CN219073831U - Bioreactor and cell culture bottle cleaning device - Google Patents
Bioreactor and cell culture bottle cleaning device Download PDFInfo
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- CN219073831U CN219073831U CN202223413867.9U CN202223413867U CN219073831U CN 219073831 U CN219073831 U CN 219073831U CN 202223413867 U CN202223413867 U CN 202223413867U CN 219073831 U CN219073831 U CN 219073831U
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- pressure cleaning
- bioreactor
- cell culture
- heads
- cleaning
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- 238000004140 cleaning Methods 0.000 title claims abstract description 115
- 238000004113 cell culture Methods 0.000 title claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 74
- 239000002699 waste material Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 210000002105 tongue Anatomy 0.000 description 18
- 239000004734 Polyphenylene sulfide Substances 0.000 description 4
- 229920000069 polyphenylene sulfide Polymers 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 238000011086 high cleaning Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a cleaning device for a bioreactor and a cell culture bottle, and belongs to the technical field of bioreactor cleaning. The cleaning device comprises a frame, a water pipe is fixedly connected to the frame, a plurality of first high-pressure cleaning heads and second high-pressure cleaning heads are communicated with the water pipe, the first high-pressure cleaning heads and the second high-pressure cleaning heads are connected with the water pipe through threaded joints, a plurality of evenly distributed water outlets are formed in the heads of the first high-pressure cleaning heads and the second high-pressure cleaning heads in a surrounding mode, the water pipe is externally connected with pure water, and the pure water is sprayed out through the water outlets of the first high-pressure cleaning heads and the second high-pressure cleaning heads. The utility model can clean the small bioreactor and the cell culture flask at the same time by matching the frame with the high-pressure cleaning head; the inner wall waste can be quickly cleaned, the cleaning efficiency is high, and the cleaning effect is good; the automatic cleaning can be realized, the foreign pollution is avoided, and the labor is saved; the cleaning flow is standardized, and water is saved.
Description
Technical Field
The utility model relates to a cleaning device for a bioreactor and a cell culture bottle, and belongs to the technical field of bioreactor cleaning.
Background
The bioreactor is a core device of an upstream process of cell culture, and is related to product quality, and directly influences survival, propagation, expression and downstream processes of cells. Cell culture flasks are also one of the main culture tools in the scientific laboratory. In the cell culture process, carbon dioxide, lactic acid, pyruvic acid and other wastes are continuously generated, and the wastes can be attached to the inner wall of a bioreactor or a cell culture bottle for a long time, so that the cell growth is greatly influenced. Therefore, during cell culture experiments, researchers can periodically clean bioreactors or cell culture flasks.
The preliminary cleaning bioreactor or cell culture flask is typically immersed in an alkaline solution and then rinsed by a researcher. The washing is the work that the time is longer, and conventional mode is that experimenter washs by hand, and efficiency is very low, and personnel can not leave, and can not wash completely, and extravagant a large amount of pure water, and what is more, misuse test tube brush causes the fish tail to bioreactor or cell culture bottle inner wall, and the inner wall glass of fish tail can cause the cell death.
Disclosure of Invention
The utility model aims to provide a cleaning device for a bioreactor and a cell culture flask, which can simultaneously clean the small bioreactor and the cell culture flask through the matching of a frame and a high-pressure cleaning head; the built-in high-pressure cleaning head can quickly clean the waste on the inner wall, and has high cleaning efficiency and good cleaning effect; the automatic cleaning can be realized, the hands are separated, the foreign pollution is avoided, and the labor is saved; meanwhile, the cleaning flow is standardized, and water is saved.
To achieve the purpose, the utility model is realized by adopting the following technical scheme:
the utility model provides a cleaning device for a bioreactor and a cell culture flask, which comprises a frame, wherein a water pipe is fixedly connected to the frame, the water pipe is communicated with a plurality of first high-pressure cleaning heads and second high-pressure cleaning heads, the first high-pressure cleaning heads and the second high-pressure cleaning heads are in threaded connection with the water pipe through threaded connectors, a plurality of evenly distributed water outlets are formed in the heads of the first high-pressure cleaning heads and the second high-pressure cleaning heads in a surrounding mode, the water pipe is externally connected with pure water, and the pure water is sprayed out through the water outlets of the first high-pressure cleaning heads and the second high-pressure cleaning heads.
In one embodiment of the utility model, a pressure regulator is provided on the water line.
In one embodiment of the utility model, the frame is formed by splicing a plurality of brackets.
In one embodiment of the present utility model, the material of the bracket is PPS.
In one embodiment of the present utility model, the water pipe is made of PPR.
In one embodiment of the utility model, the first high pressure cleaning head and the second high pressure cleaning head are each capable of 360 degrees of rotation.
