CN218944413U - Chromatographic column adjusting structure and chromatographic column with same - Google Patents

Abstract

The application relates to a chromatographic column adjusting structure comprising: the device comprises a lower cover, an upper cover, a micro-adjustment switch, a screw tube and a screw switch. One side of the lower cover is suitable for being connected with the chromatographic column, and the other side of the lower cover is rotatably connected with the upper cover. The micro-adjustment switch is respectively connected with the upper cover and the lower cover. The screw thread pipe penetrates through the upper cover and the lower cover in sequence. The screw tooth switch is provided with a control end and a screw tooth end, the screw tooth switch is movably arranged on the upper cover, the screw tooth end is matched with the screw tooth pipe, and the control end is suitable for controlling the engagement or the separation of the screw tooth end and the screw tooth pipe. When the screw thread end is separated from the screw thread pipe, the screw thread pipe can be directly pushed to slide between the upper cover and the lower cover, so that coarse adjustment of the pressure of the chromatographic column is realized. When the control screw thread end is meshed with the screw thread pipe, the micro-adjustment switch is controlled simultaneously to enable the upper cover and the lower cover to rotate, at the moment, the upper cover is rotated, the upper cover drives the screw thread end of the screw thread switch to rotate, and the screw thread pipe is controlled to move along the axis direction of the screw thread rotation, so that the pressure micro-adjustment of the chromatographic column is realized.

Description

Chromatographic column adjusting structure and chromatographic column with same

Technical Field

The application relates to the technical field of chromatographic experimental equipment, in particular to a chromatographic column adjusting structure and a chromatographic column with the same.

Background

Chromatography columns are the main body in gel chromatography technology, and glass tubes or organic glass tubes are generally used. A chromatographic method for separation based on the difference in partition coefficients of the components of a sample mixture between a stationary phase and a mobile phase. During the experiment, it was necessary to separate the liquid by pressurization. In order to achieve higher experimental precision, the chromatographic column not only needs to roughly adjust the pressure in the tube, but also needs to finely adjust the pressure in the tube.

Therefore, the fine adjustment of the chromatography column is a problem to be solved by those skilled in the art.

Disclosure of Invention

In view of this, this application provides a chromatographic column adjusting structure and has its chromatographic column, can realize the coarse adjusting and the fine setting to the screw thread pipe height, realizes the high regulation to the screw thread pipe is located the inside piston one end that is equipped with of body, and then realizes coarse adjusting and the fine setting to the intraductal pressure of geminate transistors.

According to an aspect of the present application, there is provided a chromatography column adjusting structure comprising:

the device comprises a lower cover, an upper cover, a fine tuning switch, a screw tube and a screw switch;

one side of the lower cover is suitable for being connected with a chromatographic column, and the other side of the lower cover is rotatably connected with the upper cover;

the fine tuning switch is respectively connected with the upper cover and the lower cover;

the screw thread pipe sequentially penetrates through the upper cover and the lower cover;

the screw tooth switch is provided with a control end and a screw tooth end, the screw tooth switch is movably arranged on the upper cover, the screw tooth end is matched with the screw tooth pipe, and the control end is suitable for controlling the screw tooth end to be meshed with or separated from the screw tooth pipe.

In one possible implementation, the lower cover is further provided with a rotation stopping part;

the outer side wall of the screw tooth pipe is provided with a rotation stopping groove, the rotation stopping groove is formed along the bus of the screw tooth pipe, and the rotation stopping groove is matched with the rotation stopping part.

In one possible implementation, the fine adjustment switch is provided with a pressing end and a locking end;

the middle part of the fine tuning switch is rotatably connected with the upper cover, the pressing end and the locking end are respectively positioned at two opposite ends of the fine tuning switch, and the locking end is movably connected with the lower cover.

In one possible implementation manner, an outer side wall of one end of the lower cover, which is close to the upper cover, is provided with a clamping portion, and the clamping portion is matched with the locking end.

In one possible implementation manner, a yielding hole is formed in the middle of the upper cover;

the screw thread pipe runs through the hole setting of stepping down, the control end with the screw thread end is located respectively the relative both ends of screw thread switch, the middle part of screw thread switch with upper cover swivelling joint, the control end is located the outside of upper cover, the screw thread end be equipped with screw thread one side be located in the hole of stepping down towards the screw thread pipe.

In one possible implementation manner, the main body of the screw tooth switch is in a Z-shaped structure, and the control end protrudes out of the upper cover towards one side away from the lower cover.

