CN218444733U - Blood sample separation container, blood sample separation device and sample analyzer - Google Patents

Abstract

The utility model discloses a blood sample separating container, a blood sample separating device and a sample analyzer, wherein the blood sample separating container is used for centrifugally separating a whole blood sample when rotating, a sample cavity, a separating cavity and a sedimentation cavity are arranged in the blood sample separating container, and the outer wall of the blood sample separating container is provided with a sample through hole communicated with the sample cavity; part of the cavity structure of the sample cavity is positioned above the separation cavity and the sedimentation cavity, and the other part of the cavity structure of the sample cavity is positioned below the separation cavity and the sedimentation cavity; the separation chamber gradually converges from an end close to the sample chamber to an end remote from the sample chamber. The utility model provides a blood sample separating vessel separates the purity of the plasma sample that obtains higher.

Description

Blood sample separation container, blood sample separation device and sample analyzer

Technical Field

The utility model relates to a blood specimen testing technical field, in particular to blood specimen separation container, blood specimen separation device and sample analyzer.

Background

Blood is one of the most common samples in clinical examination, and various physiological and pathological information of a testee can be obtained from the blood by various detection means such as biochemistry, immunity and the like, so that a basis is provided for clinical diagnosis and treatment. Currently, most tests for blood require separation of blood cell components from plasma components during the whole blood sample pretreatment stage, followed by subsequent testing of the enriched blood cells or plasma alone.

In the related art, a whole blood sample is collected by a blood collection tube, and the blood collection tube is placed in a centrifuge for centrifugal separation. Because the blood cell components and the plasma components are vertically distributed in layers after the whole blood sample in the blood collection tube is subjected to centrifugal treatment, the liquid level of the plasma layer where the plasma components are located is low, and when the blood sample is sampled through the suction tube, the blood cell components at the lower layer of the plasma components are easily mixed and sucked through the suction tube, so that the sampling purity of the blood sample is reduced.

SUMMERY OF THE UTILITY MODEL

The main object of the utility model is to provide a blood specimen separation container aims at promoting the sample purity of plasma sample.

In order to achieve the above purpose, the utility model provides a blood sample separation container, which is used for centrifugally separating a whole blood sample during rotation, and is characterized in that a sample cavity, a separation cavity and a sedimentation cavity which are sequentially communicated are arranged in the blood sample separation container, and a sample through hole communicated with the sample cavity is arranged on the outer wall of the blood sample separation container;

part of the cavity structure of the sample cavity is positioned above the separation cavity and the sedimentation cavity, and the other part of the cavity structure of the sample cavity is positioned below the separation cavity and the sedimentation cavity;

the separation chamber gradually shrinks from one end close to the sample chamber to one end far away from the sample chamber.

In an embodiment of the present invention, the sample chamber has a constricted chamber section, at least part of the chamber structure of which is located below the separation chamber;

the sample through opening is positioned above the contraction cavity section, and the contraction cavity section gradually contracts from one end close to the sample through opening to one end far away from the sample through opening.

In an embodiment of the present invention, the contracting cavity section has a first flow guiding wall near and below the separating cavity, and the separating cavity has a second flow guiding wall connected to the first flow guiding wall;

the first flow guide wall is arranged in an inclined plane or an arc surface; and/or the second flow guide wall is arranged in an inclined plane or an arc surface.

In an embodiment of the present invention, a communication channel is further disposed in the blood sample separation container;

the communicating passage is communicated with the top space of the settling chamber and the separating chamber.

In an embodiment of the present invention, the cross-sectional area of the communicating channel is smaller than the cross-sectional area of the sedimentation chamber along a direction perpendicular to the extending direction of the communicating channel.

In an embodiment of the present invention, the volume of the sample chamber is greater than the volume of the separation chamber, and the volume of the separation chamber is greater than the volume of the sedimentation chamber.

In an embodiment of the present invention, the outer wall of the blood sample separation container is provided with at least two positioning grooves, and the positioning grooves are used for clamping and fixing the blood sample separation container;

and/or the outer wall of the blood sample separation container is provided with a limiting convex part which is used for realizing the installation and fixation of the blood sample separation container;

and/or, the blood sample separation container is provided with a first connecting piece, and the first connecting piece is used for realizing the installation and fixation of the blood sample separation container.

In order to achieve the above object, the utility model discloses still provide a blood specimen separation device, blood specimen separation device includes:

a mounting seat;

the driving mechanism is arranged on the mounting seat;

the rotary table is connected with the driving mechanism, the driving mechanism drives the rotary table to rotate, and the rotary table is provided with at least one limiting hole; and

at least one above-mentioned blood sample separation container, the outer wall of blood sample separation container is equipped with spacing convex part, one blood sample separation container peg graft in one spacing downthehole, one spacing convex part with the periphery butt spacing of one spacing hole.

