CN219039079U

CN219039079U - Sample separation carrier and sample analyzer

Info

Publication number: CN219039079U
Application number: CN202223438239.6U
Authority: CN
Inventors: 蔡光熠; 汪云飞; 罗方伟
Original assignee: Zhongyuan Huiji Biotechnology Co Ltd
Current assignee: Zhongyuan Huiji Biotechnology Co Ltd
Priority date: 2022-12-20
Filing date: 2022-12-20
Publication date: 2023-05-16
Anticipated expiration: 2032-12-20

Abstract

The utility model discloses a sample separation carrier and a sample analyzer, wherein the sample separation carrier comprises a cover plate and a substrate, a first sample adding hole and a first sample sucking hole are formed in the cover plate in a penetrating way at intervals, a cover plate sealing cover is arranged on the substrate, the substrate is provided with a separation unit, the separation unit comprises a sample sucking cavity, a sample adding cavity, a separation cavity and a precipitation cavity which are sequentially communicated, the sample adding cavity is provided with a second sample adding hole communicated with the first sample adding hole, a first step is formed on the cavity wall of the sample adding cavity at the bottom of the second sample adding hole, the first step is positioned on one side of the sample adding cavity away from the separation cavity, the sample sucking cavity is communicated with the separation cavity, and the sample sucking cavity is provided with a second sample sucking hole communicated with the first sample sucking hole. According to the sample separation carrier, the first step is arranged, so that the viscous force is provided for the separation liquid generated by sample separation, and the overflow of the separation liquid in the sample separation can be prevented.

Description

Sample separation carrier and sample analyzer

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a sample separation carrier and a sample analyzer.

Background

Blood is one of the most commonly used samples for clinical examination, and various physiological and pathological information of a tested person can be obtained from the blood through various detection means such as biochemistry, immunity and the like, so that basis is provided for clinical diagnosis and treatment. Currently, most blood-directed assays require separation of blood cells from liquid components during the sample pretreatment stage, followed by subsequent testing of the enriched blood cells or serum, plasma alone. Traditional blood cell separation methods include blood collection tube centrifugation, filtration and the like, and the methods generally take longer time and have complicated operation.

POCT (Point-of-care Testing), also known as Point-of-care Testing, or rapid in-situ Testing, refers to a Testing method performed in a sampling site, which uses a portable analytical instrument and a mating reagent to rapidly obtain a test result, and comprises: low sample consumption, low reagent consumption, low cost, easy operation and the like.

However, in the POCT, a sample separation carrier is required, and the cover between the cover plate and the substrate is not tight, so that the separation liquid is easy to overflow during the separation process.

In view of the above-mentioned drawbacks, it is necessary to provide a new sample separation carrier and sample analyzer.

Disclosure of Invention

The utility model mainly aims to provide a sample separation carrier and a sample analyzer, and aims to solve the problem that the existing sample separation carrier is easy to overflow separation liquid in sample separation.

In order to achieve the above object, the present utility model provides a sample separation carrier comprising:

the cover plate is provided with first sample adding holes and first sample sucking holes in a penetrating way at intervals;

the substrate, the sealed lid of apron is located on the substrate, the substrate is equipped with the separation unit, the separation unit is including inhaling appearance chamber and the application of sample chamber, separation chamber and the precipitation chamber of communicating in proper order, the application of sample chamber have with the second application of sample hole of first application of sample hole intercommunication, the application of sample chamber is located the chamber wall of second application of sample hole bottom forms first step, first step is located the application of sample chamber is kept away from one side of separation chamber, inhale the appearance chamber with separation chamber intercommunication, inhale the appearance chamber have with the second of first application of sample hole intercommunication inhale the appearance hole.

Preferably, the first step has a first wall facing the first loading hole, the size of the first loading hole is smaller than that of the first wall, and the cover plate covers the side wall of the second loading hole to form a first interlayer.

Preferably, the first sample adding hole is a circular hole, the first wall is provided with a first circular arc edge, and the first circular arc edge and the first sample adding hole are coaxially arranged.

Preferably, the cavity wall of the sample suction cavity at the bottom of the second sample suction hole forms a second step, and the second step is located at one side of the sample suction cavity away from the separation cavity.

Preferably, the second step is provided with a second platform wall facing the first sample suction hole, the size of the first sample suction hole is smaller than that of the second platform wall, and the cover plate covers the side wall of the second sample suction hole to form a second interlayer.

