CN218938636U - Objective shielding mechanism and high-content imaging system - Google Patents
Objective shielding mechanism and high-content imaging system Download PDFInfo
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- CN218938636U CN218938636U CN202223200417.1U CN202223200417U CN218938636U CN 218938636 U CN218938636 U CN 218938636U CN 202223200417 U CN202223200417 U CN 202223200417U CN 218938636 U CN218938636 U CN 218938636U
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Abstract
The embodiment of the application discloses a high content imaging system's objective shielding mechanism and high content imaging system, high content imaging system includes objective subassembly and objective table, and objective subassembly sets up in one side of objective table, and objective shielding mechanism includes shielding piece and drive arrangement, and shielding piece movably sets up in one side that the objective table is close to objective subassembly, or movably sets up in one side that the objective table is kept away from objective subassembly; the driving device is connected with the shielding piece and is used for driving the shielding piece to move, the driving device at least comprises a shielding position and an avoiding position in the process of driving the shielding piece to move, when the high-content imaging system is idle, the driving device drives the shielding piece to move to the shielding position, so that one side of the objective lens assembly, facing the objective lens assembly, is shielded, dust is prevented from falling onto the objective lens assembly, the light treatment effect of the objective lens assembly can be improved, and the accuracy of experimental data obtained through observation is improved.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to an objective shielding mechanism and a high-content imaging system.
Background
In the related technical field, in recent years, the trend of microscope technology is to automatically image biological samples, when the biological samples are automatically observed, a high-content imaging system is often used, and high-yield imaging is realized on a large number of samples without inputting control instructions by an end user.
Disclosure of Invention
The embodiment of the application provides a high connotation imaging system's objective shelter from mechanism, when aim at high connotation imaging system idle, drive shelter from one side that the objective subassembly was towards the objective table is sheltered from to the drive to prevent that the dust from falling onto the objective subassembly, and then can improve the light treatment effect of objective subassembly, in order to improve the accuracy of the experimental data that the observation obtained.
The embodiment of the application provides an objective lens shielding mechanism of a high-content imaging system, the high-content imaging system comprises an objective lens component and an objective table, the objective lens component is arranged on one side of the objective table, the objective lens shielding mechanism comprises a shielding piece and a driving device, the shielding piece is movably arranged on one side of the objective table, which is close to the objective lens component, or is movably arranged on one side of the objective table, which is far away from the objective lens component; the driving device is connected with the shielding piece and is used for driving the shielding piece to move, and the driving device at least comprises a shielding position and a avoiding position in the process of driving the shielding piece to move, and the shielding piece shields one side of the objective lens assembly, facing the objective table, in the shielding position; in the evasive position, the shield evades the side of the objective assembly that faces the stage.
Based on the embodiment, when the objective lens assembly is required to image the experimental sample, the driving device is controlled to drive the shielding piece to move to the avoiding position so as to avoid the objective lens assembly to face one side of the objective table, thereby being convenient for the objective lens assembly to process the light of the experimental sample; and when the high content imaging system is idle, the driving device can be controlled to drive the shielding piece to move from the avoiding position to the shielding position, so that one side of the objective lens assembly, which faces the objective table, is shielded, dust is prevented from falling onto the objective lens assembly, and the light treatment effect of the objective lens assembly can be improved, so that the accuracy of experimental data obtained through observation is improved.
In some of these embodiments, the drive means comprises a first drive assembly and a second drive assembly, the first drive assembly being connected to the shield; the second drive assembly is connected with one side of the shielding piece far away from the first drive assembly, and the first drive assembly is matched with the second drive assembly and used for driving the shielding piece to switch between the shielding position and the avoiding position.
Based on the embodiment, the first driving assembly and the second driving assembly are utilized to drive the shielding piece to switch between the shielding position and the avoiding position, so that the shielding piece can be conveniently moved to the avoiding position when the high-content imaging system is used, and the shielding piece is prevented from influencing the observation of the objective lens assembly on the experimental sample; and when the high content imaging system is idle, the shielding piece can be enabled to move to a shielding position so as to prevent dust from falling onto the objective lens assembly, and then the light processing effect of the objective lens assembly can be improved, so that the accuracy of experimental data obtained by observation is improved.