In one possible implementation manner, the number of the micro-adjustment switches is more than two, and the more than two micro-adjustment switches are circumferentially arranged on the upper cover.

In one possible implementation manner, the number of the screw switches is more than two, and the more than two screw switches are circumferentially arranged on the upper cover.

In one possible implementation, the screw thread tube is further provided with an inner tube, a fixing nut and a sealing ring;

the screw tooth pipe is provided with a mounting hole, the mounting hole penetrates through the two opposite ends of the screw tooth pipe, the inner pipe is arranged in the mounting hole, the two opposite ends of the inner pipe extend out of the screw tooth pipe for arrangement, and the outer side wall of the inner pipe is provided with threads;

the fixing nut is matched with the threads of the inner tube, the fixing nut is arranged at one end of the inner tube, which is close to the upper cover, and the sealing ring is sleeved at the other end of the inner tube;

and one end of the inner tube, which is close to the sealing ring, is provided with an abutting part, and the sealing ring is positioned between the abutting part and the screw tooth tube.

According to another aspect of the present application, there is provided a chromatography column comprising:

the chromatographic column adjusting structure and the tube body of any one of the above;

one side of the lower cover, which is away from the upper cover, is connected with one end opening of the pipe body, one end of the screw thread pipe is positioned in the inner cavity of the pipe body, and the other end of the screw thread pipe protrudes out of one side of the upper cover, which is away from the lower cover.

The application is applicable to applying pressure to the interior of a chromatography column to separate liquids within the chromatography column. Through setting up the screw thread pipe, make the one end of screw thread pipe be located the inside of chromatographic column, the one end that the screw thread pipe is located the inside of chromatographic column is equipped with the piston, through the control screw thread pipe and the height of piston, realizes the control to the inside pressure of chromatographic column. The screw thread pipe runs through upper cover and lower cover setting, and the lateral wall of screw thread pipe is equipped with the screw thread, and the screw thread one end and the screw thread pipe phase-match of the screw thread switch of setting on the upper cover, and the control end of screw thread switch is used for controlling the separation and the meshing of screw thread end and screw thread pipe outer wall screw thread, when screw thread end and screw thread pipe separation, can directly promote the screw thread pipe and slide between upper cover and lower cover, realizes the pressure coarse adjustment to the chromatographic column. When the control screw thread end is meshed with the screw thread pipe, the micro-adjustment switch is controlled simultaneously to enable the upper cover and the lower cover to rotate, at the moment, the upper cover is rotated, the upper cover drives the screw thread end of the screw thread switch to rotate, and the screw thread pipe is controlled to move along the axis direction of the screw thread rotation, so that the pressure micro-adjustment of the chromatographic column is realized.

Other features and aspects of the present application will become apparent from the following detailed description of exemplary embodiments, which proceeds with reference to the accompanying drawings.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate exemplary embodiments, features and aspects of the present application and together with the description, serve to explain the principles of the present application.

FIG. 1 shows a front cross-sectional view of a chromatography column adjustment mechanism of an embodiment of the present application;

FIG. 2 shows a left side cross-sectional view of a chromatography column adjustment mechanism of an embodiment of the present application;

fig. 3 shows a main body structure diagram of a lower cover of an embodiment of the present application;

fig. 4 shows a main body structure diagram of a rotation stopper according to an embodiment of the present application;

fig. 5 shows a main body structure diagram of a chromatography column according to an embodiment of the present application.

Detailed Description

Various exemplary embodiments, features and aspects of the present application will be described in detail below with reference to the accompanying drawings. In the drawings, like reference numbers indicate identical or functionally similar elements. Although various aspects of the embodiments are illustrated in the accompanying drawings, the drawings are not necessarily drawn to scale unless specifically indicated.

It should be understood, however, that the terms "center," "longitudinal," "transverse," "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counter-clockwise," "axial," "radial," "circumferential," and the like indicate or are based on the orientation or positional relationship shown in the drawings, and are merely for convenience of describing the utility model or simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the utility model.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present utility model, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

The word "exemplary" is used herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

In addition, numerous specific details are set forth in the following detailed description in order to provide a better understanding of the present application. It will be understood by those skilled in the art that the present application may be practiced without some of these specific details. In some instances, methods, means, elements, and circuits have not been described in detail as not to unnecessarily obscure the present application.

