells (inner nuclear layer and ganglion cell layer) is high. Thus, the introduction of light-sensitive proteins (optogenetic tools) into these non-photosensitive neural cells in artificial form (optogenetics) can transform them into photosensitive neural cells, i.e. photoreceptor cells, which are capable of reacting to light. The photosensitive protein is expressed in the mitochondria of the residual photoreceptor cells, and the energy metabolism of the mitochondria of the photoreceptor cells is regulated and controlled by artificial light stimulation, so that the repair of the photoreceptor cells can be promoted, and the vision recovery is facilitated. Wherein, the optogenetic technology refers to a technology of controlling the activity of specific neurons by combining optical and genetic means. The technology uses the photosensitive ion channel to excite or inhibit the specific neuron activity, and has the advantages of millisecond-level precision time and space precision.

As shown in FIG. 1, the expression process of the specific localization of the photosensitive protein is shown, and the AAV carries a cell-specific promoter and the photosensitive opsin is injected into the target region. Viral vectors can infect cells and use transcriptional mechanisms to express genes encoding photoactive proteins. The promoter is used for expressing the photosensitive protein in specific target tissues, and specific precise control is realized.

However, the conventional optical stimulation device for applying optical stimulation is mainly an active system implanted in a living body, and is heavy and easily affects daily activities of the living body, thereby affecting daily behaviors of the living body.

In one embodiment, as shown in fig. 2, the present application further provides a light stimulation system, the light stimulation system comprising: a monitoring assembly 42, a transmitting coil 41 and a photo-stimulated cornea shaping mirror 2. Wherein the photo-stimulated cornea shaping lens 2 comprises a flexible substrate 21, an induction coil 22, a photo-stimulation assembly 23 and a driving assembly 24. The induction coil 22, the optical stimulation component 23 and the driving component 24 are arranged on the flexible substrate 21, and the driving component 24 is respectively connected with the induction coil 22 and the optical stimulation component 23. The monitoring component 42 is connected to the transmitting coil 41, and is used for collecting an eye electric signal of a living body, and controlling the transmitting coil 41 to transmit energy to the induction coil 22, so that the induction coil 22 generates the resonance current, and the driving component 24 drives the optical stimulation component 23 to generate an optical signal according to the resonance current.

In application, sleep states can be divided into four stages of falling asleep, shallow sleep, deep sleep and continuous deep sleep, and eye activity parameters of each stage, such as frequency of an eye electric signal, have corresponding characteristics, and the sleep state of an organism can be determined according to the eye electric signal. Accordingly, the monitoring assembly 42 may include a corresponding processing module that may determine the sleep state of the living being based on the ocular electrical signals after the monitoring assembly 42 collects the ocular electrical signals of the living being. When the monitoring component 42 determines that the organism enters a deep sleep state, the transmitting coil 41 is controlled to transmit energy to the induction coil 22, so that the transmitting coil 41 and the induction coil 22 resonate at the same frequency, and thus the driving component 24 is wirelessly powered, so that the driving component 24 drives the light stimulation component 23 to generate light signals, the light stimulation is carried out on the photoreceptor cells 31 of the organism under the condition that the sleeping quality is not affected, and the restoration of the photoreceptor cells 31 is promoted.

Optionally, the monitoring component 42 may also control the transmitting coil 41 to transmit a wireless signal to the induction coil 22 when determining that the living being enters the deep sleep state according to the electro-oculogram signal, so as to control the driving component 24 through the wireless signal, and enable the driving component 24 to drive the optical signal with the appropriate wavelength and precise timing of the optical stimulation component 23.

The flexible substrate 21 may include a flexible circuit board on which the induction coil 22, the light stimulation assembly 23, and the driving assembly 24 are disposed. The drive assembly 24 may include a driver. The light stimulation component 23 comprises a light emitting unit, and the light emitting unit emits light under the drive of the driving component 24 to perform light stimulation on the photoreceptor cells 31, promote the restoration of the photoreceptor cells 31 and help vision recovery. The light emitting unit may include a light emitting diode. As shown in FIG. 3, which shows the cellular response process under light stimulation, transmembrane transport of ion 311 is achieved when the receptor cells are successfully assigned to the "light genes". Under the stimulation of light of different wavelengths, different ion pumps or ion channels 312 are opened to polarize the cells, changing the potential state of the cell membrane 313, thereby activating the activities of the photoreceptor cells 31.

