CN218969228U - Optical fiber electrode mounting structure for biological reaction bag and biological reaction bag - Google Patents

Abstract

The utility model provides an optical fiber electrode mounting structure for a biological reaction bag and the biological reaction bag, and relates to the technical field of medical instruments. The optical fiber electrode mounting structure for the biological reaction bag comprises a bag inner pipe, a built-in catheter, an optical fiber electrode wire, an optical fiber electrode plug for mounting an optical fiber electrode sensor and a double-head connecting seat arranged on the biological culture bag; one end of the built-in conduit is inserted into the inner wall of the optical fiber electrode plug, and the other end of the built-in conduit is inserted into the inner wall of the double-end connecting seat; one end of the bag inner tube is sleeved on the outer wall of the optical fiber electrode plug, and the other end of the bag inner tube is sleeved on the outer wall of the double-end connecting seat. The bioreactor bag includes a fiber optic electrode mounting structure for the bioreactor bag. The technical effect that the optical fiber electrode wire is inserted into the bag inner tube in a smooth way is achieved.

Description

Optical fiber electrode mounting structure for biological reaction bag and biological reaction bag

Technical Field

The utility model relates to the technical field of medical equipment, in particular to an optical fiber electrode mounting structure for a biological reaction bag and the biological reaction bag.

Background

The wave type bioreactor is a non-intervention wave type shaking mixed bioreactor, and comprises a shaking table assembly, a wave type biological culture bag and a shaking assembly, wherein the wave type biological culture bag and the shaking assembly are fixed on the shaking table assembly, the shaking assembly provides shaking motion for the shaking table assembly, then provides shaking motion power for culture fluid in the wave type biological culture bag, waves are generated in the culture fluid, the waves enable gas to be in contact with the surface of a culture material to realize oxygen transmission, so that a culture environment with low shear force and relatively high oxygen transmission efficiency is generated, and efficient culture growth of cells and production of target products are realized. In order to provide optimal growth conditions, the wave bioreactor requires strict monitoring and control of the cells and culture fluid in the cell culture bag, including swing speed, temperature, pH, dissolved oxygen, etc. As a key variable, pH and dissolved oxygen must be monitored strictly in order to achieve automated precise control of the cell culture process.

The current wave-type bioreactor usually adopts a disposable patch type optical fiber electrode sensor to test the pH value and the dissolved oxygen amount, wherein the optical fiber electrode sensor for measurement is fixed in a culture solution in a wave-type biological culture bag, and an optical fiber electrode wire is inserted into the wave-type biological culture bag through a hose provided with a plug in the use process until the optical fiber electrode wire can interact with the optical fiber electrode sensor, so that the real-time test of the pH value and the dissolved oxygen amount is performed. The optical fiber electrode wire is inserted into the culture solution through the hose, so that the contact liquid is not needed, and the operations of sterilizing and cleaning the optical fiber electrode wire are omitted, so that the optical fiber electrode wire can be simply and repeatedly used, and the service life of the optical fiber electrode wire is prolonged.

However, as the fiber electrode wire is hard, the bag inner tube is made of soft tube, generally made of silica gel and the like, and the soft tube has steps formed due to bending, bending and the like, the condition that the end part of the fiber electrode is propped against the inner wall of the bag inner tube easily occurs when the fiber electrode is inserted into the bag inner tube, so that the fiber electrode wire cannot be penetrated in place and cannot interact with the fiber electrode sensor at the plug, the pH value and the dissolved oxygen amount are inaccurate to test, and the cell culture failure can be caused when the fiber electrode is serious.

Accordingly, it is an important technical problem to be solved by those skilled in the art to provide a fiber electrode mounting structure for a bioreactor bag and a bioreactor bag, which enable a fiber electrode wire to be smoothly threaded.

Disclosure of Invention

The utility model aims to provide an optical fiber electrode mounting structure for a biological reaction bag and the biological reaction bag, so as to relieve the technical problem that the penetration of an optical fiber electrode wire is blocked in the prior art.

