CN219048796U - Ablation system for lung passages - Google Patents
Ablation system for lung passages Download PDFInfo
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- CN219048796U CN219048796U CN202223599216.3U CN202223599216U CN219048796U CN 219048796 U CN219048796 U CN 219048796U CN 202223599216 U CN202223599216 U CN 202223599216U CN 219048796 U CN219048796 U CN 219048796U
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Abstract
An ablation system for a lung passageway is disclosed. An ablation system for a lung passageway comprising: a sinusoidal electrical signal generator for generating a sinusoidal electrical signal; an ablation device coupled to the sinusoidal electrical signal generator, at least a portion of the ablation device being extendable toward the tissue such that the ablation device is capable of delivering a sinusoidal electrical signal to the tissue, wherein the sinusoidal electrical signal comprises a plurality of sinusoidal signal units, each sinusoidal signal unit comprising at least one sinusoidal minimum period in succession. According to the ablation system for the lung channel, provided by the embodiment of the utility model, the ablation device can deliver the specific sinusoidal electric signal to the tissue, so that apoptosis or necrosis is induced, and the abnormal functional cells in the target area are cleared. In the process of ablation by adopting the specific sinusoidal electric signal, the action potential distribution to peripheral tissues can be reduced, and muscle contraction can be reduced or even avoided.
Description
Technical Field
The utility model relates to the field of ablation, in particular to an ablation system for a lung channel.
Background
Irreversible electroporation (irreversible electroporation, IRE) is a tissue ablation technique that produces perforations in the cell membrane by extremely short but powerful electric fields, which is capable of inducing apoptosis or necrosis.
When the ablation system is used for tissue ablation in the related technology, the tissue is easy to stimulate to cause muscle contraction, so that a main body to be ablated generates stronger uncomfortable feeling, and the ablation effect is influenced.
Disclosure of Invention
The utility model provides an ablation system for a lung passageway, which reduces tissue muscle contraction caused during ablation.
An embodiment of the present utility model provides an ablation system for a lung passageway, the ablation system for a lung passageway comprising: a sinusoidal electrical signal generator for generating a sinusoidal electrical signal; an ablation device coupled to the sinusoidal electrical signal generator, at least a portion of the ablation device being extendable toward tissue such that the ablation device is capable of delivering the sinusoidal electrical signal to the tissue, wherein the sinusoidal electrical signal comprises a plurality of sinusoidal signal units, each of the sinusoidal signal units comprising a succession of at least one sinusoidal minimum period.
According to the foregoing embodiment of the present utility model, there is an interval time between adjacent sinusoidal signal units in the sinusoidal electrical signal, and a duration of each of the sinusoidal signal units is 1s or less.
According to any one of the preceding embodiments of the present utility model, a duration of each of the sine wave minimum periods is 0.5ns or more and 100us or less.
According to any one of the foregoing embodiments of the present utility model, the frequency of each of the sinusoidal signal units is 1kHz or more and 10MHz or less.
According to any of the preceding embodiments of the utility model, the amplitude of each of the sinusoidal signal units is 0.5kV/cm to 50kV/cm.
According to any one of the preceding embodiments of the present utility model, the sinusoidal electrical signal comprises a plurality of first signal groups arranged in succession and identical to each other, each of the first signal groups comprising at least one of the sinusoidal signal units.
According to any of the foregoing embodiments of the present utility model, the sinusoidal electrical signal includes a third signal group composed of at least one first signal group and at least one second signal group arranged in succession, the first signal group includes at least one first sinusoidal signal unit, the second signal group includes at least one second sinusoidal signal unit, the first sinusoidal signal unit and the second sinusoidal signal unit have the same amplitude, and frequencies and/or durations between the first sinusoidal signal unit and the second sinusoidal signal unit are different.
