CN218917123U

CN218917123U - Blood sample analyzer and optical detection device

Info

Publication number: CN218917123U
Application number: CN202221741494.5U
Authority: CN
Inventors: 刘杨赞; 汪东生
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2022-07-06
Filing date: 2022-07-06
Publication date: 2023-04-25
Anticipated expiration: 2032-07-06

Abstract

The utility model is suitable for the field of medical instruments and discloses a blood sample analyzer and an optical detection device. The blood sample analyzer comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller; the optical detection device comprises a flow chamber, a front light component, a light shaping component and a light receiving component, wherein the light shaping component comprises a first condensing lens and a reflecting mirror, and the first condensing lens is at least used for converging first scattered light and second scattered light generated by the irradiation of the front light component to particles; the reflector is provided with a first light-transmitting part and a first reflecting part, the light receiving assembly comprises a first detector and a second detector, the first detector is used for receiving light which is formed by converging first scattered light through a first condensing lens and transmitting the first light-transmitting part, and the second detector is used for receiving light which is formed by converging second scattered light through the first condensing lens and reflecting the first reflecting part. The optical detection device has simple structure and low cost.

Description

Blood sample analyzer and optical detection device

Technical Field

The utility model relates to the field of medical instruments, in particular to a blood sample analyzer and an optical detection device.

Background

The related art provides a blood sample analyzer, which adopts the following laser scattering principle to measure the particle parameters of a blood sample: particles in a sample obtained by treating a blood sample with a reagent pass through a flow chamber one by one under the action of fluid mechanics, form a scattering signal under the irradiation of laser, emit scattered light to the whole space, and a photoelectric conversion sensor receives the scattered light to acquire particle information. Different scattered light collection angles correspond to different information of the particle. In the related art, a detector is generally adopted to collect scattered light in three angle ranges of small-angle forward scattered light, medium-angle forward scattered light and large-angle forward scattered light, and the scattered light is not converged, and the angle diaphragm is directly used for restraining and receiving the scattered light, so that the following defects exist in the specific application of the blood sample analyzer: the quality of the optical signals collected by the detector is poor, and the scattered light needs to be received by using the detector with a large target surface, so that the problems of poor detection signals, large volume and high cost of the detector provided by the related technology are common.

Disclosure of Invention

A first object of the present utility model is to provide a blood sample analyzer, which aims to solve the technical problems of large size and high cost of a large target surface detector for receiving scattered light in different angle ranges in the related art.

In order to achieve the first object, the present utility model provides the following solutions: a blood sample analyzer, comprising a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

wherein the sample distribution device is used for collecting a blood sample from a sample container and distributing at least part of the collected blood sample to the reaction tank;

the reagent distributing device is used for distributing reagent to the reaction tank;

the reaction tank is used for providing a reaction field for the blood sample and the reagent so as to prepare a sample;

the sample conveying device is used for driving the sample to be conveyed from the reaction cell to the optical detection device;

the optical detection device comprises a flow chamber, a front light component, a light shaping component and a light receiving component, wherein the flow chamber is used for receiving the sample conveyed by the sample conveying device so as to enable particles of the sample to be queued to pass through under the wrapping of sheath liquid, and the front light component is used for irradiating light rays towards the flow chamber;

The light shaping assembly comprises a first condensing lens and a reflecting mirror, wherein the first condensing lens is at least used for converging first scattered light rays which are generated by the front light assembly and irradiated to the particles in a first angle range and second scattered light rays which are generated by the front light assembly and irradiated to the particles in a second angle range, and each angle of the first angle range is smaller than each angle of the second angle range;

the body of the reflector is provided with a first light transmission part and a first reflection part, the first light transmission part is used for transmitting light formed by converging the first scattered light through the first condensing lens, and the first reflection part is used for reflecting light formed by converging the second scattered light through the first condensing lens;

the light receiving assembly comprises a first detector and a second detector, the first detector is used for receiving light rays which are formed by the first scattered light rays which are converged by the first condensing lens and penetrate through the first light transmitting part, and the second detector is used for receiving light rays which are formed by the second scattered light rays which are converged by the first condensing lens and reflected by the first reflecting part;

The controller is used for analyzing and obtaining a measurement result of the blood sample at least according to the feedback information of the first detector and the second detector.

As an implementation manner, the first condensing lens is further used for converging third scattered light which is generated by the irradiation of the front light component to the particles and is in a third angle range, the body of the reflecting mirror is further provided with a second reflecting part, the second reflecting part is used for reflecting the light which is formed by converging the third scattered light through the first condensing lens, and each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range;

the light receiving assembly further comprises a third detector, wherein the third detector is used for receiving light rays which are formed by the third scattered light rays through the first condensing lens in a converging mode and reflected by the second reflecting part;

the controller is also used for analyzing and obtaining a measurement result of the blood sample according to the feedback information of the first detector, the second detector and the third detector.

As an implementation manner, the first condensing lens is further configured to collect third scattered light generated by the particle irradiated by the front light component and within a third angle range, and the body of the reflector is further provided with a second light-transmitting portion, where the second light-transmitting portion is configured to transmit light formed by the third scattered light after being collected by the first condensing lens, and each angle of the third angle range is greater than each angle of the first angle range and is smaller than each angle of the second angle range;

The light receiving assembly further comprises a third detector, wherein the third detector is used for receiving light which is formed by the third scattered light, converged by the first condensing lens and transmitted through the second light transmitting part;

As one embodiment, each angle of the first angular range is greater than 0 ° and less than 10 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than 20 ° and less than or equal to 70 °.

As one embodiment, each angle of the first angle range is greater than or equal to 1 ° and less than or equal to 5 °, each angle of the third angle range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angle range is greater than or equal to 22 ° and less than or equal to 43 °.

As an implementation mode, the light shaping assembly further comprises a first diaphragm, the first diaphragm is arranged between the first condensing lens and the reflecting mirror along the optical axis of the light emitted by the front light assembly, the first diaphragm is provided with a first straight blocking part, a first through hole, a second through hole and a third through hole, the first straight blocking part is at least used for blocking the light irradiated to the particles by the front light assembly and penetrating the particles and the first condensing lens directly, the first through hole is used for allowing the light formed by the first scattered light after passing through the first condensing lens to pass through, the second through hole is used for allowing the light formed by the second scattered light after passing through the first condensing lens to pass through, and the third through hole is used for allowing the light formed by the third scattered light after passing through the third condensing lens to pass through.

As an implementation manner, the second through hole and the third through hole are respectively arranged at two opposite sides of the first straight blocking part, and the distance from the third through hole to the center of the first diaphragm is greater than the distance from the first through hole to the center of the first diaphragm and is smaller than the distance from the second through hole to the center of the first diaphragm; and/or the number of the groups of groups,

the number of the first through holes is two, and the two first through holes are respectively arranged on two opposite sides of the first straight blocking part.

As one embodiment, the first condensing lens is configured to condense the first scattered light, the second scattered light, and the third scattered light into light gradually converging toward the optical axis; and/or the number of the groups of groups,

at least one of the incident surface and the emergent surface of the first condensing lens is an aspheric surface.

As one embodiment, the light shaping assembly further includes a second condenser lens disposed between the reflecting mirror and the second detector and between the reflecting mirror and the third detector along a propagation path of the light reflected by the reflecting mirror, the second condenser lens being configured to converge and irradiate the light reflected by the first reflecting portion to the second detector and to converge and irradiate the light reflected by the second reflecting portion to the third detector;

Wherein, preferably, the second condensing lens is a cylindrical lens.

As one embodiment, the light shaping assembly further includes a second diaphragm and a third diaphragm, the second diaphragm is disposed between the reflector and the first detector along an optical axis of the light emitted by the front light assembly, the second diaphragm is provided with a second straight blocking portion and a fourth through hole, the second straight blocking portion is at least used for blocking the light irradiated to the particle by the front light assembly and passing through the particle and the first condensing lens, and the fourth through hole is used for allowing the light formed by the first scattered light after passing through the first condensing lens and passing through the first light transmitting portion to pass through;

the third diaphragm is arranged between the reflector and the second detector along the propagation path of the light reflected by the reflector and between the reflector and the third detector, the third diaphragm is provided with a fifth through hole and a sixth through hole, the fifth through hole is used for allowing the light which is formed by the second scattered light after being converged by the first condensing lens and reflected by the first reflecting part to pass through, and the sixth through hole is used for allowing the light which is formed by the third scattered light after being converged by the first condensing lens and reflected by the second reflecting part to pass through.

As one embodiment, the light shaping assembly further includes a third condenser lens and a fourth condenser lens, the third condenser lens is disposed between the second diaphragm and the first detector along an optical axis of the light emitted by the front light assembly, and the third condenser lens is configured to converge and irradiate the light transmitted through the first light transmitting portion to the first detector;

the fourth condensing lens is arranged between the third diaphragm and the second detector and between the third diaphragm and the third detector along the propagation path of the light reflected by the reflecting mirror, and is used for converging and irradiating the light reflected by the first reflecting part to the second detector and converging and irradiating the light reflected by the second reflecting part to the third detector.

As one embodiment, the controller is configured to analyze and obtain a white particle classification count value of the blood sample based at least on feedback information from the first detector, the second detector, and the third detector.

A second object of the present utility model is to provide a blood sample analyzer comprising a sample distribution device, a reagent distribution device, a reaction cell, a sample delivery device, an optical detection device, and a controller;

the reaction tank is used for providing a reaction field for a blood sample and a reagent so as to prepare a sample;

the light shaping assembly comprises a first condensing lens and a reflecting mirror, wherein the first condensing lens is at least used for converging first scattered light rays which are generated by the front light assembly and irradiated to the particles in a first angle range and third scattered light rays which are generated by the front light assembly and irradiated to the particles in a third angle range, each angle of the first angle range is larger than 0 DEG and smaller than 10 DEG, and each angle of the third angle range is larger than or equal to 10 DEG and smaller than or equal to 20 DEG;

The body of the reflector is provided with a first light transmission part and a second reflection part, the first light transmission part is used for transmitting light formed by converging the first scattered light through the first condensing lens, and the second reflection part is used for reflecting light formed by converging the third scattered light through the first condensing lens;

the light receiving assembly comprises a first detector and a third detector, the first detector is used for receiving light rays which are formed by the first scattered light rays which are converged by the first condensing lens and penetrate through the first light transmitting part, and the third detector is used for receiving light rays which are formed by the third scattered light rays which are converged by the first condensing lens and reflected by the second reflecting part;

the controller is used for analyzing and obtaining a measurement result of the blood sample at least according to the feedback information of the first detector and the third detector.

A third object of the present utility model is to provide a blood sample analyzer comprising a sample distribution device, a reagent distribution device, a reaction cell, a sample delivery device, an optical detection device, and a controller;

the light shaping assembly comprises a first condensing lens and a reflecting mirror, wherein the first condensing lens is at least used for converging first scattered light rays which are generated by the front light assembly and irradiated to the particles within a first angle range and second scattered light rays which are generated by the front light assembly and irradiated to the particles within a second angle range, each angle of the first angle range is larger than 0 DEG and smaller than 10 DEG, and each angle of the second angle range is larger than 20 DEG and smaller than or equal to 70 DEG;

the body of the reflector is provided with a third light transmission part and a third reflection part, the third light transmission part is used for transmitting light rays formed by converging the second scattered light rays through the first condensing lens, and the third reflection part is used for reflecting light rays formed by converging the first scattered light rays through the first condensing lens;

The light receiving assembly comprises a first detector and a second detector, the first detector is used for receiving light rays which are formed by the first scattered light rays which are converged by the first condensing lens and reflected by the third reflecting part, and the second detector is used for receiving light rays which are formed by the second scattered light rays which are converged by the first condensing lens and transmitted through the third light transmitting part;

As an embodiment, the first condensing lens is further configured to condense third scattered light generated by the front light component irradiating the particles and within a third angle range, each angle of the third angle range is greater than each angle of the first angle range and is smaller than each angle of the second angle range, a second reflecting portion is further disposed on the body of the reflecting mirror, the second reflecting portion is configured to reflect light formed by condensing the third scattered light through the first condensing lens, the light receiving component further includes a third detector, the third detector is configured to receive light formed by condensing the third scattered light through the first condensing lens and reflecting by the second reflecting portion, and the controller is configured to parse a measurement result of a blood sample according to feedback information of the first detector, the second detector and the third detector; or alternatively, the process may be performed,

The first condensing lens is further used for converging third scattered light which is generated by the particles and irradiated by the front light component and is in a third angle range, each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range, the body of the reflecting mirror is further provided with a second light transmitting part, the second light transmitting part is used for allowing the light which is formed by the third scattered light after being converged by the first condensing lens to penetrate through, the light receiving component further comprises a third detector, the third detector is used for receiving the light which is formed by the third scattered light after being converged by the first condensing lens and penetrating through the second light transmitting part, and the controller is used for obtaining a measurement result of a blood sample according to feedback information of the first detector, the second detector and the third detector.

