CN218589073U

CN218589073U - Noninvasive distal limb ischemia device for experimental animals

Info

Publication number: CN218589073U
Application number: CN202221594808.3U
Authority: CN
Inventors: 肖衡; 李鹏; 谢佳新; 吴玉; 周思敏; 钟志凤; 董华平; 黄沛; 李娅灵
Original assignee: Third Military Medical University TMMU
Current assignee: Third Military Medical University TMMU
Priority date: 2022-06-24
Filing date: 2022-06-24
Publication date: 2023-03-10
Anticipated expiration: 2032-06-24

Abstract

The utility model provides an experimental animals is with creating blood device of wound distal end limbs, include: a frame; the forward rotation mechanism is hollow; the reverse rotation mechanism is hollow and is stacked with the forward rotation mechanism; the elastic telescopic strip is positioned in the forward rotation mechanism and the reverse rotation mechanism; the two ends of the rotary mechanism are respectively connected with the forward rotation mechanism and the reverse rotation mechanism; the driving mechanism is arranged on the rack, is respectively connected with the forward rotation mechanism and the reverse rotation mechanism, and is used for driving the forward rotation mechanism and the reverse rotation mechanism to rotate; wherein, the positive rotation mechanism and the reverse rotation mechanism are opposite in rotation direction and are rotatably arranged on the frame. The utility model drives the positive rotation mechanism and the negative rotation mechanism to rotate in opposite directions through the driving mechanism, and winds the elastic expansion strip in the positive rotation mechanism and the negative rotation mechanism on the limbs of the experimental animal; the winding degree of the elastic expansion strip on the limbs of the experimental animal can be conveniently and quickly adjusted.

Description

Non-invasive distal limb ischemia device for experimental animals

Technical Field

The utility model relates to a limbs ischemia experiment technical field, concretely relates to experimental animals is with creating ischemia device of distal end limbs of wound.

Background

The method for preparing the remote limb ischemia model comprises a limb cerclage method and a direct artery blocking method. The limb circumferential ligation method is to ring and tie substances such as external bandages, tourniquets or rubber bands and the like to the roots of one-side or two-side limbs of animals, and then perfuse the animals for a period of time, thereby achieving the purpose of transient ischemia. The remote limb ischemia pretreatment is mainly performed for 5-10min of ischemia and 5-10min of reperfusion, and the circulation is repeated for multiple times. The limb cerclage method is non-invasive, and has smaller damage to experimental animals compared with the direct artery blocking method.

In the market, few devices aiming at the far-end limb ischemia experiment are provided, for example, a blocking bandage for the noninvasive far-end limb ischemia experiment disclosed in patent CN202122137317.8, the limbs of an experimental animal can be banded, but the tightness degree of banding cannot be quantified, and the consistency of the experiment is difficult to ensure; and the magic tape used in the patent is easy to fall off in use.

SUMMERY OF THE UTILITY MODEL

To the not enough that exists among the prior art, the utility model provides an experimental animals is with creating no blood device of wound distal end limbs to improve the convenience.

The utility model provides an experimental animals is with creating ischemia device of wound distal end limbs, include:

a frame;

the forward rotation mechanism is hollow;

the reverse rotation mechanism is hollow and is stacked with the forward rotation mechanism;

the elastic telescopic strip is positioned in the forward rotation mechanism and the reverse rotation mechanism; the two ends of the rotary mechanism are respectively connected with the forward rotation mechanism and the reverse rotation mechanism;

the driving mechanism is arranged on the rack, is respectively connected with the forward rotation mechanism and the reverse rotation mechanism, and is used for driving the forward rotation mechanism and the reverse rotation mechanism to rotate;

wherein, the positive rotation mechanism and the reverse rotation mechanism are opposite in rotation direction and are rotatably arranged on the frame.

Compared with the prior art, the utility model discloses following beneficial effect has:

in the technology of the utility model, the driving mechanism drives the positive rotation mechanism and the negative rotation mechanism to rotate in opposite directions, and the elastic expansion strip in the positive rotation mechanism and the negative rotation mechanism is wound on the limbs of the animal; the winding degree of the elastic expansion strip on the limbs of the animal can be conveniently and quickly adjusted.