Preferably, the first sample suction hole is a round hole, the second wall is provided with a second circular arc edge, and the second circular arc edge and the first sample suction hole are coaxially arranged.

Preferably, the sample application cavity comprises a first sample application section and a second sample application section which are mutually communicated, one end of the first sample application section, which is far away from the second sample application section, is provided with the second sample application hole, the first sample application section comprises two first cavity walls which are oppositely arranged, the distance between the two first cavity walls is gradually increased from one end which is close to the second sample application hole to the direction which is close to the separation cavity, the second sample application section comprises two second cavity walls which are oppositely arranged, and the distance between the two second cavity walls is gradually reduced from one end which is close to the second sample application hole to the direction which is close to the separation cavity.

Preferably, the separation unit further comprises a first channel and a second channel, the sample adding cavity is communicated with the separation cavity through the first channel, the separation cavity is communicated with the precipitation cavity through the second channel, and the arrangement directions of the first channel and the second channel are consistent with the arrangement directions of the sample adding cavity, the separation cavity and the precipitation cavity.

Preferably, the separation unit further comprises a third channel, the separation cavity and the precipitation cavity are further communicated through the third channel, and the third channel and the sample suction cavity are respectively located at two sides of the separation cavity.

Preferably, the bottom of the second channel is higher than the bottom wall of the sedimentation cavity, and a third step is formed at the joint of the bottom wall of the sedimentation cavity and the side wall of the sedimentation cavity.

Preferably, a first slope is formed on a cavity wall of one end of the sample adding cavity far away from the second sample adding hole, and the distance between the first slope and the cover plate gradually decreases from one end close to the second sample adding hole to one end far away from the second sample adding hole; and/or, a second slope is arranged on a cavity wall of one end of the separation cavity far away from the second sample suction hole, and the distance between the second slope and the cover plate gradually decreases from one end close to the second sample suction hole to one end far away from the second sample suction hole.

Preferably, the number of the separation units is a plurality, the separation units are in a circumferential array and form a circumferential structure, the sample adding cavity, the separation cavity and the sedimentation cavity are arranged from inside to outside along the radial direction of the circumferential structure, the number of the first sample adding holes and the number of the first sample sucking holes are consistent with the number of the separation units and correspond to each other one by one, the first sample adding holes are communicated with the corresponding second sample adding holes of the separation units, and the first sample sucking holes are communicated with the corresponding second sample sucking holes of the separation units.

Preferably, the depth and the width of the sample suction cavity are not more than 5mm; the depth of the separation cavity is d, and d is more than or equal to 3mm; and/or the thickness of the cover plate is t, and t is more than or equal to 0.5mm.

In addition, in order to achieve the above object, the present utility model also provides a sample analyzer, which includes a rotation device and the sample separation carrier as described above, the rotation device includes a rotation shaft, the sample separation carrier is provided with a fixing hole fixed to the outer periphery of the rotation shaft, the sample adding cavity, the separation cavity and the precipitation cavity are sequentially arranged along the radial direction of the rotation shaft, and the sample adding cavity is close to the rotation shaft.

According to the technical scheme, the sample separation carrier comprises a cover plate and a substrate, wherein a first sample adding hole and a first sample sucking hole are formed in the cover plate in a penetrating mode at intervals, a cover plate sealing cover is arranged on the substrate, a separation unit is arranged on the substrate, the separation unit comprises a sample sucking cavity, a sample separating cavity and a precipitation cavity which are sequentially communicated, the sample adding cavity is provided with a second sample adding hole communicated with the first sample adding hole, a first step is formed on the cavity wall of the bottom of the second sample adding hole, the first step is located on one side, far away from the separation cavity, of the sample adding cavity, the sample sucking cavity is communicated with the separation cavity, and the sample sucking cavity is provided with a second sample sucking hole communicated with the first sample sucking hole. According to the sample separation carrier, the first step is arranged, so that the viscous force is provided for the separation liquid generated by sample separation, and the overflow of the separation liquid in the sample separation can be prevented.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of a substrate according to an embodiment of the utility model;

FIG. 2 is a schematic view illustrating an angle structure of a separation unit according to an embodiment of the utility model;

FIG. 3 is a schematic view illustrating another angle structure of a separation unit according to an embodiment of the present utility model;

