CN218475288U

CN218475288U - Stirring device for Suzuki coupling reaction

Info

Publication number: CN218475288U
Application number: CN202222983255.7U
Authority: CN
Inventors: 汪明中; 苏道; 朱明新
Original assignee: Ma'anshan Noante Pharmaceutical Technology Co ltd
Current assignee: Ma'anshan Noante Pharmaceutical Technology Co ltd
Priority date: 2022-11-09
Filing date: 2022-11-09
Publication date: 2023-02-14
Anticipated expiration: 2032-11-09

Abstract

The utility model discloses a Suzuki coupling reaction agitating unit relates to the fine chemistry industry field. Suzuki coupling reaction agitating unit, including base and retort, the retort is installed on the base, still include: the support plate is vertically and fixedly connected to one side of the base; the lifting assembly is arranged on the support plate; the driving motor is fixedly connected above the lifting assembly close to the reaction tank; the output shaft is fixedly connected to the output end of the driving motor; the utility model discloses compare with current reaction agitating unit, stirring speed as required carries out accurate regulation to its rotational speed that stirs the subassembly to be convenient for make the device can be applicable to the preparation work of the higher different amino acids of stirring speed requirement, improved the device's suitability effectively.

Description

Stirring device for Suzuki coupling reaction

Technical Field

The utility model belongs to the technical field of fine chemistry industry, specifically speaking relates to Suzuki coupling reaction agitating unit.

Background

The Suzuki coupling reaction is also called Suzuki reaction, has wide application range in organic synthesis, and has strong substrate adaptability and functional group tolerance, so that the Suzuki coupling reaction is applied to synthesis of numerous natural products, medical intermediates and organic materials, and when solid and liquid materials exist in an amino acid Suzuki coupling reaction system, such as arylphenylboronic acid and halogenated aromatic amino acid, a stirring device is usually needed to stir and mix a solid phase and a liquid phase in a reaction stage.

In the prior art, the application number is CN202010133061.0, which is named as a reaction device for Suzuki coupling reaction and discloses a device for coupling reaction; the reaction kettle comprises a support frame, a reaction kettle body arranged on the support frame and an inner container arranged in the reaction kettle body, wherein a hollow cavity is arranged between the inner container and the reaction kettle body, a liquid inlet communicated with the hollow cavity is formed in the bottom end of the reaction kettle body, a liquid outlet communicated with the hollow cavity is formed in the side surface of the top end of the reaction kettle body, at least two discharge ports are formed in the bottom end of the inner container, and a filter screen is arranged at one end, close to the inner container, of one discharge port; the inner bag inner wall is equipped with vortex baffle subassembly, and vortex baffle subassembly includes a plurality of vortex baffles, and a plurality of vortex baffles set up along the equidistant of inner bag inner wall. The invention realizes the function of separating liquid and solid in the product and realizes the multifunctional use of single equipment; the chemical reaction is more sufficient, and the production efficiency is improved.

The turbulence baffle is added on the inner container, although the materials can generate vortex motion relative to the turbulence baffle during stirring, the stirring uniformity of various materials is greatly improved; the vortex baffle direction of rotation when having changed the material stirring makes the reaction with higher speed between the material, improves production efficiency, but the coupling in-process is because the system is heterogeneous, for example aqueous phase and organic phase, can not become the homogeneous phase completely, consequently need use the subassembly that can the accurate adjustment stirring speed to stir the reactant, and the stirring subassembly of above-mentioned patent can not the accurate adjustment stirring speed, in view of this special suggestion the utility model discloses a high pressure heater is used to the stirring subassembly of high pressure heater.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the present invention is to overcome the deficiencies of the prior art and to provide a stirring device for Suzuki coupling reaction, which can overcome the above problems or at least partially solve the above problems.

In order to solve the technical problem, the utility model adopts the following basic concept: suzuki coupling reaction agitating unit, including base and retort, the retort is installed on the base, still include: the support plate is vertically and fixedly connected to one side of the base; the lifting assembly is arranged on the support plate; the driving motor is fixedly connected above the lifting assembly close to the reaction tank; the output shaft is fixedly connected to the output end of the driving motor; the speed regulating gear set is fixedly connected to the output shaft; the transmission rod is rotationally connected above the reaction tank; the transmission gear set is fixedly connected to the transmission rod, a plurality of gears with different diameters are arranged on the speed regulating gear set and the transmission gear set, the diameters of the plurality of gears on the output shaft are sequentially decreased from top to bottom, the diameters of the plurality of gears on the transmission rod are sequentially increased from top to bottom, and the positions of the gears on the speed regulating gear set and the transmission gear set are matched with each other; and the stirring assembly is arranged in the reaction tank, and the upper end of the stirring assembly is fixedly connected with the transmission rod.

