CN218815458U

CN218815458U - Positive pressure gas protection nucleic acid sampling analysis operation laboratory

Info

Publication number: CN218815458U
Application number: CN202222140979.5U
Authority: CN
Inventors: 崔静涛; 王敦刚; 李波
Original assignee: Sichuan Kete Air Conditioning Purification Co ltd
Current assignee: Sichuan Kete Air Conditioning Purification Co ltd
Priority date: 2022-08-15
Filing date: 2022-08-15
Publication date: 2023-04-07
Anticipated expiration: 2032-08-15

Abstract

The application relates to a positive pressure gas protection nucleic acid sampling analysis operation laboratory, including: the box body unit is internally provided with a cavity; the top panel is arranged in the box body unit and is used for dividing the cavity into an upper air inlet cavity and a plurality of lower functional cavities; the primary and intermediate effect combined filter is arranged on the box body unit and is used for filtering gas entering the gas inlet cavity; and the FFU is arranged on the top panel in the air inlet cavity and is used for guiding the gas in the air inlet cavity into a part of the functional cavity. The utility model discloses simple structure, similar mechanical seal's design can effectively prevent the phenomenon of infiltration. The sampling personnel carry out the sampling operation in the operation laboratory, need not to wear the protective clothing, and convenient operation can improve sampling efficiency greatly.

Description

Positive pressure gas protection nucleic acid sampling analysis operation laboratory

Technical Field

The utility model relates to a malleation gas protection nucleic acid sampling analysis operation laboratory technical field, more specifically the saying so relates to a malleation gas protection nucleic acid sampling analysis operation laboratory.

Background

After the collection of general nucleic acid samples is finished, medical personnel can carry out professional sealing on the samples, put into a special transfer box and transport the samples to a corresponding nucleic acid detection laboratory by a special vehicle for special persons.

At present, most of nucleic acid detection laboratories of units such as hospitals at all levels, disease control institutions and the like belong to the PCR laboratory, and the method faces the problems of small original area, long construction period, high transformation difficulty and the like.

The fixed PCR cannot be applied to all hospitals and institutions, is limited by a plurality of fields, has higher cost of manpower, material resources and the like, and makes up the defects in the aspect by a mobile nucleic acid detection laboratory.

SUMMERY OF THE UTILITY MODEL

The utility model provides a malleation gas protection nucleic acid sampling analysis operation laboratory to solve above-mentioned technical problem.

A positive pressure gas-shielded nucleic acid sampling analysis operations laboratory, comprising:

the box body unit is internally provided with a cavity;

the top panel is arranged in the box body unit and is used for dividing the cavity into an upper air inlet cavity and a plurality of lower functional cavities;

the primary and intermediate effect combined filter is arranged on the box body unit and is used for filtering gas entering the gas inlet cavity;

and the FFU is arranged on the top panel in the air inlet cavity and is used for guiding the gas in the air inlet cavity into a part of the functional cavity.

In some embodiments, the functional chambers are a nucleic acid sampling chamber, a nucleic acid analysis chamber, and a dressing chamber that are independent of each other; a sliding door for mutual communication is arranged between the nucleic acid sampling chamber and the nucleic acid analysis chamber; a clean airtight door for mutual communication is arranged between the nucleic acid analysis chamber and the dressing chamber; the dressing room is provided with a clean airtight door for independent access.

In some embodiments, the FFUs include a first FFU for introducing gas within the gas inlet chamber into the nucleic acid sampling chamber and a second FFU for introducing gas within the gas inlet chamber into the nucleic acid analysis chamber.

In some embodiments, the nucleic acid sampling chamber has an observation window on one side, the observation window is provided with two operation passage ports connected with the outside, a glove for collecting nucleic acid is arranged on the operation passage port, and a containing box is arranged below the corresponding operation port on the outer side of the observation window.

In some embodiments, a laminar flow hood is disposed within the nucleic acid analysis chamber.

In some embodiments, the box unit comprises a box body, a top plate and a peripheral plate, wherein the top plate is overlapped on the box body, and the peripheral plate is respectively connected with the box body and the top plate.