Fig. 1 shows a front cross-sectional view of a chromatography column adjustment structure according to an embodiment of the present application. Fig. 2 shows a left side cross-sectional view of a chromatography column adjustment structure according to an embodiment of the application. Fig. 3 shows a main body structure diagram of a lower cover according to an embodiment of the present application. Fig. 4 shows a main structural view of a rotation stopper according to an embodiment of the present application. Fig. 5 shows a main body structure diagram of a chromatography column according to an embodiment of the application. As shown in fig. 1 and 2, the column adjusting structure includes: the lower cover 200, the upper cover 100, the micro-adjustment switch 500, the screw tube 300 and the screw switch 400. One side of the lower cap 200 is adapted to be coupled to a chromatography column, and the other side of the lower cap 200 is rotatably coupled to the upper cap 100. The micro-adjustment switch 500 is connected to the upper cover 100 and the lower cover 200, respectively. The screw pipe 300 is sequentially disposed through the upper cover 100 and the lower cover 200. The screw switch 400 is provided with a control end 410 and a screw end 420, the screw switch 400 is movably arranged on the upper cover 100, the screw end 420 is matched with the screw pipe 300, and the control end 410 is suitable for controlling the screw end 420 to be engaged with or separated from the screw pipe 300.

The application is applicable to applying pressure to the interior of a chromatography column to separate liquids within the chromatography column. By arranging the screw thread pipe 300, one end of the screw thread pipe 300 is positioned in the chromatographic column, a piston is arranged at one end of the screw thread pipe 300 positioned in the chromatographic column, and the control of the pressure in the chromatographic column is realized by controlling the heights of the screw thread pipe 300 and the piston. The screw thread pipe 300 runs through the upper cover 100 and the lower cover 200, threads are arranged on the outer side wall of the screw thread pipe 300, one end of a screw thread of the screw thread switch 400 arranged on the upper cover 100 is matched with the screw thread pipe 300, the control end 410 of the screw thread switch 400 is used for controlling the separation and engagement of the screw thread end 420 and the screw thread of the outer wall of the screw thread pipe 300, and when the screw thread end 420 is separated from the screw thread pipe 300, the screw thread pipe 300 can be directly pushed to slide between the upper cover 100 and the lower cover 200, so that the coarse adjustment of the pressure of a chromatographic column is realized. When the control screw thread end 420 is meshed with the screw thread pipe 300, the micro-adjustment switch 500 is controlled to rotate between the upper cover 100 and the lower cover 200, at this time, the upper cover 100 is rotated, the upper cover 100 drives the screw thread end 420 of the screw thread switch 400 to rotate, and the screw thread pipe 300 is controlled to move along the axial direction thereof through screw thread rotation, so that the pressure micro-adjustment of the chromatographic column is realized.

In one possible implementation, the lower cover 200 is further provided with a rotation stop 220. The outer side wall of the screw thread tube 300 is provided with a rotation stopping groove which is formed along the generatrix of the screw thread tube 300 and is matched with the rotation stopping part 220. When the chromatographic column is finely adjusted, the rotation stopping part 220 and the rotation stopping groove matched with the rotation stopping part are arranged, so that the screw thread pipe 300 can only move along the axial direction of the screw thread pipe 300 relative to the lower cover 200, circumferential rotation can not occur, and the upper cover 100 can be conveniently rotated to control the screw thread pipe 300.

Here, as shown in fig. 4, a yielding hole is formed in the middle of the rotation stopping portion 220, the yielding hole is used for avoiding the screw thread tube 300, a protrusion is formed on an inner side wall of the yielding hole, and the protrusion is matched with the rotation stopping groove. The whole structure is simpler, and the production cost is effectively reduced.

In one possible implementation, as shown in fig. 2, the micro-switch 500 is provided with a push end 510 and a locking end 520. The middle part of the micro-adjustment switch 500 is rotatably connected with the upper cover 100, the pressing end 510 and the locking end 520 are respectively positioned at two opposite ends of the micro-adjustment switch 500, and the locking end 520 is movably connected with the lower cover 200. By pressing the pressing end 510, the locking end 520 can be separated from the lower cap 200, the upper cap 100 can be rotated relative to the lower cap 200, and the pressing end 510 is released, so that the locking end 520 is engaged with the lower cap 200, the upper cap 100 and the lower cap 200 are kept relatively stationary, and the finely-adjusted screw tube 300 is kept stable during use.

In one possible implementation, as shown in fig. 3, an outer sidewall of one end of the lower cover 200, which is close to the upper cover 100, is provided with a clamping portion 210, where the clamping portion 210 is matched with the locking end 520, and by providing the clamping portion 210, the locking end 520 can clamp the clamping portion 210, so as to achieve locking between the upper cover 100 and the lower cover 200.

