CN218687221U

CN218687221U - Filtration purification device of recombinant collagen

Info

Publication number: CN218687221U
Application number: CN202222986676.5U
Authority: CN
Inventors: 徐林; 金玉; 徐念沁; 鲁锦标; 徐松泉; 常开金
Original assignee: Nanjing Tzong Blotechnology Co ltd
Current assignee: Nanjing Tzong Blotechnology Co ltd
Priority date: 2022-11-09
Filing date: 2022-11-09
Publication date: 2023-03-24
Anticipated expiration: 2032-11-09

Abstract

The utility model discloses a filtration and purification device for recombinant collagen, which comprises a raw liquid tank, an outer cylinder and a filtration inner cylinder, wherein the filtration inner cylinder is arranged in the outer cylinder through a vibration motor, the raw liquid tank is arranged at the upper part of the outer cylinder and is communicated with the filtration inner cylinder, and the bottom of the raw liquid tank is provided with a first filter plate; the upper part of the filtering inner cylinder is provided with a return spring connected with the outer cylinder; the inside from the top down of filtering the inner tube installs second filter and third filter in proper order, the utility model discloses be equipped with vibrating motor, filter inner tube, reset spring, first filter, second filter and third filter, reorganization collagen carries out double filtration fast under the vibration of filtering the inner tube on second filter and third filter, can filter the purification fast to reorganization collagen, promotes reorganization collagen's purification purity, improves reorganization collagen's filtration purification efficiency simultaneously.

Description

Filtration purification device of recombinant collagen

Technical Field

The utility model belongs to the technical field of reorganization collagen preparation facilities, concretely relates to reorganization collagen's filtration purification device.

Background

The recombinant collagen generally refers to recombinant human collagen, is collagen prepared by using a DNA recombination technology, and has an amino acid sequence which can be designed and improved according to requirements, wherein the gene sequence of the recombinant collagen is highly consistent with the gene sequence of a human body, and the recombinant collagen has good tissue compatibility, can be directly absorbed by the human body and participates in the construction of collagen to help tissue repair and site filling, various types of collagen exist in the human body, including I type, II type, III type, V type and XI type, in normal skin tissues, the collagen mainly exists in the form of I type and II type collagen fibers, the content of the III type collagen in the middle of the skin of an infant accounts for more than 80 percent, the recombinant collagen has excellent elasticity and repair functions, is reduced along with the increase of age, has a synthesis speed which is not higher than a loss speed, and has aging phenomena of wrinkles, looseness and the like, the gene sequence of the recombinant human collagen is highly consistent with the gene sequence of the human body, has good tissue compatibility, is not easy to induce an rejection reaction, and can enter a dermis layer to be absorbed and assimilated smoothly, the elasticity of the skin is enhanced, the skin is repaired, the expansion of the skin, the skin is restored, the skin has the effects of skin, the water supplement and the effects of the water and the like.

Chinese granted patent publication No. CN212315988U discloses a separation and purification device for recombinant human type III collagen, which comprises a liquid storage tank, a liquid transfer pipe, a delivery pump, an agitating mechanism, a primary filtering component, a depth filtering component, a discharging pipe and a collecting tank, wherein a discharging end of the liquid storage tank is connected with a feeding end of the agitating mechanism through the liquid transfer pipe, the delivery pump is installed on the liquid transfer pipe, a feeding end of the primary filtering component is connected with a discharging end of the agitating mechanism, a feeding end of the depth filtering component is connected with a discharging end of the primary filtering component, the collecting tank is connected with a discharging end of the depth filtering component through the discharging pipe, the technical scheme can efficiently separate the human type III collagen from bacterial crushing liquid, and the purity of a final product is ensured through multilayer filtration.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a filtration purification device of reorganization collagen to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: a filtration and purification device for recombinant collagen comprises a raw liquid tank, an outer cylinder and a filtration inner cylinder, wherein the filtration inner cylinder is arranged in the outer cylinder through a vibration motor, the raw liquid tank is arranged at the upper part of the outer cylinder and is communicated with the filtration inner cylinder, and a first filter plate is arranged at the bottom of the raw liquid tank;

the upper part of the filtering inner cylinder is provided with a return spring connected with the outer cylinder;

and a second filter plate and a third filter plate are sequentially arranged in the filter inner cylinder from top to bottom.

