CN218629623U - Continuous blood glucose monitoring equipment based on self-powered biosensor - Google Patents
Continuous blood glucose monitoring equipment based on self-powered biosensor Download PDFInfo
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- CN218629623U CN218629623U CN202221002961.2U CN202221002961U CN218629623U CN 218629623 U CN218629623 U CN 218629623U CN 202221002961 U CN202221002961 U CN 202221002961U CN 218629623 U CN218629623 U CN 218629623U
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Abstract
The utility model discloses a continuous type blood glucose monitoring equipment based on self-power biosensor, it includes: the glucose monitoring device comprises a main controller, a battery management circuit, a glucose sensor and a storage battery, wherein the main controller is in wireless communication with an upper computer, the battery management circuit is in two-way communication with the main controller, the glucose sensor is connected with the battery management circuit, the glucose sensor is connected with the main controller through an ADC (analog to digital converter), and the storage battery is connected with the battery management circuit and used for storing electricity and supplying electricity to the glucose sensor when monitoring blood sugar. The utility model discloses a glucose sensor and battery management circuit are connected, make it use as the sensor when monitoring blood sugar, give battery power supply as biofuel cell when the dormancy, in addition obtain the electric quantity in the dormancy period on the basis capacity of original battery promptly to effectively prolong the life of equipment, and do not influence the volume of equipment.
Description
Technical Field
The utility model relates to a blood glucose meter equipment technical field, more specifically say, relate to a continuous type blood glucose monitoring equipment based on self-power biosensor.
Background
For diabetics, measuring blood sugar is an indispensable daily matter, and the most common blood sugar testing device at present is a blood sugar meter, but has great limitation because the blood sugar value of the patient at a certain single time point can only be detected, and the blood sugar level cannot be continuously monitored, so that continuous blood sugar monitoring devices are produced at the same time.
A continuous blood glucose monitoring device is an implantable medical device based on a glucose sensor. At present, continuous blood sugar monitoring equipment in the prior art uses a lithium battery for power supply, and the service life is 3 to 14 days. With the trend of miniaturization of monitoring devices, the continuous blood glucose monitoring device is required to be further reduced in volume, and the capacity of the battery is further compressed, so that how to prolong the service life of the continuous blood glucose monitoring device by reducing the volume of the device becomes a new research direction.
Therefore, the prior art is in need of improvement.
SUMMERY OF THE UTILITY MODEL
The continuous blood sugar monitoring equipment in the prior art is powered by the lithium battery, the service life is short, the volume requirement of the continuous blood sugar monitoring equipment is further reduced under the trend of miniaturization monitoring equipment, and the service life of the continuous blood sugar monitoring equipment is prolonged under the condition of reducing the volume of the equipment.
The present invention aims to alleviate or solve at least one of the above mentioned problems to at least some extent. The utility model provides a continuous type blood glucose monitoring equipment based on self-power biosensor, a serial communication port, include:
the main controller is in wireless communication with the upper computer;
a battery management circuit in bidirectional communication with the master controller;
the glucose sensor is connected with the battery management circuit and is connected with the main controller through an ADC (analog-to-digital converter);
and the storage battery is connected with the battery management circuit and used for storing electricity and supplying power to the glucose sensor when monitoring blood sugar.
According to above-mentioned scheme the utility model discloses, a serial communication port, main control controller's main control chip model is STM32RCT6.
According to above-mentioned scheme the utility model discloses, its characterized in that still includes bluetooth module, bluetooth module with main control unit connects, and it is used for with main control unit's monitoring result send to the host computer.
According to above-mentioned scheme the utility model discloses, its characterized in that still includes temperature compensation circuit, main control unit with temperature compensation circuit connects.
According to above-mentioned scheme the utility model discloses, its characterized in that, be equipped with biofuel cell in the glucose sensor, biofuel cell pass through electrochemical sensor modulate circuit with the ADC converter is connected.
Further, the glucose sensor is a three-electrode system sensor, and comprises a working electrode WE, a reference electrode RE and a counter electrode CE, wherein the reference electrode RE is used for determining the potential of the working electrode, the counter electrode CE and the working electrode WE form a measurement loop, and the working electrode WE and the reference electrode RE form a polarization loop.
Still further, the electrochemical sensor conditioning circuit comprises: constant potential rectifier circuit, acquisition circuit, transimpedance amplifier circuit:
the potentiostat circuit is connected with a first bias voltage Vref1 and is used for ensuring the potentials of the reference electrode RE and the counter electrode CE are constant;
the acquisition circuit is connected with the working electrode WE and is used for acquiring current signals;
the transimpedance amplifier circuit is connected with a second bias voltage Vref2 and used for converting the current into voltage and outputting the voltage.
