CN218824189U

CN218824189U - Trace sample processing apparatus of online pH monitoring

Info

Publication number: CN218824189U
Application number: CN202222813532.XU
Authority: CN
Inventors: 张真庆; 魏羽瑶; 李笃信; 易琳
Original assignee: Suzhou University
Current assignee: Suzhou University
Priority date: 2022-10-25
Filing date: 2022-10-25
Publication date: 2023-04-07
Anticipated expiration: 2032-10-25

Abstract

The utility model discloses a trace sample processing device for online pH monitoring, wherein a top cover is arranged at the upper end of a trace sample analysis pool; the pH sensing module comprises an upper pH sensing probe and a lower signal transmission line, and the circuit signal transmission module is connected with the pH sensing module through the signal transmission line; the online pH display instrument comprises a shell, a control chip arranged at the bottom in the shell and a display screen arranged outside the shell, and the bottom end of the circuit signal transmission module is connected with the control chip. The utility model transmits the pH value of the micro sample analysis pool sensed by the pH sensing module to the circuit signal transmission module through the signal transmission line, and the circuit signal transmission module transmits the pH result of the micro sample analysis pool to the online pH display instrument through the control chip, so that the real-time monitoring can be realized, the proper pH target value can be selected, the structure is simple, and the operation is flexible; through the magnetic paste, a plurality of trace sample processing devices for online pH monitoring can be connected in series, a plurality of samples can be analyzed simultaneously, and the operability is high.

Description

Trace sample processing apparatus of online pH monitoring

Technical Field

The utility model belongs to the technical field of laboratory instrument and device, concretely relates to trace sample processing apparatus of online pH monitoring.

Background

Pretreatment of a micro sample is a very time-consuming, tedious and easily introduced analytical determination error process. There are many components which interfere with the measurement, and the components to be measured must be extracted by physical, chemical or other methods, and in the case of samples of drugs, protein-bound drugs, metabolites, glucuronides, sulfate conjugates and the like, acid hydrolysis or alkaline hydrolysis is often used. For example, heparin drugs are usually subjected to acidolysis on samples when qualitative and quantitative analysis of aminosugars is performed, and after the acidolysis link is finished, a trace amount of acidolysis solution is required to be taken to adjust the pH value to be neutral, so that constant volume can be performed and the sample can be transferred to a sample stock solution for subsequent experiments, and different solubilities of proteins in the solution are utilized. The solubility of proteins depends on the type and charge number of the amino acids in the molecule, and is altered by changing the buffer pH, ionic strength, dielectric constant, or temperature. In determining total amino acids in a protein, the protein must first be hydrolyzed to free amino acids. Acid hydrolysis, base hydrolysis and enzymatic hydrolysis methods can be used, with acid hydrolysis being the most widely used.

In the laboratory treatment of the above-mentioned acid or alkaline hydrolysis microsamples, it is often necessary to adjust their pH to the value required for the experiment. The conventional procedure is to suck up a micro sample and put it in a small centrifuge tube (EP tube), and add dropwise a prepared acid or alkali solution to the micro sample to reach a target value, but the following problems occur in the process. Firstly, after the regulating solution is dripped into a sample each time, the sample is uniformly mixed by using a vortex instrument, but the pH value is often adjusted once without a method, and then the sample needs to be repeatedly opened, and unnecessary impurities may be introduced in the process; secondly, for the trace sample, the pH value is determined by using a pH test paper, which causes another problem, and a point of solution is taken from the trace sample every time to measure the pH value, so that on one hand, the loss of the sample is caused, and the concentration of the sample is possibly inaccurate; the above is a tedious process for processing a sample, and if the consistency evaluation of the medicine is performed, the process of adjusting the pH value is time-consuming and labor-consuming when a large quantity of trace samples need to be processed at one time.

Disclosure of Invention

The utility model aims at providing a trace sample processing apparatus of online pH monitoring.