A fourth object of the present utility model is to provide a blood sample analyzer comprising a sample distribution device, a reagent distribution device, a reaction cell, a sample delivery device, an optical detection device, and a controller;

the light shaping assembly comprises a first condensing lens and a reflecting mirror, wherein the first condensing lens is used for converging first scattered light rays which are generated by the front light assembly and irradiated to the particles in a first angle range, second scattered light rays which are generated by the front light assembly and irradiated to the particles in a second angle range and third scattered light rays which are generated by the front light assembly and irradiated to the particles in a third angle range, each angle of the first angle range is smaller than each angle of the second angle range, and each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range;

The body of the reflector is provided with a first light transmission part, a third light transmission part and a second reflection part, wherein the first light transmission part is used for transmitting light rays formed by converging the first scattered light rays through the first condensing lens, the third light transmission part is used for transmitting light rays formed by converging the second scattered light rays through the first condensing lens, and the second reflection part is used for reflecting light rays formed by converging the third scattered light rays through the first condensing lens;

the light receiving assembly comprises a first detector, a second detector and a third detector, wherein the first detector is used for receiving light rays formed by the first scattered light rays which are converged by the first condensing lens and penetrate through the first light transmitting part, the second detector is used for receiving light rays formed by the second scattered light rays which are converged by the first condensing lens and penetrate through the third light transmitting part, and the third detector is used for receiving light rays formed by the third scattered light rays which are converged by the first condensing lens and reflected by the second reflecting part;

the controller is used for analyzing and obtaining a measurement result of the blood sample according to feedback information of the first detector, the second detector and the third detector.

A fifth object of the present utility model is to provide a blood sample analyzer comprising a sample distribution device, a reagent distribution device, a reaction cell, a sample delivery device, an optical detection device, and a controller;

The body of the reflector is provided with a first reflecting part, a third reflecting part and a second light transmitting part, the third reflecting part is used for reflecting light rays formed by converging the first scattered light rays through the first condensing lens, the first reflecting part is used for reflecting light rays formed by converging the second scattered light rays through the first condensing lens, and the second light transmitting part is used for transmitting the light rays formed by converging the third scattered light rays through the first condensing lens;

the light receiving assembly comprises a first detector, a second detector and a third detector, wherein the first detector is used for receiving light rays formed by the first scattered light rays which are converged by the first condensing lens and reflected by the third reflecting part, the second detector is used for receiving light rays formed by the second scattered light rays which are converged by the first condensing lens and reflected by the first reflecting part, and the third detector is used for receiving light rays formed by the third scattered light rays which are converged by the first condensing lens and transmitted through the second light transmitting part;

A sixth object of the present utility model is to provide a blood sample analyzer comprising a sample distribution device, a reagent distribution device, a reaction cell, a sample transport device, an optical detection device, and a controller;

the light shaping assembly comprises a first condensing lens and a first diaphragm, the first condensing lens is arranged between the flow chamber and the first diaphragm along an optical axis of light emitted by the front light assembly, the first condensing lens is used for converging first scattered light generated by the front light assembly when the front light assembly irradiates the particles and within a first angle range, second scattered light generated by the front light assembly when the front light assembly irradiates the particles and within a second angle range, and third scattered light generated by the front light assembly when the front light assembly irradiates the particles and within a third angle range, each angle of the first angle range is smaller than each angle of the second angle range, and each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range;

The first diaphragm is provided with a first straight blocking part, a first through hole, a second through hole and a third through hole, the first straight blocking part is at least used for absorbing the light which is irradiated to the particles by the front light component and directly irradiates through the particles and the first condensing lens, the first through hole is used for allowing the light which is formed by converging the first scattered light through the first condensing lens to pass through, the second through hole is used for allowing the light which is formed by converging the second scattered light through the first condensing lens to pass through, and the third through hole is used for allowing the light which is formed by converging the third scattered light through the first condensing lens to pass through;

the light receiving assembly comprises a first detector, a second detector and a third detector, wherein the first detector is used for receiving light rays which are formed by the first scattered light rays, which are converged by the first condensing lens and pass through the first through hole, the second detector is used for receiving light rays which are converged by the second scattered light rays, which are converged by the first condensing lens and pass through the second through hole, and the third detector is used for receiving light rays which are converged by the third scattered light rays, which are converged by the first condensing lens and pass through the third through hole;

Optionally, the second through hole and the third through hole are respectively arranged at two opposite sides of the first straight blocking part, and the distance from the third through hole to the center of the first diaphragm is greater than the distance from the first through hole to the center of the first diaphragm and less than the distance from the second through hole to the center of the first diaphragm; and/or the number of the groups of groups,

A seventh object of the present utility model is to provide an optical inspection apparatus including a flow cell, a front light assembly, a light shaping assembly, and a light receiving assembly;

wherein the flow chamber is used for allowing particles of a sample to pass through in a queuing way under the wrapping of sheath liquid;

the front light component is used for irradiating light rays towards the flow chamber;

the light receiving assembly comprises a first detector and a second detector, the first detector is used for receiving light which is formed by the fact that the first scattered light passes through the first condensing lens to be converged and penetrates through the first light transmitting part, and the second detector is used for receiving light which is formed by the fact that the second scattered light passes through the first condensing lens to be converged and is reflected by the first reflecting part.

As one embodiment, the first condensing lens is further configured to condense third scattered light generated by the front light component irradiating the particles and within a third angle range, each angle of the third angle range is greater than each angle of the first angle range and is smaller than each angle of the second angle range, a second reflecting portion is further disposed on the body of the reflecting mirror, the second reflecting portion is configured to reflect light formed by condensing the third scattered light through the first condensing lens, and the light receiving component further includes a third detector configured to receive light formed by condensing the third scattered light through the first condensing lens and reflecting by the second reflecting portion; or alternatively, the process may be performed,

The first condensing lens is further used for converging third scattered light which is generated by the particles and irradiated by the front light component and is in a third angle range, each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range, the body of the reflecting mirror is further provided with a second light transmitting part, the second light transmitting part is used for allowing the third scattered light to pass through the first condensing lens and to be transmitted through the light formed by the first condensing lens, and the light receiving component further comprises a third detector, and the third detector is used for receiving the light which is formed by the third scattered light, passes through the first condensing lens and is transmitted through the second light transmitting part.

As an implementation mode, the light shaping assembly further comprises a first diaphragm, the first diaphragm is arranged between the first condensing lens and the reflecting mirror along an optical axis of the light emitted by the front light assembly, the first diaphragm is provided with a first straight blocking part, a first through hole, a second through hole and a third through hole, the first straight blocking part is at least used for absorbing the light which is irradiated to the particles by the front light assembly and is transmitted through the particles and the first condensing lens directly, the first through hole is used for transmitting the light which is formed by the first scattered light after the first scattered light is converged by the first condensing lens, the second through hole is used for transmitting the light which is formed by the second scattered light after the second scattered light is converged by the first condensing lens, and the third through hole is used for transmitting the light which is formed by the third scattered light after the third scattered light is converged by the first condensing lens.

As one embodiment, the first condensing lens is configured to condense the first scattered light, the second scattered light, and the third scattered light into light gradually converging toward the optical axis, and at least one of an incident surface and an exit surface of the first condensing lens is an aspherical surface; and/or the number of the groups of groups,

the light shaping assembly further comprises a second light converging lens, the second light converging lens is arranged between the reflecting mirror and the second detector and between the reflecting mirror and the third detector along the propagation path of the light reflected by the reflecting mirror, the second light converging lens is used for converging and irradiating the light reflected by the first reflecting part to the second detector and converging and irradiating the light reflected by the second reflecting part to the third detector, and the second light converging lens is a cylindrical lens.

An eighth object of the present utility model is to provide an optical inspection apparatus including a flow cell, a front light assembly, a light shaping assembly, and a light receiving assembly;

the flow chamber is used for allowing particles of a sample to pass through in a queuing way under the wrapping of sheath liquid;

the light receiving assembly comprises a first detector and a third detector, the first detector is used for receiving light rays which are formed by the first scattered light rays through the first condensing lens in a converging mode and penetrating through the first light transmitting part, and the third detector is used for receiving light rays which are formed by the third scattered light rays through the first condensing lens in a converging mode and reflected by the second reflecting part.

A ninth object of the present utility model is to provide an optical inspection apparatus including a flow cell, a front light assembly, a light shaping assembly, and a light receiving assembly;

The light receiving assembly comprises a first detector and a second detector, the first detector is used for receiving light rays which are formed by the first scattered light rays through the first condensing lens in a converging mode and reflected by the third reflecting portion, and the second detector is used for receiving light rays which are formed by the second scattered light rays through the first condensing lens in a converging mode and transmitted through the third light transmitting portion.

A tenth object of the present utility model is to provide an optical inspection apparatus including a flow cell, a front light assembly, a light shaping assembly, and a light receiving assembly;

the light receiving assembly comprises a first detector, a second detector and a third detector, wherein the first detector is used for receiving light rays formed by the first scattered light rays converging through the first condensing lens and penetrating through the first light transmitting part, the second detector is used for receiving light rays formed by the second scattered light rays converging through the first condensing lens and penetrating through the third light transmitting part, and the third detector is used for receiving light rays formed by the third scattered light rays converging through the first condensing lens and reflecting through the second reflecting part.

An eleventh object of the present utility model is to provide an optical inspection apparatus including a flow cell, a front light assembly, a light shaping assembly, and a light receiving assembly;

The light receiving assembly comprises a first detector, a second detector and a third detector, wherein the first detector is used for receiving light rays formed by the first scattered light rays converging through the first condensing lens and reflecting through the third reflecting portion, the second detector is used for receiving light rays formed by the second scattered light rays converging through the first condensing lens and reflecting through the first reflecting portion, and the third detector is used for receiving light rays formed by the third scattered light rays converging through the first condensing lens and penetrating through the second light transmitting portion.

A twelfth object of the present utility model is to provide an optical inspection apparatus including a flow cell, a front light assembly, a light shaping assembly, and a light receiving assembly;

the light receiving assembly comprises a first detector, a second detector and a third detector, wherein the first detector is used for receiving light rays which are formed by the first scattered light rays, the first scattered light rays are converged by the first condensing lens and pass through the first through hole, the second detector is used for receiving light rays which are formed by the second scattered light rays, the third detector is used for receiving light rays which are formed by the third scattered light rays, the first scattered light rays, the third scattered light rays and the third scattered light rays, and the first scattered light rays are converged by the first condensing lens and pass through the third through hole.

According to the blood sample analyzer and the optical detection device provided by the seventh object, scattered light generated by irradiation of the front light component to the particles is converged through the first condensing lens, the first scattered light in the first angle range and the second scattered light in the second angle range, which are larger than the first angle range, are separated through the first light transmitting part and the first reflecting part of the reflecting mirror, the first scattered light converged through the first condensing lens and formed through the first light transmitting part is received through the first detector, and the second scattered light converged through the first condensing lens and formed through the first reflecting part is received through the second detector, so that the scattered light in two different angle ranges is received through the two detectors respectively, the quality of optical signals received by each detector is improved, and the target area, the volume and the cost of each detector are reduced. In addition, adopt the separation of two angle scope scattered light of different structures realization on the speculum, its simple structure, and the less first scattered light of angle adopts the mode of permeating the speculum to collect, and the great second scattered light of angle adopts the mode of reflection to collect, can more do benefit to the realization. The converging effect of the first condensing lens is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, the volume and the cost of a single detector.

According to the blood sample analyzer and the optical detection device provided by the eighth object, scattered light generated by irradiation of the front light component to the particles is converged through the first condensing lens, the first scattered light within the range of 0-10 degrees and the third scattered light within the range of 10-20 degrees are separated through the first light transmission part and the second reflecting part of the reflecting mirror, the first scattered light is received through the first detector, the light converged by the first condensing lens and formed by penetrating the first light transmission part is received through the third detector, and the light converged by the third scattered light through the first condensing lens and formed by reflecting the second reflecting part is received through the third detector, so that the scattered light in two different angle ranges is received by the two detectors respectively, the quality of optical signals received by each detector is improved, and the target area, the volume and the cost of each detector are reduced. In addition, adopt the separation of two angle scope scattered light of different structures realization on the speculum, its simple structure, and the less first scattered light of angle adopts the mode of permeating the speculum to collect, and the great third scattered light of angle adopts the mode of reflection to collect, can more do benefit to the realization. The converging effect of the first condensing lens is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, the volume and the cost of a single detector.

According to the blood sample analyzer provided by the third object and the optical detection device provided by the ninth object, scattered light generated by irradiation of the front light component to the particles is converged through the first condensing lens, the second scattered light within the range of 20-70 degrees and the first scattered light within the range of 0-10 degrees are separated through the third light transmission part and the third reflecting part of the reflecting mirror, the first detector is used for receiving the light formed by converging the first scattered light through the first condensing lens and reflecting the first scattered light through the third reflecting part, and the second detector is used for receiving the light formed by converging the second scattered light through the first condensing lens and transmitting the third light transmission part, so that the two detectors are used for respectively receiving the scattered light within two different angle ranges, the quality of optical signals received by each detector is improved, and the target area, the volume and the cost of each detector are reduced. In addition, the separation of scattered light in two angle ranges is realized by adopting different structures on one reflecting mirror, and the structure is simple. The converging effect of the first condensing lens is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, the volume and the cost of a single detector.