Furthermore, the glucose sensor has a double-sided structure, the working electrode WE and the reference electrode RE are on the same surface, the counter electrode CE is on the surface opposite to the working electrode WE, and the working electrode WE and the reference electrode RE are connected through an insulating layer.
The utility model provides a continuous type blood glucose monitoring equipment based on self-power biosensor's beneficial effect lies in at least: this continuous type blood glucose monitoring equipment based on self-powered biosensor includes: the glucose sensor is driven by the battery management circuit to have a first state of acquiring an AD value and collecting detection current for the main controller when blood sugar is monitored, and a second state of charging the storage battery when the storage battery is in a dormant state. The utility model discloses a glucose sensor and battery management circuit are connected, make it use as the sensor when monitoring blood sugar, give the battery power supply as biofuel cell when the dormancy, in addition obtain the electric quantity in the dormancy period on the basis capacity of original dress battery promptly to effectively prolong the life of equipment, and do not influence the volume of equipment.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the embodiments or the prior art descriptions will be briefly described below, it is obvious that the drawings in the following descriptions are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a continuous blood glucose monitoring device based on a self-powered biosensor according to a preferred embodiment of the present invention;
fig. 2 is a schematic circuit diagram of a battery management circuit of a continuous blood glucose monitoring device based on a self-powered biosensor according to an embodiment of the present invention.
Fig. 3 is a schematic circuit diagram of an electrochemical sensor conditioning circuit of a continuous blood glucose monitoring device based on a self-powered biosensor according to an embodiment of the present invention.
Detailed Description
In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to illustrate the present invention in further detail. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention.
The continuous blood sugar monitoring equipment in the prior art is powered by the lithium battery, the service life is short, the volume requirement of the continuous blood sugar monitoring equipment is further reduced under the trend of miniaturization monitoring equipment, and the service life of the continuous blood sugar monitoring equipment is prolonged under the condition of reducing the volume of the equipment.
Referring to fig. 1, the present invention provides a continuous blood glucose monitoring device based on a self-powered biosensor, which includes: a main controller, a battery management circuit, a storage battery and a glucose sensor (also called a biofuel cell). The main controller is in wireless communication with the upper computer and sends a monitoring result to the upper computer for blood sugar calculation; the battery management circuit is connected with the main controller, the storage battery is connected with the battery management circuit, the storage battery is used for storing electricity and supplying power to the main controller when monitoring blood sugar, and the glucose sensor is respectively connected with the battery management circuit and the main controller. The battery management circuit is used for carrying out charge and discharge management, so that when the glucose sensor carries out data monitoring, the tail gas of the storage battery supplies power; the glucose sensor is in the sleep mode when idling, the glucose sensor generates oxidation reaction on the working electrode to generate current, and then the glucose sensor charges the storage battery, so that the self-powered function of the continuous blood glucose monitoring equipment is realized.
The glucose sensor is called a biofuel cell, and is a three-electrode system sensor which comprises a working electrode WE, a reference electrode RE and a counter electrode CE, wherein the reference electrode RE is used for determining the potential of the working electrode, the counter electrode CE and the working electrode WE form a measurement loop, and the working electrode WE and the reference electrode RE form a polarization loop.
Concretely, this continuous type blood glucose monitoring equipment based on self-power supply biosensor includes main control unit, battery management circuit, the battery, the glucose sensor, the ground, temperature compensation circuit and bluetooth module, wherein connect on the main control unit and be provided with ADC converter (analog-to-digital converter), the ADC converter is used for main control unit to acquire the AD value, the ADC converter passes through electrochemical sensor conditioning circuit and is connected with the glucose sensor, electrochemical sensor conditioning circuit is used for converting the current that the glucose sensor detected into voltage, for main control unit passes through the ADC converter and acquires the AD value.
In this embodiment, the temperature compensation circuit is connected to the main controller. The temperature compensation circuit is established ties by temperature sensitive resistance and a fixed resistance and is constituted, and temperature sensitive resistance changes the resistance along with temperature change, then changes appears adding the voltage above that, is connected the collection voltage with main control unit's ADC converter port, can obtain the temperature through the formula, and specific temperature compensation algorithm can adopt current algorithm, the utility model discloses do not make specific improvement, so do not detail.
And calculating the current blood sugar by the upper computer through a temperature compensation algorithm and a blood sugar algorithm in combination with the AD value of the temperature compensation and the AD value of the glucose sensor. The process of calculating the blood sugar by the upper computer (such as a computer) can be realized by using the existing algorithm, and is not limited specifically here.
In this embodiment, the bluetooth module is connected with the master controller for the master controller sends the AD value to the host computer.