Preferably, a first spring mounting groove is formed in the upper portion of the filtering inner cylinder, a second spring mounting groove is formed in the top of the inner portion of the outer cylinder, and the upper end and the lower end of the return spring are fixedly mounted in the second spring mounting groove and the first spring mounting groove respectively.

Preferably, the vibration motor is installed at the bottom of the inner part of the outer cylinder body, and the vibration output end of the vibration motor is connected with the middle part of the bottom of the filtering inner cylinder.

Preferably, a stirring assembly for stirring the recombinant collagen stock solution is arranged on the stock solution tank, the stirring assembly comprises a stirring motor, a stirring roller and stirring support rods, the stirring motor is arranged in the middle of the upper part of the stock solution tank, the output end of the stirring motor is arranged in the stock solution tank through a bearing, the output end of the stirring motor is connected with the stirring roller, and the stirring support rods distributed in a circular array are arranged on the outer peripheral side of the stirring roller.

Preferably, the bottom of the stock solution tank is provided with a conical confluence channel, and the first filter plate is arranged at the bottom end of the conical confluence channel.

Preferably, the raw liquid tank and the outer cylinder are fixedly connected through a locking bolt.

Preferably, a stock solution inlet is formed in the upper portion of the stock solution tank, a collecting pipe is connected to the bottom of the filtering inner cylinder, the collecting pipe extends out of the outer cylinder, and an adjusting opening is formed in the position, corresponding to the collecting pipe, of the outer circumferential side of the outer cylinder.

Preferably, the bottom of the outer cylinder body is provided with a shock absorption base.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses be equipped with vibrating motor, filter the inner tube, reset spring, first filter, second filter and third filter, carry the reorganization collagen stoste to the stoste jar through the stoste import, then start agitator motor, agitator motor rotates and drives stirring roller and stirring branch rotation, stirring roller and stirring branch carry out the intensive mixing to the reorganization collagen stoste in the stoste jar, then carry out primary filtration to the reorganization collagen stoste through first filter, then through the reorganization collagen stoste of primary filtration get into filter the inner tube in, the vibrating motor vibration this moment, drive and filter the inner tube and vibrate from top to bottom, in the vibration process of filtering the inner tube, reset spring can reset the removal from top to bottom, guarantee to filter the inner tube and normally vibrate in the outer tube, then reorganization collagen stoste is under the vibration of filtering the inner tube, carry out double filtration on second filter and third filter fast, can filter the purification to the reorganization collagen, promote the purity of reorganization collagen, improve the filtration purification efficiency of reorganization collagen simultaneously;

2. the utility model has the advantages that the inner filtering cylinder and the vibrating motor carry out vibration filtering in the outer cylinder body, the noise can be reduced in the outer cylinder body, and the noise volume of the working environment is reduced;

3. the raw liquid tank and the outer barrel are fixedly connected through the locking bolt, so that the raw liquid tank and the outer barrel are convenient to disassemble, and the raw liquid tank and the filtering inner barrel are cleaned.

Drawings

Fig. 1 is a schematic perspective view of the present invention;

fig. 2 is a schematic perspective view of the present invention;

FIG. 3 is a schematic sectional perspective view of the present invention;

FIG. 4 is a schematic perspective view of the filter cartridge of the present invention;

fig. 5 is a schematic sectional view of the outer cylinder and the filter inner cylinder of the present invention.