In some of these embodiments, the shield is a flexible shield and the first drive assembly includes a first spool and a first drive, the first spool being connected to an end of the flexible shield remote from the second drive assembly; the output shaft of the first driving member is connected with the first reel for driving the first reel to rotate around a first direction, so that the flexible shielding member can be at least partially wound to the peripheral side of the first reel, and the flexible shielding member can be moved to the avoiding position.
Based on the above embodiment, when the high content imaging system is required to be used, the first driving member can be utilized to drive the first reel to rotate around the first direction, so that at least part of the flexible shielding member is wound to the circumference side of the first reel, the flexible shielding member is enabled to move to the avoidance position, and the objective lens assembly is convenient for observing the experimental sample.
In some embodiments, the second driving assembly comprises an elastic element, the elastic element is connected with one end of the flexible shielding element away from the first scroll, when the flexible shielding element is at the avoiding position, the flexible shielding element is at least partially wound on the periphery of the first scroll, and the elastic element is in a stretching state; when the flexible shielding member is in the shielding position, the elasticity of the elastic member enables the flexible shielding member to be kept in the shielding position.
Based on the above embodiment, when the high content imaging system is required to be used, the first driving member can be utilized to drive the first scroll to rotate around the first direction so as to wind at least part of the flexible shielding member to the peripheral side of the first scroll and stretch the elastic member, so that the elastic member is elastically deformed, and the flexible shielding member is moved to the avoiding position, thereby facilitating the observation of the experimental sample by the objective lens assembly; when the high-content imaging system is idle, the first driving piece drives the first scroll to rotate around the second direction, the elastic piece guides the flexible shielding piece to move to the shielding position, and the flexible shielding piece is kept at the shielding position so as to shield one side of the objective lens assembly, which faces the objective lens assembly, and therefore dust is prevented from falling onto the objective lens assembly.
In some of these embodiments, the resilient member comprises at least one of a coil spring, a spring, and a resilient rubber strip; or the number of the elastic pieces is two, and the two elastic pieces are symmetrically arranged relative to the self motion direction of the flexible shielding piece.
Based on the above embodiment, the flexible shielding member is driven to move by the two elastic members, so that the flexible shielding member can be uniformly stressed.
In some embodiments, the flexible shielding member comprises a flexible shielding part and two flexible connecting parts, the flexible shielding part is connected with the first scroll, the two flexible connecting parts are connected with one end of the flexible shielding part far away from the first scroll, a light transmission area is arranged between the two flexible connecting parts, the second driving assembly comprises a second scroll and a second driving member, the second scroll is connected with one end of each flexible connecting part far away from the flexible shielding part, and the axis of the second scroll is parallel to the axis of the first scroll; the output shaft of the second driving piece is connected with the second scroll and is used for driving the second scroll to rotate; when the first driving piece drives the first scroll to rotate around the first direction and the second driving piece drives the second scroll to rotate around the first direction, the flexible shielding piece can be driven to move to an avoidance position, and the light-transmitting area and the objective lens component are arranged opposite to each other; when the first driving piece drives the first scroll to rotate around the second direction and the second driving piece drives the second scroll to rotate around the second direction, the flexible shielding piece can be driven to move to a shielding position, the flexible shielding part and the objective lens component are opposite to each other, and the first direction is opposite to the second direction.
Based on the embodiment, when the high content imaging system is required to be used, the first driving piece drives the first scroll to rotate around the first direction, and the second driving piece drives the second scroll to rotate around the first direction, the flexible shielding piece can be driven to move to the avoiding position, and the light transmission area is arranged opposite to the objective lens assembly, so that the objective lens assembly can observe an experimental sample conveniently; when the high-content imaging system is idle, the first driving piece drives the first scroll to rotate around the second direction, and the second driving piece drives the second scroll to rotate around the second direction, the flexible shielding piece can be driven to move to a shielding position, and the flexible shielding part and the objective lens component are opposite to each other, so that one side of the objective lens component facing the objective table is shielded.