Preferably, the forward rotation mechanism includes a forward rotation ring; two sides of the positive rotating ring are respectively provided with an annular groove;

the reverse mechanism comprises two reverse rings which are coaxial with the forward ring; the positive rotating ring is positioned between the two reverse rotating rings; a plurality of sliding blocks are arranged on one surface of the reversing ring facing to the annular groove on the same side; the sliding block is inserted in the annular groove in a clearance mode;

the elastic telescopic strips comprise a forward strip and two reverse strips; the two reverse strips are connected with one end of the forward strip; one end of the forward strip, which is far away from the reverse strip, is connected with the inner wall of the forward rotation ring; one end of each reverse strip, which is far away from the forward strip, is connected with the inner walls of the reverse rings on two sides respectively.

Preferably, the forward strips and the reverse strips are both rubber tubes, and the forward strips are communicated with the reverse strips; the end part of the forward strip, which is far away from the reverse strip, is connected with an internal threaded pipe; the end part of the reverse strip far away from the forward strip is connected with an internal threaded pipe;

an air pump is arranged on the inner wall of the forward rotation ring, and external threaded pipes are respectively arranged on the air pump and the inner wall of the reverse rotation ring; the positive bar is communicated with the air pump through the threaded connection of the internal threaded pipe and the external threaded pipe; the reverse strip is connected with an external thread pipe on the inner wall of the reverse ring through an internal thread pipe to realize end part sealing.

Preferably, two sides of the inward strip are communicated with a plurality of air bags; the opposite sides of the two reverse strips are respectively communicated with a plurality of air bags.

Preferably, the frame comprises two pairs of arc-shaped bars located outside the two inversion rings; the center of the arc-shaped strip is positioned on the axis of the reverse rotation ring; the outer sides of the two reverse rotating rings are respectively provided with an annular fixed groove; a pair of arc strips on the same side are symmetrically arranged and are in sliding fit with the fixed groove.

Preferably, the outer peripheral walls of the forward rotating ring and the reverse rotating ring are provided with racks which are connected end to end;

the drive mechanism includes:

two driving components are arranged and positioned on two sides of the positive rotating ring;

the first gear column is meshed with the racks on the outer walls of the two reversing rings;

the second gear is meshed with the rack on the outer wall of the forward rotation ring;

wherein, the first gear column and the second gear are respectively connected with the driving component at the same side.

Preferably, the driving member comprises:

the first fixed block is connected with the rack and is provided with a fixed hole;

the second fixed block is connected with the frame and is provided with a through transition hole;

the prism is coaxially connected with the first gear column or the second gear, one end of the prism is inserted in the fixing hole in a clearance mode, and the other end of the prism is connected with a limiting block after penetrating through the transition hole;

the locking rod is provided with a prismatic hole matched with the prism and is sleeved on the prism through the prismatic hole;

the locking rod is positioned between the second fixing block and the limiting block; the prism is sleeved with a locking spring, and two ends of the locking spring are respectively abutted against the locking rod and the limiting block; the transition hole expands towards the orifice of the locking rod to be a conical hole; conical teeth are laid in the conical holes; one end of the locking rod facing the conical hole is connected with a coaxial conical gear; the conical gear is sleeved on the prism.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.

Fig. 1 is a front view of a non-invasive distal limb ischemia apparatus for laboratory animals according to an embodiment of the present invention;

FIG. 2 is a top view of the non-invasive distal limb ischemia apparatus for laboratory animals of FIG. 1;

FIG. 3 is a BB sectional view of the noninvasive distal limb ischemia apparatus for experimental animals of FIG. 1;

fig. 4 is a schematic diagram of the internal structure at the position a of the noninvasive distal limb ischemia device for experimental animals of fig. 2.

Reference numerals:

1. a frame; 11. an arc-shaped strip;

2. a forward rotation mechanism; 21. positively rotating the ring; 22. an annular groove; 23. an air pump;

3. a reversing mechanism; 31. a reverse rotation ring; 32. a slider; 33. an air bag; 34. fixing the groove;

4. an elastic expansion strip; 41. a forward bar; 42. a reverse strip;

5. a drive mechanism; 51. a drive member; 511. a first fixed block; 512. a second fixed block; 513. a prism; 514. a limiting block; 515. a lock lever; 516. a locking spring; 517. a tapered hole; 518. a bevel gear; 52. a first gear column; 53. a second gear.

Detailed Description

Embodiments of the present invention will be described in detail with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.