In a first aspect, an embodiment of the present utility model provides an optical fiber electrode mounting structure for a bioreactor bag, including a bag inner tube, a built-in catheter, an optical fiber electrode wire, an optical fiber electrode plug for mounting an optical fiber electrode sensor, and a double-ended connection seat disposed on a bioreactor bag;

one end of the built-in catheter is inserted into the inner wall of the optical fiber electrode plug, and the other end of the built-in catheter is inserted into the inner wall of the double-end connecting seat;

one end of the bag inner tube is sleeved on the outer wall of the optical fiber electrode plug, and the other end of the bag inner tube is sleeved on the outer wall of the double-end connecting seat.

With reference to the first aspect, the embodiment of the present utility model provides a possible implementation manner of the first aspect, where the dual-head connection seat includes a first connection head and a second connection head;

the first connector and the second connector are communicated with each other;

the inner wall of the first connector is connected with the built-in catheter, and the outer wall of the first connector is connected with the bag inner tube;

and the second connector is connected with a protective hose.

With reference to the first aspect, an embodiment of the present utility model provides a possible implementation manner of the first aspect, where the dual-head connection seat further includes a sealing ring, the first connection head and the second connection head are respectively disposed on two sides of the sealing ring, and the first connection head and the second connection head are in a symmetrical structure.

With reference to the first aspect, the embodiment of the present utility model provides a possible implementation manner of the first aspect, where the outer walls of the first connector and the second connector are provided with expansion elements.

With reference to the first aspect, the embodiment of the present utility model provides a possible implementation manner of the first aspect, wherein the expansion element adopts an expansion ring, and an outer diameter of the expansion ring gradually increases from one end facing away from the sealing ring to the other end.

With reference to the first aspect, the embodiment of the present utility model provides a possible implementation manner of the first aspect, wherein a length of the expansion ring along an axial direction of the expansion ring is smaller than a length of the first connector along an axial direction of the expansion ring.

With reference to the first aspect, an embodiment of the present utility model provides a possible implementation manner of the first aspect, where a clamping piece for clamping and fixing the fiber electrode wire is provided on the protection hose.

With reference to the first aspect, the embodiment of the present utility model provides a possible implementation manner of the first aspect, wherein the clamping member adopts a clip.

With reference to the first aspect, an embodiment of the present utility model provides a possible implementation manner of the first aspect, where an end of the fiber electrode plug facing away from the built-in catheter is provided with a mounting groove for mounting a fiber electrode sensor.

In a second aspect, embodiments of the present utility model provide a bioreactor bag comprising the fiber optic electrode mounting structure for a bioreactor bag.

The beneficial effects are that:

the utility model provides an optical fiber electrode mounting structure for a biological reaction bag, which comprises a bag inner pipe, a built-in catheter, an optical fiber electrode wire, an optical fiber electrode plug for mounting an optical fiber electrode sensor and a double-head connecting seat arranged on a biological culture bag; one end of the built-in conduit is inserted into the inner wall of the optical fiber electrode plug, and the other end of the built-in conduit is inserted into the inner wall of the double-end connecting seat; one end of the bag inner tube is sleeved on the outer wall of the optical fiber electrode plug, and the other end of the bag inner tube is sleeved on the outer wall of the double-end connecting seat.

Specifically, through setting up built-in pipe in the bag inner tube, when wearing to establish the optic fibre electrode line, the optic fibre electrode line penetrates from the one end of double-end connecting seat, then enters into built-in pipe from the other end of double-end connecting seat, then can follow built-in pipe along the smooth to the optical fibre electrode end cap advance to insert the optical fibre electrode end cap, make the optical fibre electrode line can with the optical fibre electrode sensor interact that sets up on the optical fibre electrode end cap, thereby test the pH value or the dissolved oxygen volume of culture solution and export.

The utility model provides a biological reaction bag, which comprises an optical fiber electrode mounting structure for the biological reaction bag. The bioreactor bag has the above advantages over the prior art and will not be described in detail here.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a cross-sectional view of an optical fiber electrode mounting structure for a bioreactor bag according to an embodiment of the present utility model;

fig. 2 is an exploded view of an optical fiber electrode mounting structure for a bioreactor bag according to an embodiment of the present utility model.