In some embodiments, the top plate is provided with a water outlet, the water outlet is connected with a water discharge pipe, the top of the side wall of the box body is provided with a bending part, the top plate is provided with a step, and the top plate is lapped on the bending part through the step.

In some embodiments, the box body comprises a box body surrounding frame composed of box body vertical plates and a bottom supporting frame used for supporting the box body surrounding frame, and a floor is installed at the bottom of the box body surrounding frame.

In some embodiments, an air conditioner is installed on the case unit.

In some embodiments, the bottom of the case unit is fitted with heavy duty casters.

Drawings

One or more embodiments are illustrated by way of example in the accompanying drawings, which correspond to the figures in which like reference numerals refer to similar elements and which are not to scale unless otherwise specified.

FIG. 1 is a diagram showing the internal layout of a nucleic acid sampling analysis operation laboratory in this example

FIG. 2 is a schematic side view of a nucleic acid sampling analysis operation laboratory according to the present embodiment

FIG. 3 is a top view of a laboratory for conducting a nucleic acid sampling analysis operation according to the present embodiment

FIG. 4 is a schematic view of the bottom structure of the laboratory for nucleic acid sampling analysis operation in this example

Fig. 5 is a schematic view of the FFU mounting structure of the present embodiment.

In the figure: 1-box unit, 2-top plate, 3-first FFU, 4-observation window, 5-primary and medium effect combined filter, 6-second FFU, 7-laminar flow hood, 8-air conditioner, 9-water discharge pipe, 10-clean airtight door, 11-nucleic acid sampling chamber, 12-sliding door, 13-bottom support frame, 14-heavy-load caster, 15-nucleic acid analysis chamber, 16-dressing chamber, 17-glove, 18-containing box, 19-peripheral plate, 20-box vertical plate, 21-water discharge pipe, 22-bending part, 23-step, 25-floor, 26-top panel, 27-flow dispersing plate, 28-high efficiency filter and 29-centrifugal fan.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the technical solutions in the embodiments of the present application will be described in more detail below with reference to the accompanying drawings in the preferred embodiments of the present application. In the drawings, the same or similar reference numerals denote the same or similar components or components having the same or similar functions throughout. The embodiments described are some, but not all embodiments of the disclosure. The embodiments described below with reference to the accompanying drawings are illustrative and intended to explain the present application and should not be construed as limiting the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Embodiments of the present application will be described in detail below with reference to the accompanying drawings.

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

In the embodiment of the present application, all directional indicators (such as up, down, left, right, front, and rear' \8230;) are used only to explain the relative positional relationship or movement of the components at a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein may be combined with other embodiments.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

A positive pressure gas-shielded nucleic acid sampling analysis laboratory according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 5. It should be noted that the following examples are merely illustrative of the present application and are not intended to limit the present application. The positive pressure gas protection nucleic acid sampling analysis operation laboratory of this application is the setting device of tobacco cake.

In one embodiment as shown in fig. 1, a positive pressure gas-blanketed nucleic acid sampling analysis operations laboratory, comprising: the filter comprises a box body unit 1, a top panel 26, a primary and intermediate effect combined filter 5 and an FFU (fan filter unit), wherein a cavity is arranged in the box body unit 1; the cavity is used for isolating the space in the box body unit 1 from the external space, so that the nucleic acid collection and analysis and a series of operations are convenient to perform.

The top panel 26 is arranged in the box body unit 1 and is used for dividing the cavity into an upper air inlet cavity and a plurality of lower functional cavities; the gas inlet cavity is used for pre-filtering gas entering the functional cavity, and the functional cavity can be further divided into a nucleic acid sampling chamber, a nucleic acid analysis chamber and a dressing chamber 16; a sliding door for mutual communication is arranged between the nucleic acid sampling chamber and the nucleic acid analysis chamber; a clean airtight door for mutual communication is arranged between the nucleic acid analysis chamber and the dressing chamber 16; the dressing room 16 is provided with a clean airtight door for independent entrance and exit.