According to any of the foregoing embodiments of the present utility model, the sinusoidal electrical signal includes a third signal group composed of at least one first signal group and at least one second signal group arranged in succession, the first signal group including at least one first sinusoidal signal unit, the second signal group including at least one second sinusoidal signal unit, the first sinusoidal signal unit and the second sinusoidal signal unit being different in amplitude.
According to any of the foregoing embodiments of the present utility model, the sinusoidal electrical signal includes a third signal group formed by at least one first signal group and at least one second signal group arranged in succession, the first signal group includes at least one first sinusoidal signal unit and at least one second sinusoidal signal unit, the first sinusoidal signal unit is different from the second sinusoidal signal unit in amplitude, the second signal group includes at least one third sinusoidal signal unit and at least one fourth sinusoidal signal unit, and the third sinusoidal signal unit is different from the fourth sinusoidal signal unit in amplitude.
According to any of the preceding embodiments of the utility model, the first signal group and the second signal group have an interval time of 50ns or more.
According to any of the preceding embodiments of the utility model, the sinusoidal electrical signal comprises a fourth signal set comprising at least two of the third signal sets.
According to any of the foregoing embodiments of the utility model, the ablation device comprises at least one ablation electrode having an electrode ablation end or at least one ablation catheter having an ablation head end, the electrode ablation end, the ablation head end being extendable toward the tissue.
An ablation system for a lung passageway according to an embodiment of the present utility model includes a sinusoidal electrical signal generator for generating a sinusoidal electrical signal, wherein the sinusoidal electrical signal includes a plurality of sinusoidal signal units, each sinusoidal signal unit including at least one sine wave minimum period in succession, and an ablation device. The ablation device can deliver the specific sinusoidal electric signals to the tissues so as to induce apoptosis or necrosis and realize the removal of abnormal functional cells in the targeted area. In the process of ablation by adopting the specific sinusoidal electric signal, the action potential distribution to peripheral tissues can be reduced, and muscle contraction can be reduced or even avoided.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a block diagram of a first embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 2 is a schematic illustration of an ablation device in a first embodiment of an ablation system for a lung passageway in accordance with the present utility model;
FIG. 3 is a timing diagram of sinusoidal electrical signals in a first embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 4 is a timing diagram of sinusoidal electrical signals in a second embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 5 is a timing diagram of sinusoidal electrical signals in a third embodiment of an ablation system for a lung passageway in accordance with the present utility model;
FIG. 6 is a timing diagram of sinusoidal electrical signals in a fourth embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 7 is a timing diagram of sinusoidal electrical signals in a fifth embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 8 is a timing diagram of sinusoidal electrical signals in a sixth embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 9 is a timing diagram of sinusoidal electrical signals in a seventh embodiment of an ablation system for a lung passageway according to the present utility model;
FIG. 10 is a flow chart of one embodiment of a control method of the present utility model for an ablation system for a lung passageway;
fig. 11 is a schematic hardware configuration of an embodiment of a control device of the ablation system for lung passages according to the present utility model.
Reference numerals illustrate:
110-a sinusoidal electrical signal generator; 120-an ablation device; 121-ablating the head end;
210-memory; 220-a processor; 230-a communication interface; 240-bus.
The achievement of the objects, functional features and advantages of the present utility model will be further described with reference to the accompanying drawings, in conjunction with the embodiments.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
It should be noted that all directional indicators (such as up, down, left, right, front, and rear … …) in the embodiments of the present utility model are merely used to explain the relative positional relationship, movement, etc. between the components in a particular posture (as shown in the drawings), and if the particular posture is changed, the directional indicator is changed accordingly.
Furthermore, the description of "first," "second," etc. in this disclosure is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present utility model.
The embodiment of the utility model provides an ablation system for a lung channel. The ablation system for lung passages may be used for chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD). Fig. 1 is a block diagram of a first embodiment of an ablation system for a lung passageway of the present utility model, including a sinusoidal electrical signal generator 110 and an ablation device 120. The sinusoidal electrical signal generator 110 is used to generate a sinusoidal electrical signal. Ablation device 120 is coupled to sinusoidal electrical signal generator 110 such that at least a portion of ablation device 120 is capable of extending toward tissue such that ablation device 120 is capable of delivering sinusoidal electrical signals to tissue.
