CN218445432U - Dissolution tester for drug research and development - Google Patents

Abstract

The utility model discloses a degree of dissolution apparatus for medicine research and development, including the survey organism, be fixed with on the survey organism and deposit the liquid cup, install the pivot in depositing the liquid cup, the stirring leaf has been linked firmly in the pivot, the interior bottom of depositing the liquid cup is equipped with the fixed axle, the cover that the lower extreme of pivot can move about from top to bottom is located on the fixed axle, still including locating the control shaft of fixed axle top, it is used for control to link firmly on the survey organism control shaft pivoted motor, the control shaft lower extreme has linked firmly the electro-magnet, the upper end of pivot has linked firmly magnetism to inhale the piece, when the electro-magnet is not switched on, the interval sets up about electro-magnet and the magnetism inhale the piece. The utility model discloses can be through the convenient realization of mode of magnetism absorption the dismantlement of pivot and stirring leaf is changed to improve the work efficiency of clean maintenance processing, and can not influence the continuous dissolution rate survey of medicine.

Description

Dissolution tester for drug research and development

Technical Field

The utility model relates to a degree of dissolving out survey technical field, concretely relates to degree of dissolving out apparatus for medicine research and development.

Background

Dissolution rate refers to the rate and extent of dissolution of a drug from a solid preparation such as a tablet in a predetermined solvent. Dissolution rate is an important index for controlling the quality of tablets, and the dissolution rate of insoluble medicines is generally checked. In the case of a preparation for checking dissolution rate, no longer checking the disintegration time period, most oral solid preparations must be absorbed into the blood circulation after administration to achieve a certain blood concentration before they are effective, so that the drug is released from the preparation and dissolved in the body fluid under the premise that the drug is absorbed, which is called dissolution in biopharmaceuticals, and the rate and degree of dissolution is called dissolution, which is the rate and degree of dissolution of a drug from a solid preparation such as a tablet or capsule in a given solvent from the viewpoint of drug testing, the rate of absorption of a drug in the body is often determined by the rate of dissolution, the drug in a solid preparation must be disintegrated and dissolved before being absorbed and then converted into a solution, and if the drug is not easily released from the preparation or the rate of dissolution of the drug is extremely slow, there may be a problem in the rate or degree of absorption of the drug in the preparation, on the other hand, some pharmacological actions are severe, the safety index is small, and if the rate of drug absorption is too fast, there may be a significant adverse reaction, and the time for maintaining the drug efficacy is shortened.

However, in the use process of the traditional dissolution tester, the stirring paddle is difficult to install and detach on the stirring shaft, so that the stirring paddle is inconvenient to replace or clean and maintain regularly, and the working efficiency of replacement or clean and maintenance of the stirring paddle is reduced.

SUMMERY OF THE UTILITY MODEL

1. Technical problem to be solved by the utility model

The utility model aims to solve the technical problem that exists among the prior art, provide a degree of dissolution apparatus for medicine research and development, it can be through the convenient realization of the mode of magnetism inhale the dismantlement change of pivot and stirring leaf to improve the work efficiency of clean maintenance processing, and can not influence the continuous degree of dissolution survey of medicine.

2. Technical scheme

In order to solve the above problem, the utility model provides a technical scheme does:

the utility model provides a degree of dissolution apparatus for medicine research and development, includes the survey organism, be fixed with on the survey organism and deposit the liquid cup, install the pivot in depositing the liquid cup, the stirring leaf has been linked firmly in the pivot, the interior bottom of depositing the liquid cup is equipped with the fixed axle, the cover that the lower extreme of pivot can be moved about from top to bottom is located on the fixed axle, still including locating the control shaft of fixed axle top, it is used for control to link firmly on the survey organism control shaft pivoted motor, the control shaft lower extreme has linked firmly the electro-magnet, the upper end of pivot has linked firmly magnetism and has inhaled the piece, when the electro-magnet is not switched on, electro-magnet and magnetism inhale the piece from top to bottom the interval setting.

Optionally, the rotating shaft is fixedly connected with an upper sealing cover, and the upper sealing cover is located above the liquid storage cup.

Optionally, the upper cover is provided with a feeding port.

Optionally, a feeding baffle is mounted on the upper cover at the position of the feeding port, and the feeding baffle can rotate upwards to open the feeding port.

Optionally, the upper end face of the feeding baffle is fixedly connected with a handle.

Optionally, a stop block capable of sliding relatively is mounted on the upper sealing cover, the stop block and the feeding stop plate are located in the same radial direction, the stop block is connected to the rotating shaft through a spring, the spring is used for pulling the stop block inwards, and a limiting structure used for limiting the sliding direction of the stop block is further arranged on the upper sealing cover.