In some of these embodiments, the drive means drives rotation of the shutter to switch the shutter between the stowed position and the blocking position.
In some embodiments, the objective shielding mechanism of the high-content imaging system further comprises a controller and two position sensors, wherein the controller is electrically connected with the driving device; the two position sensors are electrically connected with the controller and are respectively used for detecting whether the shielding piece reaches the shielding position and the avoiding position, and the controller controls the driving device to work according to detection signals of the two position sensors.
Based on the above embodiment, the two position sensors are respectively used for detecting whether the shielding member reaches the shielding position and the avoiding position, and the controller controls the driving device to work according to the detection signals of the two position sensors.
In some embodiments, the objective lens barrier mechanism of the high content imaging system further comprises two guide assemblies, each guide assembly comprising a guide rail, the length extension direction of the guide rail being parallel to the movement direction of the barrier, the barrier being disposed on the guide rail.
Based on the embodiment, the guide rail can be used for providing guidance for the movement of the shielding element, so that the driving device can conveniently drive the shielding element to move.
In a second aspect, an embodiment of the present application further provides a high content imaging system, including a condenser lens barrel, an objective table, an objective lens assembly, an objective lens shielding mechanism of the high content imaging system, and an imaging device; the objective table is arranged on the light-emitting side of the light-gathering lens cone; the objective lens component is arranged on one side of the objective table, which is away from the light gathering lens cone; the objective shielding mechanism is arranged at one side of the objective component facing the objective table; the imaging device is used for imaging the light rays processed by the objective lens assembly.
Based on the above embodiment, the shutter is driven to move to the blocking position by the driving means so that the shutter blocks the side of the objective lens assembly facing the stage, thereby preventing dust from falling onto the objective lens assembly.
The objective shielding mechanism of the high-content imaging system comprises an objective assembly, wherein the objective shielding mechanism comprises a shielding piece and a driving device, and the shielding piece is movably arranged on one side of the objective table close to the objective assembly or on one side of the objective table far away from the objective assembly; the driving device is connected with the shielding piece and is used for driving the shielding piece to move, and the driving device at least comprises a shielding position and a avoiding position in the process of driving the shielding piece to move, and the shielding piece shields one side of the objective lens assembly, facing the objective table, in the shielding position; when the objective lens assembly is required to be used for carrying out light treatment on the experimental sample, the driving device is controlled to drive the shielding piece to move to the avoiding position so as to avoid the objective lens assembly to face one side of the objective lens assembly, and therefore the objective lens assembly is convenient for carrying out light treatment on the experimental sample; and when the high content imaging system is idle, the driving device can be controlled to drive the shielding piece to move from the avoiding position to the shielding position, thereby realizing shielding of one side of the objective lens component facing the objective table, preventing dust from falling onto the objective lens component, and further improving the light treatment effect of the objective lens component so as to improve the accuracy of experimental data obtained by observation.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a high content imaging system in one embodiment of the present application;
FIG. 2 is a schematic view of an objective lens shielding mechanism according to an embodiment of the present application, with a shielding member in a shielding position;
FIG. 3 is a schematic view of an objective lens shielding mechanism according to an embodiment of the present application, with a shielding member in an retracted position;
fig. 4 is a schematic view of an objective lens shielding mechanism according to still another embodiment of the present application, where the shielding member is in the retracted position.
Reference numerals: 1. an objective shielding mechanism; 11. a shield; 111. a flexible shielding portion; 112. a flexible connection portion; 113. a light-transmitting region; 12. a driving device; 121. a first drive assembly; 1211. a first reel; 1212. a first driving member; 122. a second drive assembly; 1221. an elastic member; 1222. a second reel; 1223. a second driving member; 13. a position sensor; 14. a guide assembly; 141. a guide rail; 2. a high content imaging system; 21. a condenser tube; 22. an objective table; 23. an objective lens assembly; A. a first direction; B. a second direction.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.