According to the blood sample analyzer and the optical detection device provided by the tenth object, scattered light generated by irradiation of the front light component to the particles is converged through the first condensing lens, the first scattered light in the first angle range, the second scattered light in the second angle range and the angles larger than the first angle range are separated through the first light transmitting part, the third light transmitting part and the second reflecting part of the reflecting mirror, and the third scattered light in the third angle range and the angles smaller than the second angle range and the angles larger than the first angle range are respectively received through the first detector, the light formed by the first scattered light converged through the first condensing lens and transmitted through the first light transmitting part is received through the second detector, the light formed by the third scattered light converged through the first condensing lens and reflected by the second reflecting part is received through the third detector, and therefore the fact that the three detectors are adopted to respectively receive the scattered light in the three different angle ranges is achieved, the quality of each detector is improved, and the cost of each target area is reduced. In addition, the separation of scattered light in three angle ranges is realized by adopting different structures on one reflecting mirror, and the structure is simple. The first scattered light with small angle and the second scattered light with large angle are collected by adopting a mode of transmitting a reflector, and the third scattered light with medium angle is collected by adopting a mode of reflecting. The converging effect of the first condensing lens is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, the volume and the cost of a single detector.

According to the blood sample analyzer and the optical detection device provided by the eleventh object, scattered light generated by irradiation of the front light component to the particles is converged through the first condensing lens, the first scattered light in the first angle range, the second scattered light in the second angle range and with angles larger than the first angle range are separated through the third reflecting part, the first reflecting part and the second transmitting part of the reflecting mirror, and the third scattered light in the third angle range and with angles larger than the first angle range and with angles smaller than the second angle range is received through the first detector, the light formed by the first scattered light converged through the first condensing lens and reflected by the third reflecting part is received through the second detector, the light formed by the third scattered light converged through the first condensing lens and transmitted through the second transmitting part is received through the third detector, and therefore the fact that the three detectors are adopted to respectively receive the scattered light in the three different angle ranges is achieved, the quality of each detector is improved, and the cost of each target area is reduced. In addition, the separation of scattered light in three angle ranges is realized by adopting different structures on one reflecting mirror, and the structure is simple. The first scattered light with small angle and the second scattered light with large angle are collected in a reflection mode, and the third scattered light with medium angle is collected in a transmission mirror mode. The converging effect of the first condensing lens is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, the volume and the cost of a single detector.

According to the blood sample analyzer and the optical detection device provided by the twelfth object, scattered light generated by irradiation of the front light component to the particles is converged through the first condensing lens, the direct light is separated through the first straight blocking part, the first through hole, the second through hole and the third through hole of the first diaphragm, the first scattered light in the first angle range, the second scattered light in the second angle range and with angles larger than the first angle range, and the third scattered light in the third angle range and with angles larger than the first angle range and with angles smaller than the second angle range are converged through the first condensing lens, the light formed by the first scattered light passing through the first through hole is received through the first detector, the light formed by the second scattered light passing through the first condensing lens and the second through hole is received through the third detector, the scattered light formed by the third scattered light passing through the third condensing lens and the third through hole is received, and therefore the scattered light in the three different angle ranges is received through the third detector, the quality of each detector is improved, and the cost of each target area is reduced. In addition, the three-in-one diaphragm is adopted to realize the separation of scattered light rays in three angle ranges through different through holes, and the structure is simple. The converging effect of the first condensing lens is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, the volume and the cost of a single detector.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram showing the composition of a blood sample analyzer according to a first embodiment of the present utility model;

FIG. 2 is a schematic diagram showing light propagation of an optical detection device according to a first embodiment of the present utility model;

FIG. 3 is a schematic diagram showing light propagation of an optical detection device according to a first embodiment of the present utility model;

fig. 4 is a schematic structural diagram of a first diaphragm according to a first embodiment of the present utility model;

fig. 5 is a schematic diagram illustrating light propagation of an optical detection device according to a second embodiment of the present utility model;

FIG. 6 is a schematic diagram illustrating light propagation of an optical detection device according to a third embodiment of the present utility model;

fig. 7 is a schematic diagram illustrating light propagation of an optical detection device according to a fifth embodiment of the present utility model;

Fig. 8 is a schematic diagram illustrating light propagation of an optical detection device according to a sixth embodiment of the present utility model.

Reference numerals illustrate: 10. a blood sample analyzer; 100. an optical detection device; 110. a flow chamber; 120. a front light assembly; 130. a light shaping assembly; 131. a reflecting mirror; 1311. a first light-transmitting portion; 1312. a first reflection section; 1313. a second reflection part; 1314. a second light-transmitting portion; 1315. a third light-transmitting portion; 1316. a third reflection section; 132. a first condenser lens; 133. a first diaphragm; 1331. a first straight portion; 1332. a first through hole; 1333. a second through hole; 1334. a third through hole; 134. a second condenser lens; 135. a fourth diaphragm; 1351. a seventh through hole; 136. a fifth diaphragm; 1361. an eighth through hole; 137. a second diaphragm; 1371. a second straight portion; 1372. a fourth through hole; 138. a third diaphragm; 1381. a fifth through hole; 1382. a sixth through hole; 139. a third condenser lens; 1301. a fourth condensing lens; 140. a light receiving assembly; 141. a first detector; 142. a second detector; 143. a third detector; 200. a sample distribution device; 300. a reagent dispensing device; 400. a reaction tank; 500. a sample transport device; 600. a controller; 700. and a diluent conveying device.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

It should be noted that all directional indications (such as up, down, left, right, front, and rear … …) in the embodiments of the present utility model are merely used to explain the relative positional relationship between the components, the movement condition, etc. in a specific posture, and if the specific posture is changed, the directional indication is changed accordingly.

It will also be understood that when an element is referred to as being "mounted" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be indirectly connected to the other element through intervening elements.

Furthermore, the description of "first," "second," etc. in this disclosure is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present utility model.

Embodiment one:

as shown in fig. 1 to 4, a blood sample analyzer 10 according to a first embodiment of the present utility model includes a sample distribution device 200, a reagent distribution device 300, a reaction cell 400, a sample transport device 500, an optical detection device 100, and a controller 600; wherein the sample distribution device 200 is used for collecting a blood sample from a sample container and distributing at least part of the collected blood sample to the reaction cell 400; the reagent dispensing device 300 is used to dispense a reagent to the reaction cell 400; the reaction cell 400 is used for providing a reaction field for a blood sample and a reagent so as to prepare a sample; the sample transfer apparatus 500 is for driving the transfer of a sample from the reaction cell 400 to the optical detection apparatus 100; the optical detection device 100 is used for optically detecting a sample, and the controller 600 is used for analyzing and obtaining a measurement result of the blood sample according to feedback information of the optical detection device 100.

As an embodiment, the optical detection device 100 includes a flow cell 110, a front light assembly 120, a light shaping assembly 130, and a light receiving assembly 140, where the flow cell 110 is configured to receive a sample delivered by the sample delivery device 500 such that particles of the sample are queued to pass under the sheath fluid, i.e., the flow cell 110 is configured to provide a location where the detected particles are irradiated by a light beam. The front light assembly 120 is used to irradiate light towards the flow cell 110, i.e. the front light assembly 120 is used to provide a beam of light for irradiating the particles to be detected. The light shaping assembly 130 is configured to shape scattered light generated by the front light assembly 120 irradiating the particles, the light receiving assembly 140 is configured to receive light formed by shaping the scattered light by the light shaping assembly 130, and the controller 600 is configured to obtain a measurement result of the blood sample according to feedback information of the light receiving assembly 140.

As an embodiment, the light shaping assembly 130 includes a mirror 131, and a first light transmitting portion 1311 and a first reflecting portion 1312 are disposed on a body of the mirror 131, the first light transmitting portion 1311 is used for transmitting a first scattered light generated by the front light assembly 120 when the particles are irradiated thereto, and the first reflecting portion 1312 is used for reflecting a second scattered light generated by the front light assembly 120 when the particles are irradiated thereto and within a second angle range. The first scattered light within the first angular range specifically refers to: scattered light is generated by the front light assembly 120 impinging on the particle and is at a first angular range from the optical axis of the light emitted by the front light assembly 120. The second scattered light within the second angular range specifically refers to: scattered light generated by the particles irradiated by the front light assembly 120 and having an included angle within a second angular range with respect to the optical axis of the light emitted by the front light assembly 120. The angles of the first angle range are smaller than those of the second angle range, that is, the included angle between the first scattered light and the optical axis of the light emitted by the front light component 120 is smaller than the included angle between the second scattered light and the optical axis of the light emitted by the front light component 120. The first light-transmitting portion 1311 and the first reflecting portion 1312 are provided on the same reflecting mirror 131, that is, the first light-transmitting portion 1311 and the first reflecting portion 1312 are provided on one integral member. In this embodiment, the light scattered in two angle ranges is separated by adopting different structures on one reflecting mirror 131, which has a simple structure and is beneficial to reducing the volume and cost of the optical detection device 100. In addition, the first scattered light with smaller angle is collected by transmitting through the reflecting mirror 131, and the second scattered light with larger angle is collected by reflecting, which is more beneficial to realization and reduction of the volume of the optical detection device 100.

As an embodiment, the light receiving assembly 140 includes a first detector 141 and a second detector 142, the first detector 141 is configured to receive light formed by the first scattered light passing through the first light transmitting portion 1311, and the second detector 142 is configured to receive light formed by the second scattered light being reflected by the first reflecting portion 1312. The controller 600 is configured to parse the measurement result of the blood sample according to at least the feedback information of the first detector 141 and the second detector 142. In this embodiment, the first light transmitting portion 1311 and the first reflecting portion 1312 of the reflecting mirror 131 separate the first scattered light and the second scattered light, and the first detector 141 receives the light formed by the first scattered light penetrating the first light transmitting portion 1311, and the second detector 142 receives the light formed by the second scattered light reflecting the first reflecting portion 1312, so that the two detectors are adopted to respectively receive the scattered light in two different angle ranges, which is beneficial to improving the quality of the optical signal received by each detector and reducing the target area, volume and cost of each detector.

As an embodiment, the light shaping assembly 130 further includes a first condensing lens 132, where the first condensing lens 132 is at least configured to condense a first scattered light generated by the front light assembly 120 when the particles are irradiated thereto and within a first angular range and a second scattered light generated by the front light assembly 120 when the particles are irradiated thereto and within a second angular range. Specifically, the first light-transmitting portion 1311 is configured to transmit light formed by converging the first scattered light through the first condensing lens 132, and the first reflecting portion 1312 is configured to reflect light formed by converging the second scattered light through the first condensing lens 132. The first detector 141 is configured to receive the light beam formed by the first scattered light beam converging through the first condensing lens 132 and passing through the first light transmitting portion 1311, and the second detector 142 is configured to receive the light beam formed by the second scattered light beam converging through the first condensing lens 132 and reflecting from the first reflecting portion 1312. In this embodiment, the first condensing lens 132 is used to collect the scattered light, which is beneficial to reducing the receiving light spots of the first detector 141 and the second detector 142, and further beneficial to further reducing the target area, volume and cost of the single detector.

As an embodiment, the light receiving component 140 further includes a third detector 143, where the third detector 143 is configured to receive the light formed by shaping the third scattered light; the third scattered light is the scattered light generated by the front light assembly 120 impinging on the particle and within a third angular range, each angle of the third angular range being greater than each angle of the first angular range and less than each angle of the second angular range. The controller 600 is further configured to parse the feedback information from the first detector 141, the second detector 142, and the third detector 143 to obtain a measurement result of the blood sample. Specifically, the first scattered light is a scattered light with a small angle, the second scattered light is a scattered light with a large angle, and the third scattered light is a scattered light with a medium angle. In this embodiment, scattered light in three angle ranges is collected by the three detectors, which is beneficial to obtaining more particle information, thereby improving accuracy and reliability of particle parameter measurement.

As an embodiment, the first condensing lens 132 is further configured to collect third scattered light generated by the front light assembly 120 irradiating the particles and within a third angle range, and the body of the reflector 131 is further provided with a second reflecting portion 1313, where the second reflecting portion 1313 is configured to reflect the light formed by the third scattered light after being collected by the first condensing lens 132. The third detector 143 is configured to receive light rays formed by the third scattered light rays condensed by the first condensing lens 132 and reflected by the second reflecting portion 1313. In this embodiment, the light scattered in three different angle ranges is separated by using different structures on one reflecting mirror 131, and the structure is simple. The first condensing lens 132 is used for condensing the third scattered light, so that the receiving light spot of the third scattered light is reduced, and the target area, the volume and the cost of the third detector 143 are reduced.