FIG. 4 is a schematic view of a sample separation carrier according to an embodiment of the utility model;

FIG. 5 is a schematic view of a sample separation carrier according to an embodiment of the utility model;

FIG. 6 is a schematic partial view of a separation unit according to an embodiment of the present utility model;

FIG. 7 is a schematic view of a portion of a separation unit according to an embodiment of the present utility model;

FIG. 8 is a schematic partial view of a separation unit according to an embodiment of the present utility model;

FIG. 9 is a partial schematic view of a separation unit according to an embodiment of the present utility model;

FIG. 10 is a schematic view of a portion of a separation unit according to an embodiment of the present utility model;

FIG. 11 is a partial schematic view of a separation unit according to an embodiment of the utility model;

FIG. 12 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

FIG. 13 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

FIG. 14 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

FIG. 15 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

FIG. 16 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

FIG. 17 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

FIG. 18 is a partial schematic view of a separation unit according to another embodiment of the present utility model;

fig. 19 is a schematic structural view of a cover plate according to an embodiment of the utility model.

Reference numerals illustrate:

the achievement of the objects, functional features and advantages of the present utility model will be further described with reference to the accompanying drawings, in conjunction with the embodiments.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

It should be noted that all directional indicators (such as up, down, left, right, front, and rear … …) in the embodiments of the present utility model are merely used to explain the relative positional relationship, movement, etc. between the components in a particular posture (as shown in the drawings), and if the particular posture is changed, the directional indicator is changed accordingly.

Furthermore, descriptions such as those referred to as "first," "second," and the like, are provided for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implying an order of magnitude of the indicated technical features in the present disclosure. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present utility model, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.

In the present utility model, unless specifically stated and limited otherwise, the terms "connected," "affixed," and the like are to be construed broadly, and for example, "affixed" may be a fixed connection, a removable connection, or an integral body; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

In addition, the technical solutions of the embodiments of the present utility model may be combined with each other, but it is necessary to be based on the fact that those skilled in the art can implement the technical solutions, and when the technical solutions are contradictory or cannot be implemented, the combination of the technical solutions should be considered as not existing, and not falling within the scope of protection claimed by the present utility model.

The utility model provides a sample separation carrier and a sample analyzer, and aims to solve the problem that the existing sample separation carrier is easy to overflow separation liquid in sample separation.

Referring to fig. 1 to 3 and 19, the sample separation carrier includes a cover plate 1 and a substrate 2, the cover plate 1 is penetrated and provided with a first sample loading hole 11 and a first sample sucking hole 12 which are arranged at intervals, a cover plate 1 is sealed and cover-mounted on the substrate 2, the substrate 2 is provided with a separation unit 21, the separation unit 21 includes a sample sucking cavity 214, a sample loading cavity 211, a separation cavity 212 and a precipitation cavity 213 which are sequentially communicated, the sample loading cavity 211 is provided with a second sample loading hole 2111 communicated with the first sample loading hole 11, a cavity wall of the sample loading cavity 211 at the bottom of the second sample loading hole 2111 forms a first step 2112, the first step 2112 is positioned at one side of the sample loading cavity 211 far from the separation cavity 212, the sample sucking cavity 214 is communicated with the separation cavity 212, and the sample sucking cavity 214 is provided with a second sample sucking hole 2141 communicated with the first sample sucking hole 12. The sample separation carrier of the present utility model can prevent the overflow of the separation liquid during the sample separation by providing the first step 2112 to have a viscous force on the separation liquid generated during the sample separation.

The sample separation carrier of the present utility model may be a whole blood sample, hereinafter, the centrifugal motion of the whole blood sample is described to describe the sample separation carrier of the present utility model, the sample separation carrier includes a cover plate 1 and a base plate 2, the cover plate 1 and the base plate 2 may be bonded by laser, thermo-compression, ultrasound, etc., the cover plate 1 may be made of a hard sheet with a thickness not less than 0.5mm, materials including but not limited to PC, PP, PMMA, etc., the separation unit 21 on the base plate 2 includes a sample suction cavity 214 and a sample loading cavity 211, a separation cavity 212 and a sedimentation cavity 213 which are sequentially connected, the sample suction cavity 214 is to bear the plasma sample from the region after the separation is to be filled with the plasma sample suction cavity 214 in both the vertical direction and the horizontal direction, the separation cavity 212 is mainly used to hold the plasma sample separated after the centrifugation, the sedimentation cavity 213 is mainly used to hold the blood cell sample separated after the centrifugation, during the separation process, please combine with the materials shown in fig. 6 to fig. 16, the liquid flows through the first step 2, the first step 2 has a better capillary action on the first step 2, and thus, the overflow phenomenon can be prevented from being generated, and the overflow phenomenon can be prevented. The sample separation carrier has viscous force on the separation liquid generated by sample separation by arranging the first step 2112, so that the overflow of the separation liquid in the sample separation and the sample overflow in the sample adding process can be prevented.