Referring to fig. 1, an embodiment of the present application provides a high-content imaging system 2, which includes a condenser lens barrel 21, a stage 22, an objective lens assembly 23, and an imaging device (not shown). In a specific embodiment, stage 22 is disposed on the light-emitting side of condenser tube 21; the objective lens assembly 23 is arranged on one side of the objective table 22 away from the condenser lens cone 21; the imaging device is arranged on the light emitting side of the objective lens assembly 23, when the experimental sample on the objective table 22 is observed, the light collecting lens barrel 21 illuminates the experimental sample, the objective lens assembly 23 captures the light emitted by the experimental sample through the objective table 22 and processes the light, and the imaging device images the processed light, so that the image data of the experimental sample are obtained.
Referring to fig. 1-3, an objective lens shielding mechanism 1 of a high-content imaging system is provided, wherein the objective lens shielding mechanism 1 comprises a shielding member 11 and a driving device 12, and the shielding member 11 is movably arranged on one side of a stage 22 close to an objective lens assembly 23; the driving device 12 is connected with the shielding element 11 and is used for driving the shielding element 11 to move, and the driving device 12 at least comprises a shielding position and an avoiding position in the process of driving the shielding element 11 to move, wherein the shielding element 11 shields one side of the objective lens assembly 23, which faces the objective table 22; in the retracted position, the shield 11 is retracted to the side of the objective assembly 23 facing the stage 22.
The shielding member 11 is arranged on one side of the objective table 22 close to the objective lens assembly 23, and can shield one side of the objective lens assembly 23 facing the objective table 22 when the high content imaging system 2 is idle so as to prevent dust from falling onto the objective lens assembly 23; the objective lens assembly 23 can be avoided towards one side of the objective table 22 when the high content imaging system 2 is required to be used, so that the objective lens assembly 23 can process light rays of an experimental sample conveniently.
The driving device 12 is used for driving the shielding piece 11 to move so that the shielding piece 11 can be switched between an avoidance position and a shielding position, and the shielding device is convenient and quick.
When the objective lens assembly 23 is required to process the light of the experimental sample, the driving device 12 is controlled to drive the shielding piece 11 to move to the avoiding position so as to avoid the side of the objective lens assembly 23 facing the objective table 22, thereby facilitating the objective lens assembly 23 to process the light of the experimental sample; and when the high content imaging system 2 is idle, the driving device 12 can be controlled to drive the shielding piece 11 to move from the avoiding position to the shielding position, thereby shielding the objective lens assembly 23 towards one side of the objective table 22, preventing dust from falling onto the objective lens assembly 23, and further improving the light treatment effect of the objective lens assembly 23 so as to improve the accuracy of experimental data.
It will be appreciated that in a particular embodiment, the shield 11 can also be movably disposed on the side of the stage 22 remote from the objective assembly 23, thereby shielding the viewing window of the stage 22 on the side of the stage 22 remote from the objective assembly 23, and thereby preventing dust from falling onto the objective assembly 23 through the viewing window of the stage 22, as well as improving the accuracy of experimental data.
Referring to fig. 1-3, in a specific embodiment, the driving device 12 includes a first driving assembly 121 and a second driving assembly 122, where the first driving assembly 121 is connected to the shielding member 11; the second driving component 122 is connected with one side of the shielding element 11 far away from the first driving component 121, and the first driving component 121 is matched with the second driving component 122 and used for driving the shielding element 11 to switch between a shielding position and an avoiding position, so that the shielding element 11 can be conveniently moved to the avoiding position when the high content imaging system 2 is used, and the shielding element 11 is prevented from influencing the objective lens component 23 to process light rays of an experimental sample; and when the high content imaging system 2 is idle, the shielding piece 11 can be enabled to move to a shielding position so as to prevent dust from falling onto the objective lens assembly 23, and then the effect of the objective lens assembly 23 on light treatment of experimental samples can be improved, so that the accuracy of experimental data is improved.