Here, the method is carried out. It should be noted that, the device further includes a reset piece, where the reset piece is in one-to-one correspondence with the thread switch 400 and the micro-adjustment switch 500, and the reset piece is adapted to reset the corresponding thread switch 400 and micro-adjustment switch 500, and the reset piece can be implemented by adopting a common technical means in the art, and only the reset thread switch 400 can be meshed with the thread tube 300, and the micro-adjustment switch 500 is locked with the lower cover 200.

Here, it should be noted that, the clamping portion 210 is a tooth-shaped structure arranged circumferentially, so that the overall structure is simpler, and the production cost is effectively reduced.

In one possible implementation, the middle portion of the upper cover 100 is provided with a relief hole. The screw thread pipe 300 runs through the hole setting of stepping down, and control end 410 and screw thread end 420 are located the opposite ends of screw thread switch 400 respectively, and the middle part and the upper cover 100 rotatable coupling of screw thread switch 400, control end 410 are located the outside of upper cover 100, and screw thread end 420 be equipped with screw thread one side and be located the downthehole orientation screw thread pipe 300 of stepping down. One side of the screw thread end 420 is positioned in the cavity of the abdication hole and faces the screw thread of the screw thread pipe 300, so that the screw thread pipe 300 is convenient to be meshed.

In one possible implementation, as shown in fig. 1, the main body of the screw switch 400 has a Z-shaped structure, and the control end 410 protrudes out of the upper cover 100 toward the side facing away from the lower cover 200, so that the overall structure is simpler, and the production cost is effectively reduced.

Here, the main bodies of the upper cover 100 and the lower cover 200 are each of a circular tube structure, and one end surface of the circular tube structure of the upper cover 100 and one end surface of the circular tube structure of the lower cover 200 are rotatably connected.

Here, the main body of the micro-adjustment switch 500 has an arc plate structure, protrudes toward the screw pipe 300, and has a protruding connection portion at the protruding side, and is rotatably connected to the upper cover 100 via the protruding connection portion.

In one possible implementation, the number of the micro-switches 500 is more than two, and the micro-switches 500 are circumferentially arranged on the upper cover 100, so that the locking between the upper cover 100 and the lower cover 200 is more stable by providing more than two rotation stopping portions 220.

In one possible implementation, the number of the screw switches 400 is more than two, and the screw switches 400 are circumferentially arranged on the upper cover 100, so that the screw ends 420 are more stable when the screw pipe 300 is driven by arranging the screw switches 400.

In one possible implementation, the number of micro-switches 500 is two, and the two micro-switches 500 are disposed opposite to each other. The number of the screw switches 400 is two, and the two screw switches 400 are oppositely arranged. The whole structure is simpler, and the production cost is effectively reduced.

Further, the two micro-adjustment switches 500 and the two screw switches 400 are arranged in a cross shape on the upper cover 100, so that the micro-adjustment switches 500 and the screw switches 400 can be operated respectively.

In one possible implementation, the threaded tube 300 is further provided with an inner tube 310, a retaining nut 320 and a sealing ring. The screw thread pipe 300 is equipped with the mounting hole, and the mounting hole runs through screw thread pipe 300's relative both ends, and inner tube 310 sets up in the mounting hole, and the screw thread pipe 300 setting is all visited out at inner tube 310's relative both ends, and inner tube 310's lateral wall is equipped with the screw thread. The fixing nut 320 is matched with the thread of the inner tube 310, the fixing nut 320 is arranged at one end of the inner tube 310 close to the upper cover, and the sealing ring is sleeved at the other end of the inner tube 310. An abutting portion is arranged at one end, close to the sealing ring, of the inner tube 310, and the sealing ring is located between the abutting portion and the screw thread tube 300. The fixation nut 320 is located the outside of chromatography column body, and the sealing washer is located the inside of body, through rotatory fixation nut 320, can adjust inner tube 310 in screw thread pipe 300, and then the control sets up the butt end at the screw thread pipe 300 other end and the distance between the screw thread pipe 300 terminal surface, when this distance is less, butt end and screw thread pipe 300 extrusion sealing washer, make the sealing washer take place deformation, strengthen the inside leakproofness of chromatography column body, when this distance is great, the sealing washer resumes the original form and is convenient for carry out fine setting or coarse adjustment.