In an embodiment of the present invention, the turntable is provided with a plurality of positioning elastic pieces, and when a blood sample separation container is inserted into a limiting hole, the outer wall of the blood sample separation container abuts against one of the positioning elastic pieces for limiting;

and/or each blood sample separation container is provided with a first connecting piece, the rotary disc is provided with a plurality of second connecting pieces, and when one blood sample separation container is inserted into one limiting hole, the first connecting piece on the blood sample separation container and one second connecting piece are fixed in a magnetic attraction manner.

In an embodiment of the present invention, the blood sample separator further includes a coded disc, the driving mechanism has an output shaft connected to the rotary disc, and the coded disc is sleeved on the output shaft and located between the rotary disc and the driving mechanism;

the coded disc is provided with a plurality of gaps, the mounting seat is provided with a first sensor, and the first sensor is used for sensing the gaps; and/or a stop block is arranged on one side, back to the rotary disc, of the coded disc, and a second sensor is arranged on the mounting seat and used for sensing the stop block.

In order to achieve the above object, the present invention further provides a sample analyzer, which comprises the above blood sample separation device.

The utility model discloses technical scheme makes the partial structure in sample chamber be located disengagement chamber and sedimentation chamber top through set up sample chamber, disengagement chamber and the sedimentation chamber that communicates in proper order in blood specimen separation container, and another partial structure is located disengagement chamber and sedimentation chamber below, and the whole that sample chamber, disengagement chamber and sedimentation chamber make up is horizontal distribution, sets up the disengagement chamber to shrink gradually from the one end that is close to the sample chamber to the one end of keeping away from the sample chamber simultaneously. In this way, when the whole blood sample is added into the sample cavity through the sample through opening and the blood sample separation container is rotated, the whole blood sample in the sample cavity enters the separation cavity along the inclined bottom wall of the separation cavity under the action of the rotating centrifugal force and then enters the sedimentation cavity. Because the density of the blood cell components in the whole blood sample is greater than that of the plasma components, and the centrifugal force to which the blood cell components are subjected is greater than that to which the plasma components are subjected, the blood cell components enter the sedimentation cavity and then fill the inner space of the sedimentation cavity and squeeze the plasma components, so that the plasma components flow into the separation cavity, and the separation of the blood cell components and the plasma components is realized. In the process that the blood sample separation carrier decelerates to stop rotating, plasma components obtained by separation flow back to the sample cavity along the inclined bottom wall of the separation cavity under the inertia effect to become a plasma sample; the blood cell components remain in the sedimentation chamber as a blood cell sample. At the moment, the blood cell sample is contained in the sedimentation cavity, the plasma sample is contained in the sample cavity, the blood cell sample and the plasma sample are contained in the sub-cavities, and when the plasma sample in the sample cavity is extracted through the sample through opening, the blood cell sample in the sedimentation cavity cannot be extracted, so that the sampling purity of the plasma sample can be improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a schematic structural view of the blood sample separation container of the present invention;

FIG. 2 is a perspective, block diagram of the blood sample separation container of FIG. 1 in one embodiment;

FIG. 3 is a perspective, block diagram of the blood sample separation container of FIG. 1 in another embodiment;

FIG. 4 is a perspective, block diagram of the blood sample separation container of FIG. 1 in yet another embodiment;

fig. 5 is a schematic structural view of the blood sample separation device of the present invention;

FIG. 6 is a side view of the blood sample separation device of FIG. 5;

fig. 7 shows the positioning spring of fig. 5 engaged with the blood sample separation container.

The reference numbers illustrate:

reference numerals	Name (R)	Reference numerals	Name (R)
				1	Blood sample separation container	2	Mounting seat
1a	Sample chamber	3	Driving mechanism
				1a1	Contracting cavity section	31	Output shaft
1a2	First flow guide wall	4	Rotary disc
				1b	Separation chamber	4a	Limiting hole
1b1	Second flow guide wall	41	Positioning spring plate
				1c	Sedimentation chamber		5	Code wheel
1d	Sample through port	5a	Gap
				1e	Communication channel		51	Stop block
1f	Locating slot	6	First sensor
				11	Limiting convex part	7	Second sensor
12	First connecting piece

The objects, features and advantages of the present invention will be further described with reference to the accompanying drawings.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

It should be noted that all directional indicators (such as upper, lower, left, right, front, and rear … …) in the embodiments of the present invention are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indicator is changed accordingly.

In the present application, unless expressly stated or limited otherwise, the terms "connected" and "fixed" are to be construed broadly, e.g., "fixed" may be fixedly connected or detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be interconnected within two elements or in a relationship where two elements interact with each other unless otherwise specifically limited. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

In addition, descriptions in the present application as to "first", "second", and the like are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicit to the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. The meaning of "and/or" appearing throughout is the same and is meant to encompass three juxtapositions, exemplified by "A and/or B" and including either scheme A, scheme B, or both schemes A and B. In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.