Icon:

100-bag inner tube;

200-embedding a catheter;

300-an optical fiber electrode wire;

400-optical fiber electrode plugs; 410-a fiber optic electrode sensor;

500-double-head connecting seats; 510-a first connector; 520-second connector; 521-a protective hose; 530-a seal ring; 540-an expansion member; 550-clamping piece;

600-biological culture bag.

Detailed Description

The following description of the embodiments of the present utility model will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the utility model are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In the description of the present utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present utility model.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present utility model, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

In the present utility model, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

The utility model will now be described in further detail with reference to specific examples thereof in connection with the accompanying drawings.

Referring to fig. 1 and 2, the present embodiment provides an optical fiber electrode mounting structure for a bioreactor bag, comprising a bag inner tube 100, a built-in catheter 200, an optical fiber electrode wire 300, an optical fiber electrode plug 400 for mounting an optical fiber electrode sensor 410, and a double-ended connection holder 500 provided on a bioreactor bag 600; one end of the built-in catheter 200 is inserted into the inner wall of the optical fiber electrode plug 400, and the other end is inserted into the inner wall of the double-end connecting seat 500; one end of the bag inner tube 100 is sleeved on the outer wall of the optical fiber electrode plug 400, and the other end is sleeved on the outer wall of the double-end connecting seat 500.

Specifically, by disposing the built-in catheter 200 in the bag inner tube 100, when the optical fiber electrode wire 300 is threaded, the optical fiber electrode wire 300 is threaded from one end of the double-ended connection seat 500, then enters the built-in catheter 200 from the other end of the double-ended connection seat 500, and then can smoothly advance toward the optical fiber electrode plug 400 along the built-in catheter 200 and be inserted into the optical fiber electrode plug 400, so that the optical fiber electrode wire can interact with the optical fiber electrode sensor 410 disposed on the optical fiber electrode plug 400, thereby testing the pH value or dissolved oxygen amount of the culture solution and outputting.

It should be noted that, in the prior art, the bag inner tube 100 is a hose, and is generally made of a material such as silica gel, and because the material of the optical fiber electrode wire 300 is hard, the optical fiber electrode wire 300 interferes with the bag inner tube 100 during the threading process, so that the optical fiber electrode wire 300 is very easy to be threaded in place. The fiber electrode mounting structure for a bioreactor bag provided in this embodiment is provided with the built-in catheter 200 with a harder material in the bag inner tube 100, so that the fiber electrode wire 300 can smoothly reach the fiber electrode plug 400 through the built-in catheter 200 with a harder material in the penetrating process.

The inner catheter 200 may be a plastic tube, and in addition, a person skilled in the art may select the material of the inner catheter 200 according to the actual requirement, which will not be described herein.

Wherein a mounting groove for mounting the fiber electrode sensor 410 is provided at an end of the fiber electrode plug 400 facing away from the built-in catheter 200.

In an alternative to the present embodiment, as shown in fig. 1 and 2, the dual-headed connection socket 500 includes a first connection head 510 and a second connection head 520; the first connector 510 and the second connector 520 are communicated with each other; the inner wall of the first connector 510 is connected with the built-in catheter 200, and the outer wall of the first connector 510 is connected with the bag inner tube 100; the second connection head 520 is connected with a protection hose 521.

Wherein, the dual-head connecting seat 500 further comprises a sealing ring 530, the first connecting head 510 and the second connecting head 520 are respectively arranged at two sides of the sealing ring 530, and the first connecting head 510 and the second connecting head 520 are in a symmetrical structure.

Specifically, sealing ring 530 is capable of sealing connection with biological growth bag 600, thereby ensuring a seal on biological growth bag 600 at double-ended connection seat 500.

In an alternative to the present embodiment, both the outer walls of the first connector 510 and the second connector 520 are provided with an expansion member 540, as shown in fig. 1 and 2.

Wherein the expansion member 540 employs an expansion ring having an outer diameter that gradually increases from one end facing away from the sealing ring 530 to the other end.

Wherein the length of the expansion ring in its axial direction is smaller than the length of the first coupling head 510 in its axial direction.

Specifically, one end of the bag inner tube 100 can be expanded through the arrangement of the expansion ring, so that the friction force between the bag inner tube 100 and the first connector 510 is improved, and the bag inner tube 100 and the first connector 510 can be tightly matched; in addition, the expansion ring can expand one end of the protection hose 521, and improve the friction between the protection hose 521 and the second connector 520, so that the protection hose 521 is tightly matched with the second connector 520.