As one embodiment, each angle of the first angular range is greater than 0 °, each angle of the third angular range is greater than or equal to 10 °, and each angle of the second angular range is greater than 20 °.

As one embodiment, each angle of the first angular range is greater than 0 ° and less than 10 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than 20 ° and less than or equal to 45 °.

As one embodiment, each angle of the first angular range is greater than 0 ° and less than 10 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than 20 ° and less than or equal to 70 °. Scattered light rays with different angles are collected, and different information of the particles can be reflected correspondingly. Specifically, 0-10 degrees of first scattered light is collected and is mainly used for reflecting the volume size of the measured particles. Since the third scattered light of 10-20 degrees is more sensitive to the refractive indexes of cell membranes, cytoplasm and nuclear membranes, the third scattered light of 10-20 degrees is collected and is mainly used for reflecting the granularity (complexity) information of the particle particles. And collecting the second scattered light of 20-70 degrees, which is mainly used for increasing the accuracy of particle identification. In a specific embodiment, the optical detection device 100 is used for detecting the differential count value of the white blood cells, in which if only the first scattered light and the third scattered light are collected, eosinophils are not well distinguished from neutrophils when testing a sample with more eosinophils, and if the first scattered light, the second scattered light and the third scattered light are collected at the same time, the accuracy of cell identification can be increased by using the collected scattered light in three angle ranges, so that three-dimensional data of the particles to be tested can be obtained. By collecting scattered light in a large angle range, more particle information can be obtained, and further the accuracy of particle classification can be improved.

As one embodiment, each angle of the first angular range is greater than or equal to 1 ° and less than or equal to 5 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than or equal to 22 ° and less than or equal to 43 °. Here, through carrying out optimal design to three collection angle scope, can do benefit to the interference that reduces unnecessary light to do benefit to the optics SNR that further improves three angle scattering light, and then improve measurement data's accuracy and reliability. Of course, in a specific application, the three angular ranges are not limited thereto, for example, as an alternative embodiment, the first angular range is greater than or equal to 1 ° and less than or equal to 4 °, the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and the second angular range is greater than or equal to 22 ° and less than or equal to 43 °. Or, as another alternative embodiment, the first angular range is greater than or equal to 1 ° and less than or equal to 10 °, the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and the second angular range is greater than or equal to 22 ° and less than or equal to 43 °; or, as yet another alternative embodiment, the first angular range is greater than or equal to 1 ° and less than or equal to 8 °, the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and the second angular range is greater than or equal to 23 ° and less than or equal to 40 °.

As an embodiment, the first light-transmitting portion 1311 is a through hole penetrating the reflecting mirror 131, and has a simple structure and is easy to implement. Of course, in a specific application, the first light-transmitting portion 1311 may also be a light-transmitting member embedded in the reflector 131 as an alternative embodiment.

As an embodiment, the reflecting mirror 131 forms an included angle with the optical axis of the light emitted by the front light component 120, that is, the reflecting mirror 131 is disposed at an acute angle with respect to the optical axis of the light emitted by the front light component 120. The inclined arrangement of the mirror 131 may facilitate better adjustment of the reflection direction and position of the second scattered light and the third scattered light.

As an embodiment, the second detector 142 and the third detector 143 are disposed side by side, i.e., the second detector 142 and the third detector 143 are equidistant from the optical axis of the light emitted from the front light assembly 120.

In one embodiment, the controller 600 is configured to parse the leukocyte classification count value of the blood sample based at least on the feedback information from the first detector 141, the second detector 142, and the third detector 143. Specifically, the controller 600 may count the leukocytes into five types of neutrophils, lymphocytes, monocytes, eosinophils, and basophils, respectively, based on feedback information from the first, second, and

third probes

141, 142, and 143. In this embodiment, the laser scattering principle is used to measure the differential count of the white blood cells, and the differential count mode of the white blood cells is to collect forward scattered light in the small, medium and large three angles, so that the sample does not need to be subjected to fluorescent staining and related fluorescent detection elements are arranged, so that the differential count device has the characteristics of simple structure and low cost. In this embodiment, the differential count of the white blood cells by the blood sample analyzer 10 is five differential counts, however, in a specific application, the differential count of the white blood cells by the blood sample analyzer 10 is not limited to five differential counts, for example, may be four differential counts, i.e., differential counts of the white blood cells into four classes of lymphocytes, monocytes, neutrophils, and eosinophils, or may be three differential counts, which may be set according to actual requirements in a specific application.

In one embodiment, in performing the differential white blood cell count test, the reagent dispensing device 300 adds a reagent to the reaction cell 400 that includes a hemolyzing agent capable of lysing red blood cells in a sample to be tested and distinguishing between different white blood cell types and a staining reagent capable of staining white blood cells. The dyeing reagent can be a chemical dyeing reagent. Of course, in particular applications, the hemolyzing agent and staining agent may be replaced by a reagent having both erythrocyte lysing and staining effects, as alternative embodiments.

In one embodiment, the optical detection device 100 may be used to measure the count of reticulocytes in addition to the classified count of leukocytes.

As an embodiment, the blood sample analyzer 10 may include other types of detection devices in addition to the optical detection device 100, for example, the blood sample analyzer 10 may further include at least one of a hemoglobin detection device for detecting a hemoglobin parameter, an impedance count detection device for detecting red blood cells and/or platelets, and the like. Wherein the hemoglobin detection apparatus is used for detecting the concentration of hemoglobin; the impedance counting detection device is used for performing impedance counting detection such as erythrocyte number detection and/or platelet count detection.

As an embodiment, the light shaping assembly 130 further includes a first diaphragm 133, where the first diaphragm 133 is disposed between the first condensing lens 132 and the reflecting mirror 131 along an optical axis of the light emitted by the front light assembly 120, the first diaphragm 133 is provided with a first straight blocking portion 1331, a first through hole 1332, a second through hole 1333, and a third through hole 1334, the first straight blocking portion 1331 is at least used for blocking the light irradiated to the particle by the front light assembly 120 and penetrating the particle and the first condensing lens 132, the first through hole 1332 is used for passing the light formed by the first scattered light after being converged by the first condensing lens 132, the second through hole 1333 is used for passing the light formed by the second scattered light after being converged by the first condensing lens 132, and the third through hole 1334 is used for passing the light formed by the third scattered light after being converged by the first condensing lens 132. The first through hole 1332, the second through hole 1333, and the third through hole 1334 are mostly through holes penetrating the first diaphragm 133. The direct light transmitted through the particles is blocked by the first blocking portion 1331, so that the saturation of the small-angle scattering signal (i.e., the first scattering light) can be prevented, and the effective identification of the small-angle scattering signal can be further ensured. The first straight portion 1331, the first through hole 1332, the second through hole 1333, and the third through hole 1334 are formed on the same diaphragm member. The first diaphragm 133 is a three-in-one diaphragm, which can simultaneously restrict and separate light rays in three angle ranges, and by adopting the arrangement mode, the structure of the optical detection device 100 can be simplified, and the cost and the volume of the optical detection device 100 can be reduced.

As one embodiment, the first straight blocking portion 1331 blocks the light beam irradiated to the particles by the front light unit 120 and transmitted through the particles and the first condensing lens 132 by absorbing the light beam.

As an embodiment, the second through hole 1333 and the third through hole 1334 are respectively disposed at two opposite sides of the first straight portion 1331, and a distance from the third through hole 1334 to the center of the first diaphragm 133 is greater than a distance from the first through hole 1332 to the center of the first diaphragm 133 and less than a distance from the second through hole 1333 to the center of the first diaphragm 133. In this embodiment, the second through hole 1333 and the third through hole 1334 are arranged on one side, so that separation and collection of the second scattered light and the third scattered light can be facilitated, and separation arrangement of the second detector 142 and the third detector 143 can be facilitated; on the other hand, the reliability of the structure of the first diaphragm 133 can be ensured.

As an implementation manner, the number of the first through holes 1332 is two, and the two first through holes 1332 are respectively arranged on two opposite sides of the first straight blocking portion 1331, so that more light rays formed by shaping the first scattered light rays can be collected.

As an embodiment, the two first through holes 1332 are symmetrically disposed on two opposite sides of the first straight blocking portion 1331, which is beneficial to improving accuracy of data measurement.

As an embodiment, the projected area of the first through hole 1332 on the first diaphragm 133 is smaller than the projected area of the second through hole 1333 on the first diaphragm 133, and smaller than the projected area of the third through hole 1334 on the first diaphragm 133. In this embodiment, the first through hole 1332 is set to be the smallest through hole among the three through holes on the first diaphragm 133, that is, the size of the first through hole 1332 for restricting the light scattered at a small angle is smaller than the size of the third through hole 1334 for restricting the light scattered at a medium angle and smaller than the size of the second through hole 1333 for restricting the light scattered at a large angle.

As an embodiment, the projection area of the second through hole 1333 on the first diaphragm 133 is larger than the projection area of the third through hole 1334 on the first diaphragm 133, that is, the size of the second through hole 1333 for restraining the large-angle scattered light is larger than the size of the third through hole 1334 for restraining the medium-angle scattered light, so that more scattered light in a large angle range can be collected, and the accuracy of particle classification can be improved.

As one embodiment, the first condensing lens 132 is used to condense the first scattered light, the second scattered light, and the third scattered light into light gradually converging toward the optical axis. The converging action of the first condensing lens 132 can make the first scattered light, the second scattered light and the third scattered light converge into smaller light spots, so as to facilitate reducing the target surface areas of the first detector 141, the second detector 142 and the third detector 143.

As one embodiment, at least one of the incident surface and the exit surface of the first condenser lens 132 is an aspherical surface. In this embodiment, the first condensing lens 132 adopts an aspheric arrangement, which is beneficial to better collect light.

As one embodiment, both the incident surface and the exit surface of the first condenser lens 132 are aspherical surfaces.

As an embodiment, the light shaping assembly 130 further includes a second condensing lens 134, where the second condensing lens 134 is disposed between the reflecting mirror 131 and the second detector 142 and between the reflecting mirror 131 and the third detector 143 along a propagation path of the light reflected by the reflecting mirror 131, and the second condensing lens 134 is configured to converge and irradiate the light reflected by the first reflecting portion 1312 to the second detector 142 and to converge and irradiate the light reflected by the second reflecting portion 1313 to the third detector 143. The second condensing lens 134 may further condense light, so as to facilitate reducing light spots irradiated on the second detector 142 and the third detector 143, and further reduce target surface areas of the second detector 142 and the third detector 143, and finally facilitate reducing volumes and costs of the second detector 142 and the third detector 143.

In one embodiment, the second condenser lens 134 is a cylindrical lens, and both the incident surface and the exit surface of the first condenser lens 132 are planar.

As an embodiment, the light shaping assembly 130 further includes a fourth diaphragm 135, where the fourth diaphragm 135 is disposed between the second condenser lens 134 and the second detector 142 along a propagation path of the light reflected by the reflector 131, the fourth diaphragm 135 is disposed between the second condenser lens 134 and the third detector 143 along a propagation path of the light reflected by the reflector 131, the fourth diaphragm 135 is provided with a seventh through hole 1351 in a penetrating manner, and the seventh through hole 1351 is used for passing and irradiating the light beam formed by the second scattered light beam after being converged by the first condenser lens 132, reflected by the first reflector 1312, and converged by the second condenser lens 134 to the second detector 142, and for passing and irradiating the light beam formed by the third scattered light beam after being converged by the first condenser lens 132, reflected by the second reflector 1313, and converged by the second condenser lens 134 to the third detector 143. The fourth diaphragm 135 is used for shielding the stray light irradiated to the second detector 142 and the third detector 143, so that the quality of the optical signals collected by the second detector 142 and the third detector 143 can be further improved, and the optical signal-to-noise ratio can be improved.

As an embodiment, the light shaping assembly 130 further includes a fifth diaphragm 136, where the fifth diaphragm 136 is disposed between the reflecting mirror 131 and the first detector 141 along the optical axis of the light emitted by the front light assembly 120, the fifth diaphragm 136 is provided with an eighth through hole 1361 in a penetrating manner, the eighth through hole 1361 is used for allowing the light formed by the first scattered light passing through the first light-collecting lens 132 after being collected and passing through the first light-transmitting portion 1311 to pass through and irradiate to the first detector 141, and the fifth diaphragm 136 is used for shielding the stray light irradiated to the first detector 141, so that the quality of the optical signal collected by the first detector 141 can be further improved, and the optical signal-to-noise ratio is advantageously improved.

In one embodiment, flow cell 110 is a transparent cell having a detection aperture through which sheath fluid can pass around particles. Specifically, the flow chamber 110 has a detection aperture, a first inlet for the sample to enter, a second inlet for the sheath fluid to enter, and an outlet for discharging the liquid after detection, the first inlet, the second inlet, and the outlet being in communication with the detection aperture, respectively.

