CN218833616U

CN218833616U - Crystallization device is used in production of monatiravir

Info

Publication number: CN218833616U
Application number: CN202222846479.3U
Authority: CN
Inventors: 侯鹏翼
Original assignee: Fujian Weijia Biomedical Co ltd
Current assignee: Fujian Weijia Biomedical Co ltd
Priority date: 2022-10-27
Filing date: 2022-10-27
Publication date: 2023-04-11
Anticipated expiration: 2032-10-27

Abstract

The utility model relates to a crystallization device for producing moania-birasvir, which comprises a vapor-liquid separator and a crystallizer which are distributed up and down; the vapor-liquid separator is provided with a vapor outlet and a feed inlet; the crystallizer is provided with a discharge hole, and a cavity is formed in the side wall of the crystallizer; a heat exchange coil is arranged in the cavity; the upper end of the heat exchange coil is connected with a circulating heat exchange mechanism; the lower end of the heat exchange coil is connected with a circulating heat exchange mechanism through a hose; the heat exchange coil is in close contact with the inner side wall of the cavity. A heat exchange medium can circularly flow in the heat exchange coil pipe by arranging the heat exchange coil pipe in the cavity of the crystallizer and connecting the circulating heat exchange mechanism with the heat exchange coil pipe; because heat exchange coil and cavity inside wall direct contact, so heat medium can incessantly absorb the heat of inside liquid to transfer to and dispel the heat in the middle of circulating heat transfer mechanism, make the heat transfer cooling.

Description

Crystallization device is used in production of mazopyr

Technical Field

The utility model relates to a crystallization device specifically is a crystallization device is used in production of monatiravir belongs to pharmaceutical products production facility technical field.

Background

Munebiravir (Molnopiravir) (code MK-4482 or EIDD-2801) is an oral drug developed by Molosedong corporation of America as a small molecule antiviral drug for cytidine. The company, 9/23/2021, disclosed a process for the preparation of monatiravir, in which a crystallization step was provided. The application is based on a crystallization device designed based on the method. In the conventional crystallization process, the liquid circulation needs to be subjected to flash evaporation, precipitation and crystallization; in the process of precipitation and crystallization, because the liquid after flash evaporation has higher temperature and can not be cooled to the temperature required by crystallization in a short time, the crystallization efficiency is lower, and the liquid circulation process is prolonged; in the prior art, partial crystallization equipment improves the cooling speed by additionally arranging a heat dissipation device on the outer side of a tank body; however, this method still fails to satisfy the high requirements.

Therefore, further improvements are awaited.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model provides a crystallization device is used in production of monatiravir for overcoming the defect among the prior art, improves crystallization efficiency for cycle period, and simple structure is reasonable, promotes cooling rate.

The utility model discloses the following technical scheme of accessible realizes:

a crystallization device for producing monatiravir comprises a vapor-liquid separator and a crystallizer which are distributed up and down; the vapor-liquid separator is provided with a vapor outlet and a feed inlet; the crystallizer is provided with a discharge hole and is characterized in that: a cavity is formed in the side wall of the crystallizer; a heat exchange coil is arranged in the cavity; the upper end of the heat exchange coil is connected with a circulating heat exchange mechanism; the lower end of the heat exchange coil is connected with a circulating heat exchange mechanism through a hose; the heat exchange coil is in close contact with the inner side wall of the cavity.

Preferably, the inner side wall of the cavity is made of a heat-conducting metal material; the heat exchange coil is coiled in the cavity and is tightly attached to the outer surface of the inner side wall.

Preferably, the circulating heat exchange mechanism comprises a heat dissipation cold drain and a circulating pump which are arranged in sequence; the upper side surface of the crystallizer is provided with a mounting bracket; the heat dissipation cold drain and the circulating pump are arranged on the mounting bracket.

Preferably, the circulating pump is provided with a liquid inlet end and a liquid outlet end; the liquid inlet end is connected with a liquid outlet of the cold discharge pipe; the liquid outlet end is connected with the upper end of the heat exchange coil.

Preferably, the heat dissipation cold row is also provided with a liquid inlet; the liquid inlet is connected with one end of the hose; the other end of the hose is connected with the lower end of the heat dissipation coil pipe.

Preferably, the heat dissipation cold row is provided with a liquid passing cavity; the surface of the liquid passing cavity is provided with radiating fins; the lower ends of the radiating fins are positioned in the liquid passing cavity.

Preferably, the heat dissipation cold row is also provided with a fan; the fan is fixedly arranged on the surface of the radiating fin; the air outlet direction of the fan is opposite to the radiating fins.

The utility model discloses possess following beneficial effect: the heat exchange medium can circularly flow in the heat exchange coil pipe by arranging the replacement heat coil pipe in the cavity of the crystallizer and connecting the circulating heat exchange mechanism with the heat exchange coil pipe; because the heat exchange coil is in direct contact with the inner side wall of the cavity, the heat exchange medium can uninterruptedly absorb the heat of the internal liquid and is transferred to the circulating heat exchange mechanism for heat dissipation, so that the heat exchange is cooled; so reciprocal, adopt the mode of liquid cooling, the inside heat of continuous taking away the crystallizer, very big cooling rate of having accelerated promotes crystallization efficiency.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic connection diagram of the heat exchange coil and the circulating heat exchange mechanism.