Further, the lifting assembly comprises a first lifting plate, a vertical rod, a second lifting plate and an electric lifting rod, a through chute is formed in the upper portion of the support plate, the vertical fixed connection of the vertical rod is formed in the through chute, the first lifting plate and the second lifting plate are respectively connected to the upper position and the lower position of the through chute in a sliding mode, and are fixedly connected with the vertical rod, reinforcing ribs are fixedly connected between the first lifting plate and the second lifting plate, the support plate is close to a fixed plate fixedly connected with the lower portion of the second lifting plate, the electric lifting rod is fixedly connected to the fixed plate, and the telescopic end of the electric lifting rod is fixedly connected with the second lifting plate.

Furtherly, the stirring subassembly includes dwang, puddler and filter plate, the dwang rotates to be connected in the retort, the puddler is the equidistant fixed connection of circumference on the dwang, the equidistant fixed connection of filter plate is on the puddler, the first scraper blade of the vertical fixedly connected with of one end of dwang is kept away from to the puddler, first scraper blade pastes with the retort inner wall slides mutually.

In order to facilitate making first scraper blade strike off the material of adhesion on the retort inner wall fully, can also improve the effect of arylphenylboronic acid and the mixture of halogenated aromatic ring amino acid simultaneously, further, the lower extreme of dwang runs through in the retort, and fixedly connected with eccentric wheel, be equipped with the spacing spout of round annular on the eccentric wheel, symmetrical sliding connection has two T type pieces in the spacing spout of annular, the both sides upper end fixedly connected with T type gag lever post of retort, sliding connection has the arc on the T type gag lever post, through connecting rod fixed connection between arc lower extreme and the adjacent T type piece, the equidistant fixedly connected with multiseriate of one side that the arc is close to the retort strikes the piece, the annular groove has been seted up near the position of striking the piece to the retort outer wall.

In order to improve the stability of meshing between the transmission gear set and the speed regulation gear set, furthermore, the rotating rod is penetrated through the reaction tank and is fixedly connected with a rotating plate, the transmission rod is fixedly connected to the rotating plate, a circle of T-shaped sliding groove is formed in the upper end of the reaction tank, T-shaped sliding rods are symmetrically and fixedly connected to two sides of the lower end of the rotating plate, and the T-shaped sliding rods are connected in the T-shaped sliding grooves in a sliding mode.

In order to facilitate the abundant material discharge with in the retort, furthermore, one side lower extreme of retort is equipped with the bin outlet, be close to a plurality of second scraper blades of equidistant fixedly connected with of inside lower extreme of retort on the dwang, the second scraper blade slides with the bottom of retort and pastes mutually.

After the technical scheme is adopted, compared with the prior art, the utility model following beneficial effect has: the utility model discloses compare with current reaction agitating unit, stirring speed as required carries out accurate regulation to its rotational speed that stirs the subassembly to be convenient for make the device can be applicable to the preparation work of the higher different amino acids of stirring speed requirement, improved the device's suitability effectively.

The following describes embodiments of the present invention in further detail with reference to the attached drawings.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention, are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without undue limitation. It is obvious that the drawings in the following description are only some embodiments and that for a person skilled in the art, other drawings can also be derived from them without inventive effort.

In the drawings:

FIG. 1 is a schematic structural diagram of a stirring device for Suzuki coupling reaction provided by the present invention;

FIG. 2 is a schematic structural diagram of part A in FIG. 1 of a stirring apparatus for Suzuki coupling reaction according to the present invention;

FIG. 3 is a schematic structural diagram of a portion B in FIG. 1 of a stirring apparatus for Suzuki coupling reaction according to the present invention;

fig. 4 is the utility model provides an arc, strike the structural sketch map of piece among the stirring apparatus of Suzuki coupled reaction.