In some embodiments, the ablation device 120 includes at least one ablation electrode or at least one ablation catheter. Fig. 2 is a schematic structural view of an ablation device in a first embodiment of an ablation system for a lung passageway according to the present utility model, wherein the ablation device 120 includes an ablation catheter having an ablation head 121, the ablation head 121 being capable of extending toward tissue. In other embodiments, the ablation device 120 includes at least one ablation electrode having an electrode ablation tip or at least one ablation catheter having an ablation tip, the electrode ablation tip, the ablation tip being extendable toward tissue.
Fig. 3 is a timing diagram of sinusoidal electrical signals in a first embodiment of an ablation system for a lung passageway in accordance with the present utility model. In the present embodiment, the sinusoidal electrical signal includes a plurality of sinusoidal signal units SU, each sinusoidal signal unit SU including at least one sine wave minimum period in succession.
In some embodiments, there is an interval time IT1 between adjacent sinusoidal signal units SU in the sinusoidal electrical signal, and the duration DT1 of each sinusoidal signal unit SU is 1s (seconds) or less.
In some embodiments, the duration of each sine wave minimum period is greater than or equal to 0.5ns (nanoseconds) and less than or equal to 100us (microseconds). For example, the duration of each sine wave minimum period may be 0.5ns, 8ns, 16ns, 50ns, 100ns, 600ns, 1us, 60us, 100us, etc.
In some embodiments, the frequency of each sinusoidal signal unit SU is greater than or equal to 1kHz and less than or equal to 10MHz. For example, the frequency of each sinusoidal signal unit SU may be 1kHz, 60kHz, 200kHz, 1MHz, 8MHz, 10MHz, etc.
For example, in the first embodiment, each sinusoidal signal unit SU includes two or more consecutive sine wave minimum periods. The frequency of each sinusoidal signal unit SU is 100kHz.
In some embodiments, the amplitude of each sinusoidal signal unit SU is 0.5kV/cm to 50kV/cm. For example, the amplitude of the sinusoidal signal unit SU may be 0.5kV/cm, 3kV/cm, 26kV/cm, 50kV/cm, etc.
Fig. 4 is a timing diagram of a sinusoidal electrical signal in a second embodiment of an ablation system for a pulmonary tract according to the utility model, in which the sinusoidal electrical signal comprises a plurality of first signal sets M1 arranged one after the other and identical to each other, each first signal set M1 comprising at least one sinusoidal signal unit SU, the sinusoidal signal units SU comprising at least one minimum period of a sine wave in succession.
Fig. 5 is a timing diagram of a sinusoidal electrical signal in a third embodiment of an ablation system for pulmonary passages according to the present utility model, in which the sinusoidal electrical signal includes a third signal group M3 formed by at least one first signal group M1 and at least one second signal group M2 arranged in succession, the first signal group M1 includes at least one first sinusoidal signal unit SU1, the second signal group M2 includes at least one second sinusoidal signal unit SU2, the amplitudes of the first sinusoidal signal unit SU1 and the second sinusoidal signal unit SU2 are the same, and the frequencies and/or durations between the first sinusoidal signal unit SU1 and the second sinusoidal signal unit SU2 are different.
Fig. 6 is a timing diagram of a sinusoidal electrical signal in a fourth embodiment of an ablation system for pulmonary passages according to the present utility model, in which the sinusoidal electrical signal includes a third signal group M3 formed by at least one first signal group M1 and at least one second signal group M2 arranged in sequence, the first signal group M1 includes at least one first sinusoidal signal unit SU1, the second signal group M2 includes at least one second sinusoidal signal unit SU2, and the magnitudes of the first sinusoidal signal unit SU1 and the second sinusoidal signal unit SU2 are different.