Referring to fig. 1 and 2, in a specific embodiment, the shielding member 11 is a flexible shielding member 11, the first driving assembly 121 includes a first reel 1211 and a first driving member 1212, and the first reel 1211 is connected to an end of the flexible shielding member 11 away from the second driving assembly 122; the output shaft of the first driver 1212 is coupled to the first reel 1211 for driving the first reel 1211 to rotate about the first direction a so that the flexible shutter 11 can be at least partially wound around the first reel 1211 and so that the flexible shutter 11 can be moved to the retracted position, and when the high content imaging system 2 is desired to be used, the first reel 1211 can be driven to rotate about the first direction a by the first driver 1212 so that at least a portion of the flexible shutter 11 can be wound around the first reel 1211 so that the flexible shutter 11 can be moved to the retracted position so that the objective lens assembly 23 can process light from the experimental sample. The material of the flexible shielding element 11 may be, but is not limited to, rubber or flexible plastic, and the transparency of the flexible shielding element 11 is not limited in this embodiment; the first spool 1211 may be made of metal or plastic, and the first driver 1212 may be a motor or a rotary cylinder. In the embodiment of the present application, the material of the first reel 1211 is not limited, and the specific embodiment of the first driving element 1212 is not limited, and the first reel 1211 can be driven to rotate.
Referring to fig. 1 and 2, specifically, the first driving element 1212 may be a motor, the motor is connected with the frame of the high content imaging system 2 through a mounting plate by a bolt, a motor shaft is fixedly connected with one end of the first reel 1211 coaxially through a coupling, one end of the first reel 1211 far away from the motor is rotatably connected with a bearing seat, and the bearing seat is fixedly connected with the frame, so that the motor is utilized to drive the first reel 1211 to rotate through the coupling to wind the flexible shielding plate 11. The motor, the coupler and the bearing seat can be selected according to actual use requirements.
Referring to fig. 1-3, in a specific embodiment, the second driving assembly 122 includes an elastic member 1221, the elastic member 1221 is connected to an end of the flexible shielding member 11 away from the first reel 1211, when the flexible shielding member 11 is in the retracted position, the flexible shielding member 11 is at least partially wound around the circumference of the first reel 1211, and the elastic member 1221 is in a stretched state; when the flexible shielding member 11 is in the shielding position, the elasticity of the elastic member 1221 enables the flexible shielding member 11 to be kept in the shielding position, and when the high content imaging system 2 is required to be used, the first driving member 1212 can be utilized to drive the first scroll 1211 to rotate around the first direction A so as to wind at least part of the flexible shielding member 11 to the periphery of the first scroll 1211, the elastic member 1221 is enabled to generate elastic deformation, and the flexible shielding member 11 is enabled to move to the avoiding position, so that the objective lens assembly 23 is convenient for processing the light rays of the experimental sample; while the high content imaging system 2 is idle, the first driver 1212 drives the first reel 1211 to rotate about the second direction B, and the resilient member 1221 guides the flexible shutter 11 to the shutter position, and the resilient member 1221 is still in tension, so that the flexible shutter 11 is held in the shutter position to block the side of the objective lens assembly 23 facing the stage 22, thereby preventing dust from falling onto the objective lens assembly 23. Wherein the resilient member 1221 may be, but is not limited to, a coil spring, a spring or a resilient rubber strip. Wherein the first direction a is opposite to the second direction B.
Referring to fig. 1-3, in a specific embodiment, the second driving assembly 122 may include a plurality of elastic members 1221, where the plurality of elastic members 1221 are connected to an end of the flexible shielding member 11 away from the first reel 1211, so as to make the movement state of the flexible shielding member 11 more stable. In this embodiment of the present application, the second driving element may include two elastic elements 1221, where the two elastic elements 1221 are symmetrically disposed about a central axis of the flexible shielding element 11 parallel to the self movement direction, so that the flexible shielding element 11 is stressed uniformly, and when the first driving element 1212 drives the first reel 1211 to rotate about the second direction B, the flexible shielding element 11 is wound, so that the rated power of the first driving element 1212 can be reduced, so as to reduce the development cost.