The utility model provides a blood sample separation container 1 for realize the centrifugal separation of plasma composition and blood cell composition in the whole blood sample.

In an embodiment of the present invention, as shown in fig. 1 and fig. 2, a sample chamber 1a, a separation chamber 1b and a sedimentation chamber 1c are disposed in the blood sample separation container 1, and a sample through hole 1d communicating with the sample chamber 1a is disposed on an outer wall of the blood sample separation container 1; wherein, part of the cavity structure of the sample cavity 1a is positioned above the separation cavity 1b and the sedimentation cavity 1c, and the other part of the cavity structure of the sample cavity 1a is positioned below the separation cavity 1b and the sedimentation cavity 1 c; the separation chamber 1b gradually contracts from an end close to the sample chamber 1a to an end distant from the sample chamber 1 a.

In the present embodiment, the sample chamber 1a is used for adding and storing a whole blood sample, the separation chamber 1b is used for separating a blood cell component and a plasma component in the whole blood sample, and the sedimentation chamber 1c is used for storing and sedimenting the blood cell component.

Sample chamber 1a, separation chamber 1b and precipitation chamber 1c communicate in proper order, and sample chamber 1 a's partial cavity structures is located separation chamber 1b and precipitation chamber 1c top, another partial cavity structures of sample chamber 1a is located separation chamber 1b and precipitation chamber 1c below, make sample chamber 1a, separation chamber 1b and precipitation chamber 1c non-along the vertical arrangement of direction of gravity, for example sample chamber 1a, separation chamber 1b and precipitation chamber 1c can follow the horizontal direction and distribute in proper order, or sample chamber 1a, the whole that separation chamber 1b and precipitation chamber 1c constitute distributes along the horizontal direction, but sample chamber 1a, separation chamber 1b and precipitation chamber 1c stagger the setting from top to bottom. The arrangement mode of the sample cavity 1a, the separation cavity 1b and the sedimentation cavity 1c ensures that when the blood sample separation container 1 rotates, a whole blood sample in the sample cavity 1a can laterally flow into the separation cavity 1b and the sedimentation cavity 1c under the action of a rotating centrifugal force, when blood cell components and plasma components in the whole blood sample are separated, the blood cell components and the plasma components are respectively contained in the sedimentation cavity 1c and the sample cavity 1a, and are respectively contained in the chambers in the horizontal direction, but the blood cell components and the plasma components are not vertically layered like the blood cell components in a blood collection tube centrifugal scheme, so that the blood cell components cannot be mixed and sucked when the plasma components are sampled through the sample cavity 1 a.

The separation cavity 1b is gradually contracted from one end close to the sample cavity 1a to one end far away from the sample cavity 1a, so that the bottom wall of the separation cavity 1b becomes an inclined slope, a circular arc surface or a wavy surface and the like, the highest point of the bottom wall of the separation cavity 1b is close to the sedimentation cavity 1c, the lowest point of the bottom wall of the separation cavity 1b is close to the sample cavity 1a, the inclined bottom wall of the separation cavity 1b reduces the resistance of the whole blood sample in the sample cavity 1a entering the separation cavity 1b during centrifugation, and the plasma sample obtained by separation in the separation cavity 1b flows back to the sample cavity 1a, so that the plasma sample in the sample cavity 1a can be conveniently extracted through the sample through opening 1 d. Specifically, when a whole blood sample is added into the sample chamber 1a through the sample through port 1d and the present blood sample separation container 1 is rotated, the whole blood sample in the sample chamber 1a enters the separation chamber 1b along the inclined bottom wall of the separation chamber 1b by the centrifugal force of rotation and then enters the sedimentation chamber 1 c. Because the density of the blood cell component in the whole blood sample is greater than that of the plasma component, and the centrifugal force to which the blood cell component is subjected is greater than that to which the plasma component is subjected, the blood cell component will fill the space inside the sedimentation chamber 1c and push the plasma component out after entering the sedimentation chamber 1c, so that the plasma component flows into the separation chamber 1b, and the separation of the blood cell component from the plasma component is realized. In the process that the blood sample separation carrier decelerates to stop rotating, plasma components obtained by separation flow back into the sample cavity 1a along the inclined bottom wall of the separation cavity 1b under the inertia effect to become a plasma sample; the blood cell component is left in the sedimentation chamber 1c to become a blood cell sample. Because the blood cell sample is accommodated in the sedimentation cavity 1c, the plasma sample is accommodated in the sample cavity 1a, the blood cell sample and the plasma sample are accommodated in the sub-cavity, and when the plasma sample in the sample cavity 1a is extracted through the sample through opening 1d, the blood cell sample in the sedimentation cavity 1c is not extracted, so that the sampling purity of the plasma sample can be improved.