Fig. 7 is a timing diagram of a sinusoidal electrical signal in a fifth embodiment of an ablation system for pulmonary passages according to the present utility model, in which the sinusoidal electrical signal includes a third signal group M3 formed by at least one first signal group M1 and at least one second signal group M2 arranged in sequence, the first signal group M1 includes at least one first sinusoidal signal unit SU1 and at least one second sinusoidal signal unit SU2, the first sinusoidal signal unit SU1 and the second sinusoidal signal unit SU2 have different magnitudes, the second signal group M2 includes at least one third sinusoidal signal unit SU3 and at least one fourth sinusoidal signal unit SU4, and the third sinusoidal signal unit SU3 and the fourth sinusoidal signal unit SU4 have different magnitudes. The first signal group M1 and the second signal group M2 are not identical to each other.
In the embodiment having the first signal group M1 and the second signal group M2, an interval time of 50ns (nanoseconds) or more may be provided between the first signal group M1 and the second signal group M2.
In some embodiments, the sinusoidal electrical signal may include a fourth signal set including at least two third signal sets.
For example, fig. 8 is a timing diagram of a sinusoidal electrical signal in a sixth embodiment of an ablation system for a lung passageway according to the present utility model, wherein the sinusoidal electrical signal includes a fourth signal set M4, the fourth signal set M4 including at least two of the third signal sets M3 of the aforementioned third embodiment. For example, fig. 9 is a timing diagram of sinusoidal electrical signals in a seventh embodiment of an ablation system for a lung passageway according to the present utility model, wherein the sinusoidal electrical signals include a fourth signal set M4, the fourth signal set M4 including at least two of the third signal sets M3 of the aforementioned fourth embodiment. In other embodiments, the fourth signal group M4 may include other types of third signal groups M3, for example, the third signal group M3 of the fifth embodiment may also be included.
An ablation system for a lung passageway according to an embodiment of the present utility model includes a sinusoidal electrical signal generator 110 and an ablation device 120, the sinusoidal electrical signal generator 110 being configured to generate a sinusoidal electrical signal, wherein the sinusoidal electrical signal includes a plurality of sinusoidal signal units SU, each sinusoidal signal unit SU including at least one sine wave minimum period in succession. The ablation device 120 is capable of delivering the specific sinusoidal electrical signals to tissue to induce apoptosis or necrosis to effect removal of abnormal functioning cells from the targeted area. In the process of ablation by adopting the specific sinusoidal electric signal, the action potential distribution to peripheral tissues can be reduced, and muscle contraction can be reduced or even avoided.
In some of the embodiments described above, sinusoidal electrical signals are applied to biological tissue via ablation device 120 for a specific duration and manner of application, thereby inducing apoptosis or necrosis. In some embodiments, sinusoidal electrical signals may act on cell membrane structures, disrupting the lipid bilayer of the cell membrane, causing the intracellular and extracellular balance to break down and die. In some embodiments, sinusoidal electrical signals may also act with the inside of the cell, inducing functional damage to intracellular organelles, initiating death signaling pathways, and causing apoptotic death.
The ablation system for the lung channel can be used for COPD, and in the process of ablation by adopting the specific sinusoidal electric signals, the sinusoidal electric signals can be transmitted to the airway wall to clear abnormal functional cells in the targeted area. During ablation with the specific sinusoidal electrical signals described above, the sinusoidal electrical signals may preserve extracellular matrix structure and adjacent critical conduit structural integrity while damaging abnormal cells. After the ablation process is completed, normal and newly generated healthy cells or healthy tissues replace abnormal functional cells cleared by the ablation process.
The embodiment of the utility model also provides a control method of the ablation system for the lung channel, which is used for controlling the ablation system for the lung channel in any of the previous embodiments.
Fig. 10 is a flow chart of one embodiment of a control method of the ablation system for a lung passageway of the present utility model. The control method includes steps S110 to S130.