Referring to fig. 1 and 4, in still another specific embodiment, the flexible shielding member 11 includes a flexible shielding portion 111 and two flexible connection portions 112, the flexible shielding portion 111 is connected to a first reel 1211, the two flexible connection portions 112 are connected to an end of the flexible shielding portion 111 away from the first reel 1211, a light-transmitting area 113 is disposed between the two flexible connection portions 112, the second driving assembly 122 may include a second reel 1222 and a second driving member 1223, the second reel 1222 is connected to an end of each flexible connection portion 112 away from the flexible shielding portion 111, and an axis of the second reel 1222 is parallel to an axis of the first reel 1211; the output shaft of the second driving member 1223 is connected to the second reel 1222 for driving the second reel 1222 to rotate; when the high content imaging system 2 is required to be used, the first driving piece 1212 drives the first scroll 1211 to rotate around the first direction a, and the second driving piece 1223 drives the second scroll 1222 to rotate around the first direction a, so that the flexible shielding piece 11 can be driven to move to the avoiding position, and the light transmission area 113 and the objective lens assembly 23 are arranged opposite to each other, so that the objective lens assembly 23 can conveniently obtain light of the experimental sample from the light transmission area 113; when the first driving member 1212 drives the first reel 1211 to rotate around the second direction B and the second driving member 1223 drives the second reel 1222 to rotate around the second direction B, the flexible shielding member 11 is driven to move to the shielding position, and the flexible shielding portion 111 is disposed opposite to the objective lens assembly 23, so as to shield one side of the objective lens assembly 23 facing the objective table 22, and further prevent dust from falling onto the objective lens assembly 23.
It will be appreciated that in one particular embodiment, when the flexible shutter 11 is moved to the retracted position, the objective lens assembly 23 is able to pass through the light-transmitting region 113 to move in a direction toward the stage 22, thereby effecting positional adjustment of the objective lens assembly 23 so that the objective lens assembly 23 captures light from the experimental sample at the corresponding position.
It will be appreciated that in a particular embodiment, the driving means 12 can drive the shutter 11 to rotate, for example, the object side of the objective lens assembly 23 has a rotation plane, and the rotation plane is perpendicular to the optical axis of the objective lens assembly 23, one surface of the shutter 11 is located in the rotation plane, the driving means 12 can drive the shutter 11 to rotate in the rotation plane, the rotation axis of the shutter 11 is parallel to the optical axis of the objective lens assembly 23, and the shutter 11 has at least a blocking position in which the objective lens assembly 23 faces the object stage 22 and a dodging position in which the objective lens assembly 23 is dodged toward the object stage 22 during rotation of the shutter 11 by the driving means 12. It will be appreciated that the driving device 12 may also drive the shielding member 11 to rotate, and the rotation axis of the shielding member 11 is located in a different plane with the optical axis of the objective lens assembly 23 and perpendicular to the optical axis of the objective lens assembly 23, the driving device 12 may drive the shielding member 11 to rotate to the avoiding position so that the objective lens assembly 23 processes the light of the experimental sample, and the driving device 12 may drive the shielding member 11 to rotate to the shielding position so as to prevent dust from falling onto the objective lens assembly 23, thereby improving the accuracy of the objective lens assembly 23 in processing the light of the experimental sample, and further improving the accuracy of the experimental data. Of course, the driving device 12 can also drive the shielding member 11 to rotate in other forms, which is not described in detail in the embodiment of the present application, only when the high content imaging system 2 is used, the shielding member 11 can avoid the side of the objective lens assembly 23 facing the objective table 22, and when the high content imaging system 2 is idle, the shielding member 11 can shield the side of the objective lens assembly 23 facing the objective table 22.
It will be appreciated that the driving device 12 may also drive the shielding member 11 in a more complex movement form, and in this embodiment, the specific form in which the driving device 12 drives the shielding member 11 to move is not limited, and may be reasonably designed according to the internal space of the high-content imaging system 2 to meet the use requirement.
In a specific embodiment, the driving device 12 drives the flexible shielding member 11 to move in a winding manner, so that the flexible shielding member 11 can move in a rotating manner in comparison with the internal space of the high content imaging system 2 occupied by switching between the shielding position and the avoiding position, and the internal space of the high content imaging system 2 occupied by switching between the shielding position and the avoiding position of the flexible shielding member 11 can be smaller, so that the occupation of the internal space of the high content imaging system 2 can be reduced, and the development trend of miniaturization of the high content imaging system 2 can be met.