In the figure: 1. a base; 101. a reaction tank; 102. a second squeegee; 2. a support plate; 3. a first lifter plate; 4. a vertical rod; 5. a second lifter plate; 6. an electric lifting rod; 7. a drive motor; 8. an output shaft; 9. a speed-regulating gear set; 10. rotating the rod; 11. a transmission rod; 12. a drive gear set; 13. a rotating plate; 14. a stirring rod; 15. a first squeegee; 16. an eccentric wheel; 17. a T-shaped block; 18. an arc-shaped plate; 1801. a connecting rod; 19. knocking the block; 20. a filter orifice plate; 21. t type gag lever post.

It should be noted that the drawings and the description are not intended to limit the scope of the inventive concept in any way, but to illustrate the inventive concept by those skilled in the art with reference to specific embodiments.

Detailed Description

To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the attached drawings in the embodiments of the present invention are combined below to clearly and completely describe the technical solution in the embodiments, and the following embodiments are used to illustrate the present invention, but do not limit the scope of the present invention.

Example 1:

referring to fig. 1-4, the stirring apparatus for suzuki coupling reaction includes a base 1 and a reaction tank 101, wherein the reaction tank 101 is installed on the base 1, and further includes: the support plate 2 is vertically and fixedly connected to one side of the base 1; the lifting assembly is arranged on the support plate 2; the driving motor 7 is fixedly connected above the lifting assembly close to the reaction tank 101; the output shaft 8 is fixedly connected to the output end of the driving motor 7; the speed regulating gear set 9 is fixedly connected to the output shaft 8; the transmission rod 11 is rotatably connected above the reaction tank 101; the transmission gear set 12 is fixedly connected to the transmission rod 11, wherein a plurality of gears with different diameters are arranged on the speed regulating gear set 9 and the transmission gear set 12, the diameters of the plurality of gears on the output shaft 8 are sequentially decreased from top to bottom, the diameters of the plurality of gears on the transmission rod 11 are sequentially increased from top to bottom, and the positions of the gears on the speed regulating gear set 9 and the transmission gear set 12 are matched with each other; the stirring assembly is arranged in the reaction tank 101, and the upper end of the stirring assembly is fixedly connected with the transmission rod 11;

the lifting assembly comprises a first lifting plate 3, a vertical rod 4, a second lifting plate 5 and an electric lifting rod 6, a through chute is formed above the support plate 2, the vertical rod 4 is vertically and fixedly connected in the through chute, the first lifting plate 3 and the second lifting plate 5 are respectively and slidably connected to the upper position and the lower position of the through chute and fixedly connected with the vertical rod 4, a reinforcing rib is fixedly connected between the first lifting plate 3 and the second lifting plate 5, a fixing plate is fixedly connected below the support plate 2 close to the second lifting plate 5, the electric lifting rod 6 is fixedly connected onto the fixing plate, and the telescopic end of the electric lifting rod is fixedly connected with the second lifting plate 5;

the stirring assembly comprises a rotating rod 10, a stirring rod 14 and a filter hole plate 20, the rotating rod 10 is rotatably connected in the reaction tank 101, the stirring rod 14 is in circumferential equidistant fixed connection on the rotating rod 10, the filter hole plate 20 is in equidistant fixed connection on the stirring rod 14, the stirring rod 14 is far away from a first scraper 15 of one end vertical fixed connection of the rotating rod 10, and the first scraper 15 is attached to the inner wall of the reaction tank 101 in a sliding manner.

When the aryl phenylboronic acid powder and the halogenated aromatic ring amino acid solution are required to be prepared into the amino acid, at the moment, a worker firstly moves the reaction stirring device to a specified working position, then switches on an electric device on the device, then the aryl phenylboronic acid and the halogenated aromatic ring amino acid can be sequentially added into the reaction tank 101 through a feeding port according to a certain ratio, then the electric lifting rod 6 is started, the electric lifting rod 6 drives the first lifting plate 3 to adjust the position up and down through the second lifting plate 5, then the driving motor 7 can adjust the position of the gear on the speed regulating gear set 9 through the output shaft 8, so that the corresponding gear on the speed regulating gear set 9 is meshed with the corresponding gear on the transmission gear set 12 according to the required rotating speed, then the driving motor 7 can be started, then the driving motor 7 can drive the rotating rod 10 to drive the stirring rod 14 to rotate at the specified rotating speed through the transmission rod 11, so that the aryl phenylboronic acid and the halogenated aromatic ring amino acid can be stirred and mixed and react through the electric lifting rod 20, so that the aryl phenylboronic acid and the halogenated aromatic ring 6 can be fully reacted on the aromatic ring 20, and the aromatic ring reaction tank can be further improved through the stirring rod 14, and the aromatic ring reaction tank can be fully reacted, and the aryl phenylboronic acid can be further reacted through the aromatic ring 6, and the aromatic ring reaction tank, and the stirring rod 7, and the aromatic ring reaction tank can be carried out through the reaction tank, and the aromatic ring reaction tank, and the stirring rod 6, and the stirring rod can be carried out, the speed regulating gear set 9, the transmission rod 11 and the transmission gear set 12 are matched for use, so that the rotating speed of the stirring component can be accurately regulated according to the required stirring speed, the device can be conveniently suitable for preparation work with high requirement on the stirring speed, and the applicability of the device is effectively improved;