The operation laboratory is entered from the outside to the dressing room 16 for dressing, and dust and the like brought into the outside from the clothes are prevented. Then enters the nucleic acid analysis chamber from the dressing chamber 16 for nucleic acid analysis work, and enters the nucleic acid sampling chamber from the nucleic acid analysis chamber 15 for sampling work.

In order to improve the filtering and purifying effect of the air, a plate type medium-efficiency filter is arranged at the air inlet. Furthermore, in order to improve the air filtering effect, a primary filter is arranged at the air inlet. In order to facilitate the installation and replacement of the filter, the primary and secondary efficient filters are integrated into a whole and are installed in the interlayer from the outside of the operating room inwards, so that the filter screen is convenient to clean and replace later.

The primary and intermediate effect combined filter 5 is arranged on the box body unit 1, an air inlet is formed in the middle of one side face of the box body unit 1 and is positioned in the range of the air inlet cavity, and a primary filter and a plate type intermediate effect filter which are composed of steel plate nets and nylon nets are arranged at the air inlet to form the primary and intermediate effect combined filter 5; for filtering gas entering the gas inlet chamber. The primary filter and the plate-type medium-efficiency filter are air filtering units which are well-developed in the prior art, and are not described in detail here.

The FFU is arranged on a top panel 26 in the air inlet cavity and is used for guiding the air in the air inlet cavity into a part of the functional cavity. But FFU fan filter screen unit modularization connects the use, uses FFU wide application in application occasions such as toilet, clean workbench, clean production line, assembled toilet and local hundredth level. The FFU is provided with a primary and a high-efficiency two-stage filter screen. The fan sucks air from the top of the FFU, the air is filtered by the primary and high-efficiency filters 28, and the filtered clean air is sent out at a constant speed of 0.45M/S +/-20% on the whole air outlet surface.

In some embodiments, the FFUs include a first FFU3 for introducing gas within the gas inlet chamber into the nucleic acid sampling chamber and a second FFU6 for introducing gas within the gas inlet chamber into the nucleic acid analysis chamber 15. The FFU is arranged in an interlayer between a top panel 26 and the top plate 2, the FFU is provided with a centrifugal fan 29 and a high-efficiency filter 28, an air outlet of the high-efficiency filter 28 is connected with the top panel 26, and a plurality of vent holes are formed in the top panel 26 corresponding to the air outlet of the high-efficiency filter 28; through the vent into the nucleic acid sampling chamber and the nucleic acid analysis chamber 15.

When sampling and detecting the throat swab, the protection of workers and the guarantee that the throat swab sample is not polluted are very important. One side of nucleic acid sampling chamber is observation window 4, and observation window 4 can adopt transparent organic glass, be provided with two operation access mouths that link to each other with the outside on the observation window 4, dispose on the operation access mouth that nucleic acid was gathered and use gloves 17, this gloves 17 can adopt special latex rubber gloves 17, and the operation mouth below that the 4 outsides of observation window correspond is provided with containing box 18. Thus, a person who collects nucleic acid does not need to wear a protective garment which is particularly heavy and dense, and a collector in the nucleic acid sampling chamber samples nucleic acid from an external person to be collected by both hands through the gloves 17 and then places the sampling result in the storage box 18. Particularly, when the protective clothing is worn outdoors in summer, the phenomenon of heatstroke and the like is easy to cause when the protective clothing is thick and dense.

When the nucleic acid analysis operation laboratory works, after the FFU internal centrifugal fan 29 arranged in the nucleic acid analysis room 15 and the nucleic acid sampling room is started, a certain pressure difference is formed between the inside and the outside of the laboratory, the outside air is filtered by the combined type primary and intermediate efficiency filter, the sucked air is filtered and purified, and finally the clean air is sent into the nucleic acid analysis room 15 and the nucleic acid sampling room after being filtered by the high efficiency filter 28 of the FFU, so that the positive pressure in the nucleic acid analysis room 15 and the nucleic acid sampling room is always ensured. During sampling, the special gloves 17 for nucleic acid sampling are arranged on the operation port, and a sampling person can perform sampling operation by observing the external person to be sampled through transparent organic glass by using two hands through the gloves 17 on the operation channel port in a sampling chamber. When the analysis and detection are performed in the nucleic acid analysis chamber 15, the operation is performed in a laminar flow hood strictly following the nucleic acid detection procedure.