In step S110, the sinusoidal electrical signal generator is controlled to generate a sinusoidal electrical signal.
In step S120, the sinusoidal electrical signal is configured to include a plurality of sinusoidal signal units, each sinusoidal signal unit including at least one sine wave minimum period in succession.
In step S130, the ablation device is controlled to deliver the sinusoidal electrical signal to tissue.
In some embodiments, there is a separation time between adjacent sinusoidal signal units in the sinusoidal electrical signal, each sinusoidal signal unit having a duration of less than or equal to 1s.
In some embodiments, the duration of each sine wave minimum period is greater than or equal to 0.5ns and less than or equal to 100us.
In some embodiments, the frequency of each sinusoidal signal unit is greater than or equal to 1kHz and less than or equal to 10MHz.
In some embodiments, the amplitude of each sinusoidal signal unit is 0.5kV/cm to 50kV/cm.
Optionally, in step S120, the sinusoidal electrical signal includes a plurality of first signal groups that are arranged in succession and identical to each other, and each first signal group includes at least one sinusoidal signal unit.
Optionally, in step S120, the sinusoidal electrical signal includes a third signal group formed by at least one first signal group and at least one second signal group arranged in sequence, where the first signal group includes at least one first sinusoidal signal unit, the second signal group includes at least one second sinusoidal signal unit, the first sinusoidal signal unit and the second sinusoidal signal unit have the same amplitude, and frequencies and/or durations between the first sinusoidal signal unit and the second sinusoidal signal unit are different.
Optionally, in step S120, the sinusoidal electrical signal includes a third signal group formed by at least one first signal group and at least one second signal group arranged in sequence, where the first signal group includes at least one first sinusoidal signal unit, and the second signal group includes at least one second sinusoidal signal unit, and the magnitudes of the first sinusoidal signal unit and the second sinusoidal signal unit are different.
Optionally, in step S120, the sinusoidal electrical signal includes a third signal group formed by at least one first signal group and at least one second signal group arranged in sequence, where the first signal group includes at least one first sinusoidal signal unit and at least one second sinusoidal signal unit, the first sinusoidal signal unit and the second sinusoidal signal unit have different magnitudes, and the second signal group includes at least one third sinusoidal signal unit and at least one fourth sinusoidal signal unit, and the third sinusoidal signal unit and the fourth sinusoidal signal unit have different magnitudes.
In some embodiments, the first signal group and the second signal group have an interval time of 50ns or more therebetween.
In some embodiments, in step S120, the sinusoidal electrical signal comprises a fourth signal set comprising at least two third signal sets. The fourth signal group may comprise the third signal group of any of the preceding embodiments.
According to the control method of the ablation system for the lung channel, disclosed by the embodiment of the utility model, the sinusoidal electric signal generator can be controlled to generate the sinusoidal electric signal, and the sinusoidal electric signal is configured to comprise a plurality of sinusoidal signal units, wherein each sinusoidal signal unit comprises at least one continuous minimum sine wave period. And controlling the ablation device to deliver the sinusoidal electric signal to the tissue so as to induce apoptosis or necrosis and realize the elimination of abnormal functional cells in the targeted area. In the process of ablation by adopting the specific sinusoidal electric signal, the action potential distribution to peripheral tissues can be reduced, and muscle contraction can be reduced or even avoided.
In some of the embodiments described above, sinusoidal electrical signals are applied to biological tissue via an ablation device for a specific duration and manner of application, thereby inducing apoptosis or necrosis. In some embodiments, sinusoidal electrical signals may act on cell membrane structures, disrupting the lipid bilayer of the cell membrane, causing the intracellular and extracellular balance to break down and die. In some embodiments, sinusoidal electrical signals may also act with the inside of the cell, inducing functional damage to intracellular organelles, initiating death signaling pathways, and causing apoptotic death.