In one embodiment of the utility model, the inside of the second high-pressure cleaning head is connected with a pressurizing inner tongue through a plurality of inner tongue brackets, one end of the pressurizing inner tongue facing the water outlet is annular, an annular gap is formed between the pressurizing inner tongue and the inner wall of the second high-pressure cleaning head, and one end of the pressurizing inner tongue facing the water pipe is spike-shaped.
In one embodiment of the utility model, the second high pressure cleaning head has a size that is larger than the size of the first high pressure cleaning head.
In one embodiment of the utility model, the number of first high pressure cleaning heads is five.
In one embodiment of the present utility model, the number of the internal tongue supports is four.
The beneficial effects of the utility model are as follows:
1. the utility model has simple structure and low cost, and fully operates automatically, thereby improving the working efficiency and saving the labor cost.
2. The utility model can clean the small bioreactor and the cell culture flask at the same time by matching the frame with the high-pressure cleaning head; the built-in high-pressure cleaning head can quickly clean the waste on the inner wall, and has high cleaning efficiency and good cleaning effect; the automatic cleaning can be realized, the hands are separated, the foreign pollution is avoided, and the labor is saved; meanwhile, the cleaning flow is standardized, and water is saved.
3. The water pipe is provided with the pressure regulator, and the water flow speed in the water pipe can be regulated through the pressure regulator so as to control the water flow speed sprayed out from the water outlet.
4. According to the utility model, the first high-pressure cleaning head and the second high-pressure cleaning head can both rotate 360 degrees so as to realize cleaning at different angles and improve cleaning efficiency and cleaning effect.
5. The inside of the second high-pressure cleaning head is connected with the pressurizing inner tongues through the plurality of inner tongue brackets, when pure water in the water pipe enters the second high-pressure cleaning head, the water flow is pressurized and split through the spike shape of the pressurizing inner tongues, so that the water flow is uniformly and rapidly sprayed out from the plurality of water outlets through annular gaps, and the aim of rapidly and thoroughly cleaning a relatively large-volume bioreactor can be fulfilled.
Drawings
Fig. 1 is a perspective view of a cleaning apparatus according to the present utility model.
Fig. 2 is a schematic view of the structure of the first high-pressure cleaning head of the present utility model.
Fig. 3 is a schematic view of the structure of a second high pressure cleaning head according to the present utility model.
In the figure, 1, a frame; 2. a first high pressure cleaning head; 3. a water pipe; 4. a pressure regulator; 5. a second high pressure cleaning head; 6. a water outlet; 7. a threaded joint; 8. pressurizing the inner tongue; 9. an inner tongue support.
Detailed Description
The utility model is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the utility model and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present utility model are shown in the drawings.
In the present utility model, unless explicitly specified and limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
In the present utility model, the terms "upper", "lower", "left", "right", and the like are based on the orientation or positional relationship shown in the drawings, and are merely for convenience of description and simplicity of operation, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the utility model. Furthermore, the terms "first," "second," and the like, are used merely for distinguishing between descriptions and not for distinguishing between them.
Example 1
As shown in fig. 1-3, a cleaning device for a bioreactor and a cell culture flask comprises a frame 1, a water pipe 3 is fixedly connected to the frame 1, the water pipe 3 is communicated with a plurality of first high-pressure cleaning heads 2 and second high-pressure cleaning heads 5, the first high-pressure cleaning heads 2 and the second high-pressure cleaning heads 5 are in threaded connection with the water pipe 3 through threaded connectors 7, a plurality of evenly distributed water outlets 6 are formed in the heads of the first high-pressure cleaning heads 2 and the second high-pressure cleaning heads 5 in a surrounding mode, pure water is externally connected to the water pipe 3, and the pure water is sprayed out through the water outlets 6 of the first high-pressure cleaning heads 2 and the second high-pressure cleaning heads 5.
Optionally, a pressure regulator 4 is provided on the water pipe 3, and the water flow speed in the water pipe 3 can be regulated by the pressure regulator 4 to control the water flow speed sprayed from the water outlet 6.
Optionally, the frame 1 is formed by splicing a plurality of brackets.
Optionally, the material of the bracket is PPS (polyphenylene sulfide), and the material of the water pipe 3 is PPR (random copolymer polypropylene).
Optionally, the number of the first high-pressure cleaning heads 2 is five.
Optionally, the first high-pressure cleaning head 2 and the second high-pressure cleaning head 5 can both rotate 360 degrees, so that cleaning at different angles is realized, and cleaning efficiency and cleaning effect are improved.