In the figure: 1. a stock solution tank; 2. an outer cylinder; 3. an inner filtering cylinder; 4. a vibration motor; 5. a first filter plate; 6. a return spring; 7. a second filter plate; 8. a third filter plate; 9. a first spring mounting groove; 10. a second spring mounting groove; 11. a stirring assembly; 1101. a stirring motor; 1102. a stirring roller; 1103. stirring the supporting rod; 12. a tapered converging channel; 13. locking the bolt; 14. a stock solution inlet; 15. a collection pipe; 16. an adjustment port; 17. a cushioning base.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-5, the filtering and purifying device for recombinant collagen provided by the present invention comprises a raw material tank 1, an outer cylinder 2 and a filtering inner cylinder 3, wherein a cushioning base 17 is disposed at the bottom of the outer cylinder 2, the filtering inner cylinder 3 is installed in the outer cylinder 2 through a vibration motor 4, the vibration motor 4 is installed at the inner bottom of the outer cylinder 2, and a vibration output end of the vibration motor 4 is connected with the middle portion of the bottom of the filtering inner cylinder 3, the raw material tank 1 is installed at the upper portion of the outer cylinder 2, and the raw material tank 1 is communicated with the filtering inner cylinder 3, a first filter plate 5 is disposed at the bottom of the raw material tank 1, a tapered converging channel 12 is disposed at the bottom of the tapered converging channel 12, a stirring assembly 11 for stirring the recombinant collagen raw material is disposed on the raw material tank 1, the stirring assembly 11 comprises a stirring motor 1101, a stirring roller 1102 and a stirring rod 1103, the stirring motor 1101 is installed at the middle portion of the upper portion of the raw material tank 1, an output end of the stirring motor is installed inside the raw material tank 1 through a bearing, an output end of the stirring motor is connected with a stirring roller 1102, a second spring 3, a return spring 7 is disposed at the top of the filtering inner cylinder 3, and a second return spring 7 disposed at the top of the inner cylinder 3, the collecting pipe 15 extends out of the outer side of the outer cylinder body 2, and an adjusting opening 16 is formed in the position, corresponding to the collecting pipe 15, of the outer periphery side of the outer cylinder body 2;

the utility model discloses be equipped with vibrating motor 4, filter inner tube 3, reset spring 6, first filter 5, second filter 7 and third filter 8, during the use, carry the reorganization collagen stoste to stoste jar 1 through stoste import 14, then start agitator motor 1101, agitator motor 1101 rotates and drives agitator roller 1102 and stirring branch 1103 and rotate, agitator roller 1102 and stirring branch 1103 fully stir the reorganization collagen stoste in stoste jar 1, then carry out primary filtration to the reorganization collagen stoste through first filter 5, then through the reorganization collagen stoste of primary filtration get into filter inner tube 3, vibrating motor 4 vibrates this moment, drive and filter inner tube 3 vibration from top to bottom, filter inner tube 3 vibration in-process, reset spring 6 can carry out the upper and lower removal that resets, guarantee to filter inner tube 3 normal vibration in outer barrel 2, then reorganization collagen stoste is under the vibration of filtering inner tube 3, carry out double filtration fast on second filter 7 and third filter 8, can filter the purification fast to reorganization collagen, promote the purity of collagen, improve the purification efficiency of reorganization collagen simultaneously;

the utility model discloses well filter inner tube 3 and vibrating motor 4 carry out vibration filter in outer barrel 2, can noise reduction in outer barrel 2, reduce operational environment's noise volume.

In this embodiment, as shown in fig. 1, the raw liquid tank 1 and the outer cylinder 2 are fixedly connected by a locking bolt 13, so that the raw liquid tank 1 and the outer cylinder 2 are conveniently detached, and the raw liquid tank 1 and the filter inner cylinder 3 are cleaned.