it should be noted that although some conventional motors also have a speed regulation function, the speed regulation precision is not accurate enough, and the device can accurately regulate the stirring speed of the stirring assembly by designing the diameter of the gear in the speed regulation gear set 9 and the diameter of the gear in the transmission gear set 12 to be a specified diameter according to requirements, thereby improving the preparation effect of the amino acid.

Example 2:

referring to FIGS. 1-4, a stirring apparatus for Suzuki coupling reaction, which is substantially the same as that of example 1, is further provided: the lower end of the rotating rod 10 penetrates through the reaction tank 101, the eccentric wheel 16 is fixedly connected with the lower end of the reaction tank 101, a circle of annular limiting sliding groove is formed in the eccentric wheel 16, two T-shaped blocks 17 are symmetrically and slidably connected in the annular limiting sliding groove, T-shaped limiting rods 21 are fixedly connected to the upper ends of the two sides of the reaction tank 101, an arc plate 18 is slidably connected to the upper ends of the T-shaped limiting rods 21, the lower end of the arc plate 18 is fixedly connected with the adjacent T-shaped blocks 17 through connecting rods 1801, a plurality of rows of knocking blocks 19 are fixedly connected to one side, close to the reaction tank 101, of the arc plate 18 at equal intervals, an annular groove is formed in the outer wall of the reaction tank 101, when the rotating rod 10 drives the stirring rod 14 to stir a mixture of arylphenylboronic acid and halogenated aromatic amino acid, the eccentric wheel 16 is driven to rotate at the same time, then the eccentric wheel 16 drives the connecting rod 1801 to reciprocate left and right through the T-shaped blocks 17, the connecting rod 1801 drives the arc plate 18 to reciprocate left and right through the cooperation of the T-shaped limiting rods 21, then the knocking block 19 can knock the reaction tank 101, the first scraper plate 15 can sufficiently scrape the aromatic amino acid adhered to the inner wall of the reaction tank 101, and the aromatic halobenzene mixed material, and the aromatic ring mixed device can effectively improve the effect of the aryl benzene mixed material;

the rotating rod 10 penetrates through the reaction tank 101 and is fixedly connected with the rotating plate 13, the transmission rod 11 is fixedly connected to the rotating plate 13, a circle of T-shaped sliding groove is formed in the upper end of the reaction tank 101, T-shaped sliding rods are symmetrically and fixedly connected to two sides of the lower end of the rotating plate 13 and are connected to the T-shaped sliding groove in a sliding mode, and the rotating plate 13 and the T-shaped sliding rods are arranged to improve the meshing stability between the transmission gear set 12 and the speed regulating gear set 9, so that gears on the speed regulating gear set 9 can stably drive the rotating rod 10 to rotate through the gears on the transmission gear set 12, and the transmission stability is effectively improved;

one side lower extreme of retort 101 is equipped with the bin outlet, a plurality of second scraper blades 102 of equidistant fixedly connected with of inside lower extreme that are close to retort 101 on the dwang 10, second scraper blade 102 slides with retort 101's bottom and pastes mutually, setting through second scraper blade 102, when the material in retort 101 passes through the bin outlet and discharges, the material of surplus portion then can be under the transmission of second scraper blade 102, whole discharge retort 101, thereby be convenient for abundant discharge of the material with in the retort 101.

The utility model discloses an electric lift pole 6, lifting unit, driving motor 7, output shaft 8, speed governing gear group 9, transfer line 11, transmission gear group 12's cooperation is used, can carry out accurate regulation to its stirring subassembly's rotational speed as required stirring speed to be convenient for make the device can be applicable to the preparation work that requires higher to stirring speed, improved the device's suitability effectively.