In an embodiment of the present invention, as shown in fig. 2 and 4, the sample chamber 1a has a contracting chamber section 1a1, and at least a part of the chamber structure of the contracting chamber section 1a1 is located below the separation chamber 1 b; the sample through hole 1d is located above the contraction cavity section 1a1, and the contraction cavity section 1a1 gradually contracts from one end close to the sample through hole 1d to one end far away from the sample through hole 1 d.

In this embodiment, the sample through hole 1d is located above the sample cavity 1a and is communicated with the sample cavity 1a, and the sample through hole 1d is used for the sample adding needle to add the whole blood sample into the sample cavity 1a and for the sampling needle to extract the plasma sample obtained by separation in the sample cavity 1 a.

The plasma sample obtained by separation is finally contained in the sample cavity 1a, so that the separation cavity 1b is provided with the contraction cavity section 1a1, at least part of cavity structure of the contraction cavity section 1a1 is positioned below the separation cavity 1b, the bottom cavity structure of the sample cavity 1a can become a cavity with gradually reduced space, and therefore when the plasma sample is contained in the sample cavity 1a, the liquid level of the plasma sample is improved, so that the plasma sample in the sample cavity 1a can be more conveniently sampled through the sample adding port, the problem that the sampling needle is easy to collide with the bottom wall of the sample cavity 1a during sampling is avoided, and the sampling precision requirement of the sampling needle is lowered.

In an embodiment of the present invention, as shown in fig. 2 and 4, the above-mentioned contracting cavity section 1a1 has a first flow guiding wall 1a2 close to the separating cavity 1b and located below the separating cavity 1b, and the first flow guiding wall 1a2 is an inclined plane or an arc surface.

In this embodiment, the first flow guide wall 1a2 is set to be an inclined surface or an arc surface, so that the highest point of the first flow guide wall 1a2 is close to the separation chamber 1b, and the inclined surface or the arc surface with a higher end and a lower end of the first flow guide wall 1a2 has smaller resistance to the circulation of the whole blood sample, so that the whole blood sample in the sample chamber 1a can smoothly flow into the separation chamber 1b along the first flow guide wall 1a2 under the centrifugal force during the separation procedure, thereby completing the subsequent separation procedure. In addition, when the separation process is finished, the blood sample separation container 1 is decelerated to stop rotating, and the plasma sample separated in the separation cavity 1b can smoothly flow back to the sample cavity 1a along the first flow guide wall 1a2 under the inertia effect, so that the separated plasma sample is enriched in the contraction cavity section 1a1 in the sample cavity 1a, and the capacity and the purity of the plasma sample extracted in the sampling process are improved.

In an embodiment of the present invention, as shown in fig. 2 and 4, the separation chamber 1b has a second flow guiding wall 1b1 connected to the first flow guiding wall 1a2, and the second flow guiding wall 1b1 is an inclined plane or an arc surface.

In this embodiment, the second flow guide wall 1b1 is configured to be an inclined surface or an arc surface, so that the highest point of the second flow guide wall 1b1 is close to the sedimentation chamber 1c, and the inclined surface or the arc surface with a higher end and a lower end at one end of the second flow guide wall 1b1 has smaller resistance to the flow of the blood sample, so that the blood cell component in the separation chamber 1b can smoothly flow into the sedimentation chamber 1c along the second flow guide wall 1b1 under the centrifugal force during the separation process, thereby realizing the separation of the blood cell component and the plasma component. At the end of the separation process, the separated plasma components in the separation chamber 1b can smoothly flow back to the sample chamber 1a along the second flow guide wall 1b1, so that the plasma sample is discharged.

One end of the second flow guide wall 1b1 extends towards the sedimentation cavity 1c, the other end of the second flow guide wall 1b1 extends towards the first flow guide wall 1a2 and is connected with the first flow guide wall 1a2, the second flow guide wall 1b1 is connected with the first flow guide wall 1a2 to form a flow guide surface, the flow guide surface can allow a whole blood sample in the sample cavity 1a to smoothly enter the separation cavity 1b in a separation procedure, and can also allow a plasma sample separated from the separation cavity 1b to smoothly flow back to the sample cavity 1a when the separation procedure is finished, so that the flow resistance of a blood sample between the sample cavity 1a and the separation cavity 1b is reduced, and the blood sample separation and sample output efficiency is improved.

In an embodiment of the present invention, as shown in fig. 2 and 4, a communication channel 1e is further disposed in the blood sample separation container 1; the communication passage 1e communicates with the headspace of the settling chamber 1c and the separation chamber 1 b.