The sample separation carrier of the utility model can be used in the following detection steps: the whole blood sample is added into the first sample adding hole 11, and the sample separating carrier rotates along the rotating shaft under any acceleration condition according to specific requirements, so that the whole blood sample in the sample separating carrier is centrifuged, the centrifugation direction is consistent with the position of the first sample sucking hole 12 relative to the separating unit 21, if the first sample sucking hole 12 is positioned on the right side of the separating unit 21, the whole blood sample is centrifuged anticlockwise, otherwise, the first sample sucking hole 12 is positioned on the left side of the separating unit 21, the whole blood sample is centrifuged clockwise, and the centrifugation rotating speed can be set as follows: after the whole blood sample is separated, the sample separation carrier needs to be suddenly stopped to obtain enough deceleration after the whole blood sample is separated, so that the separated blood plasma moves into the sample suction cavity 214, for example, the sample separation carrier can be suddenly stopped from 1000r/min to 0r/min, and then the separated blood plasma is sucked from the first sample suction hole 12 by adopting a pipette or an automatic sampling needle, so that the sample adding quantity a, the volume b of the precipitation cavity 213, the volume c of the second channel 216 and the depth d of the separation cavity 212 are satisfied with 0.7 < (d-c)/d < 0.7a/b < 0.9 during sample adding.

In one embodiment, as shown in fig. 4, the first step 2112 has a first wall 2113 facing the first loading hole 11, the size of the first loading hole 11 is smaller than that of the first wall 2113, and the cover plate 1 covers the side wall of the second loading hole 2111 to form a first interlayer 22. The shape of the first wall 2113 may be any of a circle, a square, etc., the size of the first loading hole 11 is smaller than the size of the first wall 2113, so that the first interlayer 22 is formed above the second loading hole 2111, the first interlayer 22 prevents the sample in the loading chamber 211 from overflowing from the first loading hole 11 to the upper surface of the cover plate 1 during the loading process, as shown in fig. 17 and 18, the structural edge between the first step 2112 and the first interlayer 22 generates a larger viscous force to the liquid flow when the liquid flows through the first step 2112 and the first interlayer 22, and the capillary action formed between the interlayers also prevents the liquid from overflowing, so that a good anti-overflow action can be generated.

Further, the first loading hole 11 is a circular hole, and the first wall 2113 has a first circular arc edge, and the first circular arc edge is coaxially disposed with the first loading hole 11. In order to facilitate the processing of the first loading hole 11 and the first wall 2113, the first loading hole 11 may be formed as a circular hole, the outer periphery of the first wall 2113 may be formed as an arc, and the first loading hole 11 and the first arc are coaxially disposed, thereby facilitating the assembly and the detection.

In addition, referring to fig. 5, in an embodiment, the wall of the sample sucking cavity 214 at the bottom of the second sample sucking hole 2141 forms a second step 2142, and the second step 2142 is located at a side of the sample sucking cavity 214 away from the separation cavity 212. The second sample suction hole 2141 is provided with a second step 2142, and the second step 2142 can have a viscous force on the plasma generated by separating the whole blood sample, so that the plasma can be prevented from overflowing to the upper surface of the cover plate 1, and meanwhile, the effect of preventing the backflow of the plasma from inertia into the sample suction cavity can be also achieved.

The second step 2142 has a second wall 2143 facing the first sample hole 12, the size of the first sample hole 12 is smaller than that of the second wall 2143, and the cover plate 1 covers the side wall of the second sample hole 2141 to form a second interlayer 23. The shape of the second platform wall 2143 may be any shape such as a circle, a square, etc., and the size of the first sample suction hole 12 is smaller than the size of the second platform wall 2143, so that a second interlayer 23 may be formed above the second sample suction hole 2141, and the second interlayer 23 may be used to lock the inertia to the plasma in the sample suction cavity 214, so that the plasma fills the whole sample suction cavity 214 vertically.