Optionally, the limiting structure includes a limiting block arranged along the radial sliding direction of the stop block, and a limiting groove matched with the side edge of the stop block is formed in the limiting block.

Optionally, a cup holder is arranged on the measuring machine body, and a cup groove for accommodating the liquid storage cup is formed in the cup holder.

3. Advantageous effects

Adopt the technical scheme provided by the utility model, compare with prior art, have following beneficial effect:

this a dissolution rate apparatus for medicine research and development accessible magnetism inhale convenient realization of mode the dismantlement of pivot and stirring leaf is changed to improve the work efficiency of clean maintenance processing, and can not influence the continuous dissolution rate survey of medicine, can have the liquid cup of depositing of new pivot through the quick replacement after once dissolution rate survey is accomplished and begin next dissolution rate survey.

Drawings

Fig. 1 is a schematic structural diagram of a dissolution rate tester for drug development according to an embodiment of the present invention;

FIG. 2 is an enlarged partial view of FIG. 1 at A;

fig. 3 is a schematic cross-sectional view of a dissolution rate tester for drug development according to an embodiment of the present invention;

1. measuring the organism; 2. a liquid storage cup; 3. a rotating shaft; 4. stirring blades; 5. a fixed shaft; 6. a control shaft; 7. a motor; 8. an electromagnet; 9. a magnetic member; 10. an upper sealing cover; 11. a feeding baffle plate; 12. a stopper; 13. a spring; 14. and a limiting block.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail with reference to the accompanying drawings and the following detailed description. It should be understood that the detailed description and specific examples, while indicating the scope of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

It will be understood that when an element is referred to as being "fixed," "disposed," "secured" or "disposed" to another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. Further, when one element is considered to be "fixedly connected" to another element, the two elements may be fixed by way of detachable connection, or may be fixed by way of non-detachable connection, such as sleeving, clamping, integrally-formed fixing, welding, etc., which can be implemented in the prior art, and is not cumbersome. When an element is perpendicular or nearly perpendicular to another element, it is desirable that the two elements are perpendicular, but some vertical error may exist due to manufacturing and assembly effects. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The references to "first" and "second" in the present invention do not denote any particular quantity or order, but rather are merely used to distinguish one name from another.

With reference to the accompanying drawings 1-3, the dissolution tester for drug development of the embodiment comprises a tester body 1, wherein the tester body 1 is provided with a cup base and a liquid storage cup 2, the upper end of the liquid storage cup 2 is open, a cup groove for accommodating the liquid storage cup 2 is arranged in the cup base, the liquid storage cup 2 is fixedly arranged in the cup groove, a rotating shaft 3 is arranged in the liquid storage cup 2, the rotating shaft 3 is vertically arranged, a stirring blade 4 is fixedly connected to the rotating shaft 3, a fixed shaft 5 is arranged at the inner bottom of the liquid storage cup 2, the lower end of the rotating shaft 3 is movably sleeved on the fixed shaft 5 and can be detached relatively, the dissolution tester further comprises a control shaft 6 arranged above the fixed shaft 5, the control shaft 6 is vertically arranged above the rotating shaft 3 and coaxially arranged with the rotating shaft 3, the last control that is used for of survey organism 1 control shaft 6 pivoted motor 7, the output shaft of motor 7 with the upper end of control shaft 6 links firmly, 6 lower extremes of control shaft have linked firmly electro-magnet 8, the upper end of pivot 3 has linked firmly magnetism and has inhaled piece 9, when electro-magnet 8 circular telegram, through the cooperation that electro-magnet 8 and magnetism inhale piece 9 will pivot 3 upwards is inhaled and can synchronous control the rotatory stirring of pivot 3, when electro-magnet 8 is not switched on, pivot 3 can sink a segment distance, and this moment electro-magnet 8 and magnetism inhale piece 9 upper and lower interval setting, so that will pivot 3 and deposit liquid cup 2 together take off from survey organism 1 and carry out subsequent washing change, and this moment survey organism 1 can directly carry out the degree of dissolution survey of next medicine.

This a dissolution rate apparatus for medicine research and development accessible magnetism inhale convenient realization of mode pivot 3 and stirring leaf 4 are dismantled and are changed to improve the work efficiency of clean maintenance processing, and can not influence the continuous dissolution rate survey of medicine, once can have the new solution cup 2 of depositing of pivot 3 through quick replacement after the dissolution rate survey is accomplished and begin the next dissolution rate survey.