Optionally, the second high-pressure cleaning head 5 is connected with a pressurizing inner tongue 8 through a plurality of inner tongue brackets 9, one end of the pressurizing inner tongue 8 facing the water outlet 6 is annular and is provided with an annular gap with the inner wall of the second high-pressure cleaning head 5, one end of the pressurizing inner tongue 8 facing the water pipe 3 is spike-shaped, and when pure water in the water pipe 3 enters the second high-pressure cleaning head 5, pressurizing and shunting are performed through the spike-shaped of the pressurizing inner tongue 8, so that water flow is uniformly and rapidly sprayed out from the plurality of water outlets 6 through the annular gap.
Optionally, the number of the inner tongue brackets 9 is four.
Optionally, the second high pressure cleaning head 5 is larger in size than the first high pressure cleaning head 2.
The working principle of the utility model is as follows: before cleaning, the cleaning device is fixed above a laboratory water tank, and then the small cell bioreactor and the cell culture flask are inverted in a frame 1 formed by PPS supports and fixed. The water pipe 3 is connected with a pure water system or a pure water instrument, pure water flows to a plurality of first high-pressure cleaning heads 2 and second high-pressure cleaning heads 5 along the water pipe 3 and is evenly ejected out through a plurality of water outlets 6 at high pressure, so that the inner walls of the inverted small-sized cell bioreactor and the cell culture flask are cleaned. The second high-pressure cleaning head 5 corresponds to a small-sized cell bioreactor, and can be pressurized by controlling the pressure regulator 4 and the set pressurizing inner tongue 8 due to the large tank body of the bioreactor, so that the aim of rapid cleaning is fulfilled. The high-pressure cleaning head can spray at 360 degrees under high pressure, thoroughly clean waste in the small cell bioreactor and the cell culture flask, and greatly reduce the use amount of pure water. After cleaning, the cleaning device can be detachably placed at a fixed position, and is simple and convenient.
The scope of the present utility model is not limited to the above-described embodiments, but is intended to be limited to the appended claims, any modifications, equivalents, improvements and alternatives falling within the spirit and principle of the inventive concept, which can be made by those skilled in the art.
Claims (10)
1. The utility model provides a belt cleaning device of bioreactor and cell culture bottle, its characterized in that, includes the frame, fixedly connected with water pipe on the frame, the water pipe intercommunication has a plurality of first high pressure cleaning heads and second high pressure cleaning heads, first high pressure cleaning heads and second high pressure cleaning heads all through screwed joint with water pipe threaded connection, the head of first high pressure cleaning heads and second high pressure cleaning heads all encircles there is a plurality of evenly distributed's delivery port, the external pure water of water pipe, and pure water passes through the delivery port blowout of first high pressure cleaning heads and second high pressure cleaning heads.
2. The bioreactor and cell culture flask cleaning device of claim 1, wherein a pressure regulator is provided on said water line.
3. The bioreactor and cell culture flask cleaning device of claim 1, wherein said frame is formed by splicing a plurality of brackets.
4. A bioreactor and cell culture flask cleaning device as claimed in claim 3, wherein the support is PPS.
5. The bioreactor and cell culture flask cleaning device of claim 1, wherein the water pipe is made of PPR.
6. The bioreactor and cell culture flask cleaning device of claim 1, wherein said first high pressure cleaning head and said second high pressure cleaning head are each capable of 360 degrees of rotation.
7. The device for cleaning a bioreactor and a cell culture flask according to claim 1, wherein the second high-pressure cleaning head is internally connected with a pressurizing inner tongue through a plurality of inner tongue brackets, one end of the pressurizing inner tongue facing the water outlet is annular, an annular gap is formed between the pressurizing inner tongue and the inner wall of the second high-pressure cleaning head, and one end of the pressurizing inner tongue facing the water pipe is spike-shaped.
8. The bioreactor and cell culture flask cleaning device of claim 1, wherein said second high pressure cleaning head is sized larger than said first high pressure cleaning head.
9. The bioreactor and cell culture flask cleaning device of claim 1, wherein said first high pressure cleaning heads are five in number.
10. The bioreactor and cell culture flask cleaning device of claim 7, wherein said number of internal tongue supports is four.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223413867.9U CN219073831U (en) | 2022-12-16 | 2022-12-16 | Bioreactor and cell culture bottle cleaning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223413867.9U CN219073831U (en) | 2022-12-16 | 2022-12-16 | Bioreactor and cell culture bottle cleaning device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219073831U true CN219073831U (en) | 2023-05-26 |
Family
ID=86405765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223413867.9U Active CN219073831U (en) | 2022-12-16 | 2022-12-16 | Bioreactor and cell culture bottle cleaning device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219073831U (en) |
-
2022
- 2022-12-16 CN CN202223413867.9U patent/CN219073831U/en active Active
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