The control method of the ablation system for the lung channel can be used for COPD, and in the process of ablation by adopting the specific sinusoidal electric signals, the sinusoidal electric signals can be transmitted to the airway wall to remove abnormal functional cells in the targeted area. During ablation with the specific sinusoidal electrical signals described above, the sinusoidal electrical signals may preserve extracellular matrix structure and adjacent critical conduit structural integrity while damaging abnormal cells. After the ablation process is completed, normal and newly generated healthy cells or healthy tissues replace abnormal functional cells cleared by the ablation process.
The embodiment of the utility model also provides a control device for the ablation system of the lung channel. Fig. 11 is a schematic hardware configuration of an embodiment of a control device of the ablation system for lung passages according to the present utility model. The control device comprises a memory 210 and at least one processor 220, the memory 210 having instructions stored therein, the at least one processor 220 invoking the instructions in the memory 210, causing the control device to perform a control method for an ablation system for a lung passageway according to any of the preceding embodiments of the utility model.
The control method comprises the following steps: controlling a pulse electric signal generator to generate a pulse electric signal; controlling a sinusoidal electric signal generator to generate a sinusoidal electric signal; configuring a sinusoidal electrical signal to include a plurality of sinusoidal signal units, each sinusoidal signal unit including a succession of at least one sine wave minimum period; the ablation device is controlled to deliver the sinusoidal electrical signal to tissue.
In particular, the processor 220 may comprise a Central Processing Unit (CPU), or an application specific integrated circuit (Application Specific Integrated Circuit, ASIC), or may be configured as one or more integrated circuits that implement embodiments of the present utility model.
In one example, the control device may also include a communication interface 230 and a bus 240. The processor 220, memory 210, and communication interface 230 are coupled to and communicate with each other via a bus 240.
The communication interface 230 is primarily used to implement communication between modules, devices, units, and/or apparatuses in an embodiment of the present utility model.
In addition, in combination with the control method of the ablation system for lung passages in the above embodiments, embodiments of the present utility model may be implemented by providing a computer-readable storage medium. The computer readable storage medium has stored thereon instructions which, when executed by a processor, implement a method of controlling an ablation system for a lung passageway according to any of the above embodiments.
The control method comprises the following steps: controlling a pulse electric signal generator to generate a pulse electric signal; controlling a sinusoidal electric signal generator to generate a sinusoidal electric signal; configuring a sinusoidal electrical signal to include a plurality of sinusoidal signal units, each sinusoidal signal unit including a succession of at least one sine wave minimum period; the ablation device is controlled to deliver the sinusoidal electrical signal to tissue.
The present utility model is not limited to the specific configurations and processes described above and shown in the drawings. For the sake of brevity, a detailed description of known methods is omitted here. In the above embodiments, several specific steps are described and shown as examples. However, the method processes of the present utility model are not limited to the specific steps described and shown, and those skilled in the art can make various changes, modifications and additions, or change the order between steps, after appreciating the spirit of the present utility model.
The functional blocks shown in the above block diagrams may be implemented in hardware, software, firmware, or a combination thereof. When implemented in hardware, it may be, for example, an electronic circuit, an Application Specific Integrated Circuit (ASIC), suitable firmware, a plug-in, a function card, or the like. When implemented in software, the elements of the utility model are the programs or code segments used to perform the required tasks. The program or code segments can be stored in a computer readable medium or transmitted over transmission media or communication links by data signals carried in carrier waves. "computer-readable medium" may include any medium capable of storing or transmitting information. Examples of a computer readable medium include an electronic circuit, a semiconductor memory device, a ROM, a flash memory, an Erasable ROM (EROM), a floppy disk, a CD-ROM, an optical disk, a hard disk, a fiber optic medium, a Radio Frequency (RF) link, and so forth. The code segments may be downloaded via computer networks such as the internet, intranets, etc.
It should also be noted that the exemplary embodiments mentioned in this disclosure describe some methods or systems based on a series of steps or devices. However, the present utility model is not limited to the order of the above-described steps, that is, the steps may be performed in the order mentioned in the embodiments, or may be performed in a different order from the order in the embodiments, or several steps may be performed simultaneously.