Further, in order to achieve multiple functions, the first sample suction hole 12 is a circular hole, and the second wall 2143 has a second circular arc edge, and the second circular arc edge is coaxially disposed with the first sample suction hole 12. In order to facilitate the processing of the first sample suction hole 12 and the second platform wall 2143, the first sample suction hole 12 may be formed as a circular hole, the outer periphery of the second platform wall 2143 is formed as an arc, and the first sample suction hole 12 and the second arc are coaxially arranged, thereby facilitating the assembly and the detection.

In addition, as shown in fig. 2, in the above embodiment, the sample loading chamber 211 includes a first sample loading section 2114 and a second sample loading section 2115 which are mutually communicated, the second sample loading hole 2111 is provided at one end of the first sample loading section 2114 away from the second sample loading section 2115, the first sample loading section 2114 includes two first chamber walls 2116 which are oppositely disposed, the distance between the two first chamber walls 2116 gradually increases from one end close to the second sample loading hole 2111 to a direction close to the separation chamber 212, the second sample loading section 2115 includes two second chamber walls 2117 which are oppositely disposed, and the distance between the two second chamber walls 2117 gradually decreases from one end close to the second sample loading hole 2111 to a direction close to the separation chamber 212. The radially expanded first loading segment 2114 is mainly used for preventing the sample liquid level which is bent and advanced in the loading process from generating laplace pressure which prevents the sample from overflowing from the outside of the sample to the surface of the disc, when the sampling needle or the injector injects the sample into the loading cavity 211 from the first loading hole 11, the sample continuously advances in the loading cavity 211 under the thrust of the injector, the front-protruding bent liquid level can be formed due to viscous resistance between the sample and the cavity wall, the two sides of the bent liquid level can generate pressure difference with the direction opposite to the protruding liquid level, the sample is prevented from advancing, when the loading cavity 211 is an expanded cavity, the curvature radius of the bent liquid level gradually increases, and the laplace pressure difference at two sides of the generated liquid level is smaller because the laplace pressure difference is inversely proportional to the curvature radius of the bent liquid level, so that the resistance generated at two sides of the bent liquid level is smaller and smaller when the sample advances in the expanded cavity, the sample is more favorable for ensuring that the sample does not overflow from the loading hole in the rapid loading, and the shrinkage type of the sample is easier to overflow from the sample cavity 211 along with the gradual curvature increase of the bent liquid level; in addition, the radial expansion type sample addition chamber 211 can fully utilize the space of the substrate 2.

In an embodiment, as shown in fig. 2, the separation unit 21 further includes a first channel 215 and a second channel 216, where the sample loading chamber 211 is communicated with the separation chamber 212 through the first channel 215, the separation chamber 212 is communicated with the sedimentation chamber 213 through the second channel 216, and the arrangement directions of the first channel 215 and the second channel 216 are consistent with the arrangement directions of the sample loading chamber 211, the separation chamber 212 and the sedimentation chamber 213. The first channel 215 mainly serves to connect the sample addition chamber 211 and the separation chamber 212 during centrifugation, and the second channel 216 mainly serves to connect the separation chamber 212 and the sedimentation chamber 213 during centrifugation.

Further, the separation unit 21 further comprises a third channel 217, the separation chamber 212 and the sedimentation chamber 213 are further communicated through the third channel 217, and the third channel 217 and the sample suction chamber 214 are respectively located at two sides of the separation chamber 212. The third channel 217 mainly plays a role in pressure relief, and in the centrifugation process, the third channel 217 can prevent the situation that the gas in the sedimentation cavity 213 cannot be discharged in time and the sample splashes.

Further, as shown in fig. 3, the bottom of the second channel 216 is higher than the bottom wall of the settling chamber 213, and a third step 2161 is formed at the connection with the side wall of the settling chamber 213. The third step 2161 is arranged at the connection position between the bottom of the second channel 216 and the cavity wall of the sedimentation cavity 213, so that the second channel 216 is higher than the sedimentation cavity 213, the width of the second channel 216 is narrower than that of the sedimentation cavity 213, the phenomenon that blood cells are mixed into blood plasma again due to the fact that blood cells sink under the action of gravity after centrifugation is finished can be effectively solved, and the purity of separated blood plasma is further ensured. It should be noted that the step may be inclined, and only the height of the second channel 216 is ensured to be higher than that of the sedimentation chamber 213, so as to prevent blood cells in the sedimentation chamber 213 from flowing back to the second channel 216 after centrifugation.

