CN219156795U - Phage antibody elution device - Google Patents
Phage antibody elution device Download PDFInfo
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- CN219156795U CN219156795U CN202223445504.3U CN202223445504U CN219156795U CN 219156795 U CN219156795 U CN 219156795U CN 202223445504 U CN202223445504 U CN 202223445504U CN 219156795 U CN219156795 U CN 219156795U
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- beaker
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- phage antibody
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The utility model discloses a phage antibody elution device which comprises a support frame, wherein a beaker is arranged in the support frame, positioning structures are arranged on two sides of the interior of the support frame, each positioning structure comprises a wire hole, each wire hole is arranged on two sides of the interior of the support frame, a screw rod is arranged in each wire hole, a pressing block is arranged on one side of each screw rod, and an ultrasonic generator is arranged at the top end of each ultrasonic amplitude transformer. According to the beaker supporting device, the beaker can be placed in the supporting frame through the positioning structure, the screw rod can rotate in the screw hole through rotating the screw rod, meanwhile, the screw rod can drive the pressing block to rotate, the pressing block can move to one side during rotation, one side of the pressing block can be contacted with the outer wall of the beaker, the beaker can be pressed, the beaker can be fixed in the supporting frame, and meanwhile, the beakers with different sizes can be fixed through stretching of the pressing block.
Description
Technical Field
The utility model relates to the technical field of phage antibody preparation, in particular to a phage antibody elution device.
Background
The phage antibody library technology is a new genetic engineering antibody technology developed in recent years, which is characterized in that in vitro cloned antibody gene fragments are inserted into phage vectors, engineering bacteria are transfected for expression, then antigen screening is used for obtaining specific monoclonal phage antibodies, the principle of phage antibody library technology is that the whole set of antibody heavy chain variable region and light chain variable region genes are amplified from human immune cells by PCR technology, cloned on phage vectors and expressed on the surfaces of the phage vectors in the form of fusion proteins, the technology is used for obtaining fully humanized antibodies, the technology has unique superiority in the aspects of diagnosis and treatment of virus infection such as HIV and tumors, phage antibodies need to be subjected to multiple rounds of antigen adsorption, elution and amplification during preparation, and the elution process in the phage antibody library screening process can use an elution device.
At present, in the process of elution, the beaker needs to be placed in the support frame, cold water is injected into the beaker, then the beaker is covered, the immune tube is placed in the beaker, elution of phage antibodies is achieved through the ultrasonic generator, and the support frame with the corresponding size needs to be replaced when the beaker with other sizes is used, so that a positioning structure is designed, the beaker can be positioned, and meanwhile, the support frame is applicable to beakers with different sizes.
Disclosure of Invention
First, the technical problem to be solved
The present utility model is directed to a phage antibody eluting device, which solves the problems set forth in the background art.
(II) summary of the utility model
In order to solve the technical problems, the utility model provides the following technical scheme: the utility model provides a phage antibody elution device, includes the support frame, the inside of support frame is provided with the beaker, the inside both sides of support frame all are provided with location structure, location structure includes the wire hole, the wire hole all sets up in the inside both sides of support frame, the inside of wire hole is provided with the lead screw, and one side of lead screw is installed and is supported the briquetting, the both sides on support frame top all are provided with the closing cap structure, the top of beaker is provided with the apron, and one side of apron inside all is provided with the tube hole, the inside of tube hole is provided with the immune tube, the intermediate position department of apron inside is provided with water injection structure, the inside opposite side of apron is provided with the mounting hole, and the inside of mounting hole is provided with ultrasonic amplitude transformer, ultrasonic generator is installed on ultrasonic amplitude transformer's top.
Preferably, two pressing blocks are arranged, and the two pressing blocks are symmetrically distributed relative to the central line of the supporting frame.
Preferably, the sealing cover structure comprises preformed holes, the preformed holes are formed in the edges of two sides of the cover plate, threaded columns are arranged in the preformed holes, supporting blocks are fixed to the bottom ends of the threaded columns, and nuts are arranged at the tops of the outer sides of the threaded columns.
Preferably, the bottom of supporting shoe is fixedly connected with the top of support frame, preformed hole is symmetrical distribution about the central line of apron.
Preferably, the inner side of the nut is provided with an internal thread, the outer side of the threaded column is provided with an external thread, and the nut is in threaded connection with the threaded column.
Preferably, the water injection structure comprises a hole body, the hole body is arranged at the middle position of the inner part of the cover plate, a sealing plug is arranged in the hole body, a connecting sheet is fixed at the top end of the sealing plug, and an auxiliary sheet is fixed at the top end of the connecting sheet.
Preferably, the outer diameter of the sealing plug is smaller than the inner diameter of the hole body, and the sealing plug is matched with the hole body.