In this embodiment, when the blood sample separation container 1 rotates, the whole blood sample in the separation chamber 1b is subjected to the dual actions of centrifugal force and gravity, wherein the centrifugal force to which the blood cell components and the plasma components in the whole blood sample are subjected is much larger than their respective gravity, the density of the blood cell components is higher than that of the plasma components, and the centrifugal force to which the blood cell components are subjected is higher than that of the plasma components, so that the blood cell components subjected to the stronger centrifugal force will more easily enter the communication channel 1e near the top of the sedimentation chamber 1c through the second flow guide wall 1b1 to enter the sedimentation chamber 1c, and simultaneously the plasma components possibly existing in the sedimentation chamber 1c are expelled into the separation chamber 1b through the communication channel 1e, thereby realizing the separation of the blood cell components and the plasma components in the whole blood sample, and improving the purity of the plasma sample separated in the separation chamber 1 b. In addition, the communicating channel 1e is arranged close to the top of the sedimentation cavity 1c, so that the blood cell components separated in the sedimentation cavity 1c can be effectively prevented from being settled, and the blood cell components flow back to the separation cavity 1b through the communicating channel 1e to be mixed with the separated blood plasma components, so that the purity of the finally separated blood plasma sample is reduced.

In an embodiment of the present invention, as shown in fig. 2 and 4, the cross-sectional area of the communicating channel 1e is smaller than that of the settling chamber 1c along the direction perpendicular to the extending direction of the communicating channel 1 e.

In this embodiment, the cross-sectional area of the communication channel 1e is designed to be smaller than the cross-sectional area of the sedimentation chamber 1c, so that the communication channel 1e has a narrow channel structure, and therefore, when the blood sample separation container 1 is decelerated and rotated after the separation process is completed, the blood cell component separated in the sedimentation chamber 1c can be prevented from flowing back to the separation chamber 1b through the communication channel 1e and mixing with the separated plasma component in the sample chamber 1a, thereby reducing the purity of the plasma sample.

In an embodiment of the present invention, as shown in fig. 2 and 4, the volume of the sample chamber 1a is greater than the volume of the separation chamber 1b, and the volume of the separation chamber 1b is greater than the volume of the sedimentation chamber 1 c.

In this embodiment, the volume of the sample chamber 1a is greater than the volume of the separation chamber 1b, and the volume of the separation chamber 1b is greater than the volume of the sedimentation chamber 1c, so that the sample chamber 1a can accommodate a whole blood sample with a larger initial volume, the separation chamber 1b can accommodate a plasma component with a larger content than a blood cell component in the whole blood sample, and the sedimentation chamber 1c can accommodate a blood cell component with a smaller content in the whole blood sample, and the volumes of the sample chamber 1a, the separation chamber 1b, and the sedimentation chamber 1c are set to be gradually decreased, so that the sample chamber 1a, the separation chamber 1b, and the sedimentation chamber 1c can have more reasonable volume sizes, the volumes of the sample chamber 1a, the separation chamber 1b, and the sedimentation chamber 1c can be decreased as much as possible, and the volume and material cost of the blood sample separation container 1 can be reduced. The volumes of the sample chamber 1a, the separation chamber 1b and the sedimentation chamber 1c can be designed according to actual needs, for example, the volume ratio of the sample chamber 1a to the separation chamber 1b to the sedimentation chamber 1c can be designed to be 5:4:3, to meet the requirements of blood sample separation and blood sample accommodation under normal conditions. When the volume of the whole blood sample added into the sample chamber 1a is larger than the volume of the separation chamber 1b, the whole blood sample in the sample chamber 1a is difficult to completely enter the separation chamber 1b and the precipitation chamber 1c during the separation procedure, and the separation of the whole blood sample is easily insufficient. When the liquid level of the whole blood sample added into the sample chamber 1a is higher than the position of the connection between the separation chamber 1b and the sedimentation chamber 1c, the whole blood sample in the sample chamber 1a easily enters the sedimentation chamber 1c through the separation chamber 1b and remains to form a dead sample, which also makes it difficult to sufficiently separate the whole blood sample. In order to avoid this situation, the sample amount of the whole blood sample can be controlled, so that the volume of the whole blood sample added into the sample chamber 1a is not larger than the volume of the separation chamber 1b, and the liquid level of the whole blood sample in the sample chamber 1a is not higher than the position of the communication position of the separation chamber 1b and the sedimentation chamber 1 c.

In an embodiment of the present invention, as shown in fig. 2 and fig. 4, the outer wall of the blood sample separation container 1 is provided with at least two positioning grooves 1f, and the positioning grooves 1f are used for clamping and fixing the blood sample separation container 1.