As an embodiment, the light emitted by the front light component 120 forms an elliptical light spot at the center of the flow chamber 110, the minor axis direction of the elliptical light spot is parallel to the flow direction of the particles to be measured of the sample, and the major axis direction of the elliptical light spot is perpendicular to the flow direction of the particles to be measured. When the particle to be measured passes through the beam irradiation area (elliptical spot at the center of the flow cell 110) of the front light assembly 120, scattered light emitted to the whole space is generated at the same time. The forward scatter detection assembly 130, the fluorescence detection assembly 140, and the side scatter detection assembly 150 are used for collecting the low angle scattered light (forward scattered light), the high angle scattered light (side scattered light), and the fluorescence light, respectively.

In one embodiment, the elliptical spot formed by the front light module 120 in the flow cell 110 has a dimension of 9um to 25um in the direction of the short axis and a dimension of 200um to 400um in the direction of the long axis perpendicular to the direction of the flow of the sample in the flow cell 110.

As one embodiment, the front light assembly 120 includes a light source and a front dimming assembly. The front dimming component is disposed between the light source and the flow chamber 110. The light source is used for emitting light, and the front dimming component is mainly used for shaping and focusing the light emitted by the light source. The light source may be a laser.

As an embodiment, the front light assembly 120, the flow chamber 110, the first condensing lens 132, the first diaphragm 133, the reflecting mirror 131, the fifth diaphragm 136, and the first detector 141 are sequentially disposed along an optical axis of the front light assembly 120 emitting light, and the second condensing lens 134, the fourth diaphragm 135, the second detector 142, and the third detector 143 are disposed at sides of the optical axis of the front light assembly 120 emitting light, that is, the second condensing lens 134, the fourth diaphragm 135, the second detector 142, and the third detector 143 are not on the optical axis of the front light assembly 120 emitting light.

As one embodiment, the sample dispensing device 200 includes a sampling member, a first motion motive element for driving the sampling member to move, and a first syringe for driving the sampling member to aspirate and discharge a sample. The sampling member may be a sample needle or a sample pipette, etc. The sampling member may be moved to a sample container (e.g., a cuvette, etc.) for sampling under the drive of the power element, and then moved to the reaction cell 400 for dispensing the sample under the drive of the power element.

In one embodiment, the sample transfer apparatus 500 includes a sample preparation line connected between the flow chamber 110 and the reaction cell 400, and a second syringe connected to the sample preparation line for sucking the sample in the reaction cell 400 into the sample preparation line and pushing the sample in the sample preparation line into the flow chamber 110. The first syringe and the second syringe may be the same syringe or two syringes independent of each other. Of course, in a specific application, the manner in which the sample is transferred from the reaction cell 400 to the flow cell 110 is not limited to a syringe drive, and may be driven by a pump, for example.

In one embodiment, the sheath fluid used to hold the test particles through the flow cell 110 is a diluent. The blood sample analyzer 10 further includes a diluent delivery device 700, the diluent delivery device 700 for driving the diluent delivery to the flow cell 110 such that particles of the sample are queued through the flow cell 110 under entrainment of the diluent.

In one embodiment, the blood sample analyzer 10 further includes a reservoir, and the diluent delivery device 700 includes a diluent delivery line connected between the reservoir and the flow chamber 110, and a third syringe for pumping and pushing the diluent in the reservoir to the flow chamber 110. Of course, in particular applications, the manner in which the diluent is delivered from within the reservoir to the flow chamber 110 is not limited to being driven by a syringe, and may be driven by a pump or pneumatic pressure, for example; the sheath liquid is not limited to the diluent liquid, and other liquids may be used.

As an embodiment, the reagent dispensing device 300 comprises a reagent needle, a second motion power element for driving the reagent needle to move, and a liquid path driving element for driving the reagent needle to aspirate, discharge the reagent, which may be a syringe or a dosing pump or other dosing device.

The present embodiment also provides an optical detection device 100, where the optical detection device 100 includes a flow cell 110, a front light assembly 120, a light shaping assembly 130, and a light receiving assembly 140; wherein the flow chamber 110 is used for allowing particles of the sample to pass through in a queue under the wrapping of the sheath fluid; the front light assembly 120 is used for illuminating light rays towards the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, where the first condensing lens 132 is at least used for converging a first scattered light generated by the front light assembly 120 and irradiated to the particle in a first angle range and a second scattered light generated by the front light assembly 120 and irradiated to the particle in a second angle range, and each angle of the first angle range is smaller than each angle of the second angle range; the body of the reflector 131 is provided with a first light-transmitting portion 1311 and a first reflecting portion 1312, the first light-transmitting portion 1311 is used for transmitting light formed by converging first scattered light through the first condensing lens 132, and the first reflecting portion 1312 is used for reflecting light formed by converging second scattered light through the first condensing lens 132; the light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and transmitted through the first light transmitting portion 1311, and a second detector 142 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and reflected by the first reflecting portion 1312. The principles of the optical detection device 100 are described with reference to the blood sample analyzer 10 described above and will not be described in detail herein.

The other parts and the working principle of the optical detection device 100 provided in this embodiment can refer to the optical detection device 100 in the blood sample analyzer 10, and will not be described in detail herein.

As an embodiment, the optical detection device 100 operates as follows:

the beam of light emitted by the front light assembly 120 forms an elliptical spot at the center of the flow cell 110, with its minor axis aligned with the sample flow direction and its major axis perpendicular to the sample flow direction. When particles in the sample pass through the light beam irradiation area (elliptical spot at the center of the flow cell 110), scattered light emitted to the whole space is generated, and the scattered light is converged by the aspherical lens (the first condenser lens 132) and the angle of the first diaphragm 133 is selected to form a small-angle scattered signal LAS, a medium-angle scattered signal MAS and a large-angle scattered signal WAS. The direct light transmitted through the particles is condensed by the aspherical lens and blocked by the first diaphragm 133. The scattered signals generated by the particles irradiated by the front light assembly 120 penetrate the flow chamber 110 and are converged by the aspheric lens to determine the maximum angle of signal collection, and then the scattered light is spatially restricted by the first diaphragm 133 to be divided into three angle distributions, specifically, a middle small hole (i.e. a first through hole 1332) is used for ensuring that the small angle scattered signals pass through, a small semicircular hole (i.e. a third through hole 1334) which is bare at the right side of the middle small hole is used for ensuring that the medium angle scattered signals pass through, and a small semicircular hole which is bare at the left side of the small hole is used for ensuring that the large angle scattered signals pass through. After passing through the aspherical lens and the first diaphragm 133, the scattered light signals are in a converging state, and in order to spatially separate the three angle signals at the receiving position of the detector, when the scattered light beam passes through the reflecting mirror 131, the scattered light beam with a small angle (i.e., the first scattered light beam) passes through the reflecting mirror 131, and then is restrained by the fifth diaphragm 136 and received by the first detector 141. The light beams of the middle angle scattered light (i.e., the third scattered light) and the large angle scattered light (i.e., the second scattered light) are reflected to a direction at an angle with respect to the optical axis by the reflecting mirror 131, and then the converged light beams are compressed again by the cylindrical lens (i.e., the second condenser lens 134), the middle angle scattered light is restrained by the fourth diaphragm 135 and received by the third detector 143, and the large angle scattered light is restrained by the fourth diaphragm 135 and received by the third detector 143. After the scattered light signals of small, medium and large angles are converged and compressed, the effect of shielding the stray light by the diaphragm positioned in front of the detector is added, so that the quality and the signal to noise ratio of the light signals can be improved, the target surface of the detector is effectively reduced, scattered light can be received by the detector with a small target surface, and the cost is reduced.

Embodiment two:

referring to fig. 1 to 3 and fig. 5, the difference between the blood sample analyzer 10 and the optical detection device 100 provided in this embodiment and the first embodiment is mainly that the shaping path and the receiving position of the middle-angle scattered light (i.e. the third scattered light) are different, and the specific steps are as follows: in the first embodiment, the middle-angle scattered light propagates to the third detector 143 by being reflected by the reflecting mirror 131; in this embodiment, the middle-angle scattered light propagates to the third detector 143 through the transparent portion of the reflecting mirror 131.

Specifically, in the present embodiment, the body of the reflecting mirror 131 is further provided with a second light-transmitting portion 1314, and the first condensing lens 132 is further configured to collect third scattered light generated by the particles irradiated by the front light assembly 120 and within a third angle range, and the second light-transmitting portion 1314 is configured to transmit light formed by the third scattered light after being collected by the first condensing lens 132. The light receiving assembly 140 further includes a third detector 143, and the third detector 143 is configured to receive the light beam formed by the third scattered light beam converged by the first condensing lens 132 and transmitted through the second light transmitting portion 1314.

In one embodiment, the controller 600 is further configured to parse the measurement result of the blood sample according to the feedback information of the first detector 141, the second detector 142, and the third detector 143.

In this embodiment, the first scattered light with a small angle and the third scattered light with a medium angle are collected in a transmission manner, the second scattered light with a large angle is collected in a reflection manner, the effect of separating the scattered light with three angle ranges by adopting different structures on one reflector 131 is also achieved, and the scattered light with three different angle ranges separated by the reflector 131 is respectively received by adopting three detectors, so that the quality of optical signals received by each detector is improved, and the target area, volume and cost of each detector are reduced. The converging effect of the condensing lens is beneficial to further reducing the receiving light spots of the detector, and further beneficial to further reducing the target surface area, volume and cost of a single detector.

As an embodiment, the first light-transmitting portion 1311 and the second light-transmitting portion 1314 are two independent and separated holes, or the first light-transmitting portion 1311 and the second light-transmitting portion 1314 are holes that are connected as a single body and communicate.

As an embodiment, the eighth through hole 1361 of the fifth diaphragm 136 is used for passing and irradiating the light formed by the first scattered light converged by the first condensing lens 132 and passing through the first light transmitting portion 1311 to the first detector 141, and for passing and irradiating the light formed by the third scattered light converged by the first condensing lens 132 and passing through the second light transmitting portion 1314 to the third detector 143.

In addition to the above-mentioned differences, the other structures and the working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can be referred to as the first embodiment, and will not be described in detail herein.

Embodiment III:

referring to fig. 1 to 3 and fig. 6, the difference between the blood sample analyzer 10 and the optical detection device 100 provided in the present embodiment and the first embodiment is mainly that the arrangement mode of the diaphragm is different, specifically: in the first embodiment, three-in-one diaphragms are used for restraining scattered light rays in three angle ranges; in this embodiment, the scattered light in three angle ranges is respectively restricted by more than two diaphragms.

Specifically, in the present embodiment, the light shaping assembly 130 further includes a second aperture 137 and a third aperture 138, where the second aperture 137 is configured to constrain the scattered light in the first angular range, and the third aperture 138 is configured to constrain the scattered light in the second angular range and the scattered light in the third angular range. In this embodiment, the second aperture 137 is used to constrain the scattered light with a small angle, and the third aperture 138 is used to constrain the scattered light with a medium angle and a large angle, i.e. the third aperture 138 is a two-in-one aperture. Of course, in specific applications, the scattered light rays with medium and large angles can also be respectively restrained by adopting two independent diaphragms.

Specifically, the second diaphragm 137 is disposed between the reflecting mirror 131 and the first detector 141 along the optical axis of the light emitted by the front light assembly 120, the second diaphragm 137 is provided with a second blocking portion 1371 and a fourth through hole 1372, the second blocking portion 1371 is at least used for blocking the light irradiated to the particles by the front light assembly 120 and penetrating the particles and the first condensing lens 132, and the fourth through hole 1372 is used for allowing the light formed by the first scattered light after being converged by the first condensing lens 132 and penetrating the first light transmitting portion 1311 to pass through.

Specifically, the third diaphragm 138 is disposed between the mirror 131 and the second detector 142 along the propagation path of the light reflected by the mirror 131 and between the mirror 131 and the third detector 143, the third diaphragm 138 is provided with a fifth through hole 1381 and a sixth through hole 1382, the fifth through hole 1381 is used for allowing the light formed by the second scattered light after being converged by the first condensing lens 132 and reflected by the first reflecting portion 1312 to pass through, and the sixth through hole 1382 is used for allowing the light formed by the third scattered light after being converged by the first condensing lens 132 and reflected by the second reflecting portion 1313 to pass through.

As an embodiment, the light shaping assembly 130 further includes a third condenser lens 139 and a fourth condenser lens 1301, and the third condenser lens 139 is configured to focus and irradiate the light transmitted through the first light transmitting portion 1311 to the first detector 141. The fourth condenser lens 1301 is configured to converge and irradiate the light reflected by the first reflecting portion 1312 to the second detector 142 and to converge and irradiate the light reflected by the second reflecting portion 1313 to the third detector 143.

As an embodiment, the third condenser lens 139 is disposed between the second diaphragm 137 and the first detector 141 along the optical axis of the light emitted from the front light assembly 120. Of course, in a specific application, the setting position of the third condenser lens 139 is not limited thereto, and for example, as an alternative embodiment, the third condenser lens 139 is disposed between the mirror 131 and the second diaphragm 137 along the optical axis of the light emitted by the front light assembly 120.