The technical scheme of the utility model is that: a trace sample processing device for online pH monitoring comprises an online pH display instrument, a trace sample analysis pool arranged at the upper end of the online pH display instrument, a pH induction module arranged at the bottom in the trace sample analysis pool and a circuit signal transmission module arranged in the online pH display instrument; the top cover is arranged at the upper end of the micro sample analysis pool, so that sample pollution and loss caused by splashing when samples are mixed can be avoided; the pH sensing module comprises an upper pH sensing probe and a lower signal transmission line, and the circuit signal transmission module is connected with the pH sensing module through the signal transmission line; the online pH display instrument comprises a shell, a control chip arranged at the bottom in the shell and a display screen arranged outside the shell, wherein the bottom end of the circuit signal transmission module is connected with the control chip, and a result is transmitted to the online pH display instrument through the signal transmission line.

Furthermore, the pH sensing module and the bottom of the micro sample analysis pool are integrated during design.

Furthermore, online pH display still including setting up the magnet of the outside left and right sides of casing, it is a plurality of online pH monitoring's trace sample processing apparatus can pass through the magnet is established ties, puts and can analyze a plurality of samples simultaneously on the shaking table.

Furthermore, the pH sensing probe is positioned at the bottom of the micro sample analysis pool and is arched-bottom concave.

Furthermore, the pH sensing probe is made of a glass sensitive film, the diameter of the glass sensitive film is 5mm, and the height of the glass sensitive film is 5mm.

Furthermore, the micro sample analysis pool is made of borosilicate glass.

Further, the micro sample analysis cell has a specification of 1.5mL, a diameter of 12mm and a height of 35mm.

Further, the micro sample analysis cell has a specification of 5mL, a diameter of 15mm and a height of 50mm.

Further, the position of 2/3 height of the outer surface of the micro sample analysis pool from bottom to top is provided with a highest water level line prompt.

The utility model has the advantages that:

1. the utility model transmits the pH value of the micro sample analysis pool sensed by the pH sensing module to the circuit signal transmission module through the signal transmission line, the circuit signal transmission module transmits the pH result of the micro sample analysis pool to the online pH display instrument through the control chip, the pH value of the micro sample is monitored in real time, and the proper pH target value can be selected at any time, the structure is simple, the manufacture is convenient, and the operation is flexible;

2. a plurality of trace sample processing devices for online pH monitoring can be connected in series through the magnetic paste, a plurality of samples are analyzed simultaneously, and the operability is high.

Drawings

The invention will be further described with reference to the following drawings and examples:

fig. 1 is a schematic structural view of the present invention;

fig. 2 is a front view of the present invention;

fig. 3 is a schematic structural diagram of the pH sensing module of the present invention.

Wherein: 1. the device comprises a top cover, a micro sample analysis pool 2, a maximum water level line prompt 21, a pH sensing module 3, a pH sensing probe 31, a pH sensing probe 32, a signal transmission line 4, a circuit signal transmission module 5, an online pH display instrument 51, a shell 52, a control chip 53, a magnetic patch 54 and a display screen.

Detailed Description

Example (b): referring to fig. 1-2, a trace sample processing device for online pH monitoring includes an online pH display 5, a trace sample analysis cell 2 disposed at an upper end of the online pH display 5, a pH sensing module 3 disposed at a bottom of the trace sample analysis cell 2, and a circuit signal transmission module 4 disposed inside the online pH display 5; a highest water level line prompt 21 is arranged at the height of 2/3 of the outer surface of the micro sample analysis pool 2 from bottom to top; the top cover 1 is arranged at the upper end of the micro sample analysis pool 2, so that sample pollution and loss caused by splashing when samples are mixed can be avoided; the pH sensing module 3 and the bottom of the micro sample analysis pool 2 are integrated during design; the pH sensing module 3 comprises an upper pH sensing probe 31 and a lower signal transmission line 32, and the circuit signal transmission module 4 is connected with the pH sensing module 3 through the signal transmission line 32; the online pH display instrument 5 comprises a shell 51, a control chip 52 arranged at the bottom in the shell 51 and a display screen 54 arranged outside the shell 51, wherein the bottom end of the circuit signal transmission module 4 is connected with the control chip 52, and the result is transmitted to the online pH display instrument 5 through a signal transmission line 32.

The online pH display instrument 5 further comprises magnetic pastes 53 arranged on the left side and the right side of the outer part of the shell 51, and a plurality of online pH monitoring trace sample processing devices can be connected in series through the magnetic pastes 53 and can be placed on a shaking table to analyze a plurality of samples simultaneously.