It will be appreciated that, in the case of wearing the optical-stimulation cornea shaping lens 2 on a living body, when the transmitting coil 41 generates an alternating electromagnetic field, if the sensing coil 22 is in the alternating electromagnetic field, an induced current will be generated in the sensing coil 22, and when the sensing coil 22 and the transmitting coil 41 resonate at the same frequency, the same-frequency resonance of the two resonant coils can realize wireless signal interaction and energy transmission at a far-near distance, at this time, the sensing coil 22 will generate a resonant current, and power is supplied to the driving component 24, so that the driving component 24 drives the optical-stimulation component 23 to generate an optical signal, and the optical-stimulation is performed on the photoreceptor cells 31 of the living body, thereby promoting the restoration of the photoreceptor cells 31. Therefore, the photo-stimulated cornea shaping lens 2 of the embodiment does not need a battery, thereby greatly reducing the volume weight, being not influenced by the activity of the organism and not influencing the normal activity of the organism.

In the above-mentioned optical stimulation system, the monitoring component 42 controls the transmitting coil 41 to transmit energy to the induction coil 22, so that the induction coil 22 generates the resonant current, and the driving component 24 is powered, so that the driving component 24 drives the optical stimulation component 23 to generate an optical signal, thereby performing optical stimulation on the photoreceptor cells 31 of the organism, promoting the restoration of the photoreceptor cells 31, and achieving the vision restoration effect. The photo-stimulated cornea shaping lens 2 in the process does not need to use a battery, and realizes the photo-stimulated process in a wireless power supply mode, so that the problem of high difficulty in periodic replacement or charging of the battery is effectively avoided. In addition, the optical stimulation cornea shaping lens 2 is adopted as an optical stimulation device, can be worn on the cornea of the eyeball 11, can be worn and taken down at any time, is convenient to use, and cannot influence the daily activities of organisms.

In one embodiment, as shown in fig. 4, the monitoring assembly 42 includes at least two bioelectric sensors 421, each bioelectric sensor 421 configured to collect bioelectric signals of a location around an eye of a living being.

The bioelectric sensor 421 can include a dry electrode, and compared with a frequently used Ag/AgCl gel wet electrode, the dry electrode is comfortable to wear, is convenient to wear, can be reused, and can not distort the quality of the acquired signals due to dehydration of the conductive adhesive.

Human eye movement can cause changes in the surface potential of human skin. This potential originates from the retinal 111 pigment epithelium and photoreceptor cells 31 and is called resting potential. The positive electrode of the resting potential is located on the photoreceptor side and the negative electrode is located on the pigment epithelium side of retina 111. Since the metabolism rate of cornea is small and the metabolism rate of retina 111 is high, the current generated by the electric potential will continuously flow from the side of retina 111 to the side of cornea, so an electric field with positive electrode at cornea end and negative electrode at retina 111 end is formed, and the intensity is 0.4-10 mV. When the eyeball 11 moves, the potential difference between the cornea and the retina 111 will change, thereby forming an ocular signal. The electro-oculogram signals may be divided into vertical electro-oculogram signals and horizontal electro-oculogram signals, and horizontal electro-oculogram signals and vertical electro-oculogram signals may be generated when the eyeball 11 moves left and right and moves up and down, respectively. When the eye is stationary looking ahead, a stable reference potential can be recorded, and each time the eye moves 1 ° in the horizontal or vertical direction, the electric field will change in spatial phase, and will generate voltages of about 16 μv and 14 μv, respectively. Along with the change of the movement speed of the eyeball 11, the electro-oculogram signal also changes, and the waveform of the electro-oculogram signal has a certain corresponding relation with the direction and the amplitude of the movement of the eyeball 11.

It can be understood that the bioelectric signals of the periocular position of the living body are collected by each of the bioelectric sensors 421, and the ocular electric signals of the living body can be formed based on the collected bioelectric signals, so that the sleep state of the living body can be determined from the bioelectric signals collected by each of the bioelectric sensors 421. That is, the amplitude and the frequency of the electro-ocular signal can be changed obviously along with the depth of the sleep state, whether the amplitude and the frequency of the electro-ocular signal are in a preset range corresponding to the deep sleep state or not is judged, and if so, the sleep state is determined to be the deep sleep state.