In addition, in one embodiment, the end wall of the loading chamber 211 distant from the second loading hole 2111 has a first slope 2118, and the distance between the first slope 2118 and the cover plate 1 gradually decreases from the end near the second loading hole 2111 to the end distant from the second loading hole 2111. The wall of the sample adding cavity 211 is obliquely arranged to form the first slope 2118, so that the blocking effect of the structure on the vertical direction in the centrifugation process on blood cells in the whole blood sample is eliminated, the content of blood cells in separated plasma is greatly reduced, the centrifugation time required for separating high-purity plasma is shortened, and no sample remains in the sample adding cavity 211 after centrifugation.

In another embodiment, the end wall of the separation chamber 212 away from the second sample suction hole 2141 has a second slope 2121, and the distance between the second slope 2121 and the cover plate 1 gradually decreases from the end near the second sample suction hole 2141 to the end far from the second sample suction hole 2141. The end wall of the separation chamber 212 far from the second sample suction hole 2141 is provided with a second slope 2121, the second slope 2121 is arranged at the position of the separation chamber 212 and the second channel 216 and is connected with the second channel 216 through an inclined slope, and the inclined slope ranges from 50 degrees to 75 degrees, so that lighter blood plasma can be remained in the separation chamber 212 in the centrifuging process, and heavier blood cells are centrifuged into the sedimentation chamber 213 through the second channel 216.

Further, as shown in fig. 1, the number of the separation units 21 is plural, the plurality of separation units 21 are in a circumferential array and enclose a circumferential structure, the sample loading chambers 211, the separation chambers 212 and the sedimentation chambers 213 are arranged from inside to outside along the radial direction of the circumferential structure, the number of the first sample loading holes 11 and the number of the first sample sucking holes 12 are consistent with and in one-to-one correspondence with the number of the separation units 21, the first sample loading holes 11 are communicated with the second sample loading holes 2111 of the corresponding separation units 21, and the first sample sucking holes 12 are communicated with the second sample sucking holes 2141 of the corresponding separation units 21. In order to improve the sample processing efficiency, a plurality of separation units 21 can be arranged, the plurality of separation units 21 are in a circumferential array and form a circumferential structure, the sample adding cavity 211, the separation cavity 212 and the sedimentation cavity 213 are radially distributed from inside to outside along the radial direction of the circumferential structure, and the separation units 21 are designed in an array manner, so that the space of the substrate 2 is fully utilized, and the function of processing trace samples in a high flux manner is realized.

In addition, in one embodiment, the aspiration lumen 214 has a depth and width of no more than 5mm; the separation chamber 212 has a depth d, d.gtoreq.3 mm. The depth and width of the sample suction cavity 214 are not more than 5mm, so that the sample addition amount in the single separation unit 21 can be limited to obtain fully separated samples; the separation chamber 212 has a depth d of not less than 3mm, which facilitates separation of plasma and blood cells from the whole blood sample.

Further, the thickness of the cover plate 1 is t, and t is more than or equal to 0.5mm. The thickness of the cover plate 1 is not less than 0.5mm, and the flatness of the cover plate 1 can be ensured, so that the rotation of the sample separation carrier can be facilitated.

In addition, the utility model also provides a sample analyzer, which comprises a rotating device and the sample separation carrier, wherein the rotating device comprises a rotating shaft, the sample separation carrier is provided with a fixing hole fixed on the periphery of the rotating shaft, the sample adding cavity 211, the separation cavity 212 and the sedimentation cavity 213 are sequentially arranged along the radial direction of the rotating shaft, and the sample adding cavity 211 is close to the rotating shaft. The specific structure of the sample separation carrier in the sample analyzer refers to the above embodiments, and since the sample analyzer adopts all the technical solutions of all the embodiments, the sample analyzer has at least all the beneficial effects brought by the technical solutions of the embodiments, and will not be described in detail herein.