Referring to FIG. 3, the pH sensor probe 31 is disposed at the bottom of the micro sample analyzer 2 and is shaped like a concave arch made of a glass sensitive film with a diameter of 5mm and a height of 5mm.

The micro sample analysis pool 2 is made of borosilicate glass, and the specification of the micro sample analysis pool 2 is from 1.5mL to 5mL according to the experimental requirement, wherein the diameter of the specification of 1.5mL is 12mm, and the height is 35mm; the 5mL gauge is 15mm in diameter and 50mm high.

The utility model discloses bottom sets up pH response module 3 in trace sample analysis pond 2, the lower extreme sets up online pH display 5, inside circuit signal transmission module 4 that sets up of online pH display 5, circuit signal transmission module 4 passes through signal transmission line 32 with pH response module 3 and is connected, bottom setting control chip 52 in online pH display 5, circuit signal transmission module 4 bottom connection control chip 52, circuit signal transmission module 4 sends circuit signal transmission module 4 to through signal transmission line 32 after pH response module 3 senses trace sample analysis pond 2's pH, circuit signal transmission module 4 transmits trace sample analysis pond 2's pH result to online pH display 5 through control chip 52, can carry out real-time supervision to trace sample's pH like this, select suitable pH target value at any time, moreover, the steam generator is simple in structure, the manufacture is convenient, the flexible operation, and can establish ties a plurality of online pH monitoring's trace sample processing apparatus and analyze a plurality of samples simultaneously through magnetic paste 53, the strong operability.

The above-mentioned embodiments are only for illustrating the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and to implement the present invention, which should not be construed as limiting the scope of the present invention. All modifications made according to the spirit of the main technical scheme of the present invention shall be covered within the protection scope of the present invention.

Claims

1. The utility model provides a trace sample processing apparatus of online pH monitoring which characterized in that: the device comprises an online pH display instrument (5), a micro sample analysis pool (2) arranged at the upper end of the online pH display instrument (5), a pH induction module (3) arranged at the bottom in the micro sample analysis pool (2) and a circuit signal transmission module (4) arranged in the online pH display instrument (5); the upper end of the micro sample analysis pool (2) is provided with a top cover (1); the pH sensing module (3) comprises an upper pH sensing probe (31) and a lower signal transmission line (32), and the circuit signal transmission module (4) is connected with the pH sensing module (3) through the signal transmission line (32); the online pH display instrument (5) comprises a shell (51), a control chip (52) arranged at the bottom in the shell (51) and a display screen (54) arranged at the outer side of the shell (51), wherein the bottom end of the circuit signal transmission module (4) is connected with the control chip (52).

2. The micro-sample processing device for on-line pH monitoring according to claim 1, wherein: the pH sensing module (3) and the bottom of the micro sample analysis pool (2) are integrated during design.

3. The micro-sample processing device for on-line pH monitoring according to claim 2, wherein: the online pH display instrument (5) further comprises magnetic patches (53) arranged on the left side and the right side of the outer portion of the shell (51).

4. The on-line pH monitoring micro-sample processing device of claim 3, wherein: the pH sensing probe (31) is positioned at the bottom in the trace sample analysis pool (2) and is arch-bottom concave.

5. The on-line pH monitoring micro-sample processing device according to claim 4, wherein: the pH sensing probe (31) is made of a glass sensitive film, the diameter of the glass sensitive film is 5mm, and the height of the glass sensitive film is 5mm.

6. The micro-sample processing device for on-line pH monitoring according to claim 5, wherein: the micro sample analysis pool (2) is made of borosilicate glass.

7. The micro-sample processing device for on-line pH monitoring according to claim 6, wherein: the micro sample analysis pool (2) is 1.5mL in specification, 12mm in diameter and 35mm in height.

8. The micro-sample processing device for on-line pH monitoring according to claim 6, wherein: the specification of the micro sample analysis pool (2) is 5mL, the diameter is 15mm, and the height is 50mm.

9. A micro sample processing device for on-line pH monitoring according to claim 7 or 8, characterized in that: the outer surface of the micro sample analysis pool (2) is provided with a highest water level line prompt (21) at a height of 2/3 from bottom to top.