In the foregoing, only the specific embodiments of the present utility model are described, and it will be clearly understood by those skilled in the art that, for convenience and brevity of description, the specific working processes of the systems, modules and units described above may refer to the corresponding processes in the foregoing method embodiments, which are not repeated herein. It should be understood that the scope of the present utility model is not limited thereto, and any equivalent modifications or substitutions can be easily made by those skilled in the art within the technical scope of the present utility model, and they should be included in the scope of the present utility model.
Claims (12)
1. An ablation system for a lung passageway, comprising:
a sinusoidal electrical signal generator for generating a sinusoidal electrical signal;
an ablation device coupled to the sinusoidal electrical signal generator, at least a portion of the ablation device being extendable toward tissue such that the ablation device is capable of delivering the sinusoidal electrical signal to the tissue,
wherein the sinusoidal electrical signal comprises a plurality of sinusoidal signal units, each of the sinusoidal signal units comprising a succession of at least one sine wave minimum period.
2. The ablation system for a pulmonary tract of claim 1, wherein there is a separation time between adjacent ones of the sinusoidal signal units in the sinusoidal electrical signal, each of the sinusoidal signal units having a duration of 1s or less.
3. The ablation system for a lung passageway according to claim 1, wherein a duration of each of the sine wave minimum periods is 0.5ns or more and 100us or less.
4. The ablation system for a lung passageway according to claim 1, wherein the frequency of each of the sinusoidal signal units is 1kHz or more and 10MHz or less.
5. The ablation system for a lung passageway according to claim 1 wherein the amplitude of each of the sinusoidal signal units is 0.5kV/cm to 50kV/cm.
6. The ablation system for a pulmonary tract according to claim 1, wherein the sinusoidal electrical signal comprises a plurality of first signal sets arranged in tandem and identical to one another, each of the first signal sets comprising at least one of the sinusoidal signal units.
7. The ablation system for a pulmonary tract according to claim 1, wherein the sinusoidal electrical signal comprises a third signal set of at least one first signal set and at least one second signal set arranged in succession, the first signal set comprising at least one first sinusoidal signal unit and the second signal set comprising at least one second sinusoidal signal unit, the first sinusoidal signal unit being the same in amplitude as the second sinusoidal signal unit, the first sinusoidal signal unit being different in frequency and/or duration from the second sinusoidal signal unit.
8. The ablation system for a pulmonary tract according to claim 1, wherein the sinusoidal electrical signal includes a third signal set of at least one first signal set and at least one second signal set in a sequential order, the first signal set including at least one first sinusoidal signal unit and the second signal set including at least one second sinusoidal signal unit, the first sinusoidal signal unit and the second sinusoidal signal unit being different in amplitude.
9. The ablation system for a pulmonary tract according to claim 1, wherein the sinusoidal electrical signal comprises a third signal set of at least one first signal set and at least one second signal set arranged in succession, the first signal set comprising at least one first sinusoidal signal element, at least one second sinusoidal signal element, the first sinusoidal signal element being of a different amplitude than the second sinusoidal signal element, the second signal set comprising at least one third sinusoidal signal element, at least one fourth sinusoidal signal element, the third sinusoidal signal element being of a different amplitude than the fourth sinusoidal signal element.
10. The ablation system for a lung passageway according to any one of claims 7 to 9 wherein the first signal set and the second signal set have a separation time of 50ns or more.
11. The ablation system for a lung passageway according to any one of claims 7 to 9 wherein the sinusoidal electrical signal comprises a fourth signal set comprising at least two of the third signal sets.
12. The ablation system for a lung passageway according to claim 1 wherein the ablation device comprises at least one ablation electrode having an electrode ablation end or at least one ablation catheter having an ablation tip, the electrode ablation end, the ablation tip being extendable toward the tissue.
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