In a specific embodiment, the objective shielding mechanism 1 of the high content imaging system 2 further includes a controller (not shown in the figure) and two position sensors 13, where the controller is electrically connected to the driving device 12; the two position sensors 13 are electrically connected with the controller, and are respectively used for detecting whether the shielding piece 11 reaches the shielding position and the avoiding position, and the controller controls the driving device 12 to work according to detection signals of the two position sensors 13. The position sensor 13 may be, but not limited to, a reflective photoelectric sensor, an opposite-type photoelectric sensor, or a distance sensor, and the controller may be an internal controller of the high content imaging system 2, or may be a dedicated controller of the position sensor 13.
Referring to fig. 1-3, in a specific embodiment, the objective lens shielding mechanism 1 of the high-content imaging system 2 further includes two guide assemblies 14, each guide assembly 14 includes a guide rail 141, a guide groove is formed on a surface of the guide rail 141 facing the stage 22, the flexible connection portion 112 is at least partially disposed in the guide groove, one end of the flexible connection portion 112 located in the guide groove is connected with the flexible shielding portion 111, one component of the direction of the elastic member 1221 applying force to the flexible connection portion 112 is parallel to the bottom of the guide groove, and the other component faces the objective lens object 23, so that the flexible connection portion 112 is attached to the bottom of the guide groove, to prevent the flexible connection portion 112 from being separated from the guide groove, and then the guide groove can be used to provide guidance for the movement of the flexible shielding portion 111, so as to ensure that the shielding member 11 is stably switched between the shielding position and the avoiding position.
It will be appreciated that other components of the high content imaging system 2 disposed between the objective lens assembly 23 and the stage 22 may also be utilized to interface with the shield 11 and/or the rail 141, thereby further limiting the direction of movement of the shield 11 and preventing the flexible connection 112 from exiting the guide slot.
It will be appreciated that each guide assembly 14 may also comprise a guide rail 141 and a slider (not shown) the length of the guide rail 141 extending parallel to the direction of movement of the shutter 11; the sliding block is slidably connected with the guide rail 141 and is connected with the shielding element 11, and by means of the cooperation between the sliding block and the guide rail 141, guidance can be provided for the movement of the shielding element 11, so that the driving device 12 can conveniently drive the shielding element 11 to move. Specifically, the materials of the guide rail 141 and the slider may be metal, so as to increase the structural stability of the guide rail 141 and the slider, and prolong the service lives of the guide rail 141 and the slider, so as to ensure that the shielding member 11 is stably switched between the shielding position and the avoiding position.
The same or similar reference numerals in the drawings of the present embodiment correspond to the same or similar components; in the description of the present application, it should be understood that, if there is an azimuth or positional relationship indicated by terms such as "upper", "lower", "left", "right", etc., based on the azimuth or positional relationship shown in the drawings, this is for convenience of description and simplification of the description, but does not indicate or imply that the apparatus or element to be referred must have a specific azimuth, be constructed and operated in a specific azimuth, and thus terms describing the positional relationship in the drawings are merely used for illustration and are not to be construed as limitations of the present patent, and that the specific meaning of the terms described above may be understood by those of ordinary skill in the art according to the specific circumstances.
The foregoing description of the preferred embodiment of the present utility model is not intended to limit the utility model to the particular form disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the utility model.
Claims (10)
1. High connotation imaging system's objective shielding mechanism, a serial communication port, high connotation imaging system includes objective subassembly and objective table, objective subassembly set up in one side of objective table, objective shielding mechanism includes:
a shielding member movably arranged on one side of the objective table close to the objective lens assembly or on one side of the objective table far from the objective lens assembly;
the driving device is connected with the shielding piece and is used for driving the shielding piece to move, and the driving device at least comprises a shielding position and an avoiding position in the process of driving the shielding piece to move, and the shielding piece shields one side, facing the objective lens assembly, of the objective table in the shielding position; when the shielding piece is at the avoiding position, the shielding piece avoids the side, facing the objective lens assembly, of the objective table.
