CN218981556U - Solid-liquid two-phase reaction kettle for meropenem production - Google Patents
Solid-liquid two-phase reaction kettle for meropenem production Download PDFInfo
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- CN218981556U CN218981556U CN202223165700.5U CN202223165700U CN218981556U CN 218981556 U CN218981556 U CN 218981556U CN 202223165700 U CN202223165700 U CN 202223165700U CN 218981556 U CN218981556 U CN 218981556U
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Abstract
The utility model relates to a solid-liquid two-phase reaction kettle for meropenem production. The solid-liquid two-phase reaction kettle for producing meropenem comprises a meropenem reaction kettle body, wherein the meropenem reaction kettle body is provided with a stirring device for stirring a meropenem reaction raw material and a stirring motor for driving the stirring device to rotate; the stirring motor is in transmission connection with a stirring shaft, and the stirring shaft extends into the Meropenem reaction kettle body and is vertically suspended in the Meropenem reaction kettle body; the stirring device is fixedly connected with the stirring shaft, and the stirring motor is operated to drive the stirring shaft to rotate so as to drive the stirring device to rotate to stir the reaction raw materials in the Meropenem reaction kettle body. The stirring motor is arranged at the upper end of the Meropenem reaction kettle body of the solid-liquid two-phase reaction kettle for producing meropenem, the stirring motor is connected with a stirring shaft in a transmission manner, and the stirring shaft is connected with an upper stirring part and a lower stirring part, so that the reaction raw materials in the Meropenem reaction kettle body can be fully reacted.
Description
Technical Field
The utility model belongs to the technical field of chemical production equipment, and particularly relates to a solid-liquid two-phase reaction kettle for meropenem production.
Background
Meropenem is the first carbapenem antibiotic to be administered alone, and is also the first 1-beta-methylcarbazoles antibiotic. The antibiotics have good stability to beta-lactamase and renal dehydropeptidase-I, do not need to be combined with a dehydropeptidase inhibitor, are one of important medicaments for treating severe and multi-drug resistant bacteria infection at present, and are increasingly widely applied clinically. Meropenem is synthesized from two parts, namely a parent nucleus MAP and a side chain H, wherein the side chain H of meropenem is one of key raw materials for synthesizing meropenem.
The utility model patent with the publication number of CN104857906A discloses a double-stirring reactor, which comprises a reaction kettle body (1), a jacket (2), a rotating shaft (3), a heater (4), a discharge port (5), a baffle plate (6), a kettle cover (7), a temperature controller (8), a feed inlet (9) and a motor (33), wherein the reaction kettle body (1) is divided into an upper reaction kettle body and a lower reaction kettle body, the kettle cover (7) is positioned above the upper reaction kettle body, the upper reaction kettle body is connected with the lower reaction kettle body and is sealed, the baffle plate (6) is positioned on the inner wall of the reaction kettle body (1) and is connected with the reaction kettle body (1) into a whole through a fixed connecting piece, the temperature controller (8) enters the reaction kettle body (1) from the upper reaction kettle body and is connected with the heater (4), the jacket (2) is positioned outside the reaction kettle, the rotating shaft (3) is arranged at the center part of the upper reaction kettle body, and the upper end of the motor is connected with the lower reaction kettle body and extends into the lower stirring kettle body (31); the heater (4) is installed in the bottom of the lower reaction kettle body, and feed inlet (9) are located the upper end of the upper reaction kettle body, and discharge gate (5) are located the lower extreme of the lower reaction kettle body, and discharge gate (5) are located the upper portion of cauldron lid (7), lower agitator (31) be "U" type of opening towards cauldron lid (7) direction, axis of rotation (3) be connected with agitator (32) on, last agitator (32) be "U" type of opening towards the lower reaction kettle body bottom direction. When solid exists in the reaction raw materials, the double-stirring reactor can be easily deposited at the bottom of the reaction kettle body, so that the contact area of materials is reduced, and the reaction efficiency is reduced. The raw materials for synthesizing the meropenem comprise solid and liquid, the reaction process is in a solid-liquid two-phase state, in the process of synthesizing the meropenem, the solid raw materials can be deposited at the bottom of a reaction kettle due to insufficient stirring, so that the materials are insufficient in reaction, more byproducts are generated in the process of synthesizing the meropenem, the product yield is low, the reaction time is long, and the synthesis efficiency is influenced.