In summary, the working principle of the filtration and purification device for recombinant collagen provided by this embodiment is as follows: when the device is used, the recombined collagen stock solution is conveyed to the stock solution tank 1 through the stock solution inlet 14, then the stirring motor 1101 is started, the stirring motor 1101 rotates to drive the stirring roller 1102 and the stirring support 1103 to rotate, the stirring roller 1102 and the stirring support 1103 fully stir the recombined collagen stock solution in the stock solution tank 1, then the recombined collagen stock solution is primarily filtered through the first filter plate 5, then the recombined collagen stock solution subjected to primary filtering enters the filtering inner barrel 3, at the moment, the vibration motor 4 vibrates to drive the filtering inner barrel 3 to vibrate up and down, in the vibration process of the filtering inner barrel 3, the reset spring 6 can perform up-and-down reset movement to ensure that the filtering inner barrel 3 normally vibrates in the outer barrel 2, then the recombined collagen stock solution is rapidly subjected to double filtering on the second filter plate 7 and the third filter plate 8 under the vibration of the filtering inner barrel 3, so that the recombined collagen can be rapidly filtered and purified, the purification purity of the recombined collagen is improved, and the filtering and purification efficiency of the recombined collagen is improved.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The filtration and purification device for the recombinant collagen is characterized by comprising a raw liquid tank (1), an outer cylinder body (2) and a filtration inner cylinder (3), wherein the filtration inner cylinder (3) is arranged in the outer cylinder body (2) through a vibration motor (4), the raw liquid tank (1) is arranged at the upper part of the outer cylinder body (2), the raw liquid tank (1) is communicated with the filtration inner cylinder (3), and a first filter plate (5) is arranged at the bottom of the raw liquid tank (1);

the upper part of the filtering inner cylinder (3) is provided with a return spring (6) connected with the outer cylinder (2);

and a second filter plate (7) and a third filter plate (8) are sequentially arranged in the filter inner barrel (3) from top to bottom.

2. The filtration and purification device for recombinant collagen according to claim 1, wherein: first spring mounting groove (9) have been seted up on the upper portion of filtering inner tube (3), second spring mounting groove (10) have been seted up at the inside top of outer barrel (2), the last lower extreme of reset spring (6) is fixed mounting respectively in second spring mounting groove (10) with in first spring mounting groove (9).

3. The filtration and purification device for recombinant collagen according to claim 1, wherein: the vibration motor (4) is installed at the bottom of the inner part of the outer cylinder body (2), and the vibration output end of the vibration motor (4) is connected with the middle part of the bottom of the filtering inner cylinder (3).

4. The filtration and purification device for recombinant collagen according to claim 1, wherein: the raw material tank (1) is provided with a stirring assembly (11) for stirring the recombinant collagen raw liquid, the stirring assembly (11) comprises a stirring motor (1101), a stirring roller (1102) and stirring struts (1103), the stirring motor (1101) is installed in the middle of the upper portion of the raw material tank (1), the output end of the stirring motor (1101) is installed inside the raw material tank (1) through a bearing, the output end of the stirring motor (1101) is connected with the stirring roller (1102), and the stirring struts (1103) which are distributed in a circular array are arranged on the outer peripheral side of the stirring roller (1102).

5. The filtration and purification device for recombinant collagen according to claim 1, wherein: the bottom of stock solution jar (1) is provided with toper passageway (12) that converges, install first filter (5) the bottom of toper passageway (12) that converges.

6. The filtration and purification device for recombinant collagen according to claim 1, wherein: the raw liquid tank (1) and the outer cylinder body (2) are fixedly connected through a locking bolt (13).

7. The filtration and purification device for recombinant collagen according to claim 1, wherein: the device is characterized in that a stock solution inlet (14) is formed in the upper portion of the stock solution tank (1), a collecting pipe (15) is connected to the bottom of the filtering inner cylinder (3), the collecting pipe (15) extends out of the outer side of the outer cylinder (2), and an adjusting opening (16) is formed in the position, corresponding to the collecting pipe (15), of the outer peripheral side of the outer cylinder (2).

8. The filtration and purification device for recombinant collagen according to claim 1, wherein: and a cushioning base (17) is arranged at the bottom of the outer cylinder body (2).