CN219089780U - Composite porous bracket for segmental bone - Google Patents
Composite porous bracket for segmental bone Download PDFInfo
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- CN219089780U CN219089780U CN202320034799.0U CN202320034799U CN219089780U CN 219089780 U CN219089780 U CN 219089780U CN 202320034799 U CN202320034799 U CN 202320034799U CN 219089780 U CN219089780 U CN 219089780U
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Abstract
The utility model discloses a segmental bone composite porous scaffold which comprises a scaffold body, a high polymer carrier layer and a hydrogel carrier layer, wherein the high polymer carrier layer is positioned on the surface of the scaffold body, and the hydrogel carrier layer is positioned on the surface of the high polymer carrier layer; the bracket body is of a porous structure, and holes of the porous structure are through holes; the hydrogel carrier layer is filled in the porous structure; two ends of the bracket form bracket fixing units, and the bracket fixing units are provided with bracket fixing points; the support body is a metal support body. The utility model enables the implant to meet various performances required by materials through the design of the three-dimensional structure of the bracket and the design of the surface functional layer.
Description
Technical Field
The utility model belongs to the technical field of bone repair stents, and particularly relates to a segmental bone composite porous stent.
Background
Additive manufacturing, also called 3D printing technology, is a manufacturing method capable of realizing accurate manufacturing of complex specific structures, and solves the problem that a porous bracket cannot be manufactured by a traditional method. Based on the designed three-dimensional model, the bracket with specific structure, porosity and pore size can be conveniently and rapidly manufactured by adopting a 3D printing technology. Prior studies have shown that the pore size on bone scaffolds, the presence of through-holes, greatly affect the transport of substances and the migration, adhesion and expression of related osteogenic genes between the pores of various cells.
The existing bone repair materials mainly comprise metal, ceramic and high polymer materials, and the composite materials are rapidly applied to a small amount due to biodegradation. When the ceramic material is used as a supporting structure, the mechanical property and the biological activity cannot be simultaneously combined, and the application is less. While metals are excellent as a kind of mechanical properties, most of them are biologically inert in terms of biological activity. Therefore, in order to solve the problem of insufficient application of a single material, the existing research mostly adopts doping bioactive substances in the single material to modify the material, thereby constructing the material with excellent mechanical property and good bioactivity.
In addition, the existing bone repair process only places the prepared sample at the site of bone repair, and considering that the bone repair process is a continuous and long-term process, the bone repair process is slower only by using the bracket with single function.
Disclosure of Invention
The utility model mainly solves the technical problem of providing a segmental bone composite porous scaffold, which enables an implant to meet various performances required by materials through the design of a three-dimensional structure of the scaffold and the design of a surface functional layer.
In order to solve the technical problems, the utility model adopts a technical scheme that: the utility model provides a segmental bone composite porous scaffold which comprises a scaffold body, a high polymer carrier layer and a hydrogel carrier layer, wherein the high polymer carrier layer is positioned on the surface of the scaffold body, and the hydrogel carrier layer is positioned on the surface of the high polymer carrier layer;
the bracket body is of a porous structure, and holes of the porous structure are through holes; the hydrogel carrier layer is filled in the porous structure; two ends of the bracket form bracket fixing units, and the bracket fixing units are provided with bracket fixing points; the support body is a metal support body. The bracket fixing point is convenient for fixing with natural bones.
The support can be compounded with the shape of the bone repair position of the bearing part, and can fix the bone implant. The scaffold is structurally provided with three layers, namely a scaffold body, a polymer carrier layer and a hydrogel carrier layer. Wherein, the main function of the bracket body is to maintain the mechanical property of the bracket, and the macromolecule carrier layer is used for loading drugs and bioactive substances, thereby meeting the sustained release process. The hydrogel carrier layer is used for loading medicines and bioactive substances, promoting tissue regeneration, providing antibacterial and bone regeneration stimulation effects for cells, etc.
Further, the bracket is a cylinder, the diameter of the cylinder is 5mm-20mm, and the height of the cylinder is 5mm-30mm; the pore diameter is 50-1000 μm.
Further, the cylinder has a gradient porous structure with pore diameters becoming smaller from the center to the outside, the internal porosity is 50-90%, and the external porosity is 70% -95%.
Further, the porous structure of the cylinder is a porous structure with uniform pore size, and the porosity is 50-90%.
Further, the fixing point of the bracket is a round hole, and the diameter of the round hole is 0.5-2.5mm.