In one embodiment, as shown in fig. 5, the monitoring assembly 42 includes four bioelectric sensors 421, wherein one bioelectric sensor 421 is configured to collect bioelectric signals at a location of an outer canthus of the first eyeball 51 of the living organism, another bioelectric sensor 421 is configured to collect bioelectric signals at a location of an eye periphery directly below a pupil of the first eyeball 51, yet another bioelectric sensor 421 is configured to collect bioelectric signals at a location of a forehead region on a sagittal plane of a midline, and yet another bioelectric sensor 421 is configured to collect bioelectric signals at a location of an eyebrow directly above the second eyeball 52.

In application, the acquisition points should be as few as possible while satisfying the data acquisition integrity and comfort, so unipolar leads are employed. As shown in fig. 5, the position of the bioelectric sensor 421 disposed on the eye mask 43 is schematically shown, in this embodiment, four collection points are used, three collection points are needed for the two-channel single-stage lead, and one common-mode collection point is needed. The de-common mode acquisition point C is placed at the frontal pole on the midline sagittal plane. The collection point R is positioned on the horizontal line of the outer canthus of the first eyeball 51; the reference point Rf is positioned right below the pupil of the first eyeball 51, so as to ensure that the collecting point is positioned outside the first eyeball 51; the reference point T is located directly above the pupil of the second eye 52, avoiding hair interference at the eyebrow and myoelectric interference of the eyebrow when the eye moves. Rf is a two-channel EOG common reference point, and R/Rf and T/Rf two-channel EOG records the signal deflection of the conjugate eye movement. Therefore, by the arrangement of the four bioelectric sensors 421, the eye movement parameters can be accurately collected, and the comfort in the collection process can be ensured.

In one embodiment, the optical stimulation system further comprises an eye shield 43, and the monitoring assembly 42 and the transmitting coil 41 are disposed on the eye shield 43.

By arranging the monitoring component 42 and the transmitting coil 41 on the eyeshade 43, when the eyeshade 43 is worn by a living body, the monitoring component 42 can collect bioelectric signals of the eye of the living body, and the transmitting coil 41 and the induction coil 22 are enabled to be closer in distance, so that the energy transmission efficiency between the transmitting coil 41 and the induction coil 22 is improved conveniently.

In one embodiment, the middle part of the eye mask 43 is provided with a limiting hole which is matched with the nose bridge.

In this embodiment, the limiting hole adapted to the nose bridge is provided in the middle of the eye mask 43, so as to achieve a fool-proof effect, and when the eye mask 43 is worn on a human body, the relative positional relationship between the monitoring assembly 42, the transmitting coil 41 and the living body remains unchanged.

In one embodiment, the number of the transmitting coils 41 is two, and the two transmitting coils 41 are respectively located at two sides of the limiting hole.

It will be appreciated that an organism, such as a human body, has two eyes, and thus the number of the photo-stimulated cornea-shaping lenses 2 may be two, the two photo-stimulated cornea-shaping lenses 2 perform vision restoration on the two eyes of the organism, respectively, correspondingly, the number of the transmitting coils 41 is two, and the two transmitting coils 41 are respectively located on two sides of the limiting hole, so that the two transmitting coils 41 are respectively adapted to the two photo-stimulated cornea-shaping lenses 2, and the two transmitting coils 41 respectively perform wireless power supply on the two photo-stimulated cornea-shaping lenses 2.

In one embodiment, as shown in fig. 3, the light stimulation assembly 23 includes an array of light emitting diodes including a plurality of light emitting diodes 231.

It will be appreciated that when the induction coil 22 interacts with the emitter coil 41, the drive assembly 24 may drive the LED array to emit light, and the LEDs 231 to generate light to stimulate the photoreceptor cells 31 with the light sensitive proteins for wireless power and therapeutic purposes. The light emitting diode 231 can efficiently convert electric energy into light energy, and has a long service life and uniform illumination intensity in the irradiation range, so that the light stimulation component 23 has a long service life and can stably apply light stimulation to the photoreceptor cells 31 with the light sensitive proteins.

In one embodiment, the light emitting diodes 231 in the light emitting diode array are disposed at equal intervals.

In this embodiment, the light emitting diodes 231 in the light emitting diode array are arranged at equal intervals, so that the light emitting diodes 231 are uniformly arranged, and the photoreceptor cells 31 having the photosensitive proteins in the radiation range can be uniformly and stably stimulated, and the stability of the light stimulation can be ensured.

In one embodiment, as shown in fig. 6, the photo-stimulated cornea shaping lens 2 further includes a first cornea shaping layer 25 and a second cornea shaping layer 26, and the first cornea shaping layer 25 and the second cornea shaping layer 26 are respectively located on opposite sides of the flexible substrate 21.