Disclosure of Invention
The utility model aims to provide a solid-liquid two-phase reaction kettle for producing meropenem, which aims to solve the technical problem of low product yield caused by uneven stirring of reaction materials in the synthesis process of meropenem.
In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows: the solid-liquid two-phase reaction kettle for producing meropenem comprises a meropenem reaction kettle body, wherein the meropenem reaction kettle body is provided with a stirring device for stirring a meropenem reaction raw material and a stirring motor for driving the stirring device to rotate; the stirring motor is positioned above the meropenem reaction kettle body and is fixedly connected with the meropenem reaction kettle body; the stirring motor is in transmission connection with a stirring shaft, and the stirring shaft extends into the Meropenem reaction kettle body and is vertically suspended in the Meropenem reaction kettle body; the stirring device is fixedly connected with the stirring shaft, and the stirring motor is operated to drive the stirring shaft to rotate so as to drive the stirring device to rotate to stir the reaction raw materials in the Meropenem reaction kettle body; the stirring device comprises an upper stirring component and a lower stirring component for fully stirring the reaction raw materials of the meropenem in the meropenem reaction kettle body, and an interlayer is arranged between the upper stirring component and the lower stirring component to prevent solid raw materials for synthesizing the meropenem from depositing at the bottom of the meropenem reaction kettle body; the interlayer is made of a material which can pass through liquid but can not pass through a solid material for synthesizing meropenem; the bottom of the meropenem reaction kettle body is provided with a discharge hole, and the top of the meropenem reaction kettle body is provided with a solid feed inlet for synthesizing meropenem, a liquid feed inlet for synthesizing meropenem and an auxiliary feed inlet for synthesizing meropenem.
Further, the stirring shaft is positioned in the middle of the meropenem reaction kettle body so as to fully stir the reaction raw materials for synthesizing meropenem.
Further, the middle part cover of interlayer is established on the (mixing) shaft and with the (mixing) shaft can dismantle the connection, and the connection can be dismantled with meropenem reation kettle cauldron internal wall around the interlayer, the interlayer with behind the (mixing) shaft combination projection at the horizontal plane with the projection of meropenem reation kettle cauldron body at the horizontal plane is unanimous.
Further, the upper stirring part comprises an upper stirring paddle and a lower stirring paddle, and the upper stirring paddle and the lower stirring paddle are fixedly connected with the stirring shaft; the shape of the upper stirring paddle and the shape of the lower stirring paddle are U-shaped, the upper stirring paddle is positioned above the lower stirring shaft, and the shape formed by the upper stirring paddle and the lower stirring paddle is X-shaped.
Further, the interlayer is of a cambered surface structure which is concave downwards so that the solid materials for synthesizing meropenem are deposited downwards to the interlayer, the interlayer is a flexible interlayer, the shape of the lower stirring paddle is of an inverted U shape, and the two ends of the lower stirring paddle are tangent to the interlayer so that the interlayer vibrates when the upper stirring part rotates, and the phenomenon that the solid materials for synthesizing meropenem deposited to the interlayer are insufficient in reaction is avoided.
Further, the lower stirring component is positioned at the bottom end of the meropenem reaction kettle body; the lower stirring part comprises a left stirring paddle and a right stirring paddle which are symmetrically distributed on two sides of the stirring shaft; the lower extreme fixedly connected with connecting block of (mixing) shaft, connecting block lower extreme both sides fixedly connected with left stabilizer blade and right stabilizer blade, left side stirring rake with the connecting block with left stabilizer blade fixed connection, right stirring rake with the connecting block with right stabilizer blade fixed connection.
Further, the left stirring paddle and the right stirring paddle are U-shaped, and the upper ends of the left stirring paddle and the right stirring paddle are tangential to the interlayer.
Further, the outer wall of the meropenem reaction kettle body is of a hollow structure, and an electric heating pipe is wound inside the outer wall of the meropenem reaction kettle body so as to adjust the temperature required by the reaction.
Further, the outside of the kettle body of the meropenem reaction kettle is sleeved with a heat preservation interlayer.
Further, two support legs are arranged at the lower end of the meropenem reaction kettle body so as to support the meropenem reaction kettle body.