In the present embodiment, the positioning groove 1f cooperates with a grasping mechanism that grasps the blood sample separation container 1, and the blood sample separation container 1 is held fixed and moved by the grasping mechanism. The locating slots 1f of the corresponding quantity are arranged according to the quantity of the clamping jaws on the grabbing mechanism of the blood sample separation container 1, so that each clamping jaw on the grabbing mechanism can be matched with the locating slot 1f on the blood sample separation container 1 in a clamping mode, and the blood sample separation container 1 can be reliably grabbed. When the number of the positioning grooves 1f is two, the two positioning grooves 1f can be arranged on two opposite outer side walls of the blood sample separation container 1; when the number of the positioning grooves 1f is plural, the plural positioning grooves 1f are provided on the outer peripheral wall of the blood sample separation container 1 along the circumferential direction of the blood sample separation container 1.

The utility model discloses still provide a blood sample separator for realize the automatic centrifugal separation of plasma composition and blood cell composition in the whole blood sample.

In an embodiment of the present invention, referring to fig. 5 and fig. 6 in combination with fig. 2, the blood sample separation device includes a mounting base 2, a driving mechanism 3, a turntable 4, and at least one blood sample separation container 1, wherein the driving mechanism 3 is disposed on the mounting base 2; the rotary table 4 is connected with the driving mechanism 3, the driving mechanism 3 drives the rotary table 4 to rotate, and the rotary table 4 is provided with at least one limiting hole 4a; the outer wall of the blood sample separation container 1 is provided with a limit convex part 11, a blood sample separation container 1 is inserted into a limit hole 4a, and the limit convex part 11 is abutted with the periphery of the limit hole 4a for limiting.

In the present embodiment, the mounting seat 2 is used for mounting and fixing the driving mechanism 3, the driving mechanism 3 is used for driving the rotary disc 4 to rotate horizontally, and the rotary disc 4 is used for carrying and positioning the blood sample separation container 1. Wherein, actuating mechanism 3 accessible spiro union, modes such as welding are fixed in mount pad 2, and actuating mechanism 3 can be motor etc. and actuating mechanism 3 has output shaft 31, and its output shaft 31 rotationally wears to locate mount pad 2 to be connected with the middle part of carousel 4, in order to drive the steady rotation of carousel 4. Carousel 4 is the disc structure, carousel 4 is equipped with at least one spacing hole 4a, spacing hole 4a is used for spacing blood sample separation container 1, when the quantity more than or equal to 2 of spacing hole 4a, each spacing hole 4a interval sets up, spacing hole 4a is when a plurality of, the marginal interval distribution of carousel 4 can be followed to a plurality of spacing holes 4a, with make full use of the space of carousel 4 promote the centrifugal force that the blood sample received in the blood sample separation container 1 in each spacing hole 4a, promote the efficiency of blood sample separation procedure, shorten the time that the blood sample separation was accomplished. When blood sample separation container 1 is spacing in spacing hole 4a, spacing convex part 11 on blood sample separation container 1 and the upper surface butt of carousel 4 prevent that blood sample separation container 1 from the spacing hole 4a of slippage downwards under the dead weight effect, guarantee the reliable fixed of blood sample separation container 1 on carousel 4.

The specific structure of the blood sample separation container 1 in this embodiment refers to the above-mentioned embodiments, and since the blood sample separation device adopts all the technical solutions of all the above-mentioned embodiments, at least all the beneficial effects brought by the technical solutions of the above-mentioned embodiments are achieved, and no further description is given here.

In an embodiment of the present invention, as shown in fig. 6 and 7, the turntable 4 is provided with a plurality of positioning elastic pieces 41; when a blood sample separation container 1 is inserted into a limit hole 4a, the outer wall of the blood sample separation container 1 abuts against and is limited by a positioning elastic sheet 41.

In this embodiment, the positioning elastic sheet 41 can be disposed on the top surface or the bottom surface of the turntable 4, each positioning elastic sheet 41 extends toward a limit hole 4a, when a blood sample separation container 1 is inserted into a limit hole 4a, an elastic sheet is elastically abutted against the outer wall of the blood sample separation container 1, and the blood sample separation container 1 is pushed towards the edge of the turntable 4, the positioning elastic sheet 41 and the limit hole 4a are matched to fix the blood sample separation container 1, so that when the turntable 4 rotates, the blood sample separation container 1 can be reliably fixed on the turntable 4, so that the blood sample separation container 1 cannot swing and shift in the rotating process of the turntable 4, uncontrollable flow of the blood sample in the separation container can be avoided, and the efficiency and reliability of the blood sample separation procedure can be ensured.

In an embodiment of the present invention, as shown in fig. 3 to 5, each blood sample separation container 1 is provided with a first connecting member 12, and the rotary table 4 is provided with a plurality of second connecting members (not shown); when a blood sample separation container 1 is inserted into a limit hole 4a, the first connecting piece 12 and the second connecting piece on the blood sample separation container 1 are fixed by magnetic attraction.