(III) beneficial effects
The phage antibody elution device provided by the utility model has the advantages that: through being provided with location structure, can place the beaker in the inside of support frame, through rotatory lead screw, the lead screw can rotate in the inside of wire hole, and the lead screw can drive simultaneously and support the briquetting and rotate, supports the briquetting and can move to one side when rotating, supports one side of briquetting and can contact with the outer wall of beaker, and then can support the pressure to the beaker, can fix the beaker in the inside of support frame, can fix the beaker of different sizes through the flexible of supporting the briquetting simultaneously;
through being provided with the closing cap structure, through covering the apron on the top of beaker, overlap the preformed hole on the screw thread post, through taking the nut, rotatory screwing in the outside of screw thread post with the nut, through the mutual cooperation of nut and screw thread post, the nut can be fixed the apron at the top of beaker, and then can carry out the closing cap processing to the beaker, improves the convenience when the beaker uses;
through being provided with the water injection structure, when needs are to the inside cold water of pouring into of beaker, upwards pull up through taking assisting the piece, assisting the piece and can driving the connection piece and making the sealing plug pull out from the inside of hole, and then can make the hole be the opening form, accessible hole is to the inside cold water of pouring into of beaker, through plugging into the sealing plug to the hole, conveniently to hole sealing treatment.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic cross-sectional elevation view of the present utility model;
FIG. 2 is a schematic elevational view of the present utility model;
FIG. 3 is a schematic perspective view of a cover plate according to the present utility model;
fig. 4 is an enlarged schematic view of the structure of fig. 1 a according to the present utility model.
Reference numerals in the drawings illustrate:
1. a support frame; 2. a beaker; 3. a positioning structure; 301. a wire hole; 302. a screw rod; 303. pressing blocks; 4. an immune tube; 5. a capping structure; 501. a threaded column; 502. a nut; 503. a preformed hole; 504. a support block; 6. a cover plate; 7. pipe holes; 8. a water injection structure; 801. a connecting sheet; 802. auxiliary sheets; 803. a sealing plug; 804. a hole body; 9. a mounting hole; 10. an ultrasonic generator; 11. an ultrasonic horn.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments of the present utility model. All other embodiments, which can be made by one of ordinary skill in the art without inventive faculty, are intended to be within the scope of the present utility model, based on the embodiments of the present utility model.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
Referring to fig. 1-4, an embodiment of the present utility model is provided: the phage antibody elution device comprises a support frame 1, wherein a beaker 2 is arranged in the support frame 1, positioning structures 3 are arranged on two sides of the interior of the support frame 1, a sealing cover structure 5 is arranged on two sides of the top end of the support frame 1, a cover plate 6 is arranged on the top end of the beaker 2, a tube hole 7 is formed in one side of the interior of the cover plate 6, an immune tube 4 is arranged in the tube hole 7, a water injection structure 8 is arranged in the middle position of the interior of the cover plate 6, a mounting hole 9 is formed in the other side of the interior of the cover plate 6, an ultrasonic amplitude transformer 11 is arranged in the interior of the mounting hole 9, and an ultrasonic generator 10 is arranged on the top end of the ultrasonic amplitude transformer 11;
the positioning structure 3 comprises wire holes 301, the wire holes 301 are formed in two sides of the inside of the support frame 1, a screw rod 302 is arranged in the wire holes 301, one side of the screw rod 302 is provided with two pressing blocks 303, the two pressing blocks 303 are symmetrically distributed about the central line of the support frame 1, and beakers 2 with different sizes can be fixed through expansion and contraction of the pressing blocks 303;
specifically, as shown in fig. 1, when the structure is used, firstly, the beaker 2 is placed in the support frame 1, the screw rod 302 rotates in the screw hole 301 by rotating the screw rod 302, meanwhile, the screw rod 302 drives the pressing block 303 to rotate, the pressing block 303 moves to one side when rotating, one side of the pressing block 303 contacts with the outer wall of the beaker 2, so that the beaker 2 can be pressed, the beaker 2 can be fixed in the support frame 1, and meanwhile, the beakers 2 with different sizes can be fixed by stretching and retracting the pressing block 303;
the sealing cover structure 5 comprises reserved holes 503, wherein the reserved holes 503 are formed in the edges of two sides of the interior of the cover plate 6, threaded columns 501 are arranged in the reserved holes 503, supporting blocks 504 are fixed at the bottom ends of the threaded columns 501, nuts 502 are arranged at the tops of the outer sides of the threaded columns 501, the bottom ends of the supporting blocks 504 are fixedly connected with the top ends of the supporting frames 1, the reserved holes 503 are symmetrically distributed about the central line of the cover plate 6, internal threads are arranged at the inner sides of the nuts 502, external threads are arranged at the outer sides of the threaded columns 501, threaded connection is formed between the nuts 502 and the threaded columns 501, and the nuts 502 can fix the cover plate 6 at the tops of the beakers 2;
specifically, as shown in fig. 1 and 2, when the structure is used, firstly, the cover plate 6 is covered on the top of the beaker 2, the reserved hole 503 is sleeved on the threaded column 501, the nut 502 is rotated and screwed on the outer part of the threaded column 501 by taking the nut 502, and the nut 502 can fix the cover plate 6 on the top of the beaker 2 by the mutual matching of the nut 502 and the threaded column 501, so that the beaker 2 can be subjected to the capping treatment;
the water injection structure 8 comprises a hole body 804, the hole body 804 is arranged at the middle position in the cover plate 6, a sealing plug 803 is arranged in the hole body 804, a connecting sheet 801 is fixed at the top end of the sealing plug 803, an auxiliary sheet 802 is fixed at the top end of the connecting sheet 801, the outer diameter of the sealing plug 803 is smaller than the inner diameter of the hole body 804, and the sealing plug 803 is matched with the hole body 804, so that the sealing treatment of the hole body 804 is facilitated;
specifically, as shown in fig. 1, 2, 3 and 4, when cold water is required to be injected into the beaker 2, the auxiliary piece 802 is pulled up by taking the auxiliary piece 802, the auxiliary piece 802 drives the connecting piece 801 to pull the sealing plug 803 out of the hole 804, the hole 804 is opened, cold water is injected into the beaker 2 through the hole 804, and the sealing plug 803 is plugged into the hole 804.