When the analysis detects, in order to guarantee medical personnel's safety, need operate under the environment of negative pressure, set up the laminar flow hood for this reason in nucleic acid analysis room 15, because the air current of laminar flow hood is inward, because there is high efficiency filter 28 laminar flow hood top, even produce aerosol and also be difficult for overflowing to the laboratory, form local negative pressure region in laminar flow hood lower part, can prevent integrative excessive, guaranteed personnel's safety.

In order to prevent water seepage in the operation laboratory, the box body 1 adopts a structure similar to a mechanical labyrinth seal. The box body unit 1 comprises a box body 1, a top plate 2 and peripheral plates 19, wherein the top plate 2 is lapped on the box body 1, and the peripheral plates 19 are respectively connected with the box body 1 and the top plate 2. The top of the side wall of the box body 1 is provided with a bending part 22, the top plate 2 of the box body 1 is provided with a step 23 after being welded into a whole by a galvanized sheet, the top plate 2 is lapped on the bending part 22 through the step 23 to be directly lapped on the side wall of the box body 1, one side of the peripheral plate 19 at the top of the box body 1 is welded on the box body vertical plate 20, the other side of the peripheral plate is fixed on the top plate 2 through self-tapping self-drilling screws, and the top plate 2 is provided with a water outlet. The drain port is connected with a drain pipe 21, the drain pipe 21 penetrates through the interlayer inside the box body 1 and is directly drained to the outside, and the drain pipe 21 can be drained by running a pipe from the outside of the box body 1.

In some embodiments, in order to facilitate on-site assembly, the box body 1 comprises a box body 1 enclosing frame formed by box body vertical plates 20 and a bottom supporting frame for supporting the box body 1 enclosing frame, and a floor 25 is installed at the bottom of the box body 1 enclosing frame. The box vertical plate 20 is directly located on the bottom supporting frame, the inward-folding structure at the bottom of the box vertical plate 20 can prevent external water from permeating into the laboratory, and the floor 25 in the operation laboratory is fixed on the bottom supporting frame through self-tapping and self-drilling screws.

In order to facilitate the illumination of the operation laboratory, illumination lamps are provided at the top of the dressing room 16, the nucleic acid analysis room 15 and the nucleic acid sampling room, respectively.

To facilitate replacement and maintenance of components such as centrifugal fan 29 and hepa filter 28 within the FFU, the FFU is mounted on top panel 26 from inside the operating laboratory upwardly. Thus, the top panel 26 is provided with an installation opening for installing the FFU, and then the installation opening is sealed by the flow dispersing plate 27, and the flow dispersing plate 27 is provided with a plurality of through holes for ventilation.

In order to facilitate the communication between the medical staff and the outdoor staff, a window type interphone component for communication is arranged on the outer wall of the operation laboratory.

In order to improve the working environment of operators, an air conditioning system is configured, and an air conditioner outdoor unit is arranged on the top, so that the noise of the air conditioner outdoor unit is greatly reduced.

In order to facilitate the sampling of medical staff and ensure the safety of the medical staff, the operation channel opening arranged on the transparent organic glass is connected with the special nucleic acid collection glove 17, and the operation channel opening completely accords with the principle of human engineering, so that the working comfort of the sampling staff is improved, and the pain of the waist, the back, the legs and the feet after long-time working is avoided.

In order to observe the pressure difference inside and outside the operation laboratory, a pressure difference meter is installed in both the nucleic acid analysis chamber 15 and the nucleic acid sampling chamber.

Further, for being convenient for remove, the bottom sprag frame lower part sets up two casters and two heavy truckles 14 and heavy lower margin stationary foot cup, and wherein casters area brake function, and the effect of heavy lower margin stationary foot cup is fixed in a certain place back when clean control room, through adjusting its height, does not let the truckle atress, has just so improved the life of truckle.