Further, two bracket fixing points are arranged at the end parts of the brackets, the two brackets at the same end are arranged at 180 degrees, and the connecting line between the two bracket fixing points at one end is perpendicular to the connecting line between the two bracket fixing points at the other end.
Further, the bracket body is a titanium alloy bracket body, a titanium metal bracket body, a magnesium alloy bracket body, a magnesium metal bracket body, a stainless steel bracket body and a cobalt-chromium alloy bracket body.
Further, the bracket body is produced by adopting a 3D printing technology
Further, the macromolecule carrier layer is adhered to the surface of the bracket body; the thickness of the polymer carrier layer is 50-500 mu m.
Further, the polymer carrier layer is a polylactic acid (PLA) layer, a Polycaprolactone (PCL) layer, a polylactic acid-glycolic acid (PLGA) layer, a polymethyl methacrylate (PMMA) layer, a poly L-lactic acid (PLLA) layer, a polyethylene glycol (PEG) layer, a polyethylene glycol diacrylate (PEGDMA) layer, or a polyurethane layer.
Further, the hydrogel carrier layer is a sodium alginate layer, a silk fibroin layer, a chitosan layer, a gelatin layer or a hyaluronic acid-methacrylic acid-acylated gelatin (GelMA) layer.
The beneficial effects of the utility model are as follows:
(1) The scaffold has a porous structure which meets the requirement of bone tissue regeneration, and ensures the metabolic requirement in the bone regeneration process;
(2) The bracket body is a metal bracket body and can be applied to the bone repair of a bearing part;
(3) The utility model adopts the bioactive polymer material as the polymer carrier layer to adhere to the surface of the bracket body, thereby improving the problem of single function of the bone repair implant, leading the bone repair implant to have multiple functions and effectively improving the bioactivity and antibacterial effect of the implanted sample; in addition, the bioactive polymer material is slowly degraded, and can continuously release loaded medicines and various bioactive substances.
(4) The hydrogel carrier layer is used as the filler of the outermost layer, and the material has the characteristics of high degradation rate, and can release substances such as medicines or bioactive ions and the like, so that tissue healing caused by operation is accelerated in the early stage of bone repair.
(5) The whole mechanical property of the bracket prepared by the utility model is good, and the elastic modulus is reduced compared with that of the metal implant, so that the problem of stress shielding generated after the implantation of the metal implant with higher elastic modulus is effectively solved.
The foregoing description is only an overview of the present utility model, and is intended to provide a better understanding of the present utility model, as it is embodied in the following description, with reference to the preferred embodiments of the present utility model and the accompanying drawings.
Drawings
FIG. 1 is a model drawing of the three-dimensional structure of the porous scaffold of example 1 (porous structure is not shown);
FIG. 2 is a schematic diagram of the uniformly distributed porous structure of example 1;
FIG. 3 is a partial cross-sectional view of example 1;
FIG. 4 is a model of the gradient distributed porous structure of example 2;
fig. 5 is a sectional view of example 2.
Detailed Description
The following specific embodiments of the utility model are described in order to provide those skilled in the art with an understanding of the present disclosure. The utility model may be embodied in other different forms, i.e., modified and changed without departing from the scope of the utility model.
Example 1: a segmental bone composite porous scaffold, as shown in fig. 1 to 3, comprises a scaffold body 100, a polymer carrier layer 200 and a hydrogel carrier layer 300, wherein the polymer carrier layer is positioned on the surface of the scaffold body, and the hydrogel carrier layer is positioned on the surface of the polymer carrier layer;
the bracket body is of a porous structure, and holes of the porous structure are through holes; the hydrogel carrier layer is filled in the porous structure; two ends of the bracket form bracket fixing units 101, and the bracket fixing units are provided with bracket fixing points 102; the support body is a metal support body. The bracket fixing point is convenient for fixing with natural bones.
The support can be compounded with the shape of the bone repair position of the bearing part, and can fix the bone implant. The scaffold is structurally provided with three layers, namely a scaffold body, a polymer carrier layer and a hydrogel carrier layer. Wherein, the main function of the bracket body is to maintain the mechanical property of the bracket, and the macromolecule carrier layer is used for loading drugs and bioactive substances, thereby meeting the sustained release process. The hydrogel carrier layer is used for loading medicines and bioactive substances, promoting tissue regeneration, providing antibacterial and bone regeneration stimulation effects for cells, etc.
The bracket is a cylinder, the diameter of the cylinder is 5mm-20mm, and the height of the cylinder is 5mm-30mm; the pore diameter is 50-1000 μm.
The porous structure of the cylinder is a porous structure with uniform pore size, and the porosity is 50-90%.