As an embodiment, the fourth condensing lens 1301 is disposed between the third diaphragm 138 and the second detector 142 along the propagation path of the light reflected by the reflecting mirror 131, and is disposed between the third diaphragm 138 and the third detector 143. Of course, in a specific application, the arrangement position of the fourth condenser lens 1301 is not limited thereto, and for example, as an alternative embodiment, the fourth condenser lens 1301 is disposed between the mirror 131 and the third diaphragm 138 along the propagation path of the light reflected by the mirror 131.

In addition to the above-mentioned differences, the other structures and working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can be referred to as the first embodiment or the second embodiment, and will not be described in detail herein.

Embodiment four:

the difference between the blood sample analyzer 10 and the optical detection device 100 provided in this embodiment and the first embodiment is mainly that the main technical scheme is different in emphasis, and the difference is specifically that: the main technical solution in the first embodiment mainly protects the shaping and collecting modes of the small-angle scattered light (i.e. the first scattered light) and the large-angle scattered light (i.e. the second scattered light), and the shaping and collecting modes of the medium-angle scattered light (i.e. the third scattered light) are only used as further improved schemes; the main technical scheme of the embodiment mainly protects the collection mode of the small-angle scattered light and the medium-angle scattered light (namely, the third scattered light).

Specifically, the blood sample analyzer 10 provided in the present embodiment includes a sample dispensing device 200, a reagent dispensing device 300, a reaction cell 400, a sample delivery device 500, an optical detection device 100, and a controller 600; wherein the sample distribution device 200 is used for collecting a blood sample from a sample container and distributing at least part of the collected blood sample to the reaction cell 400; the reagent dispensing device 300 is used to dispense a reagent to the reaction cell 400; the reaction cell 400 is used for providing a reaction field for a blood sample and a reagent so as to prepare a sample; the sample transfer apparatus 500 is used to drive the transfer of a sample from the reaction cell 400 to the optical detection apparatus 100.

Specifically, the optical detection device 100 includes a flow chamber 110, a front light component 120, a light shaping component 130, and a light receiving component 140, where the flow chamber 110 is used to receive a sample conveyed by the sample conveying device 500 so as to make particles of the sample queue through under the wrapping of a sheath fluid, and the front light component 120 is used to irradiate light toward the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, the first condensing lens 132 is at least for condensing a first scattered light generated by the front light assembly 120 irradiated to the particles and within a first angle range and a third scattered light generated by the front light assembly 120 irradiated to the particles and within a third angle range, each angle of the first angle range is greater than 0 ° and less than 10 °, each angle of the third angle range is greater than or equal to 10 ° and less than or equal to 20 °.

The body of the reflector 131 is provided with a first light-transmitting portion 1311 and a second reflecting portion 1313, the first light-transmitting portion 1311 is used for transmitting light formed by converging first scattered light through the first condensing lens 132, and the second reflecting portion 1313 is used for reflecting light formed by converging third scattered light through the first condensing lens 132.

The light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and transmitted through the first light transmitting portion 1311, and a third detector 143 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and reflected by the second reflecting portion 1313; the controller 600 is configured to parse the measurement result of the blood sample according to at least the feedback information of the first detector 141 and the third detector 143.

According to the technical scheme, the two detectors are adopted to respectively receive the scattered light rays in two different angle ranges, so that the quality of the optical signals received by each detector can be improved, and the target area, the volume and the cost of each detector can be reduced. In addition, the separation of the scattered light rays in two angle ranges is realized by adopting different structures on the reflecting mirror 131, the structure is simple, the first scattered light rays with smaller angles are collected in a mode of penetrating the reflecting mirror 131, and the third scattered light rays with larger angles are collected in a mode of reflecting, so that the realization can be facilitated. The converging action of the first condenser lens 132 is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target area, volume and cost of the single detector.

The optical detection device 100 provided in this embodiment includes a flow chamber 110, a front light component 120, a light shaping component 130, and a light receiving component 140; the flow chamber 110 is used for queuing particles of the sample to pass under the wrapping of the sheath fluid; the front light assembly 120 is used for illuminating light rays towards the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, the first condensing lens 132 is at least used for converging a first scattered light generated by the front light assembly 120 irradiating to the particles and within a first angle range and a third scattered light generated by the front light assembly 120 irradiating to the particles and within a third angle range, and each angle of the first angle range is greater than 0 ° and less than 10 °, and each angle of the third angle range is greater than or equal to 10 ° and less than or equal to 20 °; the body of the reflector 131 is provided with a first light-transmitting part 1311 and a second reflecting part 1313, the first light-transmitting part 1311 is used for transmitting light formed by converging first scattered light through the first condensing lens 132, and the second reflecting part 1313 is used for reflecting light formed by converging third scattered light through the first condensing lens 132; the light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and transmitted through the first light transmitting portion 1311, and a third detector 143 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and reflected by the second reflecting portion 1313.

In this embodiment, it is not necessary to collect the scattered light (i.e., the second scattered light) in a wide angle range. Of course, in a specific application, the present embodiment may further include a second detector 142 for collecting the light scattered at a large angle, and the specific arrangement may refer to the first embodiment.

The other structures and working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can refer to the first embodiment, the second embodiment or the third embodiment, and will not be described in detail herein.

Fifth embodiment:

referring to fig. 1 to 3 and fig. 7, the difference between the blood sample analyzer 10 and the optical detection device 100 provided in this embodiment and the first embodiment is mainly that the propagation shaping of the scattered light and the arrangement positions of the detectors are different, and specifically: in the first embodiment, the light scattered at a small angle is transmitted and collected in a transmission manner, the light scattered at a medium angle and the light scattered at a large angle are transmitted and collected in a reflection manner, the detector of the light scattered at a small angle is arranged on the optical axis of the light emitted by the front light component 120, and the detector of the light scattered at a medium angle and the detector of the light scattered at a large angle are arranged on the side of the optical axis of the light emitted by the front light component 120; in this embodiment, the large-angle scattered light is transmitted and collected in a transmission manner, the small-angle scattered light is transmitted and collected in a reflection manner, the detector of the large-angle scattered light is disposed on the optical axis of the light emitted by the front light assembly 120, and the detector of the small-angle scattered light is disposed on the side of the optical axis of the light emitted by the front light assembly 120.

Specifically, the blood sample analyzer 10 provided in the present embodiment includes a sample dispensing device 200, a reagent dispensing device 300, a reaction cell 400, a sample delivery device 500, an optical detection device 100, and a controller 600; wherein the sample distribution device 200 is used for collecting a blood sample from a sample container and distributing at least part of the collected blood sample to the reaction cell 400; the reagent dispensing device 300 is used to dispense a reagent to the reaction cell 400; the reaction cell 400 is used for providing a reaction field for a blood sample and a reagent so as to prepare a sample; the sample transfer apparatus 500 is for driving the transfer of a sample from the reaction cell 400 to the optical detection apparatus 100; the optical detection device 100 includes a flow cell 110, a front light assembly 120, a light shaping assembly 130, and a light receiving assembly 140, the flow cell 110 being configured to receive a sample delivered by the sample delivery device 500 such that particles of the sample are queued to pass under the sheath fluid, the front light assembly 120 being configured to illuminate light towards the flow cell 110.

Specifically, the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, where the first condensing lens 132 is at least used to collect a first scattered light generated by the front light assembly 120 irradiating the particles and within a first angle range and a second scattered light generated by the front light assembly 120 irradiating the particles and within a second angle range, where each angle of the first angle range is greater than 0 ° and less than 10 °, and each angle of the second angle range is greater than 20 ° and less than or equal to 70 °; the body of the reflector 131 is provided with a third light-transmitting portion 1315 and a third reflecting portion 1316, the third light-transmitting portion 1315 is used for transmitting light formed by converging the second scattered light through the first condensing lens 132, and the third reflecting portion 1316 is used for reflecting light formed by converging the first scattered light through the first condensing lens 132; the light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and reflected by the third reflecting portion 1316, and a second detector 142 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and transmitted through the third light transmitting portion 1315; the controller 600 is configured to parse the measurement result of the blood sample according to at least the feedback information of the first detector 141 and the second detector 142. In this embodiment, the light scattered with small angles is reflected by the mirror 131 and then received by the first detector 141, and the light scattered with large angles is transmitted through the mirror 131 and then received by the second detector 142. The embodiment also realizes that two detectors are adopted to respectively receive the scattered light rays in two different angle ranges, thereby being beneficial to improving the quality of the optical signal received by each detector and reducing the area, the volume and the cost of the target surface of each detector. In addition, the separation of the scattered light in two angle ranges is realized by adopting different structures on one reflecting mirror 131, and the structure is simple. The converging action of the first condenser lens 132 is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target area, volume and cost of the single detector.

As an embodiment, the first condensing lens 132 is further configured to collect third scattered light generated by the front light assembly 120 irradiating the particles and within a third angle range, each angle of the third angle range is greater than each angle of the first angle range and is smaller than each angle of the second angle range, the body of the reflector 131 is further provided with a second reflecting portion 1313, the second reflecting portion 1313 is configured to reflect light formed by the third scattered light after being collected by the first condensing lens 132, and the light receiving assembly 140 further includes a third detector 143, where the third detector 143 is configured to receive light formed by the third scattered light after being collected by the first condensing lens 132 and being reflected by the second reflecting portion 1313. The controller 600 is configured to analyze the feedback information of the first detector 141, the second detector 142, and the third detector 143 to obtain a measurement result of the blood sample.

The optical detection device 100 provided in this embodiment includes a flow chamber 110, a front light component 120, a light shaping component 130, and a light receiving component 140; the flow chamber 110 is used for queuing particles of the sample to pass under the wrapping of the sheath fluid; the front light assembly 120 is used for illuminating light rays towards the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, the first condensing lens 132 is at least used for converging a first scattered light ray generated by the front light assembly 120 irradiating to the particles and within a first angle range and a second scattered light ray generated by the front light assembly 120 irradiating to the particles and within a second angle range, and each angle of the first angle range is greater than 0 ° and less than 10 °, and each angle of the second angle range is greater than 20 ° and less than or equal to 70 °; the body of the reflector 131 is provided with a third light-transmitting portion 1315 and a third reflecting portion 1316, the third light-transmitting portion 1315 is used for transmitting light formed by converging the second scattered light through the first condensing lens 132, and the third reflecting portion 1316 is used for reflecting light formed by converging the first scattered light through the first condensing lens 132; the light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and reflected by the third reflecting portion 1316, and a second detector 142 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and transmitted through the third light transmitting portion 1315.

As an embodiment of the optical detection device 100, the first condensing lens 132 is further configured to collect third scattered light generated by the front light component 120 irradiating the particles and within a third angle range, each angle of the third angle range is greater than each angle of the first angle range and is less than each angle of the second angle range, the body of the reflector 131 is further provided with a second reflecting portion 1313, the second reflecting portion 1313 is configured to reflect the light formed by the third scattered light after being collected by the first condensing lens 132, and the light receiving component 140 further includes a third detector 143, the third detector 143 is configured to receive the light formed by the third scattered light after being collected by the first condensing lens 132 and being reflected by the second reflecting portion 1313;

in addition to the above-mentioned differences, the other structures and working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can refer to the first embodiment, the second embodiment or the third embodiment, and will not be described in detail herein.

Example six:

referring to fig. 1 to 3, fig. 7 and fig. 8, the difference between the blood sample analyzer 10 and the optical detection device 100 provided in the present embodiment and the fifth embodiment is mainly that the shaping path and the receiving position of the middle-angle scattered light (i.e. the third scattered light) are different, and specifically, the following steps are: in the fifth embodiment, the middle-angle scattered light propagates to the third detector 143 by being reflected by the reflecting mirror 131; in this embodiment, the middle-angle scattered light propagates to the third detector 143 through the transparent portion of the reflecting mirror 131.

Specifically, in the present embodiment, the first condensing lens 132 is further configured to collect third scattered light generated by the front light assembly 120 irradiating the particles and within a third angle range, each angle of the third angle range is greater than each angle of the first angle range and smaller than each angle of the second angle range, the body of the reflecting mirror 131 is further provided with a second light transmitting portion 1314, the second light transmitting portion 1314 is configured to allow the light formed by the third scattered light after being collected by the first condensing lens 132 to pass through, the light receiving assembly 140 further includes a third detector 143, and the third detector 143 is configured to receive the light formed by the third scattered light after being collected by the first condensing lens 132 and passing through the second light transmitting portion 1314. The controller 600 is configured to analyze the feedback information of the first detector 141, the second detector 142, and the third detector 143 to obtain a measurement result of the blood sample.

In addition to the above-mentioned differences, the other structures and the working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can be referred to as the fifth embodiment, and will not be described in detail herein.