The utility model has the beneficial effects that:
the stirring motor is arranged at the upper end of the Meropenem reaction kettle body of the solid-liquid two-phase reaction kettle for producing meropenem, the stirring motor is connected with the stirring shaft in a transmission way, and the stirring shaft is connected with the upper stirring part and the lower stirring part, so that solid materials for synthesizing meropenem in the Meropenem reaction kettle body can be fully reacted, and the product yield is improved.
The interlayer is a flexible interlayer, the interlayer is a downward concave cambered surface structure, and is made of materials through which liquid in reaction raw materials for synthesizing meropenem can pass but solid materials cannot pass, so that the solid materials can fall onto the interlayer, and the phenomenon that the solid materials are deposited at the bottom of the body of the meropenem reaction kettle to cause insufficient reaction, so that more byproducts are caused and the product yield is low is avoided.
The lower stirring paddle, the left stirring paddle and the right stirring paddle of the solid-liquid two-phase reaction kettle for producing meropenem are tangential to the interlayer, and the interlayer can vibrate when the upper stirring component and the lower stirring component stir, so that solid materials in reaction raw materials in the synthesized meropenem can fully react.
Drawings
Fig. 1 is a schematic diagram of the overall structure of a solid-liquid two-phase reaction kettle for meropenem production in example 1.
In the figure: 1. a stirring motor; 2. an auxiliary feed port; 3. a solid feed port; 4. a meropenem reaction kettle body; 5. a heat preservation interlayer; 6. a liquid feed port; 7. a stirring shaft; 8. an electric heating tube; 9. a stirring paddle is arranged on the upper part; 10. a lower stirring paddle; 11. an interlayer; 12. an upper stirring part; 13. left stirring paddles; 14. a right stirring paddle; 15. a support leg; 16. a connecting block; 17. a discharge port; 18. a lower stirring member; 19. a left support leg; 20. and a right leg.
Detailed Description
The technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model.
An example of a solid-liquid two-phase reaction vessel for producing meropenem in the present utility model is shown in fig. 1.
Example 1
The solid-liquid two-phase reaction kettle for meropenem production of the embodiment comprises a meropenem reaction kettle body 4, wherein the outer wall of the meropenem reaction kettle body 4 is of a hollow structure, an electric heating pipe 8 is spirally wound inside the outer wall of the meropenem reaction kettle body 4 to adjust the temperature required for synthesizing meropenem, and a heat preservation interlayer 5 is sleeved outside the meropenem reaction kettle body 4. The lower end of the meropenem reaction kettle body 4 is provided with a discharge hole 17 after the reaction of the synthetic meropenem is finished, and the upper end of the meropenem reaction kettle body 4 is provided with a solid feed hole 3 for adding solid materials in the synthetic meropenem reaction raw materials, a liquid feed hole 6 for synthesizing liquid in the meropenem reaction raw materials and an auxiliary feed hole 2 for synthesizing other materials of the meropenem. Two support legs 15 are arranged at the lower end of the meropenem reaction kettle body 4 to support the meropenem reaction kettle body 4.
The Meropenem reaction kettle body 4 is connected with a stirring device for stirring reaction raw materials and a stirring motor 1 for driving the stirring device to rotate. The stirring motor 1 is positioned above the meropenem reaction kettle body 4, and the stirring motor 1 is fixedly connected with the meropenem reaction kettle body 4; the stirring motor 1 is connected with a stirring shaft 7 in a transmission way, and the stirring shaft 7 extends into the Meropenem reaction kettle body 4 and is vertically suspended in the middle position of the Meropenem reaction kettle body 4 so as to fully stir the reaction raw materials for synthesizing the meropenem. The stirring device is fixedly connected with the stirring shaft 7, and the stirring motor 1 operates to drive the stirring shaft 7 to rotate so as to drive the stirring device to rotate to stir the reaction raw materials for synthesizing meropenem in the meropenem reaction kettle body 4.