In this embodiment, the first connecting member 12 may be disposed on a bottom surface of the blood sample separation container 1, and the bottom surface may be provided with a groove body for accommodating and limiting the first connecting member 12, and the first connecting member 12 is fixed in the groove body. The carousel 4 is close to each spacing hole 4a and can be provided with the mounting panel, each mounting panel extends to a below of spacing hole 4a, be equipped with the second connecting piece on each mounting panel, the second connecting piece sets up corresponding to first connecting piece 12, when making blood sample separator 1 spacing in spacing hole 4a, first connecting piece 12 is counterpointed and mutual magnetic adsorption with the second connecting piece, make spacing convex part 11 support tightly with the periphery of spacing hole 4a, reliably be fixed in on carousel 4 with blood sample separator 1, avoid blood sample separator 1 when rotating, the uncontrollable flow appears in separator in the blood sample, guarantee the efficiency and the reliability of blood sample separation procedure.

In an embodiment of the present invention, as shown in fig. 5 to 6, the blood sample separator further includes a code wheel 5; the driving mechanism 3 is provided with an output shaft 31 connected with the rotary disc 4, and the coded disc 5 is sleeved on the output shaft 31 and is positioned between the rotary disc 4 and the driving mechanism 3; code wheel 5 is equipped with a plurality of breachs 5a, and mount pad 2 is equipped with first sensor 6, and first sensor 6 is used for responding to breach 5a.

In the embodiment, the code wheel 5 has a central hole, the output shaft 31 of the driving mechanism 3 passes through the central hole of the code wheel 5, so that the code wheel 5 is fixedly sleeved on the output shaft 31 of the driving mechanism 3, and the code wheel 5 and the rotary disc 4 are driven by the driving mechanism 3 to keep synchronous rotation. The first sensor 6 can be an infrared sensor or a photoelectric sensor, for example, the first sensor 6 is an infrared sensor, an infrared emission end and an infrared output end of the first sensor 6 are respectively located at the upper side and the lower side of the code wheel 5, the code wheel 5 has a state that a body is located between the infrared emission end and the infrared output end and shields infrared rays emitted by the infrared emission end, and the first sensor 6 is in a signal interruption state at the moment. The code wheel 5 is also provided with a notch 5a positioned between the infrared transmitting end and the infrared output end, at the moment, the infrared transmitted by the infrared transmitting end can be received by the infrared receiving end, and the first sensor 6 is in a signal receiving state. When the coded disc 5 rotates, the first sensor 6 is switched between the signal interruption state and the signal receiving state, and through setting the distance between two adjacent gaps 5a, when the first sensor 6 can reach the next signal receiving state from the signal receiving state, the rotary disc 4 rotates by a target angle, so that the distance between the gaps 5a can be set, the first sensor 6 is between any two adjacent signal receiving states, the driving mechanism 3 is controlled to drive the rotary disc 4 to rotate the target angle all the time, different blood sample separation containers 1 are sequentially moved to a target position, the sample adding and sampling operations are carried out on the blood sample separation containers 1 at the target position, and the automation of the sample adding and sampling procedures of different blood sample separation containers 1 is realized.

In an embodiment of the present invention, as shown in fig. 5 to 6, a stop 51 is disposed on a side of the code wheel 5 away from the turntable 4, the mounting base 2 is disposed with a second sensor 7, and the second sensor 7 is used for sensing the stop 51.

In the present embodiment, the second sensor 7 may be an infrared sensor, a photoelectric sensor, or the like, and when the stopper 51 moves to the vicinity of the second sensor 7 and blocks the second sensor 7, the code wheel 5 and the dial 4 have an initial state. The second sensor 7 and the driving mechanism 3 are electrically connected with a control module such as a controller, the driving mechanism 3 drives the coded disc 5 and the rotary disc 4 to rotate, and when the stop block 51 does not block the second sensor 7, the second sensor 7 sends a first electric signal to the control module; when the stopper 51 blocks the second sensor 7, the second sensor 7 sends a second electric signal to the control module; when the control module receives the second electric signal, the control motor is braked, so that the coded disc 5 and the rotary disc 4 can be reset to the initial state, and the automatic sample adding and sampling operation of each subsequent blood sample separation container 1 can be realized through the blood sample separation device.

The utility model also provides a sample analyzer, this sample analyzer includes foretell blood sample separator to separation and the detection that realizes whole blood sample.

In this embodiment, the sample analyzer includes one or more of a sample tray module, a reagent tray module, an autosampler module, an incubator module, a sample reagent needle module, a magnetic separation module, and a detection module, and the blood sample separation device described above. Wherein the sample tray module is used for providing a sample; the reagent tray module is used for providing reagents; the automatic sample introduction module is used for providing a reaction cup; the incubation disc module is used for incubating an object to be tested (the object to be tested is a mixture of a sample and a reagent) to meet the condition required by biochemical reaction, and carrying out transportation scheduling; the sample reagent needle module is used for transferring centrifuged plasma or reagent, and the magnetic separation module is used for cleaning and separating magnetic beads and unreacted waste liquid to obtain cleaned magnetic beads and injecting substrate luminescent liquid; the detection module is used for obtaining a detection result by the object to be detected.