The foregoing description is only of the preferred embodiments of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structural changes made by the description of the present utility model and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the utility model.

Claims

1. A sample separation carrier, the sample separation carrier comprising:

2. The sample separation carrier of claim 1, wherein the first step has a first land wall facing the first loading well, the first loading well has a size smaller than the first land wall, and the cover plate covers a sidewall of the second loading well to form a first sandwich.

3. The sample separation carrier of claim 2, wherein the first loading well is a circular hole, and the first wall has a first circular arc edge, and the first circular arc edge is coaxially disposed with the first loading well.

4. The sample separation carrier of claim 1, wherein a chamber wall of the sample suction chamber at the bottom of the second sample suction hole forms a second step, the second step being located on a side of the sample suction chamber remote from the separation chamber.

5. The sample separation carrier of claim 4, wherein the second step has a second land wall facing the first sample suction hole, the size of the first sample suction hole is smaller than the size of the second land wall, and the cover plate covers a side wall of the second sample suction hole to form a second interlayer.

6. The sample separation carrier of claim 5, wherein the first sample suction hole is a circular hole, and the second wall has a second circular arc edge, and the second circular arc edge is coaxially disposed with the first sample suction hole.

7. The sample separation carrier according to any one of claims 1 to 6, wherein the sample addition chamber comprises a first sample addition section and a second sample addition section which are communicated with each other, the second sample addition hole is formed in one end of the first sample addition section away from the second sample addition section, the first sample addition section comprises two first chamber walls which are oppositely arranged, the distance between the two first chamber walls gradually increases from one end close to the second sample addition hole to a direction close to the separation chamber, the second sample addition section comprises two second chamber walls which are oppositely arranged, and the distance between the two second chamber walls gradually decreases from one end close to the second sample addition hole to a direction close to the separation chamber.

8. The sample separation carrier according to any one of claims 1 to 6, wherein the separation unit further comprises a first channel and a second channel, the sample addition chamber and the separation chamber are communicated through the first channel, the separation chamber and the sedimentation chamber are communicated through the second channel, and an arrangement direction of the first channel and the second channel is identical to an arrangement direction of the sample addition chamber, the separation chamber and the sedimentation chamber.

9. The sample separation carrier of claim 8, wherein the separation unit further comprises a third channel, the separation chamber and the sedimentation chamber further communicate through the third channel, the third channel and the sample suction chamber being located on both sides of the separation chamber, respectively.

10. The sample separation carrier of claim 8, wherein the bottom of the second channel is higher than the bottom wall of the settling chamber and forms a third step at the junction with the side wall of the settling chamber.

11. The sample separation carrier of any one of claims 1 to 6, wherein an end of the loading chamber remote from the second loading well has a first slope, the distance between the first slope and the cover plate decreasing from an end proximate to the second loading well to an end remote from the second loading well;

and/or the number of the groups of groups,

the separation cavity is far away from one end cavity wall of the second sample suction hole is provided with a second slope, and the distance between the second slope and the cover plate is gradually reduced from one end close to the second sample suction hole to one end far away from the second sample suction hole.

12. The sample separation carrier according to any one of claims 1 to 6, wherein the number of the separation units is plural, the plurality of the separation units are in a circumferential array and form a circumferential structure, the sample addition chambers, the separation chambers and the sedimentation chambers are arranged from inside to outside along the radial direction of the circumferential structure, the number of the first sample addition holes and the number of the first sample suction holes are consistent with and correspond to the number of the separation units one by one, and the first sample addition holes are communicated with the corresponding second sample addition holes of the separation units, and the first sample suction holes are communicated with the corresponding second sample suction holes of the separation units.

13. The sample separation carrier according to claim 1 to 6,

the depth and the width of the sample suction cavity are not more than 5mm; the depth of the separation cavity is d, and d is more than or equal to 3mm;

and/or the number of the groups of groups,

the thickness of the cover plate is t, and t is more than or equal to 0.5mm.

14. A sample analyzer comprising a rotation device and the sample separation carrier according to any one of claims 1 to 13, the rotation device comprising a rotation shaft, the sample separation carrier being provided with a fixing hole fixed to the outer periphery of the rotation shaft, the sample addition chamber, the separation chamber and the sedimentation chamber being disposed in this order in a radial direction of the rotation shaft, and the sample addition chamber being close to the rotation shaft.