The stirring device comprises an upper stirring part 12 and a lower stirring part 18 to fully stir the reaction raw materials for synthesizing the meropenem in the meropenem reaction kettle body 4. The upper stirring part 12 comprises an upper stirring paddle 9 and a lower stirring paddle 10, and the upper stirring paddle 9 and the lower stirring paddle 10 are fixedly connected with the stirring shaft 7. The upper stirring paddle 9 and the lower stirring paddle 10 are U-shaped, the upper stirring paddle 9 is positioned above the lower stirring shaft 7, and the upper stirring paddle 9 and the lower stirring paddle 10 are X-shaped. The lower stirring part 18 is positioned at the bottom end of the meropenem reaction kettle body 4. The lower stirring part 18 comprises a left stirring paddle 13 and a right stirring paddle 14, and the left stirring paddle 13 and the right stirring paddle 14 are symmetrically distributed on two sides of the stirring shaft 7. The lower extreme fixedly connected with connecting block 16 of (mixing) shaft 7, connecting block 16 lower extreme both sides fixedly connected with left stabilizer blade 19 and right stabilizer blade 20, left stirring rake 13 and connecting block 16 and left stabilizer blade 19 fixed connection, right stirring rake 14 and connecting block 16 and right stabilizer blade 20 fixed connection.
An interlayer 11 is arranged between the upper stirring part 12 and the lower stirring part 18 to prevent solid raw materials in the reaction raw materials for synthesizing the meropenem from depositing at the bottom of the meropenem reaction kettle body 4. The interlayer 11 is a flexible interlayer, and the interlayer 11 is made of materials through which liquid in reaction raw materials for synthesizing meropenem can pass but solid materials cannot pass. The interlayer 11 is of a cambered surface structure which is concave downwards so that solid materials in reaction raw materials for synthesizing meropenem are deposited downwards to the interlayer 11, the shape of the lower stirring paddle 10 is of an inverted U shape, the shapes of the left stirring paddle 13 and the right stirring paddle 14 are of positive U shapes, and two ends of the lower stirring paddle 10, the left stirring paddle 13 and the right stirring paddle 14 are tangential to the interlayer 11 so that the interlayer 11 vibrates when the upper stirring part 12 and the lower stirring part 18 rotate, and insufficient reaction of the solid materials in the reaction raw materials for synthesizing meropenem deposited to the interlayer 11 is avoided. The middle part cover of interlayer 11 is established on (mixing) shaft 7 and can be dismantled with (mixing) shaft 7 and be connected, and the connection can be dismantled with the meropenem reation kettle cauldron body 4 inner wall around the interlayer 11, and the projection at the horizontal plane behind interlayer 11 and the (mixing) shaft 7 combination is unanimous with the projection of meropenem reation kettle cauldron body 4 at the horizontal plane.
When the solid-liquid two-phase reaction kettle for producing meropenem in this example is used, the yield of the product is 85-90%, and when the solid-liquid two-phase reaction kettle for producing meropenem in this example is not used, the yield of the product is 70-75%, and compared with the prior art, the solid-liquid two-phase reaction kettle for producing meropenem in this example is used, the raw materials of the reaction are sufficiently stirred, the byproducts are fewer, and the yield of the product is high.
The application method of the solid-liquid two-phase reaction kettle for producing meropenem comprises the following steps:
and adding the reaction raw materials for synthesizing the meropenem from the solid feed inlet, the liquid feed inlet and the auxiliary feed inlet respectively, starting the stirring motor to rotate the stirring device, and after the solid materials in the reaction raw materials for synthesizing the meropenem are completely reacted, closing the stirring motor and discharging the remaining liquid products from the discharge hole at the lower part after the reaction is finished.
Finally, it should be noted that: in the description of the present utility model, it should be noted that the azimuth or positional relationship indicated by the terms "vertical", "upper", "lower", "horizontal", etc. are based on the azimuth or positional relationship shown in the drawings, and are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the apparatus or element referred to must have a specific azimuth, be constructed and operated in a specific azimuth, and thus should not be construed as limiting the present utility model.
In the description of the present utility model, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.
