CN218689530U

CN218689530U - Derivatization reactor for HPLC-based aminopiperidine purity determination analysis

Info

Publication number: CN218689530U
Application number: CN202222688054.4U
Authority: CN
Inventors: 刘艳华; 宋小龙
Original assignee: Anhui Yongsheng Pharmaceutical Technology Co ltd
Current assignee: Anhui Yongsheng Pharmaceutical Technology Co ltd
Priority date: 2022-10-12
Filing date: 2022-10-12
Publication date: 2023-03-24
Anticipated expiration: 2032-10-12

Abstract

The utility model relates to a technical field of chemical reactor, the application discloses aminopiperidine purity measurement and analysis's derivatization reactor based on HPLC, the power distribution box comprises a box body, the apron, the retort, the inlet pipe, the discharging pipe, the ventilation groove, including a motor, an end cap, a controller, and a cover plate, the driving gear, driven part and charging fan, in reaction process, it rotates to drive the driving gear through starter motor, the driving gear drives the driven gear rotation of meshing with it, and then the charging fan who drives to install on driven gear rotates around the retort, the all-round reaction product to in the retort cools down, the wind that charging fan blew off has absorbed the heat back of retort, through ventilation groove discharge retort, the temperature of reaction product has effectively been reduced, thereby follow-up detecting instrument's fault probability has been reduced.

Description

Derivatization reactor for HPLC-based aminopiperidine purity determination analysis

Technical Field

The application relates to the technical field of chemical reactors, in particular to a derivatization reactor for aminopiperidine purity determination analysis based on HPLC.

Background

HPLC is a short term for high performance liquid chromatography, which uses liquid as a mobile phase, adopts a high pressure infusion system to pump the mobile phases such as mixed solvents, buffer solutions and the like with different proportions into a chromatographic column filled with a stationary phase, and derivatizes the separated substances after the components in the column are separated. Derivatization is a process of converting a compound into a chemical structure similar thereto using chemical transformations. The derivatization reaction process of the aminopiperidine mainly comprises the following steps: dissolving specific aminopiperidine in an organic solvent, selecting a proper derivatization reagent under a certain temperature condition, adjusting the molar ratio of the aminopiperidine to the derivatization reagent, and carrying out derivatization reaction to generate a corresponding compound. This process occurs primarily in the derivatization reactor. And then further detecting the reaction product by using a fluorescence detector or an ultraviolet detector and the like.

However, in the process of implementing the related technical scheme, at least the following technical problems are found: specific aminopiperidine can give off heat with the in-process that derivatization takes place for derivatization reagent, and the heat of giving off can gather in the reaction intracavity of reactor for the reaction product temperature is higher, and after the reaction was accomplished, the reaction product did not cool down and just directly gets into the ultraviolet detector through the discharging pipe directly and detects, causes the damage of detector easily.

SUMMERY OF THE UTILITY MODEL

This application is through providing the derivatization reactor of aminopiperidine purity survey analysis based on HPLC, thereby solved the reaction product that generates among the prior art and directly cause the problem that detecting instrument damaged easily through the discharging pipe entering follow-up detecting instrument with regard to not cooling down, cool down reaction product through setting up charging fan and cooling fan, ensured follow-up detecting instrument's normal use.

The application provides derivatization reactor of aminopiperidine purity survey analysis based on HPLC, including box and apron, inside retort and the bottom rigid coupling that is provided with of box has the supporting leg, the intercommunication has the inlet pipe on the box, one side rigid coupling of box inner wall has the motor, the output pot of motor is equipped with the driving gear, the retort overcoat is equipped with driven part, driven part is including solid fixed ring and driven gear, gu fixed ring with the rigid coupling has the connecting rod between the box, driven gear's inner wall rotates and locates solid fixed ring's surface, driven gear's tooth face is connected with the flank of tooth meshing of driving gear, one side rigid coupling of driven gear bottom surface has the connecting seat, install charging fan on the connecting seat, wind direction under the charging fan start-up state is just to retort surface, the air channel has been seted up to the upper surface of box.

Further, the ventilation groove is provided with two, the relative both sides rigid coupling of two ventilation inslot walls has the polylith heating panel, the relative safety cover upper surface slope certain angle of heating panel.

Further, the lower surface intercommunication of retort is equipped with the discharging pipe, the one end of discharging pipe is passed the box side, the bottom surface of box is seted up there is the fan groove, the inner wall rigid coupling in fan groove has cooling fan, the wind direction under the cooling fan starting state is just to the portion of bending of discharging pipe.

Furthermore, a partition plate is arranged at a position, close to the lower portion of the discharge pipe, of the inner wall of the box body, a through hole is formed in the center of the partition plate, an air supply pipe is fixedly connected to the bottom of the partition plate, the size of the cross section opening of the air supply pipe is larger than that of the cross section opening of the through hole, and the cooling fan, the air supply pipe and the through hole are located on the same axis.

Furthermore, the connecting rods are four, the bottom surfaces of the four connecting rods are fixedly connected with the quartering parts of the upper surfaces of the fixing rings respectively, and the upper surfaces of the four connecting rods are fixedly connected with the upper surface of the inner wall of the box body respectively.