It is to be noted that unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the present invention belongs.

In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience of description and simplicity of description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting.

Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.

In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and encompass, for example, both fixed and removable connections or integral parts thereof; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or may be connected through the use of two elements or the interaction of two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those of ordinary skill in the art.

In this application, unless expressly stated or limited otherwise, a first feature is "on" or "under" a second feature such that the first and second features are in direct contact, or the first and second features are in indirect contact via an intermediary. Also, a first feature "on," "above," and "over" a second feature may be directly on or obliquely above the second feature, or simply mean that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

Referring to fig. 1 to 4, a non-invasive distal limb ischemia device for laboratory animals comprises:

a frame 1;

the forward rotation mechanism 2 is hollow;

the reverse rotation mechanism 3 is hollow and is stacked with the forward rotation mechanism 2;

the elastic telescopic strip 4 is positioned in the forward rotation mechanism 2 and the reverse rotation mechanism 3; two ends of the rotary mechanism are respectively connected with the forward rotation mechanism 2 and the reverse rotation mechanism 3;

the driving mechanism 5 is arranged on the frame 1, is respectively connected with the forward rotation mechanism 2 and the reverse rotation mechanism 3, and is used for driving the forward rotation mechanism 2 and the reverse rotation mechanism 3 to rotate;

wherein, the rotation direction of the forward rotation mechanism 2 is opposite to that of the reverse rotation mechanism 3, and the forward rotation mechanism 2 and the reverse rotation mechanism 3 are rotatably arranged on the frame 1.

Limbs of an animal are placed in the normal rotation mechanism 2 and the reverse rotation mechanism 3, and the drive mechanism 5 drives the normal rotation mechanism 2 and the reverse rotation mechanism 3 to rotate respectively. The rotation process of the forward rotation mechanism 2 and the reverse rotation mechanism 3 which turn reversely inevitably leads to the elastic expansion strip 4 to be wound on the limbs of the animal, thus obstructing blood supply and leading the limbs to be ischemic. According to the different sizes of animal limbs, the angle of the corotation mechanism 2 and the contrarotation mechanism 3 is different, the adjustable elastic telescopic strip can adapt to limbs of different sizes, the number of turns of the elastic telescopic strip 4 wound on the limbs can be adjusted by adjusting the rotating angles of the corotation mechanism 2 and the contrarotation mechanism 3, so that the degree of tightness of the elastic telescopic strip 4 can be adjusted, and the adjustable elastic telescopic strip is convenient and fast.

Further, the forward rotation mechanism 2 includes a forward rotation ring 21; two sides of the positive rotation ring 21 are respectively provided with an annular groove 22;

the reversing mechanism 3 comprises two reversing rings 31 coaxial with the forward rotating ring 21; the forward rotary ring 21 is located between the two reverse rotary rings 31; a plurality of sliding blocks 32 are arranged on one surface of the reverse rotation ring 31 facing the annular groove 22 on the same side; the sliding block 32 is inserted into the annular groove 22 with a clearance;

the elastic expansion strip 4 comprises a forward strip 41 and two reverse strips 42; two reverse strips 42 are connected with one end of the forward strip 41; one end of the forward strip 41 far away from the reverse strip 42 is connected with the inner wall of the forward rotation ring 21; the ends of the two reverse strips 42 far away from the forward strip 41 are respectively connected with the inner walls of the reverse rings 31 at two sides.

After the forward rotation ring 21 is rotated, the two reverse rotation rings 31 are rotated in opposite directions relative to the forward rotation ring 21, which causes the elastic expansion strip 4 in a relaxed state to start moving, and the limb of the animal is placed at the center of the forward rotation ring 21. In the process of winding the elastic expansion strip 4 around the limbs of the animal: the animal limb is positioned at the junction of the forward strip 41 and the reverse strip 42; the forward strips 41 are wound to pass between the two reverse strips 42. It should be noted that the elastic expansion strip 4 is so provided for its reasons; if the elastic expansion strip 4 is only a rubber strip, after the elastic expansion strip is wound on the limb of an animal, two ends of one strip are dislocated (the dislocating causes poor ischemia effect), and the elastic expansion strip can be continuously wound in this way; in order to achieve the ischemia effect, the wound coil needs to be wound for several turns; if the binding method is similar to the binding belt, one end of the binding belt needs to be fixed on the limb of the animal, and the other end can be repeatedly wound in an overlapping way, but the method of fixing one end in advance is inconvenient. In the present device, the forward strips 41 and the two backward strips 42 are provided starting from the joint between the forward strips 41 and the backward strips 42, and thus, overlapping and winding are not required to be separately performed, which results in a good ischemic effect.