Claims (10)
1. The utility model provides a meropenem production is with solid-liquid two-phase reation kettle, includes meropenem reation kettle cauldron body, its characterized in that: the Meropenem reaction kettle body is provided with a stirring device for stirring meropenem reaction raw materials and a stirring motor for driving the stirring device to rotate; the stirring motor is positioned above the meropenem reaction kettle body and is fixedly connected with the meropenem reaction kettle body; the stirring motor is in transmission connection with a stirring shaft, and the stirring shaft extends into the Meropenem reaction kettle body and is vertically suspended in the Meropenem reaction kettle body; the stirring device is fixedly connected with the stirring shaft, and the stirring motor is operated to drive the stirring shaft to rotate so as to drive the stirring device to rotate to stir the reaction raw materials in the Meropenem reaction kettle body; the stirring device comprises an upper stirring component and a lower stirring component for fully stirring the reaction raw materials of the meropenem in the meropenem reaction kettle body, and an interlayer is arranged between the upper stirring component and the lower stirring component to prevent solid raw materials for synthesizing the meropenem from depositing at the bottom of the meropenem reaction kettle body; the interlayer is made of a material which can pass through liquid but can not pass through a solid material for synthesizing meropenem; the bottom of the meropenem reaction kettle body is provided with a discharge hole, and the top of the meropenem reaction kettle body is provided with a solid feed inlet for synthesizing meropenem, a liquid feed inlet for synthesizing meropenem and an auxiliary feed inlet for synthesizing meropenem.
2. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: the stirring shaft is positioned in the middle of the meropenem reaction kettle body so as to fully stir the reaction raw materials for synthesizing meropenem.
3. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: the middle part cover of interlayer is established on the (mixing) shaft and with the (mixing) shaft can dismantle the connection, around the interlayer can dismantle with the meropenem reation kettle cauldron body inner wall and be connected, the interlayer with behind the (mixing) shaft combination projection at the horizontal plane with the projection of meropenem reation kettle cauldron body at the horizontal plane is unanimous.
4. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: the upper stirring part comprises an upper stirring paddle and a lower stirring paddle, and the upper stirring paddle and the lower stirring paddle are fixedly connected with the stirring shaft; the shape of the upper stirring paddle and the shape of the lower stirring paddle are U-shaped, the upper stirring paddle is positioned above the lower stirring paddle, and the shape formed by the upper stirring paddle and the lower stirring paddle is X-shaped.
5. The solid-liquid two-phase reaction kettle for meropenem production according to claim 4, wherein: the interlayer is of a cambered surface structure which is concave downwards so that the solid materials for synthesizing the meropenem are deposited downwards to the interlayer, the interlayer is a flexible interlayer, the shape of the lower stirring paddle is of an inverted U shape, and the two ends of the lower stirring paddle are tangent to the interlayer so that the interlayer vibrates when the upper stirring part rotates, so that the solid materials for synthesizing the meropenem deposited on the interlayer are prevented from insufficient reaction.
6. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: the lower stirring component is positioned at the bottom end of the meropenem reaction kettle body; the lower stirring part comprises a left stirring paddle and a right stirring paddle which are symmetrically distributed on two sides of the stirring shaft; the lower extreme fixedly connected with connecting block of (mixing) shaft, connecting block lower extreme both sides fixedly connected with left stabilizer blade and right stabilizer blade, left side stirring rake with the connecting block with left stabilizer blade fixed connection, right stirring rake with the connecting block with right stabilizer blade fixed connection.
7. The solid-liquid two-phase reaction kettle for meropenem production according to claim 6, wherein: the left stirring paddle and the right stirring paddle are U-shaped, and the upper ends of the left stirring paddle and the right stirring paddle are tangential to the interlayer.
8. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: the outer wall of the meropenem reaction kettle body is of a hollow structure, and an electric heating pipe is wound inside the outer wall of the meropenem reaction kettle body to adjust the temperature required by the reaction.
9. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: the outside of the meropenem reaction kettle body is sleeved with a heat preservation interlayer.
10. The solid-liquid two-phase reaction kettle for meropenem production according to claim 1, wherein: two support legs are arranged at the lower end of the meropenem reaction kettle body so as to support the meropenem reaction kettle body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223165700.5U CN218981556U (en) | 2022-11-28 | 2022-11-28 | Solid-liquid two-phase reaction kettle for meropenem production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223165700.5U CN218981556U (en) | 2022-11-28 | 2022-11-28 | Solid-liquid two-phase reaction kettle for meropenem production |
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| Publication Number | Publication Date |
|---|---|
| CN218981556U true CN218981556U (en) | 2023-05-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223165700.5U Active CN218981556U (en) | 2022-11-28 | 2022-11-28 | Solid-liquid two-phase reaction kettle for meropenem production |
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| CN (1) | CN218981556U (en) |
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