It should be noted that an expansion ring is also provided on the outer wall of the fiber electrode stopper 400, so that the bag-in-tube 100 is tightly connected with the fiber electrode stopper 400.

In addition, the expansion member may employ a single pagoda head or multiple pagoda heads.

In an alternative to the present embodiment, as shown in fig. 1 and 2, a clamping member 550 for clamping and fixing the optical fiber electrode wire 300 is provided on the protection hose 521.

Wherein the clamping member 550 is a clip.

Specifically, the clamping member 550 can clamp the protection hose 521, so as to clamp the optical fiber electrode wire 300 in the protection hose 521, thereby fixing the optical fiber electrode wire 300, and preventing the optical fiber electrode wire 300 from falling out of the test position, so that the optical fiber electrode wire 300 cannot work normally with the optical fiber electrode sensor, and then the test data of pH and DO are affected.

The embodiment provides a bioreactor bag comprising an optical fiber electrode mounting structure for the bioreactor bag.

In particular, compared with the prior art, the bioreactor bag provided in this embodiment has the advantages of the above-mentioned fiber electrode mounting structure for bioreactor bags, and will not be described in detail herein.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced with equivalents; such modifications and substitutions do not depart from the spirit of the technical solutions according to the embodiments of the present utility model.

Claims (10)

1. A fiber optic electrode mounting structure for a bioreactor bag, comprising: the biological culture bag comprises a bag inner tube (100), a built-in catheter (200), an optical fiber electrode wire (300), an optical fiber electrode plug (400) for installing an optical fiber electrode sensor (410) and a double-head connecting seat (500) arranged on the biological culture bag (600);

one end of the built-in catheter (200) is inserted into the inner wall of the optical fiber electrode plug (400), and the other end of the built-in catheter is inserted into the inner wall of the double-end connecting seat (500);

one end of the bag inner pipe (100) is sleeved on the outer wall of the optical fiber electrode plug (400), and the other end of the bag inner pipe is sleeved on the outer wall of the double-end connecting seat (500).

2. The fiber optic electrode mounting structure for a bioreactor bag according to claim 1, wherein the double-ended connector base (500) comprises a first connector (510) and a second connector (520);

the first connector (510) and the second connector (520) are communicated with each other;

the inner wall of the first connector (510) is connected with the built-in catheter (200), and the outer wall of the first connector (510) is connected with the bag inner tube (100);

the second connector (520) is connected with a protection hose (521).

3. The fiber optic electrode mounting structure for a bioreactor bag according to claim 2, wherein the double-ended connection base (500) further comprises sealing rings (530), the first connection head (510) and the second connection head (520) are respectively disposed at both sides of the sealing rings (530), and both the first connection head (510) and the second connection head (520) are in a symmetrical structure.

4. A fiber optic electrode mounting structure for a bioreactor bag according to claim 3, wherein the outer walls of the first connector (510) and the second connector (520) are each provided with an expansion member (540).

5. The fiber optic electrode mounting structure for a bioreactor bag according to claim 4, wherein the expansion member (540) employs an expansion ring having an outer diameter that gradually increases from one end facing away from the sealing ring (530) to the other end.

6. The fiber optic electrode mounting structure for a bioreactor bag according to claim 5, wherein the length of the expansion ring in the axial direction thereof is smaller than the length of the first connector (510) in the axial direction thereof.

7. The fiber electrode mounting structure for a bioreactor bag according to claim 2, wherein a clamping member (550) for clamping and fixing the fiber electrode wire (300) is provided on the protection hose (521).

8. The fiber optic electrode mounting structure for a bioreactor bag according to claim 7, wherein the clamping member (550) employs a clip.

9. The fiber optic electrode mounting structure for a bioreactor bag according to any one of claims 1-8, wherein an end of the fiber optic electrode plug (400) facing away from the inner catheter (200) is provided with a mounting groove for mounting a fiber optic electrode sensor (410).

10. A bioreactor bag comprising the fiber optic electrode mounting structure for a bioreactor bag of any one of claims 1-9.

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