Embodiment seven:

the difference between the blood sample analyzer 10 and the optical detection device 100 provided in this embodiment and the first embodiment is mainly that the propagation shaping of the scattered light and the arrangement positions of the detectors are different, and the specific steps are as follows: in the first embodiment, the light scattered at a small angle is transmitted and collected in a transmission mode, the light scattered at a medium angle and the light scattered at a large angle are transmitted and collected in a reflection mode, the detector of the light scattered at a small angle is arranged on the optical axis of the light emitted by the front light component 120, and the detector of the light scattered at a medium angle and the detector of the light scattered at a large angle are arranged on the side of the optical axis of the light emitted by the front light component 120; in this embodiment, the light scattered at a small angle and the light scattered at a large angle are transmitted and collected in a transmission manner, the light scattered at a medium angle is transmitted and collected in a reflection manner, the detector of the light scattered at a small angle and the detector of the light scattered at a large angle are arranged on the optical axis of the light emitted by the front light assembly 120, and the detector of the light scattered at a medium angle is arranged on the side of the optical axis of the light emitted by the front light assembly 120.

The blood sample analyzer 10 provided in this embodiment includes a sample dispensing device 200, a reagent dispensing device 5 device 300, a reaction cell 400, a sample transporting device 500, an optical detecting device 100, and a controller 600; which is a kind of

The sample distribution device 200 is used for collecting a blood sample from a sample container and distributing at least part of the collected blood sample to the reaction cell 400; the reagent dispensing device 300 is used to dispense a reagent to the reaction cell 400; the reaction cell 400 is used for providing a reaction field for a blood sample and a reagent so as to prepare a sample; the sample transfer apparatus 500 is used to drive the transfer of a sample from the reaction cell 400 to the optical detection apparatus 100.

The optical detection device 100 includes a flow cell 110, a front light assembly 120, a light shaping assembly 130, and a light receiving assembly 140, the flow cell 110 being configured to receive a sample delivered by the sample delivery device 500 such that particles of the sample are queued to pass under the entrapment of a sheath fluid, the front light assembly 120 being configured to illuminate light towards the flow cell 110.

The light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, the first condensing lens 132 is used for converging a first scattered light 5 generated by the front light assembly 120 and irradiated to the particles within a first angle range, a second scattered light generated by the front light assembly 120 and irradiated to the particles within a second angle range, and

A third scattered light generated by the front light assembly 120 impinging on the particle and within a third angular range, each angle of the first angular range being smaller than each angle of the second angular range, each angle of the third angular range being greater than each angle of the first angular range and smaller than each angle of the second angular range;

the body of the reflector 131 is provided with a first light-transmitting part 1311, a third light-transmitting part 1315 and a second reflecting part 1313, the first light-transmitting part 1311 is used for transmitting light rays formed by converging first scattered light rays through the first condensing lens 132, the third light-transmitting part 1315 is used for transmitting light rays formed by converging second scattered light rays through the first condensing lens 132, and the second reflecting part 1313 is used for reflecting light rays formed by converging third scattered light rays through the first condensing lens 132;

the light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and transmitted through the first light transmitting portion 1311, a second detector 142 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and transmitted through the third light transmitting portion 1315, and a third detector 143,5 for receiving the light formed by the third scattered light converged by the first condensing lens 132 and reflected by the second reflecting portion 1313.

The controller 600 is configured to analyze and obtain a measurement result of the blood sample according to the feedback information of the first detector 141, the second detector 142, and the third detector 143.

In this embodiment, the first scattered light with a small angle and the second scattered light with a large angle are collected by adopting a manner of penetrating the reflecting mirror 131, and the third scattered light with a medium angle is collected by adopting a manner of reflection, so that three detectors are adopted to respectively receive the scattered light with three different angle ranges, thereby being beneficial to improving the quality of the optical signal received by each detector and reducing the target area, volume and cost of each detector. In addition, the separation of scattered light in three angle ranges is realized by adopting different structures on one reflecting mirror 131, and the structure is simple. The converging action of the first condenser lens 132 is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target area, volume and cost of the single detector.

As an embodiment, the scattered light of the small, medium and large three angle ranges is constrained by the three-in-one first diaphragm 133. Of course, in a specific application, the arrangement of the diaphragm may also adopt a scheme similar to the third embodiment, for example, as an alternative implementation, a diaphragm constraint may be adopted for the scattered light in the middle angle range, and a two-in-one diaphragm constraint may be adopted for the scattered light in the small angle range and the scattered light in the large angle range; alternatively, the scattered light in the middle angle range may be restrained by a diaphragm, the scattered light in the small angle range may be restrained by a diaphragm, and the scattered light in the large angle range may be restrained by a diaphragm.

The optical detection device 100 provided in this embodiment includes a flow chamber 110, a front light component 120, a light shaping component 130, and a light receiving component 140; wherein the flow chamber 110 is used for allowing particles of the sample to pass through in a queue under the wrapping of the sheath fluid; the front light assembly 120 is used for illuminating light rays towards the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, wherein the first condensing lens 132 is configured to condense a first scattered light generated by the front light assembly 120 irradiating the particles within a first angular range, a second scattered light generated by the front light assembly 120 irradiating the particles within a second angular range, and a third scattered light generated by the front light assembly 120 irradiating the particles within a third angular range, each angle of the first angular range being smaller than each angle of the second angular range, each angle of the third angular range being larger than each angle of the first angular range and smaller than each angle of the second angular range; the body of the reflector 131 is provided with a first light-transmitting part 1311, a third light-transmitting part 1315 and a second reflecting part 1313, the first light-transmitting part 1311 is used for transmitting light rays formed by converging first scattered light rays through the first condensing lens 132, the third light-transmitting part 1315 is used for transmitting light rays formed by converging second scattered light rays through the first condensing lens 132, and the second reflecting part 1313 is used for reflecting light rays formed by converging third scattered light rays through the first condensing lens 132; the light receiving assembly 140 includes a first detector 141, a second detector 142, and a third detector 143, the first detector 141 is configured to receive light formed by the first scattered light converging through the first condensing lens 132 and passing through the first light transmitting portion 1311, the second detector 142 is configured to receive light formed by the second scattered light converging through the first condensing lens 132 and passing through the third light transmitting portion 1315, and the third detector 143 is configured to receive light formed by the third scattered light converging through the first condensing lens 132 and reflecting from the second reflecting portion 1313.

In addition to the above-mentioned differences, the other structures and working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can refer to the first embodiment or the third embodiment, and will not be described in detail herein.

Example eight:

the difference between the blood sample analyzer 10 and the optical detection device 100 provided in this embodiment and the first embodiment is mainly that the propagation shaping of the scattered light and the arrangement positions of the detectors are different, and the specific steps are as follows: in the first embodiment, the light scattered at a small angle is transmitted and collected in a transmission mode, the light scattered at a medium angle and the light scattered at a large angle are transmitted and collected in a reflection mode, the detector of the light scattered at a small angle is arranged on the optical axis of the light emitted by the front light component 120, and the detector of the light scattered at a medium angle and the detector of the light scattered at a large angle are arranged on the side of the optical axis of the light emitted by the front light component 120; in this embodiment, the light scattered at a small angle and the light scattered at a large angle are transmitted and collected by reflection, the light scattered at a medium angle is transmitted and collected by transmission, the detector of the light scattered at a medium angle is arranged on the optical axis of the light emitted by the front light assembly 120, and the detector of the light scattered at a small angle and the detector of the light scattered at a large angle are arranged on the side of the optical axis of the light emitted by the front light assembly 120.

The optical detection device 100 includes a flow cell 110, a front light assembly 120, a light shaping assembly 130, and a light receiving assembly 140, the flow cell 110 being configured to receive a sample delivered by the sample delivery device 500 such that particles of the sample are queued to pass under the sheath fluid, the front light assembly 120 being configured to illuminate light towards the flow cell 110.

The light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, wherein the first condensing lens 132 is configured to condense a first scattered light generated by the front light assembly 120 irradiating the particles within a first angular range, a second scattered light generated by the front light assembly 120 irradiating the particles within a second angular range, and a third scattered light generated by the front light assembly 120 irradiating the particles within a third angular range, each angle of the first angular range is smaller than each angle of the second angular range, and each angle of the third angular range is larger than each angle of the first angular range and smaller than each angle of the second angular range.

The body of the reflector 131 is provided with a third reflecting portion 1316, a first reflecting portion 1312 and a second light transmitting portion 1314, wherein the third reflecting portion 1316 is configured to reflect light formed by converging first scattered light through the first condensing lens 132, the first reflecting portion 1312 is configured to reflect light formed by converging second scattered light through the first condensing lens 132, and the second light transmitting portion 1314 is configured to allow light formed by converging third scattered light through the first condensing lens 132 to transmit.

The light receiving assembly 140 includes a first detector 141, a second detector 142, and a third detector 143, the first detector 141 is configured to receive light formed by the first scattered light being collected by the first condensing lens 132 and reflected by the third reflecting portion 1316, the second detector 142 is configured to receive light formed by the second scattered light being collected by the first condensing lens 132 and reflected by the first reflecting portion 1312, and the third detector 143 is configured to receive light formed by the third scattered light being collected by the first condensing lens 132 and transmitted through the second transmitting portion 1314; the controller 600 is configured to analyze and obtain a measurement result of the blood sample according to the feedback information of the first detector 141, the second detector 142, and the third detector 143.

In this embodiment, the first scattered light with a small angle and the second scattered light with a large angle are collected by adopting a reflection mode, and the third scattered light with a medium angle is collected by adopting a mode of transmitting the reflector 131, so that three detectors are adopted to respectively receive scattered light with three different angle ranges, which is beneficial to improving the quality of optical signals received by each detector and reducing the target area, volume and cost of each detector. In addition, the separation of scattered light in three angle ranges is realized by adopting different structures on one reflecting mirror 131, and the structure is simple. The converging action of the first condenser lens 132 is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target area, volume and cost of the single detector.

The optical detection device 100 provided in this embodiment includes a flow chamber 110, a front light component 120, a light shaping component 130, and a light receiving component 140; wherein the flow chamber 110 is used for allowing particles of the sample to pass through in a queue under the wrapping of the sheath fluid; the front light assembly 120 is used for illuminating light rays towards the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a reflecting mirror 131, wherein the first condensing lens 132 is configured to condense a first scattered light generated by the front light assembly 120 irradiating the particles within a first angular range, a second scattered light generated by the front light assembly 120 irradiating the particles within a second angular range, and a third scattered light generated by the front light assembly 120 irradiating the particles within a third angular range, each angle of the first angular range being smaller than each angle of the second angular range, each angle of the third angular range being larger than each angle of the first angular range and smaller than each angle of the second angular range; the body of the reflector 131 is provided with a third reflecting part 1316, a first reflecting part 1312 and a second light transmitting part 1314, the third reflecting part 1316 is used for reflecting light rays formed by converging first scattered light rays through the first condensing lens 132, the first reflecting part 1312 is used for reflecting light rays formed by converging second scattered light rays through the first condensing lens 132, and the second light transmitting part 1314 is used for transmitting light rays formed by converging third scattered light rays through the first condensing lens 132; the light receiving assembly 140 includes a first detector 141, a second detector 142, and a third detector 143, the first detector 141 is configured to receive light formed by the first scattered light being converged by the first condensing lens 132 and reflected by the third reflecting portion 1316, the second detector 142 is configured to receive light formed by the second scattered light being converged by the first condensing lens 132 and reflected by the first reflecting portion 1312, and the third detector 143 is configured to receive light formed by the third scattered light being converged by the first condensing lens 132 and transmitted through the second transmitting portion 1314.

Example nine:

the blood sample analyzer 10 and the optical detection device 100 provided in the present embodiment mainly reside in a three-in-one diaphragm structure design.

The optical detection device 100 includes a flow cell 110, a front light assembly 120, a light shaping assembly 130, and a light receiving assembly 140, the flow cell 110 configured to receive a sample delivered by the sample delivery device 500 such that particles of the sample are queued under the sheath fluid, and the front light assembly 120 configured to illuminate light toward the flow cell 110.

The light shaping assembly 130 includes a first condensing lens 132 and a first diaphragm 133, where the first condensing lens 132 is disposed between the flow chamber 110 and the first diaphragm 133 along an optical axis of the light emitted by the front light assembly 120, and the first condensing lens 132 is configured to collect a first scattered light generated by the front light assembly 120 and irradiated to the particle in a first angular range, a second scattered light generated by the front light assembly 120 and irradiated to the particle in a second angular range, and a third scattered light generated by the front light assembly 120 and irradiated to the particle in a third angular range, and each angle of the first angular range is smaller than each angle of the second angular range, and each angle of the third angular range is larger than each angle of the first angular range and smaller than each angle of the second angular range.

The first diaphragm 133 is provided with a first straight blocking portion 1331, a first through hole 1332, a second through hole 1333 and a third through hole 1334, the first straight blocking portion 1331 is at least used for absorbing light rays irradiated to particles by the front light component 120 and penetrating the particles and the first condensing lens 132 directly, the first through hole 1332 is used for allowing light rays formed by converging first scattered light rays through the first condensing lens 132 to pass through, the second through hole 1333 is used for allowing light rays formed by converging second scattered light rays through the first condensing lens 132 to pass through, and the third through hole 1334 is used for allowing light rays formed by converging third scattered light rays through the first condensing lens 132 to pass through.