The technical scheme provided by the application at least has the following technical effects or advantages:

1. owing to set up motor, driving gear, driven part and charging fan, drive driven part and then drive charging fan and carry out the circular motion around the retort through the driving gear, realized carrying out the multi-angle cooling to retort inside product, the cooling is more even and cooling speed is fast, thereby has solved the problem that the reaction product that has not cooled directly gets into follow-up instrument and causes the instrument to damage.

Drawings

FIG. 1 is a schematic overall structure diagram of a box body in an embodiment of the present application;

FIG. 2 is a schematic cross-sectional view of a case according to an embodiment of the present disclosure;

fig. 3 is a schematic structural diagram of a driven part in the embodiment of the present application.

In the figure: 11. a box body; 12. a cover plate; 13. supporting legs; 14. a reaction tank; 131. a feed pipe; 132. a discharge pipe; 21. a motor; 22. a driving gear; 23. a driven member; 231. a fixing ring; 232. a driven gear; 24. a connecting rod; 25. a connecting seat; 26. a charging fan; 27. a ventilation slot; 271. a heat dissipation plate; 31. a fan groove; 311. a cooling fan; 32. a partition plate; 33. a through hole; 34. and a blast pipe.

Detailed Description

The embodiment of the application discloses aminopiperidine purity survey analysis's derivatization reactor based on HPLC, in the derivatization reaction process, starter motor 21 and charging fan 26, motor 21 drives the driving gear 22 rotatory, and then it is rotatory with driving gear 22 meshed driven gear 232, finally realize carrying out 360 rotations around retort 14 with charging fan 26 that driven gear 232 is connected, carry out the omnidirectional cooling to the reaction product in retort 14.

In order to better understand the technical solution, the technical solution will be described in detail with reference to the drawings and the specific embodiments.

Referring to fig. 1 and 2, the derivatization reactor includes box 11, cover plate 12, supporting leg 13, retort 14, inlet pipe 131 and discharging pipe 132, box 11 shape is cuboid and one side opening, box 11 open end is located to cover plate 12 lid, through four bolted connection between cover plate 12 and the box 11, supporting leg 13 has four, the up end of four supporting legs 13 is the plane and respectively with four edge rigid couplings of box 11 bottom, retort 14 sets up in the position of hugging closely box 11 inner wall upper surface, retort 14 shape is the cylinder, inlet pipe 131 is the pipe of bending, there is a portion of bending, the top of retort 14 is communicate after the intermediate position at box 11 top is passed to the one end of inlet pipe 131, the one end of discharging pipe 132 communicates with the central authorities of retort 14 bottom, the other end of discharging pipe 132 passes box 11 one side and communicates with subsequent detection instrument, discharging pipe 132 is the pipe of bending, there is a portion of bending. The ventilation grooves 27 are symmetrically formed in the two sides, located on the feeding pipe 131, of the top surface of the box body 11, the cross sections of the two ventilation grooves 27 are rectangular, a plurality of heat dissipation plates 271 are fixedly connected to the two opposite sides of the inner wall of each ventilation groove 27, and the heat dissipation plates 271 can prevent dust from entering the box body 11 from the ventilation grooves 27 and avoid damage to internal elements.

Referring to fig. 2 and 3, a motor 21 is fixedly connected to one side of the inner wall of the box 11, the output end of the motor 21 faces downward, a driving gear 22 is sleeved on the output end of the motor 21, a driven part 23 is sleeved on the surface of the reaction tank 14, the driven part 23 comprises a fixing ring 231 and four driven gears 232, the inner circle radius of the section of the fixing ring 231 is larger than the section radius of the reaction tank 14, the driven gears 232 are rotatably arranged on the surface of the fixing ring 231, the driven gears 232 are meshed with the tooth surface of the driving gear 22, the connecting rods 24 are cuboid in shape and four in number, the bottom surfaces of the four connecting rods 24 are fixedly connected with the quartering parts of the upper surface of the fixing ring 231 respectively, the upper surfaces of the four connecting rods 24 are fixedly connected with the upper surface of the inner wall of the box 11 respectively, the connecting seat 25 is fixedly connected to one side of the lower surface of the driven gear 232 far away from the tooth surface, the connecting seat 25 is cuboid in shape, the charging fan 26 is arranged on the bottom surface of the connecting seat 25, and the charging fan 26 can be charged by disassembling the cover plate 12.

The reaction product is heated by the heat generated in the derivatization reaction process, the driving gear 22 is driven to rotate by the starting motor 21, the driven gear 232 and the charging fan 26 are further driven to rotate around the surface of the fixing ring 231, and the air flow blown by the charging fan 26 takes away the heat on the surface of the reaction tank 14 and then is discharged to the outside of the box body 11 through the ventilation groove 27, so that the charging fan 26 can comprehensively cool the product generated in the reaction tank 14.