As the utility model discloses an alternative, last closing cap 10 has been linked firmly on pivot 3, go up closing cap 10 and be located deposit the top opening part of liquid cup 2 when electro-magnet 8 is not switched on, go up closing cap 10 support under the effect of self gravity support lean on in deposit the upper end opening department of liquid cup 2 in order to prevent that external pollutant from getting into deposit in the liquid cup 2, especially when depositing liquid cup 2 and being in the state of unused, the supporting deposit liquid cup 2 and last closing cap 10 of placing together can play and prevent contaminated purpose.

As the utility model discloses an alternative, for the ease of the input of material and solution, go up closing cap 10 and seted up the dog-house, go up closing cap 10 and go up to be located the position of dog-house is installed and is thrown material baffle 11, it can upwards rotate in order to open to throw material baffle 11 the dog-house, the up end of throwing material baffle 11 has linked firmly the handle, and during the material of throwing, user's accessible handle will throw material baffle 11 and upwards open so that the dog-house is open state.

As an alternative of the present invention, a relatively slidable stopper 12 is installed on the upper cover 10, the stopper 12 and the feeding baffle 11 are located on the same radial direction, the stopper 12 is located on the same radial direction and close to the position of the axle center of the upper cover 10, the feeding baffle 11 is located on the same radial direction and is away from the position of the axle center of the upper cover 10, the stopper 12 is connected to the rotating shaft 3 through a spring 13, the spring 13 is used for pulling the stopper 12 (inward pointing towards the position of the axle center of the upper cover 10), the upper cover 10 is further provided with a limiting structure for limiting the sliding direction of the stopper 12, the limiting structure includes a limiting block 14 arranged along the radial sliding direction of the stopper 12, the limiting block 14 is provided with a limiting groove matched with the side of the stopper 12, when the upper cover 10 rotates at a high speed along with the rotating shaft 3, the stopper 13 can slide outward at a centrifugal force, thereby slide to the upper side of the feeding baffle 11 to prevent the feeding baffle 11 from frequently vibrating up and down in the high speed rotation process, and the noise is generated when the upper cover 10 rotates at a high speed, the upper cover 10 can be opened without the action of the spring 13, thereby the upper cover 10 can be released to the upper cover 10, and the upper cover 10 can be opened without the upper cover 10.

The present invention and its embodiments have been described above schematically, and the description is not limited thereto, and what is shown in the drawings is only one of the embodiments of the present invention, and the actual structure is not limited thereto. Therefore, if a person skilled in the art should understand that without departing from the spirit of the present invention, the person skilled in the art should not inventively design the similar structural modes and embodiments to the technical solution, and all shall fall within the protection scope of the present invention.

Claims (8)

1. A dissolution rate tester for drug development, characterized in that: including the survey organism, be fixed with on the survey organism and deposit the liquid cup, deposit and install the pivot in the liquid cup, linked firmly the stirring leaf in the pivot, the interior bottom of depositing the liquid cup is equipped with the fixed axle, the cover that the lower extreme of pivot can move about from top to bottom is located on the fixed axle, still including locating the control shaft of fixed axle top, linked firmly on the survey organism and being used for control shaft pivoted motor, the control shaft lower extreme has linked firmly the electro-magnet, the upper end of pivot has linked firmly magnetism to inhale the piece, when the electro-magnet does not switch on, the interval sets up about electro-magnet and the magnetism inhale the piece.

2. A dissolution tester for pharmaceutical development according to claim 1, wherein: the rotating shaft is fixedly connected with an upper sealing cover, and the upper sealing cover is positioned above the liquid storage cup.

3. A dissolution tester for drug development according to claim 2, wherein: the upper sealing cover is provided with a feeding port.

4. A dissolution tester for pharmaceutical development according to claim 3, wherein: and a feeding baffle is arranged at the position of the feeding port on the upper sealing cover and can rotate upwards to open the feeding port.

5. A dissolution tester for drug development according to claim 3, wherein: the upper end face of the feeding baffle is fixedly connected with a handle.

6. A dissolution tester for drug development according to claim 4, wherein: the upper sealing cover is provided with a stop block capable of sliding relatively, the stop block and the feeding baffle are located in the same radial direction, the stop block is connected to the rotating shaft through a spring, the spring is used for pulling the stop block inwards, and the upper sealing cover is further provided with a limiting structure used for limiting the sliding direction of the stop block.

7. A dissolution tester for drug development according to claim 6, wherein: the limiting structure comprises a limiting block arranged along the radial sliding direction of the stop block, and a limiting groove matched with the side edge of the stop block is formed in the limiting block.

8. A dissolution tester for pharmaceutical development according to any one of claims 1 to 7, wherein: the measuring machine body is provided with a cup seat, and a cup groove for containing the liquid storage cup is formed in the cup seat.

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