In this embodiment, the first cornea shaping layer 25 and the second cornea shaping layer 26 are disposed on two opposite sides of the flexible substrate 21, so that the flexible substrate 21 and the induction coil 22, the optical stimulation component 23 and the driving component 24 thereon are encapsulated and protected by the first cornea shaping layer 25 and the second cornea shaping layer 26. In addition, the cornea of the living body can be shaped through the first cornea shaping layer 25 and the second cornea shaping layer 26, so that the effect of restoring the vision can be achieved temporarily.

In one embodiment, the first cornea shaping layer 25, the flexible substrate 21 and the second cornea shaping layer 26 are concave structures with concave central portions. Therefore, the first cornea shaping layer 25, the flexible substrate 21 and the second cornea shaping layer 26 can be stacked, so that the volume of the photo-stimulated cornea shaping lens 2 is smaller, and meanwhile, the shape of the eyeball 11 is adapted to facilitate the wearing of organisms.

In one embodiment, as shown in fig. 3, the induction coil 22 is disposed at the edge of the flexible substrate 21 and around the optical stimulation assembly 23.

In this embodiment, the optical stimulation cornea shaping lens 2 is disposed around the optical stimulation component 23, so that the light emitted from the optical stimulation component 23 to the photoreceptor cells 31 is not blocked by the induction coil 22, and the problem that the light is blocked by the induction coil 22 to affect the optical stimulation effect is avoided.

It should be noted that, the biological information (including but not limited to biological device information, biological personal information, etc.) and the data (including but not limited to data for analysis, stored data, displayed data, etc.) related to the present application are both information and data authorized by the living body or sufficiently authorized by each party, and the collection, use, and processing of the related data are required to comply with the related laws and regulations and standards of the related country and region.

The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples only represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the present application. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application shall be subject to the appended claims.

Claims (10)

1. A light stimulation system, the light stimulation system comprising: the monitoring assembly, the transmitting coil and the optical stimulus cornea shaping mirror; wherein,,

the optical stimulation cornea shaping mirror comprises a flexible substrate, an induction coil, an optical stimulation component and a driving component; the induction coil, the light stimulation component and the driving component are arranged on the flexible substrate, and the driving component is respectively connected with the induction coil and the light stimulation component;

the monitoring component is connected with the transmitting coil and used for collecting an eye electric signal of a living body and controlling the transmitting coil to transmit energy to the induction coil so that the induction coil generates resonance current, and the driving component drives the optical stimulation component to generate an optical signal according to the resonance current.

2. The optical stimulation system of claim 1, wherein the monitoring assembly comprises at least two bioelectric sensors, each of the bioelectric sensors configured to collect bioelectric signals at a location around an eye of a living being to form the ocular signal.

3. The optical stimulation system according to claim 2, wherein the monitoring assembly comprises four bioelectric sensors, wherein one of the bioelectric sensors is configured to acquire a bioelectric signal at a location of a first outer canthus of an eye of the living being, another of the bioelectric sensors is configured to acquire a bioelectric signal at a location of a periphery of the eye directly below a pupil of the first eye, yet another of the bioelectric sensors is configured to acquire a bioelectric signal at a location of a frontal area on a sagittal plane of the midline, and yet another of the bioelectric sensors is configured to acquire a bioelectric signal at a location of an eyebrow directly above a second eye.

4. The optical stimulation system of claim 2, wherein the bioelectric sensor comprises a dry electrode.

5. The light stimulation system of claim 1, wherein the light stimulation component comprises an array of light emitting diodes, the array of light emitting diodes comprising a plurality of light emitting diodes.

6. The light stimulation system of claim 5, wherein each of the light emitting diodes in the array of light emitting diodes are equally spaced.

7. The optical stimulation system of claim 1, wherein the optical stimulation keratoplasty lens further comprises a first cornea shaping layer and a second cornea shaping layer, the first cornea shaping layer and the second cornea shaping layer being located on opposite sides of the flexible substrate, respectively.

8. The optical stimulation system of claim 7, wherein the first cornea shaping layer, the flexible substrate and the second cornea shaping layer are concave structures with concave central portions.

9. The optical stimulation system of claim 1, wherein the induction coil is disposed at an edge of the flexible substrate and around the optical stimulation component.

10. The light stimulation system of any one of claims 1 to 9, wherein the flexible substrate comprises a flexible circuit board.

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