According to another aspect of the present application, there is provided a chromatography column comprising: the column conditioning structure and tube 600 of any of the above. One side of the lower cover 200, which is away from the upper cover 100, is connected with one end opening of the pipe body 600, one end of the screw thread pipe 300 is positioned in the inner cavity of the pipe body 600, and the other end of the screw thread pipe 300 protrudes out of one side of the upper cover 100, which is away from the lower cover 200.

Here, the method is carried out. The inner side wall of the end of the lower cap 200 facing away from the upper cap 100 is provided with an internal thread, and the outer side wall of the opening of the tube 600 is provided with an external thread matching the internal thread.

Further, the number of the chromatographic column adjusting structures is two, and the two chromatographic column adjusting structures are respectively positioned at the openings at the two opposite ends of the tube body 600, so that the adjusting range of the application is further increased.

The embodiments of the present application have been described above, the foregoing description is exemplary, not exhaustive, and not limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the various embodiments described. The terminology used herein was chosen in order to best explain the principles of the embodiments, the practical application, or the improvement of technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims (10)

1. A chromatographic column adjusting structure, comprising:

the device comprises a lower cover, an upper cover, a fine tuning switch, a screw tube and a screw switch;

one side of the lower cover is suitable for being connected with a tube body of the chromatographic column, and the other side of the lower cover is rotatably connected with the upper cover;

the fine tuning switch is respectively connected with the upper cover and the lower cover;

the screw thread pipe sequentially penetrates through the upper cover and the lower cover;

the screw tooth switch is provided with a control end and a screw tooth end, the screw tooth switch is movably arranged on the upper cover, the screw tooth end is matched with the screw tooth pipe, and the control end is suitable for controlling the screw tooth end to be meshed with or separated from the screw tooth pipe.

2. The chromatography column adjusting structure according to claim 1, wherein the lower cover is further provided with a rotation stopping portion;

the outer side wall of the screw tooth pipe is provided with a rotation stopping groove, the rotation stopping groove is formed along the bus of the screw tooth pipe, and the rotation stopping groove is matched with the rotation stopping part.

3. The chromatography column adjusting structure according to claim 1, wherein the micro-adjustment switch is provided with a pressing end and a locking end;

the middle part of the fine tuning switch is rotatably connected with the upper cover, the pressing end and the locking end are respectively positioned at two opposite ends of the fine tuning switch, and the locking end is movably connected with the lower cover.

4. A chromatographic column regulating structure according to claim 3, wherein an outer side wall of one end of the lower cover, which is close to the upper cover, is provided with a clamping part, and the clamping part is matched with the locking end.

5. The chromatographic column regulating structure according to claim 1, wherein a relief hole is provided in the middle of the upper cover;

the screw thread pipe runs through the hole setting of stepping down, the control end with the screw thread end is located respectively the relative both ends of screw thread switch, the middle part of screw thread switch with upper cover swivelling joint, the control end is located the outside of upper cover, the screw thread end be equipped with screw thread one side be located in the hole of stepping down towards the screw thread pipe.

6. The column chromatography adjustment mechanism of claim 5, wherein the body of the screw switch is Z-shaped, and the control end protrudes out of the upper cover toward a side facing away from the lower cover.

7. The chromatography column adjusting structure according to any one of claims 1 to 6, wherein the number of the micro-adjustment switches is two or more, and the micro-adjustment switches are circumferentially arranged on the upper cover.

8. The column chromatography adjusting structure according to claim 7, wherein the number of the screw switches is two or more, and the screw switches are circumferentially arranged on the upper cover.

9. The chromatography column adjusting structure according to claim 7, wherein the screw tube is further provided with an inner tube, a fixing nut and a sealing ring;

the screw tooth pipe is provided with a mounting hole, the mounting hole penetrates through the two opposite ends of the screw tooth pipe, the inner pipe is arranged in the mounting hole, the two opposite ends of the inner pipe extend out of the screw tooth pipe for arrangement, and the outer side wall of the inner pipe is provided with threads;

the fixing nut is matched with the threads of the inner tube, the fixing nut is arranged at one end of the inner tube, which is close to the upper cover, and the sealing ring is sleeved at the other end of the inner tube;

and one end of the inner tube, which is close to the sealing ring, is provided with an abutting part, and the sealing ring is positioned between the abutting part and the screw tooth tube.

10. A chromatography column comprising:

the column conditioning structure and tube of any one of claims 1 to 9;

one side of the lower cover, which is away from the upper cover, is connected with one end opening of the pipe body, one end of the screw thread pipe is positioned in the inner cavity of the pipe body, and the other end of the screw thread pipe protrudes out of one side of the upper cover, which is away from the lower cover.

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