Working principle: firstly, the beaker 2 is placed in the support frame 1, the screw rod 302 rotates in the screw hole 301 through rotating the screw rod 302, meanwhile, the screw rod 302 drives the pressing block 303 to rotate, the pressing block 303 moves to one side during rotation, one side of the pressing block 303 contacts with the outer wall of the beaker 2, the beaker 2 can be pressed, the beaker 2 can be fixed in the support frame 1, ice water is added into the beaker 2, the cover plate 6 covers the top of the beaker 2, the preformed hole 503 is sleeved on the screw column 501, the nut 502 is screwed outside the screw column 501 through taking the nut 502, the nut 502 can fix the cover plate 6 at the top of the beaker 2 through mutual matching of the nut 502 and the screw column 501, the immune tube 4 is inserted into the tube hole 7, the ultrasonic amplitude transformer 11 is inserted into the mounting hole 9, and ultrasonic elution is started by starting the ultrasonic generator 10.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
The apparatus embodiments described above are merely illustrative, wherein elements illustrated as separate elements may or may not be physically separate, and elements shown as elements may or may not be physical elements, may be located in one place, or may be distributed over a plurality of network elements. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment. Those of ordinary skill in the art will understand and implement the present utility model without undue burden.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model.
Claims (7)
1. Phage antibody elution device, comprising a support frame (1), characterized in that: the inside of support frame (1) is provided with beaker (2), the inside both sides of support frame (1) all are provided with location structure (3), location structure (3) are including wire hole (301), wire hole (301) all set up in the inside both sides of support frame (1), the inside of wire hole (301) is provided with lead screw (302), and one side of lead screw (302) is installed and is supported briquetting (303), the both sides on support frame (1) top all are provided with closing cap structure (5), the top of beaker (2) is provided with apron (6), and one side of apron (6) inside all is provided with tube hole (7), the inside of tube hole (7) is provided with immune tube (4), the intermediate position department of apron (6) inside is provided with water injection structure (8), the inside opposite side of apron (6) is provided with mounting hole (9), and the inside of mounting hole (9) is provided with ultrasonic wave pole (11), ultrasonic generator (10) are installed on the top of ultrasonic wave pole (11).
2. The phage antibody-eluting device of claim 1, wherein: two pressing blocks (303) are arranged, and the two pressing blocks (303) are symmetrically distributed relative to the central line of the support frame (1).
3. The phage antibody-eluting device of claim 1, wherein: the sealing cover structure (5) comprises reserved holes (503), the reserved holes (503) are formed in the edges of two sides of the cover plate (6), threaded columns (501) are arranged in the reserved holes (503), supporting blocks (504) are fixed to the bottom ends of the threaded columns (501), and nuts (502) are arranged at the tops of the outer sides of the threaded columns (501).
4. A phage antibody-eluting device according to claim 3, wherein: the bottom of the supporting block (504) is fixedly connected with the top of the supporting frame (1), and the preformed holes (503) are symmetrically distributed with respect to the central line of the cover plate (6).
5. A phage antibody-eluting device according to claim 3, wherein: the inner side of the nut (502) is provided with an internal thread, the outer side of the threaded column (501) is provided with an external thread, and the nut (502) is in threaded connection with the threaded column (501).
6. The phage antibody-eluting device of claim 1, wherein: the water injection structure (8) comprises a hole body (804), the hole body (804) is arranged at the middle position inside the cover plate (6), a sealing plug (803) is arranged inside the hole body (804), a connecting sheet (801) is fixed at the top end of the sealing plug (803), and an auxiliary sheet (802) is fixed at the top end of the connecting sheet (801).
7. The phage antibody-eluting device of claim 6, wherein: the outer diameter of the sealing plug (803) is smaller than the inner diameter of the hole body (804), and the sealing plug (803) is matched with the hole body (804).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223445504.3U CN219156795U (en) | 2022-12-22 | 2022-12-22 | Phage antibody elution device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223445504.3U CN219156795U (en) | 2022-12-22 | 2022-12-22 | Phage antibody elution device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219156795U true CN219156795U (en) | 2023-06-09 |
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ID=86637683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223445504.3U Active CN219156795U (en) | 2022-12-22 | 2022-12-22 | Phage antibody elution device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219156795U (en) |
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2022
- 2022-12-22 CN CN202223445504.3U patent/CN219156795U/en active Active
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