Further, the forward strips 41 and the reverse strips 42 are both rubber tubes, and the forward strips 41 are communicated with the reverse strips 42; the end part of the positive strip 41 far away from the reverse strip 42 is connected with an internal threaded pipe; the end part of the reverse strip 42 far away from the forward strip 41 is connected with an internal threaded pipe;

an air pump 23 is arranged on the inner wall of the forward rotating ring 21, and external threaded pipes are respectively arranged on the inner walls of the air pump 23 and the reverse rotating ring 31; the forward strips 41 are communicated with the air pump 23 through threaded connection of the internal threaded pipe and the external threaded pipe; the reversing bar 42 is closed at the end by means of an internally threaded tube connected to an externally threaded tube on the inner wall of the reversing ring 31.

When the animal limb is wrapped by the forward and reverse

strips

41, 42, a certain ischemic effect is already provided, and for the enhancement of the effect, the forward and reverse

strips

41, 42 are inflated by the air pump 23. In addition, the forward strips 41 and the reverse strips 42 are connected with the air pump 23 and the inner wall of the reverse rotation ring 31 through internal threaded pipes, and can be replaced, so that limbs of animals facing different sizes can be adapted, large animals need elastic telescopic strips 4 which are wide enough and long enough, and small animals need small sizes. The air pump 23 is a micro pump capable of pumping air and inflating air in the prior art.

Furthermore, a plurality of air bags 33 are communicated with two sides of the inward strip; opposite sides of the two opposite strips 42 are respectively communicated with a plurality of air bags 33.

After the forward strips 41 and the reverse strips 42 are wound, the air pump 23 is inflated, the air bags 33 on the forward strips 41 and the reverse strips 42 are also inflated, so that the air bags 33 are abutted against the forward strips 41 and the reverse strips 42 to prevent the forward strips 41 and the reverse strips 42 from being opened, locking at a certain degree is realized, the air bags 33 can be broken off with force, and after all, the air bags 33 are also made of rubber materials and have certain elasticity. However, under the pulling of the forward rotation ring 21 and the reverse rotation ring 31, the forward strips 41 and the reverse strips 42 are kept wound as long as the forward rotation ring 21 and the reverse rotation ring 31 do not rotate.

Further, the frame 1 comprises two pairs of arc-shaped bars 11 positioned outside the two reversing rings 31; the center of the arc-shaped strip 11 is positioned on the axis of the reverse rotation ring 31; the outer sides of the two reverse rotation rings 31 are respectively provided with an annular fixed groove 34; the pair of arc-shaped strips 11 on the same side are symmetrically arranged and are in sliding fit with the fixing groove 34.

Two pairs of two sides are provided, and two reverse rotation rings 31 and a forward rotation ring 21 are clamped in the middle by four arc-shaped bars 11; and it is ensured that the normal rotation ring 21 and the reverse rotation ring 31 can rotate on the axis.

Further, racks which are connected end to end are arranged on the outer peripheral walls of the forward rotating ring 21 and the reverse rotating ring 31;

the drive mechanism 5 includes:

two driving members 51 provided on both sides of the forward rotation ring 21;

a first gear column 52 engaged with the racks on the outer walls of the two counter-rotating rings 31;

a second gear 53 engaged with the rack on the outer wall of the forward rotation ring 21;

the first gear column 52 and the second gear 53 are respectively connected to the driving member 51 on the same side.

The first gear column 52 or the second gear 53 is driven by a different driving member 51 to move the forward rotary ring 21 and the reverse rotary ring 31, respectively.