The specific structure of the blood sample separation device in this embodiment refers to the above embodiments, and since the sample analyzer adopts all the technical solutions of all the above embodiments, at least all the beneficial effects brought by the technical solutions of the above embodiments are achieved, and no further description is given here.

The above is only the optional embodiment of the present invention, and not the scope of the present invention is limited thereby, all the equivalent structure changes made by the contents of the specification and the drawings are utilized under the inventive concept of the present invention, or the direct/indirect application in other related technical fields is included in the patent protection scope of the present invention.

Claims (11)

1. A blood sample separation container is used for centrifugally separating a whole blood sample during rotation and is characterized in that a sample cavity, a separation cavity and a precipitation cavity which are sequentially communicated are arranged in the blood sample separation container, and a sample through hole communicated with the sample cavity is formed in the outer wall of the blood sample separation container;

part of the cavity structure of the sample cavity is positioned above the separation cavity and the sedimentation cavity, and the other part of the cavity structure of the sample cavity is positioned below the separation cavity and the sedimentation cavity;

the separation chamber gradually shrinks from one end close to the sample chamber to one end far away from the sample chamber.

2. The blood sample separation container of claim 1 wherein the sample chamber has a constricted chamber section, at least part of the chamber structure of which is located below the separation chamber;

the sample through opening is positioned above the contraction cavity section, and the contraction cavity section gradually contracts from one end close to the sample through opening to one end far away from the sample through opening.

3. The blood sample separation container of claim 2 wherein the constricted chamber section has a first flow guide wall adjacent to and below the separation chamber, the separation chamber having a second flow guide wall connecting the first flow guide wall;

the first flow guide wall is arranged in an inclined plane or an arc surface; and/or the second flow guide wall is arranged in an inclined plane or an arc surface.

4. A blood sample separation container as claimed in any one of claims 1 to 3, wherein a communication channel is further provided in the blood sample separation container;

the communicating passage is communicated with the top space of the settling chamber and the separating chamber.

5. The blood sample separation container of claim 4 wherein the cross-sectional area of said communication channel is less than the cross-sectional area of said sedimentation chamber in a direction perpendicular to the direction in which said communication channel extends.

6. A blood sample separation container as claimed in any one of claims 1 to 3 wherein the volume of the sample chamber is greater than the volume of the separation chamber, which is greater than the volume of the sedimentation chamber.

7. The blood sample separation container of any one of claims 1 to 3 wherein the outer wall of the blood sample separation container is provided with at least two locating grooves for effecting a clamping securement of the blood sample separation container;

and/or the outer wall of the blood sample separation container is provided with a limiting convex part, and the limiting convex part is used for realizing the installation and fixation of the blood sample separation container;

and/or, the blood sample separation container is provided with a first connecting piece, and the first connecting piece is used for realizing the installation and fixation of the blood sample separation container.

8. A blood sample separation device, comprising:

a mounting base;

the driving mechanism is arranged on the mounting seat;

the rotary table is connected with the driving mechanism, the driving mechanism drives the rotary table to rotate, and the rotary table is provided with at least one limiting hole; and

at least one blood sample separation container according to any one of claims 1 to 7, wherein the outer wall of the blood sample separation container is provided with a limiting protrusion, a blood sample separation container is inserted into a limiting hole, and a limiting protrusion abuts against and limits the periphery of the limiting hole.

9. The blood sample separation device of claim 8, wherein the turntable is provided with a plurality of positioning spring pieces, and when the blood sample separation container is inserted into the limiting hole, the outer wall of the blood sample separation container is abutted with one of the positioning spring pieces for limiting;

and/or each blood sample separation container is provided with a first connecting piece, the rotary disc is provided with a plurality of second connecting pieces, and when one blood sample separation container is inserted into one limiting hole, the first connecting piece on the blood sample separation container and one second connecting piece are fixed in a magnetic attraction manner.

10. The blood sample separation device of claim 8 further comprising a code wheel, said drive mechanism having an output shaft coupled to said carousel, said code wheel being nested on said output shaft and located between said carousel and said drive mechanism;

the coded disc is provided with a plurality of gaps, the mounting seat is provided with a first sensor, and the first sensor is used for sensing the gaps; and/or a stop block is arranged on one side, back to the rotary disc, of the coded disc, and a second sensor is arranged on the mounting seat and used for sensing the stop block.

11. A sample analyser, comprising a blood sample separation device according to any one of claims 8 to 10.

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