In the description provided herein, numerous specific details are set forth. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and although the present invention has been disclosed with reference to the preferred embodiment, it is not intended to limit the present invention, and any person skilled in the art can make some changes or modifications to equivalent embodiments without departing from the scope of the present invention, and any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention will still fall within the scope of the present invention.

Claims

Suzuki coupling reaction agitating unit, including base (1) and retort (101), install retort (101) on base (1), its characterized in that still includes:

the support plate (2) is vertically and fixedly connected to one side of the base (1);

the lifting assembly is arranged on the support plate (2);

the driving motor (7) is fixedly connected above the lifting assembly close to the reaction tank (101);

the output shaft (8) is fixedly connected to the output end of the driving motor (7);

the speed regulating gear set (9) is fixedly connected to the output shaft (8);

the transmission rod (11) is rotatably connected above the reaction tank (101);

a transmission gear set (12) fixedly connected to the transmission rod (11),

the speed regulating gear set (9) and the transmission gear set (12) are respectively provided with a plurality of gears with different diameters, the diameters of the plurality of gears on the output shaft (8) are sequentially decreased from top to bottom, the diameters of the plurality of gears on the transmission rod (11) are sequentially increased from top to bottom, and the positions of the gears on the speed regulating gear set (9) and the transmission gear set (12) are matched with each other;

and the stirring assembly is arranged in the reaction tank (101), and the upper end of the stirring assembly is fixedly connected with the transmission rod (11).
2. The stirring device for Suzuki coupling reaction according to claim 1, wherein: the lifting assembly comprises a first lifting plate (3), a vertical rod (4), a second lifting plate (5) and an electric lifting rod (6), a through chute is formed in the top of the support plate (2), the vertical fixed connection of the vertical rod (4) is formed in the through chute, the first lifting plate (3) and the second lifting plate (5) are respectively connected to the upper position and the lower position of the through chute in a sliding mode, and are fixedly connected with the vertical rod (4), reinforcing ribs are fixedly connected between the first lifting plate (3) and the second lifting plate (5), the support plate (2) is close to a fixing plate fixedly connected with the lower portion of the second lifting plate (5), the electric lifting rod (6) is fixedly connected onto the fixing plate, and the telescopic end of the electric lifting rod is fixedly connected with the second lifting plate (5).
3. The stirring device for Suzuki coupling reaction according to claim 1, wherein: stirring subassembly includes dwang (10), puddler (14) and filter plate (20), dwang (10) are rotated and are connected in retort (101), puddler (14) are equidistant fixed connection of circumference on dwang (10), equidistant fixed connection of filter plate (20) is on puddler (14), the vertical fixedly connected with first scraper blade (15) of one end of dwang (10) are kept away from in puddler (14), first scraper blade (15) are slided mutually with retort (101) inner wall and are pasted.
4. The stirring device for Suzuki coupling reaction according to claim 3, wherein: the lower extreme of dwang (10) runs through in retort (101), and fixedly connected with eccentric wheel (16), be equipped with the annular spacing spout of round on eccentric wheel (16), symmetrical sliding connection has two T type pieces (17) in the annular spacing spout, fixedly connected with T type gag lever post (21) in the both sides upper end of retort (101), sliding connection has arc (18) on T type gag lever post (21), through connecting rod (1801) fixed connection between arc (18) lower extreme and the adjacent T type piece (17), one side equidistant fixedly connected with multiseriate that arc (18) are close to retort (101) strikes piece (19), the annular groove has been seted up near the position of striking piece (19) to retort (101) outer wall.
5. The stirring device for Suzuki coupling reaction according to claim 3, wherein: run through in retort (101) on dwang (10), and fixedly connected with rotor plate (13), transfer line (11) fixed connection is on rotor plate (13), retort (101) upper end is equipped with round T type spout, rotor plate (13) lower extreme bilateral symmetry fixedly connected with T type slide bar, T type slide bar sliding connection is in T type spout.
6. The stirring device for Suzuki coupling reaction according to claim 3, wherein: one side lower extreme of retort (101) is equipped with the bin outlet, be close to a plurality of second scraper blades (102) of the equidistant fixedly connected with of inside lower extreme of retort (101) on dwang (10), second scraper blade (102) slide with the bottom of retort (101) and paste mutually.