The light receiving assembly 140 includes a first detector 141 for receiving the light formed by the first scattered light converged by the first condensing lens 132 and passing through the first through hole 1332, a second detector 142 for receiving the light formed by the second scattered light converged by the first condensing lens 132 and passing through the second through hole 1333, and a third detector 143 for receiving the light formed by the third scattered light converged by the first condensing lens 132 and passing through the third through hole 1334; the controller 600 is configured to analyze and obtain a measurement result of the blood sample according to the feedback information of the first detector 141, the second detector 142, and the third detector 143.

According to the embodiment, the three detectors are adopted to respectively receive the scattered light rays in three different angle ranges, so that the quality of the optical signal received by each detector is improved, and the target area, the volume and the cost of each detector are reduced. In addition, the three-in-one diaphragm is adopted to realize the separation of scattered light rays in three angle ranges through different through holes, and the structure is simple. The converging action of the first condenser lens 132 is beneficial to reducing the receiving light spots of the detector, and further beneficial to further reducing the target area, volume and cost of the single detector.

As an embodiment, the second through hole 1333 and the third through hole 1334 are respectively disposed at two opposite sides of the first straight portion 1331, and a distance from the third through hole 1334 to the center of the first diaphragm 133 is greater than a distance from the first through hole 1332 to the center of the first diaphragm 133 and less than a distance from the second through hole 1333 to the center of the first diaphragm 133.

As one embodiment, the number of the first through holes 1332 is two, and the two first through holes 1332 are respectively arranged at two opposite sides of the first straight blocking portion 1331.

The optical detection device 100 provided in this embodiment includes a flow chamber 110, a front light component 120, a light shaping component 130, and a light receiving component 140; the flow chamber 110 is used for queuing particles of the sample to pass under the wrapping of the sheath fluid; the front light assembly 120 is used for illuminating light rays towards the flow chamber 110; the light shaping assembly 130 includes a first condensing lens 132 and a first diaphragm 133, where the first condensing lens 132 is disposed between the flow chamber 110 and the first diaphragm 133 along an optical axis of the light emitted by the front light assembly 120, and the first condensing lens 132 is configured to collect a first scattered light generated by the front light assembly 120 and irradiated to the particle in a first angular range, a second scattered light generated by the front light assembly 120 and irradiated to the particle in a second angular range, and a third scattered light generated by the front light assembly 120 and irradiated to the particle in a third angular range, and each angle of the first angular range is smaller than each angle of the second angular range, and each angle of the third angular range is larger than each angle of the first angular range and smaller than each angle of the second angular range. The first diaphragm 133 is provided with a first straight blocking portion 1331, a first through hole 1332, a second through hole 1333 and a third through hole 1334, the first straight blocking portion 1331 is at least used for absorbing light rays irradiated to particles by the front light component 120 and penetrating the particles and the first condensing lens 132 directly, the first through hole 1332 is used for allowing light rays formed by converging first scattered light rays through the first condensing lens 132 to pass through, the second through hole 1333 is used for allowing light rays formed by converging second scattered light rays through the first condensing lens 132 to pass through, and the third through hole 1334 is used for allowing light rays formed by converging third scattered light rays through the first condensing lens 132 to pass through; the light receiving assembly 140 includes a first detector 141 for receiving light rays collected by the first scattered light rays through the first condensing lens 132 and formed through the first through hole 1332, a second detector 142 for receiving light rays collected by the second scattered light rays through the first condensing lens 132 and formed through the second through hole 1333, and a third detector 143 for receiving light rays collected by the third scattered light rays through the first condensing lens 132 and formed through the third through hole 1334.

In addition to the above-mentioned differences, the other structures and working principles of the blood sample analyzer 10 and the optical detection device 100 according to the present embodiment can refer to the first embodiment, the second embodiment, the fourth embodiment, the fifth embodiment, the sixth embodiment, the seventh embodiment, or the eighth embodiment, and will not be described in detail herein.

The foregoing description is only of the preferred embodiments of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structural changes made by the description of the present utility model and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the utility model.

Claims

1. A blood sample analyzer, characterized by: comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

2. The blood sample analyzer of claim 1, wherein: the first condensing lens is further used for converging third scattered light which is generated by the particles irradiated by the front light component and is in a third angle range, the body of the reflecting mirror is further provided with a second reflecting part, the second reflecting part is used for reflecting light which is formed by converging the third scattered light through the first condensing lens, and each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range;

3. The blood sample analyzer of claim 1, wherein: the first condensing lens is further used for converging third scattered light which is generated by the particles irradiated by the front light component and is in a third angle range, the body of the reflecting mirror is further provided with a second light transmission part, the second light transmission part is used for transmitting light which is formed by converging the third scattered light through the first condensing lens, and each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range;

4. The blood sample analyzer of claim 2, wherein: each angle of the first angular range is greater than 0 ° and less than 10 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than 20 ° and less than or equal to 70 °.

5. A blood sample analyzer as claimed in claim 3 wherein: each angle of the first angular range is greater than 0 ° and less than 10 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than 20 ° and less than or equal to 70 °.

6. The blood sample analyzer of claim 4, wherein: each angle of the first angular range is greater than or equal to 1 ° and less than or equal to 5 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than or equal to 22 ° and less than or equal to 43 °.

7. The blood sample analyzer of claim 5, wherein: each angle of the first angular range is greater than or equal to 1 ° and less than or equal to 5 °, each angle of the third angular range is greater than or equal to 10 ° and less than or equal to 20 °, and each angle of the second angular range is greater than or equal to 22 ° and less than or equal to 43 °.

8. A blood sample analyzer according to any one of claims 2 to 7, wherein: the light shaping assembly further comprises a first diaphragm, the first diaphragm is arranged between the first condensing lens and the reflecting mirror along an optical axis of the light emitted by the front light assembly, the first diaphragm is provided with a first straight blocking part, a first through hole, a second through hole and a third through hole, the first straight blocking part is at least used for blocking the light which is irradiated to the particles by the front light assembly and directly irradiates through the particles and the first condensing lens, the first through hole is used for allowing the light which is formed by the first scattered light after converging through the first condensing lens to pass through, the second through hole is used for allowing the light which is formed by the second scattered light after converging through the first condensing lens to pass through, and the third through hole is used for allowing the light which is formed by the third scattered light after converging through the first condensing lens to pass through.

9. The blood sample analyzer of claim 8, wherein: the second through hole and the third through hole are respectively arranged on two opposite sides of the first straight blocking part, and the distance from the third through hole to the center of the first diaphragm is larger than the distance from the first through hole to the center of the first diaphragm and smaller than the distance from the second through hole to the center of the first diaphragm; and/or the number of the groups of groups,

10. The blood sample analyzer of claim 8, wherein: the first condensing lens is used for converging the first scattered light, the second scattered light and the third scattered light into light gradually converging towards the optical axis; and/or the number of the groups of groups,

11. The blood sample analyzer of claim 2, 4 or 6, wherein: the light shaping assembly further comprises a second light converging lens, wherein the second light converging lens is arranged between the reflecting mirror and the second detector and between the reflecting mirror and the third detector along the propagation path of the light reflected by the reflecting mirror, and is used for converging and irradiating the light reflected by the first reflecting part to the second detector and converging and irradiating the light reflected by the second reflecting part to the third detector;

Wherein, preferably, the second condensing lens is a cylindrical lens.

12. The blood sample analyzer of claim 2, wherein: the light shaping assembly further comprises a second diaphragm and a third diaphragm, the second diaphragm is arranged between the reflecting mirror and the first detector along the optical axis of the light emitted by the front light assembly, the second diaphragm is provided with a second straight blocking part and a fourth through hole, the second straight blocking part is at least used for blocking the light which is irradiated to the particles by the front light assembly and passes through the particles and the first condensing lens, and the fourth through hole is used for allowing the light which is converged by the first scattered light through the first condensing lens and passes through the first light transmitting part to pass through;

the third diaphragm is arranged between the reflector and the second detector along the propagation path of the light reflected by the reflector and between the reflector and the third detector, the third diaphragm is provided with a fifth through hole and a sixth through hole, the fifth through hole is used for allowing the light formed by the second scattered light after being converged by the first condensing lens and reflected by the first reflecting part to pass through, and the sixth through hole is used for allowing the light formed by the third scattered light after being converged by the first condensing lens and reflected by the second reflecting part to pass through.

13. The blood sample analyzer of claim 12, wherein: the light shaping assembly further comprises a third light condensing lens and a fourth light condensing lens, the third light condensing lens is arranged between the second diaphragm and the first detector along the optical axis of the light emitted by the front light assembly, and the third light condensing lens is used for converging and irradiating the light transmitted through the first light transmitting part to the first detector;

14. A blood sample analyzer according to any one of claims 2 to 3 or 12 or 13, wherein: the controller is used for analyzing and obtaining the white blood cell classification count value of the blood sample at least according to the feedback information of the first detector, the second detector and the third detector.

15. A blood sample analyzer, characterized by: comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

16. A blood sample analyzer, characterized by: comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

17. The blood sample analyzer of claim 16, wherein: the first condensing lens is further used for converging third scattered light which is generated by the irradiation of the front light component to the particles and is in a third angle range, each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range, the body of the reflecting mirror is further provided with a second reflecting part, the second reflecting part is used for reflecting the light which is formed by the third scattered light after being converged by the first condensing lens, the light receiving component further comprises a third detector, the third detector is used for receiving the light which is formed by the third scattered light after being converged by the first condensing lens and reflected by the second reflecting part, and the controller is used for obtaining a measurement result of a blood sample according to feedback information of the first detector, the second detector and the third detector; or alternatively, the process may be performed,

18. A blood sample analyzer, characterized by: comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

19. A blood sample analyzer, characterized by: comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

20. A blood sample analyzer, characterized by: comprises a sample distribution device, a reagent distribution device, a reaction tank, a sample conveying device, an optical detection device and a controller;

21. The blood sample analyzer of claim 20, wherein: the second through hole and the third through hole are respectively arranged on two opposite sides of the first straight blocking part, and the distance from the third through hole to the center of the first diaphragm is larger than the distance from the first through hole to the center of the first diaphragm and smaller than the distance from the second through hole to the center of the first diaphragm; and/or the number of the groups of groups,

22. An optical detection device, characterized in that: comprises a flow chamber, a front light component, a light shaping component and a light receiving component;

23. The optical detection apparatus according to claim 22, wherein: the first condensing lens is further used for converging third scattered light which is generated by the irradiation of the front light component to the particles and is in a third angle range, each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range, the body of the reflecting mirror is further provided with a second reflecting part, the second reflecting part is used for reflecting light which is formed by the third scattered light after being converged by the first condensing lens, and the light receiving component further comprises a third detector, and the third detector is used for receiving light which is formed by the third scattered light after being converged by the first condensing lens and reflected by the second reflecting part; or alternatively, the process may be performed,

24. The optical detection device of claim 23, wherein: the light shaping assembly further comprises a first diaphragm, the first diaphragm is arranged between the first condensing lens and the reflecting mirror along an optical axis of the light emitted by the front light assembly, the first diaphragm is provided with a first straight blocking part, a first through hole, a second through hole and a third through hole, the first straight blocking part is at least used for absorbing the light which is irradiated to the particles by the front light assembly and is transmitted through the particles and the first condensing lens, the first through hole is used for transmitting the light which is formed by the first scattered light after the first scattered light is converged by the first condensing lens, the second through hole is used for transmitting the light which is formed by the second scattered light after the second scattered light is converged by the first condensing lens, and the third through hole is used for transmitting the light which is formed by the third scattered light after the third scattered light is converged by the first condensing lens.

25. The optical detection apparatus according to claim 24, wherein: the first condensing lens is used for converging the first scattered light, the second scattered light and the third scattered light into light gradually converging towards the optical axis, and at least one of an incident surface and an emergent surface of the first condensing lens is an aspheric surface; and/or the number of the groups of groups,

26. An optical detection device, characterized in that: comprises a flow chamber, a front light component, a light shaping component and a light receiving component;

27. An optical detection device, characterized in that: comprises a flow chamber, a front light component, a light shaping component and a light receiving component;

28. The optical detection apparatus according to claim 27, wherein: the first condensing lens is further used for converging third scattered light which is generated by the irradiation of the front light component to the particles and is in a third angle range, each angle of the third angle range is larger than each angle of the first angle range and smaller than each angle of the second angle range, the body of the reflecting mirror is further provided with a second reflecting part, the second reflecting part is used for reflecting light which is formed by the third scattered light after being converged by the first condensing lens, and the light receiving component further comprises a third detector, and the third detector is used for receiving light which is formed by the third scattered light after being converged by the first condensing lens and reflected by the second reflecting part; or alternatively, the process may be performed,

29. An optical detection device, characterized in that: comprises a flow chamber, a front light component, a light shaping component and a light receiving component;

30. An optical detection device, characterized in that: comprises a flow chamber, a front light component, a light shaping component and a light receiving component;

31. An optical detection device, characterized in that: comprises a flow chamber, a front light component, a light shaping component and a light receiving component;