In one embodiment, the main controller may adopt a chip STM32RCT6, control the battery management circuit through an IO port output on the chip STM32RCT6, and may read an AD value corresponding to the battery voltage. The chip STM32RCT6 is connected with the Bluetooth module, is used as a slave, can broadcast and send data to the upper computer through the Bluetooth module, can receive instructions transmitted by Bluetooth broadcast of the upper computer, and executes corresponding operation.
In this embodiment, the glucose sensor is connected with the electrochemical sensor conditioning circuit, converts the detected current into voltage through the electrochemical sensor conditioning circuit, acquires an AD value by an ADC (analog to digital converter) of the main controller, and transmits the AD value to the upper computer through Bluetooth communication.
In this embodiment, please refer to fig. 2, the battery management circuit may employ a TIDA-00041 module, the TIDA-00041 module uses a BQ25504 chip, which not only has the advantages of low energy consumption and low operating current, but also can detect the operation mode of the battery in real time, and the voltage during operation is not less than 80mV, and can collect relatively small electric energy, the working electrode WE of the glucose sensor is connected to the VIN terminal of J1, the counter electrode CE is connected to the GND terminal of J1, and the output voltage is 3V through the BQ25504 boost converter.
In the embodiment, the battery management circuit is respectively connected with the glucose sensor and the storage battery, and a storage battery power supply system is used in a high power consumption mode to ensure the normal operation of the communication of the Bluetooth module; in a low power consumption mode, namely when the main controller is in a sleep mode, because the required current is small, oxidation reaction can occur on the working electrode through the glucose sensor at the moment to generate current, the battery management circuit adjusts the switch to form a charging circuit between the glucose sensor and the storage battery, and the glucose sensor is used for charging the storage battery.
Among them, the glucose sensor, also called a biofuel cell, is manufactured from a flexible electrode. The flexible electrode is of a two-sided structure, the working electrode WE and the reference electrode RE are on the same side, the counter electrode CE is on the other side, and the working electrode WE and the reference electrode RE are connected through the insulating layer, so that the sensor failure caused by the connection of the working electrode WE and the reference electrode RE is prevented. The reference electrode RE can be an AgCl/Ag coating, and the substrates of the working electrode WE and the counter electrode CE can be silk-screen carbon layers.
The glucose fuel cell adopts tissue fluid in a human body as electrolyte solution, generates current by oxidizing glucose in the tissue fluid, charges the storage battery through the battery management circuit, achieves the purpose of recycling the battery, and prolongs the service life of implanted blood glucose detection equipment through phase change.
Referring to fig. 3, the electrochemical sensor conditioning circuit is connected to a glucose sensor, which is a sensor S1, and specifically, the electrochemical sensor conditioning circuit includes: potentiostat circuit, acquisition circuit, the transimpedance amplifier circuit, negative feedback circuit and low pass filter circuit, sensor S1 includes working electrode WE, reference electrode RE and to electrode CE, the potentiostat circuit is connected with first bias voltage Vref1, a potential that is used for guaranteeing reference electrode RE and to electrode CE is invariable, acquisition circuit is connected with working electrode WE, a current signal is used for gathering, the transimpedance amplifier circuit is connected with second bias voltage Vref2, a voltage output is used for converting the electric current into, negative feedback circuit is used for the electric current to convert the stabilization effect of the after by the multiple of enlargiing and current output value, low pass filter circuit is used for filtering high frequency signal and clutter signal, obtain clean voltage signal Vout.
Specifically, the potentiostat circuit includes a first operational amplifier U1A, a first capacitor C1, a fourth capacitor C4, a first resistor R1, a fifth resistor R5, a sixth resistor R6, and an eighth resistor R8:
the positive input end of the first operational amplifier U1A is connected with a first bias voltage Vref1 through a first resistor R1;
the negative input end of the first operational amplifier U1A is sequentially connected with a sixth resistor R6, a fifth resistor R5 and a reference electrode RE;
the output terminal of the first operational amplifier U1A is connected to the counter electrode CE through an eighth resistor R8.
The positive power supply VCC of the first operational amplifier U1A is connected to the negative power supply of the first operational amplifier U1A through a fifth capacitor C5.
The acquisition circuit comprises a third resistor R3 and a second operational amplifier U1B: the working electrode WE is connected with the negative input end of the second operational amplifier U1B through a third resistor R3, and the third resistor R3 is used for collecting current signals.
The transimpedance amplifier circuit includes a second resistor R2, and a positive input terminal of the second operational amplifier U1B is connected to a second bias voltage Vref2 through the second resistor R2.
The negative feedback circuit includes: a fourth resistor R4 and a second capacitor C2, a negative input end of the second operational amplifier U1B is connected to one end of the fourth resistor R4 and one end of the second capacitor C2, respectively, and the other end of the fourth resistor R4 and the other end of the second capacitor C2 are both connected to an output end of the second operational amplifier U1B. The resistance of the fourth resistor R4 and the capacitance of the second capacitor C2 determine the stable effect of the amplification factor and the circuit output value, the resistance of the fourth resistor R4 determines the factor of the current after being converted into the amplified factor, and the second capacitor C2 is used for filtering the alternating current part in the current signal.