The positive pressure gas protection nucleic acid sampling analysis operation laboratory provided by the application has the beneficial effects of but not limited to:

1. the sampling personnel carry out sampling operation in the operation laboratory, need not to wear the protective clothing, and convenient operation can improve sampling efficiency greatly. The utility model discloses simple structure, similar mechanical seal's design can effectively prevent the phenomenon of infiltration.

2. The positive pressure environment is formed in the nucleic acid analysis chamber and the nucleic acid sampling chamber by controlling the centrifugal fan in the FFU, so that external air cannot flow in, and the sampling safety of medical personnel can be effectively protected.

3. Through primary filter and well board-like filter and FFU filtration etc. can purify the air that gets into nucleic acid analysis room, nucleic acid sampling room to block the inside and outside flow of air, make the air that gets into nucleic acid analysis room, nucleic acid sampling room be clean air, guarantee sampling personnel's safety.

4. The laminar flow cover installed in the nucleic acid analysis chamber is internally used for nucleic acid detection and analysis, and the negative pressure working condition is adopted in the laminar flow cover, so that aerosol is prevented from overflowing into the laboratory, and the safety of operators is guaranteed. The utility model discloses it is small, can realize high-efficient purification, and it is convenient to remove.

5. The mobile operation laboratory has the characteristics of short distance, low cross infection risk, rapid and flexible deployment, large data transmission and the like, can complete detection within 3 hours after sampling, and avoids potential propagation danger caused by multiple times of sample transportation.

Generally, the nucleic acid sampling analysis operation laboratory designed in the patent has the advantages of being rapid in installation, small in occupied area, high in sampling analysis efficiency, capable of reducing virus propagation range and capable of reducing sample circulation time.

The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.

Claims

1. A positive pressure gas-blanketed nucleic acid sampling analysis operations laboratory, comprising:

the box body unit is internally provided with a cavity;

2. The positive pressure gas-shielded nucleic acid sampling and analyzing operation laboratory as claimed in claim 1, wherein the functional chambers are a nucleic acid sampling chamber, a nucleic acid analyzing chamber and a dressing chamber which are independent from each other; a sliding door for mutual communication is arranged between the nucleic acid sampling chamber and the nucleic acid analysis chamber; a clean airtight door for mutual communication is arranged between the nucleic acid analysis chamber and the dressing chamber; the dressing room is provided with a clean airtight door for independent access.

3. The positive pressure gas-shielding nucleic acid sampling manipulation laboratory of claim 2 wherein the FFU comprises a first FFU for introducing gas from the gas inlet chamber into the nucleic acid sampling chamber and a second FFU for introducing gas from the gas inlet chamber into the nucleic acid analysis chamber.

4. The nucleic acid sampling and analyzing laboratory according to claim 2, wherein an observation window is provided on one side of the nucleic acid sampling chamber, two operation passage ports connected to the outside are provided on the observation window, gloves for collecting nucleic acid are disposed on the operation passage ports, and a storage box is provided below the operation port corresponding to the outside of the observation window.

5. The positive pressure gas-shielded nucleic acid sampling and analysis laboratory according to claim 2, wherein a laminar flow hood is disposed in the nucleic acid analysis chamber.

6. The nucleic acid sampling and analyzing operation laboratory according to any one of claims 1 to 5, wherein the box unit comprises a box body, a top plate and peripheral plates, the top plate is lapped on the box body, and the peripheral plates are respectively connected with the box body and the top plate.

7. The positive pressure gas-shielded nucleic acid sampling and analyzing laboratory according to claim 6, wherein the top plate has a drain outlet connected to a drain pipe, the top of the sidewall of the box body has a bending portion, the top plate has a step, and the top plate is lapped over the bending portion through the step.

8. The positive pressure gas-shielded nucleic acid sampling and analyzing operation laboratory according to claim 6, wherein the box body comprises a box body enclosure frame formed by box body vertical plates and a bottom support frame for supporting the box body enclosure frame, and a floor is installed at the bottom of the box body enclosure frame.

9. The nucleic acid sampling and analysis laboratory according to claim 1, wherein an air conditioner is installed on the box unit.

10. The positive pressure gas-shielded nucleic acid sampling and analysis operation laboratory according to claim 6, wherein a heavy caster is installed on the bottom of the case unit.