The fixed point of the bracket is a round hole, and the diameter of the round hole is 0.5-2.5mm.
Preferably, in this embodiment, the diameter of the cylinder is 10mm, the height is 20mm, the porosity is 70%, and the diameter of the round hole is 2.5mm.
The end parts of the brackets are provided with two bracket fixing points, the two brackets at the same end are arranged at 180 degrees, and the connecting line between the two bracket fixing points at one end is perpendicular to the connecting line between the two bracket fixing points at the other end.
The support body is titanium alloy support body, titanium metal support body, magnesium alloy support body, magnesium metal support body, stainless steel support body and cobalt chromium alloy support body.
The bracket body is produced by adopting a 3D printing technology.
The high polymer carrier layer is adhered to the surface of the bracket body; the thickness of the polymer carrier layer is 50-500 mu m.
The polymer carrier layer is a polylactic acid (PLA) layer, a Polycaprolactone (PCL) layer, a polylactic acid-glycolic acid (PLGA) layer, a polymethyl methacrylate (PMMA) layer, a poly L-lactic acid (PLLA) layer, a polyethylene glycol (PEG) layer, a polyethylene glycol diacrylate (PEGDMA) layer or a polyurethane layer.
The hydrogel carrier layer is sodium alginate layer, silk fibroin layer, chitosan layer, gelatin layer or hyaluronic acid methyl acrylated gelatin (GelMA) layer.
Example 2: as shown in fig. 4 and 5, a segmental bone composite porous scaffold has a structure similar to that of embodiment 1, and reference numeral 1001 denotes a hole, except that: the cylinder exhibits a gradient porous structure with a pore size decreasing from the center to the outside, an internal porosity of 50-90% and an external porosity of 70-95%, where the internal and external are relatively speaking, and the size of the respective volumes occupied by the internal and external is not particularly limited.
The inside of the bracket is larger in pore space, the connector is thick, the outside of the bracket is dense in pore space, and the connector is smaller.
The foregoing description is only illustrative of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structures made by the description of the utility model and the accompanying drawings, or direct or indirect application in other related technical fields, are included in the scope of the utility model.
Claims (7)
1. A segmental bone composite porous scaffold, characterized in that: the high-molecular carrier comprises a bracket body, a high-molecular carrier layer and a hydrogel carrier layer, wherein the high-molecular carrier layer is positioned on the surface of the bracket body, and the hydrogel carrier layer is positioned on the surface of the high-molecular carrier layer;
the bracket body is of a porous structure, and holes of the porous structure are through holes; the hydrogel carrier layer is filled in the porous structure; two ends of the bracket form bracket fixing units, and the bracket fixing units are provided with bracket fixing points; the support body is a metal support body.
2. The segmental bone composite porous scaffold of claim 1, wherein: the bracket is a cylinder, the diameter of the cylinder is 5mm-20mm, and the height of the cylinder is 5mm-30mm; the pore diameter is 50-1000 μm.
3. The segmental bone composite porous scaffold of claim 2, wherein: the cylinder has a gradient porous structure with pore diameter reduced from the center to the outside, the internal porosity is 50-90%, and the external porosity is 70-95%.
4. The segmental bone composite porous scaffold of claim 2, wherein: the porous structure of the cylinder is a porous structure with uniform pore size, and the porosity is 50-90%.
5. The segmental bone composite porous scaffold of claim 1, wherein: the fixed point of the bracket is a round hole, and the diameter of the round hole is 0.5-2.5mm.
6. The segmental bone composite porous scaffold of claim 1, wherein: the end parts of the brackets are provided with two bracket fixing points, the two brackets at the same end are arranged at 180 degrees, and the connecting line between the two bracket fixing points at one end is perpendicular to the connecting line between the two bracket fixing points at the other end.
7. The segmental bone composite porous scaffold of claim 1, wherein: the high polymer carrier layer is adhered to the surface of the bracket body; the thickness of the polymer carrier layer is 50-500 mu m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202320034799.0U CN219089780U (en) | 2023-01-06 | 2023-01-06 | Composite porous bracket for segmental bone |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202320034799.0U CN219089780U (en) | 2023-01-06 | 2023-01-06 | Composite porous bracket for segmental bone |
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| CN219089780U true CN219089780U (en) | 2023-05-30 |
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| CN202320034799.0U Active CN219089780U (en) | 2023-01-06 | 2023-01-06 | Composite porous bracket for segmental bone |
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2023
- 2023-01-06 CN CN202320034799.0U patent/CN219089780U/en active Active
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