The electrochemical sensor conditioning circuit further comprises a first field effect transistor Q1 and a sixth capacitor C6: the source electrode S of the first field effect transistor Q1 is connected with the working electrode WE; the drain electrode D of the first field effect transistor Q1 is connected with the reference electrode RE; the gate G of the first field effect transistor Q1 is connected to one end of the sixth capacitor C6.
The low-pass filter circuit comprises a seventh resistor R7 and a third capacitor C3 and is used for filtering high-frequency signals and clutter signals to obtain a clean voltage signal Vout; the output end of the second operational amplifier U1B is connected to the output voltage signal end Vout through a seventh resistor R7. The other end of the sixth capacitor C6 is connected to the output voltage signal terminal Vout through the third capacitor C3.
In this embodiment, the glucose sensor is used for operation of the electrochemical sensor conditioning circuit when in the first state. When the glucose sensor is controlled by the battery management circuit to charge the storage battery, the glucose sensor is connected with the storage battery to form a charging loop, and the charging loop is used for charging the storage battery.
To sum up, the utility model provides a continuous type blood sugar monitoring facilities based on self-power biosensor, it includes main control unit, battery management circuit, battery and glucose sensor, glucose sensor is connected with battery management circuit and main control unit respectively, and glucose sensor has the first state that acquires AD value and gather measuring current for main control unit when monitoring blood sugar through the drive of battery management circuit to and have the second state that charges for the battery when the dormancy. The utility model discloses a glucose sensor and battery management circuit are connected, make it use as the sensor when monitoring blood sugar, give the battery power supply as biofuel cell when the dormancy, in addition obtain the electric quantity in the dormancy period on the basis capacity of original dress battery promptly to effectively prolong the life of equipment, and do not influence the volume of equipment.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not intended to limit the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principles of the present invention should be included within the scope of the present invention.
Claims (5)
1. A continuous blood glucose monitoring device based on a self-powered biosensor, comprising:
the main controller is in wireless communication with the upper computer;
a battery management circuit in bidirectional communication with the master controller;
the glucose sensor is connected with the battery management circuit and is connected with the main controller through an ADC (analog-to-digital converter);
the storage battery is connected with the battery management circuit and used for storing electricity and supplying power to the glucose sensor when the glucose sensor monitors blood sugar;
wherein the glucose sensor is connected to the ADC converter through an electrochemical sensor conditioning circuit; the glucose sensor is a three-electrode system sensor and comprises a working electrode WE, a reference electrode RE and a counter electrode CE, wherein the reference electrode RE is used for determining the potential of the working electrode, the counter electrode CE and the working electrode WE form a measurement loop, and the working electrode WE and the reference electrode RE form a polarization loop;
the electrochemical sensor conditioning circuit comprises: constant potential rectifier circuit, acquisition circuit, transimpedance amplifier circuit:
the potentiostat circuit is connected to a first bias voltage Vref1 for ensuring constant potentials of the reference electrode RE and the counter electrode CE;
the acquisition circuit is connected with the working electrode WE and is used for acquiring current signals;
the transimpedance amplifier circuit is connected with a second bias voltage Vref2 and is used for converting current into voltage and outputting the voltage;
the battery management circuit adopts a TIDA-00041 module.
2. A self-powered biosensor-based continuous blood glucose monitoring device according to claim 1 wherein the master control chip model of the master controller is STM32RCT6.
3. The continuous blood glucose monitoring device based on the self-powered biosensor as recited in claim 1, further comprising a bluetooth module, wherein the bluetooth module is connected to the main controller and is configured to send the monitoring result of the main controller to the host computer.
4. The self-powered biosensor-based continuous blood glucose monitoring device of claim 1, further comprising a temperature compensation circuit, wherein the master controller is coupled to the temperature compensation circuit.
5. A self-powered biosensor-based continuous blood glucose monitoring device according to claim 1 wherein the glucose sensor is a two-sided structure with working electrode WE and reference electrode RE on the same side, counter electrode CE on the side opposite the working electrode WE, and working electrode WE and reference electrode RE are connected by an insulating layer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202221002961.2U CN218629623U (en) | 2022-04-28 | 2022-04-28 | Continuous blood glucose monitoring equipment based on self-powered biosensor |
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| CN202221002961.2U CN218629623U (en) | 2022-04-28 | 2022-04-28 | Continuous blood glucose monitoring equipment based on self-powered biosensor |
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| CN218629623U true CN218629623U (en) | 2023-03-14 |
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