2. The objective lens blocking mechanism according to claim 1, wherein the driving means includes:
a first drive assembly connected to the shield;
the second driving assembly is connected with one side, far away from the first driving assembly, of the shielding piece, and the first driving assembly is matched with the second driving assembly and used for driving the shielding piece to be switched between the shielding position and the avoiding position.
3. The objective lens barrier mechanism of claim 2, wherein the barrier is a flexible barrier, and the first drive assembly comprises:
a first reel connected to one end of the flexible shield remote from the second drive assembly;
the output shaft of the first driving piece is connected with the first scroll and used for driving the first scroll to rotate around a first direction, so that the flexible shielding piece can be at least partially wound to the periphery of the first scroll and can be moved to the avoiding position.
4. An objective lens barrier mechanism as recited in claim 3, wherein the second drive assembly includes:
the elastic piece is connected with one end, far away from the first scroll, of the flexible shielding piece, and is in a stretching state when at least the flexible shielding piece is in the avoidance position; the elasticity of the elastic member causes the flexible shutter to be held in the shielding position when the flexible shutter is in the shielding position.
5. The objective lens barrier mechanism of claim 4, wherein the elastic member comprises at least one of a coil spring, a spring, and an elastic rubber strip; or alternatively
The number of the elastic pieces is two, and the two elastic pieces are symmetrically arranged relative to the central axis of the flexible shielding piece, which is parallel to the self motion direction.
6. An objective lens barrier mechanism as recited in claim 3, wherein the flexible barrier includes a flexible barrier portion and two flexible connection portions, the flexible barrier portion being connected to the first spool, both of the flexible connection portions being connected to an end of the flexible barrier portion remote from the first spool, and there being a light transmissive region between the two flexible connection portions, the second drive assembly comprising:
the second scroll is connected with one end of each flexible connecting part far away from the flexible shielding part, and the axis of the second scroll is parallel to the axis of the first scroll;
the output shaft of the second driving piece is connected with the second scroll and is used for driving the second scroll to rotate;
the first driving piece drives the first scroll to rotate around the first direction, and the second driving piece drives the second scroll to rotate around the first direction, so that the flexible shielding piece can be driven to move to the avoiding position, and the light-transmitting area and the objective lens component are arranged opposite to each other; the first driving piece drives the first scroll to rotate around the second direction, and the second driving piece drives the second scroll to rotate around the second direction, so that the flexible shielding piece can be driven to move to the shielding position, the flexible shielding part and the objective lens component are opposite to each other, and the first direction is opposite to the second direction.
7. An objective lens barrier mechanism as claimed in claim 1, wherein the drive means drives the shutter in rotation to switch the shutter between the retracted position and the blocking position.
8. The objective lens blocking mechanism of claim 1, further comprising:
the controller is electrically connected with the driving device;
the two position sensors are electrically connected with the controller and are respectively used for detecting whether the shielding piece reaches the shielding position and the avoiding position, and the controller controls the driving device to work according to detection signals of the two position sensors.
9. The objective lens barrier mechanism of any one of claims 1 to 8, further comprising two guide assemblies, each guide assembly comprising:
the length extension direction of the guide rail is parallel to the movement direction of the shielding piece, and the shielding piece is arranged on the guide rail.
10. A high content imaging system, comprising:
a condenser tube;
a stage provided on the light-emitting side of the condenser tube;
the objective lens component is arranged on one side of the objective table, which is away from the light gathering lens cone;
the objective lens blocking mechanism according to any one of claims 1 to 9, which is provided on a side of the objective lens assembly facing the stage;
imaging means for imaging the light rays after processing via the objective lens assembly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223200417.1U CN218938636U (en) | 2022-11-30 | 2022-11-30 | Objective shielding mechanism and high-content imaging system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223200417.1U CN218938636U (en) | 2022-11-30 | 2022-11-30 | Objective shielding mechanism and high-content imaging system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218938636U true CN218938636U (en) | 2023-04-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223200417.1U Active CN218938636U (en) | 2022-11-30 | 2022-11-30 | Objective shielding mechanism and high-content imaging system |
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| Country | Link |
|---|---|
| CN (1) | CN218938636U (en) |
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2022
- 2022-11-30 CN CN202223200417.1U patent/CN218938636U/en active Active
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