In the figure: the heat-dissipation cooling system comprises a gas-liquid separator 1, a crystallizer 2, a cavity 3, a heat-exchange coil 4, a heat-dissipation cold bar 5, a circulating pump 6, a mounting support 7, a hose 8, heat-dissipation fins 9 and a fan 10.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

Terms used herein, including technical and scientific terms, have the same meaning as terms commonly understood by one of ordinary skill in the art, unless otherwise defined. It will be understood that terms, which are defined in commonly used dictionaries, have a meaning that is consistent with their meaning in the context of the present art.

Referring to fig. 1-fig. 2, a crystallization device for producing the monatiravir comprises a vapor-liquid separator 1 and a crystallizer 2 which are distributed up and down; the vapor-liquid separator 1 is provided with a vapor outlet and a feed inlet; the crystallizer 2 is provided with a discharge hole and is characterized in that: a cavity 3 is formed in the side wall of the crystallizer 2; a heat exchange coil 4 is arranged in the cavity 3; the upper end of the heat exchange coil 4 is connected with a circulating heat exchange mechanism; the lower end of the heat exchange coil 4 is connected with a circulating heat exchange mechanism through a hose; the heat exchange coil 4 is closely contacted with the inner side wall of the cavity 3.

Further, the inner side wall of the cavity 3 is made of a heat-conducting metal material; the heat exchange coil 4 is coiled in the cavity 3 and is tightly attached to the outer surface of the inner side wall.

Further, the circulating heat exchange mechanism comprises a heat dissipation cold row 5 and a circulating pump 6 which are arranged in sequence; the upper side surface of the crystallizer is provided with a mounting bracket 7; the heat dissipation cold row 5 and the circulating pump 6 are arranged on the mounting bracket 7.

Furthermore, the circulating pump 6 is provided with a liquid inlet end and a liquid outlet end; the liquid inlet end is connected with a liquid outlet of the heat dissipation cold row 5; the liquid outlet end is connected with the upper end of the heat exchange coil 6.

Furthermore, the heat dissipation cold row 5 is also provided with a liquid inlet; the liquid inlet is connected with one end of a hose 8; the other end of the hose 8 is connected with the lower end of the heat radiation coil 4.

Furthermore, the heat dissipation cold row 5 is provided with a liquid passing cavity; the surface of the liquid passing cavity is provided with radiating fins 9; the lower ends of the radiating fins 9 are positioned in the liquid passing cavity.

Further, the heat dissipation cold row is also provided with a fan 10; the fan 10 is fixedly arranged on the surface of the radiating fin; the air outlet direction of the fan is opposite to the radiating fins.

The working principle is as follows: the heat exchange coil 4 absorbs heat from the side wall of the crystallizer 2 and transfers the heat to heat exchange liquid, the heat exchange liquid can circularly enter the heat dissipation cold row 5 under the action of the circulating pump, the heat carried by the heat exchange liquid is transferred to the heat dissipation fins through each heat dissipation fin, and the heat dissipation fins are provided with fans which can continuously blast the heat dissipation fins so as to improve the cooling rate of the heat dissipation fins. Through the above-mentioned step of recirculation, can be incessant carry over the heat outwards out from crystallizer 2 for the cooling rate in the crystallizer improves greatly, and then can improve the efficiency of liquid sediment and crystallization.

Finally, it is noted that the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting, and although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced with equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should be covered by the scope of the claims of the present invention.

Claims

1. A crystallization device for producing the Muiravir comprises a vapor-liquid separator and a crystallizer which are distributed up and down; the vapor-liquid separator is provided with a vapor outlet and a feed inlet; the crystallizer is provided with a discharge port and is characterized in that: a cavity is formed in the side wall of the crystallizer; a heat exchange coil is arranged in the cavity; the upper end of the heat exchange coil is connected with a circulating heat exchange mechanism; the lower end of the heat exchange coil is connected with the circulating heat exchange mechanism through a hose; the heat exchange coil is in close contact with the inner side wall of the cavity.

2. The crystallization apparatus for producing monatiravir according to claim 1, wherein: the inner side wall of the cavity is made of a heat-conducting metal material; the heat exchange coil is coiled in the cavity and is tightly attached to the outer surface of the inner side wall.

3. The crystallization apparatus for producing monatiravir according to claim 2, wherein: the circulating heat exchange mechanism comprises a heat dissipation cold drain and a circulating pump which are arranged in sequence; the upper side surface of the crystallizer is provided with a mounting bracket; the heat dissipation cold drain and the circulating pump are arranged on the mounting bracket.

4. The crystallization apparatus for producing monatiravir according to claim 3, wherein: the circulating pump is provided with a liquid inlet end and a liquid outlet end; the liquid inlet end is connected with the liquid outlet of the cold row; the liquid outlet end is connected with the upper end of the heat exchange coil.

5. The crystallization apparatus for producing monatiravir according to claim 4, wherein: the heat dissipation cold bar is also provided with a liquid inlet; the liquid inlet is connected with one end of a hose; the other end of the hose is connected with the lower end of the heat dissipation coil pipe.

6. The crystallization apparatus for producing monatiravir according to claim 5, wherein: the heat dissipation cold row is provided with a liquid passing cavity; the surface of the liquid passing cavity is provided with radiating fins; the lower ends of the radiating fins are positioned in the liquid passing cavity.

7. The crystallization apparatus for producing monatiravir according to claim 6, wherein: the heat dissipation cold row is also provided with a fan; the fan is fixedly arranged on the surface of the radiating fin; the air outlet direction of the fan is opposite to the radiating fins.