Continuing to refer to fig. 2, a fan groove 31 is formed at the bottom of the inner wall of the box body 11, a cooling fan 311 is installed on the inner wall of the fan groove 31, and the cooling fan 311 is used for cooling the bent part of the discharge pipe 132; a partition plate 32 is fixedly connected to a position right below a discharge pipe 132 on the inner wall of a box body 11, the partition plate 32 divides the interior of the box body 11 into two parts, namely a reaction cavity and a heat dissipation cavity, a through hole 33 is formed in the middle of the partition plate 32, the through hole 33 is located right below a bent portion of the discharge pipe 132, the cross section of the through hole 33 is circular, the upper surface of an air supply pipe 34 is fixedly connected to the lower surface of the partition plate 32, the cross section radius of the air supply pipe 34 is larger than that of the through hole 33, and the lower surface of the air supply pipe 34 is right opposite to fan blades of a cooling fan 311. The air flow blown by the started cooling fan 311 reaches the through hole 33 through the air supply pipe 34, and the air speed of the air flow passing through the through hole 33 is increased due to the fact that the through hole 33 is smaller than the section radius of the air supply pipe 34, so that the bent part of the discharge pipe 132 can be cooled better.

The functional principle of the present application can be illustrated by the following operation modes: after the reaction product of derivatization is generated, a large amount of heat is generated, the driving gear 22 is driven to rotate by the starting motor 21, the driving gear 22 drives the driven gear 232 to rotate, the charging fan 26 is further driven to rotate, the charging fan 26 continuously rotates around the outer wall of the reaction tank 14 for 360 degrees, the reaction tank 14 is cooled, and therefore the temperature of the reaction product in the reaction tank 14 is reduced; then, the reaction product enters the next detection instrument through the discharge pipe 132, and at this time, the air blown by the cooling fan 311 reaches the bent part of the discharge pipe 132 through the blast pipe 34 and the through hole 33 in sequence, so that the reaction product passing through the bent part is cooled for the second time; after the heat of the reaction product is taken away by the wind blown by the charging fan 26 and the cooling fan 311, the wind is discharged out of the box body 11 through the two ventilation grooves 27, so that the temperature of the reaction product is effectively reduced, and the fault probability of a subsequent detection instrument is reduced.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims and their equivalents, the present invention is also intended to include such modifications and variations.

The above description is only for the preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can substitute or change the technical solution and its concept of the present application within the technical scope disclosed in the present application, and shall be covered by the scope of the present application.

Claims

1. Derivatization reactor of aminopiperidine purity survey analysis based on HPLC, including box (11) and apron (12), box (11) inside is provided with retort (14) and bottom rigid coupling has supporting leg (13), be provided with on box (11) with inlet pipe (131) and discharging pipe (132) of retort (14) intercommunication, its characterized in that, one side rigid coupling of box (11) inner wall has motor (21), the output cover of motor (21) is equipped with driving gear (22), retort (14) overcoat is equipped with driven part (23), driven part (23) are including solid fixed ring (231) and driven gear (232), gu fixed ring (231) with the rigid coupling has connecting rod (24) between box (11), the inner wall of driven gear (232) rotates and locates the surface of solid fixed ring (231), driven gear (232) with driving gear (22) mesh mutually, one side rigid coupling of driven gear (232) bottom surface has connecting seat (25), install charging fan (26) on connecting seat (25), charging fan (26) the starting state down the surface of wind direction just to retort (14), air groove (27) have been just seted up on box (11).

2. The derivatization reactor for aminopiperidine purity measurement and analysis based on HPLC according to claim 1, wherein there are two ventilation slots (27), a plurality of heat dissipation plates (271) are fixed to two opposite sides of the inner walls of the two ventilation slots (27), and the heat dissipation plates (271) are inclined at a certain angle relative to the upper surface of the box body (11).

3. The derivatization reactor for aminopiperidine purity measurement and analysis based on HPLC according to claim 1, wherein one end of the discharging pipe (132) is connected to the bottom surface of the reaction tank (14), the other end of the discharging pipe passes through the side surface of the box body (11), the bottom surface of the box body (11) is provided with a fan groove (31), the inner wall of the fan groove (31) is fixedly connected with a cooling fan (311), and the wind direction of the cooling fan (311) in the starting state is opposite to the bent portion of the discharging pipe (132).

4. The derivatization reactor for aminopiperidine purity measurement and analysis based on HPLC according to claim 3, wherein a partition plate (32) is disposed on the inner wall of the box body (11) near the lower portion of the discharge pipe (132), a through hole (33) is disposed at the center of the partition plate (32), an air supply pipe (34) is fixedly connected to the bottom of the partition plate (32), the cross-sectional opening of the air supply pipe (34) is larger than the cross-sectional opening of the through hole (33), and the cooling fan (311), the air supply pipe (34) and the through hole (33) are located on the same axis.

5. The derivatization reactor for aminopiperidine purity measurement and analysis based on HPLC according to claim 1, wherein four connecting rods (24) are provided, bottom surfaces of the four connecting rods (24) are fixedly connected to the four halves of the upper surface of the fixing ring (231), and upper surfaces of the four connecting rods (24) are fixedly connected to the upper surface of the inner wall of the tank (11).