Further, the driving member 51 includes:

the first fixed block 511 is connected with the frame 1 and is provided with a fixed hole;

the second fixed block 512 is connected with the frame 1 and is provided with a through transition hole;

the prism 513 is coaxially connected with the first gear column 52 or the second gear 53, one end of the prism is inserted into the fixing hole in a clearance mode, and the other end of the prism penetrates through the transition hole and then is connected with a limiting block 514;

a locking rod 515, which is provided with a prismatic hole matching with the prism 513 and is sleeved on the prism 513 through the prismatic hole;

the locking rod 515 is positioned between the second fixed block 512 and the limiting block 514; a locking spring 516 is sleeved outside the prism 513, and two ends of the locking spring 516 are respectively abutted against the locking rod 515 and the limiting block 514; the transition hole expands into a tapered hole 517 toward the orifice of the locking lever 515; conical teeth are paved in the conical holes 517; one end of the locking rod 515 facing the tapered hole 517 is connected with a coaxial tapered gear 518; bevel gear 518 is fitted over prism 513.

When operated by the operator, the prism 513 is free to rotate and the first gear post 52 and second gear 53 are rotated by pulling the locking lever 515 to disengage the teeth of the bevel gear 518 from the tapered teeth in the tapered bore 517. On the contrary, under the action of the locking spring 516, the locking rod 515 drives the bevel gear 518 to abut against the bevel gear of the tapered hole 517, so as to realize locking.

In the specification of the present invention, a large number of specific details are explained. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the scope of the embodiments of the present invention, and are intended to be covered by the claims and the specification.

Claims

1. A non-invasive distal limb ischemia device for experimental animals is characterized by comprising:

a frame;

the forward rotation mechanism is hollow;

2. The noninvasive distal limb ischemia apparatus for laboratory animals according to claim 1, wherein the forward rotation mechanism comprises a forward rotation ring; two sides of the positive rotating ring are respectively provided with an annular groove;

the reverse mechanism comprises two reverse rings which are coaxial with the forward ring; the forward rotating ring is positioned between the two reverse rotating rings; a plurality of sliding blocks are arranged on one surface of the reversing ring facing the annular groove on the same side; the sliding block is inserted in the annular groove in a clearance mode;

the elastic telescopic strip comprises a forward strip and two reverse strips; the two reverse strips are connected with one end of the forward strip; one end of the forward strip, which is far away from the reverse strip, is connected with the inner wall of the forward rotation ring; one ends of the two reverse strips, which are far away from the forward strips, are respectively connected with the inner walls of the reverse rings at the two sides.

3. The noninvasive distal limb ischemia device for experimental animals as claimed in claim 2, wherein the forward strip and the backward strip are rubber tubes, and the forward strip is communicated with the backward strip; the end part of the forward strip, which is far away from the reverse strip, is connected with an internal threaded pipe; the end part of the reverse strip far away from the forward strip is connected with an internal threaded pipe;

an air pump is arranged on the inner wall of the forward rotation ring, and external threaded pipes are respectively arranged on the air pump and the inner wall of the reverse rotation ring; the forward strips are communicated with an air pump through threaded connection of the internal threaded pipe and the external threaded pipe; the reverse bar is connected with the external thread pipe on the inner wall of the reverse ring through the internal thread pipe to realize end part sealing.

4. The noninvasive distal limb ischemia device for laboratory animals according to claim 3, wherein a plurality of air bags are connected to both sides of the inward strip; the opposite sides of the two reverse strips are respectively communicated with a plurality of air bags.

5. The noninvasive distal limb ischemia device for laboratory animals according to claim 4, wherein said frame comprises two pairs of arc-shaped bars located outside of two inversion rings; the center of the arc-shaped strip is positioned on the axis of the reverse rotation ring; the outer sides of the two reverse rotating rings are respectively provided with an annular fixed groove; a pair of arc strips on the same side are symmetrically arranged and are in sliding fit with the fixed groove.

6. The noninvasive distal limb ischemia device for laboratory animals according to claim 5, wherein the outer peripheral walls of the forward rotation ring and the reverse rotation ring are provided with racks which are connected end to end;

the drive mechanism includes:

two driving components are arranged and positioned at two sides of the positive rotating ring;

7. The noninvasive distal limb ischemia apparatus for laboratory animals defined in claim 6, wherein the actuating means comprises:

the second fixed block is connected with the rack and is provided with a through transition hole;

the locking rod is positioned between the second fixed block and the limiting block; the prism is sleeved with a locking spring, and two ends of the locking spring are respectively propped against the locking rod and the limiting block; the transition hole expands towards the orifice of the locking rod into a conical hole; conical teeth are laid in the conical holes; one end of the locking rod facing the conical hole is connected with a coaxial conical gear; the conical gear is sleeved on the prism.