CN218412404U - Liquid chromatographic column maintenance system - Google Patents
Liquid chromatographic column maintenance system Download PDFInfo
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- CN218412404U CN218412404U CN202222665142.2U CN202222665142U CN218412404U CN 218412404 U CN218412404 U CN 218412404U CN 202222665142 U CN202222665142 U CN 202222665142U CN 218412404 U CN218412404 U CN 218412404U
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Abstract
The utility model discloses a liquid chromatographic column maintenance system, which comprises a box body, wherein the box body is internally provided with a reagent switching valve, a high-pressure advection pump, a column switching valve module, a system flow path switching module and a chromatographic column constant-temperature storage module, and the high-pressure advection pump is arranged at the upper right part inside the box body; the reagent switching valve is positioned above the high-pressure advection pump; the system flow path switching module comprises a system switching valve and a waste liquid switching valve; the column switching valve module comprises a column switching valve A and a column switching valve B, and the column switching valve A and the column switching valve B are respectively positioned at the top end and the bottom end of the chromatographic column constant-temperature storage module. The utility model utilizes the combination of the switching valve and the high-pressure advection pump to realize the automatic washing and the continuous maintenance of a plurality of chromatographic columns under the condition that the chromatographic columns are connected with the liquid chromatographic pipeline; the automatic flow path switching is realized by adopting a high-pressure constant-flow pump and a system switching valve, and the maintenance scheme selection is realized by utilizing a control system and a display screen, so that the chromatographic column can be prevented from being maintained only on a liquid chromatograph.
Description
Technical Field
The utility model relates to a liquid chromatographic column maintains instrument technical field, in particular to liquid chromatographic column maintenance system.
Background
The existing chromatographic column maintenance methods are as follows: the newly started liquid chromatographic column needs to be activated by using a specified reagent according to a chromatographic column specification before being used, can be normally used after being activated, and needs to use a liquid chromatograph system to complete activation by setting a flow rate gradient according to the specification during activation; when the chromatographic column is used, the reagent needs to be replaced to store the chromatographic column, a liquid chromatograph is also needed in the process, and the maintenance after the use is finished by setting the flow rate gradient after the reagent is replaced; when other problems such as contamination or collapse of the column occur, the maintenance of the column requires a very low flow rate (0.1 ml/min) and the operation of the liquid chromatograph requires a long time.
In summary, the conventional chromatographic column must be maintained by using a liquid chromatograph, and when the liquid chromatograph is used for maintenance work related to the chromatographic column, the used reagent needs to be a liquid phase, so that the detection efficiency of the liquid chromatograph is reduced, and the risk of damaging a liquid chromatograph detector and other precision accessories exists.
SUMMERY OF THE UTILITY MODEL
An embodiment of the utility model provides a liquid chromatographic column maintenance system to solve among the prior art chromatographic column and maintain must use liquid chromatograph for the analysis and lead to liquid chromatographic detection efficiency to reduce and the accessory damages risk increase scheduling problem.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a liquid chromatographic column maintenance system comprises a box body, wherein a reagent switching valve, a high-pressure constant-flow pump, a column switching valve module, a system flow path switching module and a chromatographic column constant-temperature storage module are arranged in the box body, the high-pressure constant-flow pump is arranged at the upper right side in the box body, a front panel of the high-pressure constant-flow pump and a front panel of the box body are on the same plane, and the high-pressure constant-flow pump is used for inputting a reagent into a chromatographic column; the reagent switching valve is used for controlling the on-off of channels of different reagent types and is positioned above the high-pressure advection pump; the system flow path switching module comprises a system switching valve and a waste liquid switching valve, the system switching valve and the waste liquid switching valve are both positioned at the lower end of the high-pressure constant-current pump, and the system switching valve is used for realizing the online combination of the liquid chromatographic column maintenance system and the liquid chromatograph; the column switching valve module comprises a column switching valve A and a column switching valve B, the column switching valve A and the column switching valve B are respectively located at the top end and the bottom end of the chromatographic column constant-temperature storage module and used for achieving flow path switching of different chromatographic columns, each outlet of the column switching valve A is connected with an inlet of the chromatographic column, and each inlet of the column switching valve B is connected with an outlet of the chromatographic column.
Optionally, the high-pressure advection pump is a power source of the chromatographic column maintenance system, and is used for stably inputting the reagent into the chromatographic column according to a specified flow rate, the high-pressure advection pump includes a pump body, an emptying valve integrated with the pressure sensor, and a corresponding pump control circuit, the high-pressure advection pump adopts a push rod in a double-plunger series mode, so that the stability of the flow of the input solution is ensured, the pump has pressure feedback, and the pressure of the input solution can be fed back to the control system in real time, so that the flow and the pressure of the input solution are stable.
Optionally, the high-pressure advection pump is a binary high-pressure gradient pump or a multi-element low-pressure gradient pump.
Optionally, the reagent switching valve is a rotary switching valve or a proportional valve for achieving reagent compatibility.
Optionally, the column switching valve module is used for realizing continuous maintenance of a plurality of different types of chromatographic columns in the chromatographic column maintenance system, and the service efficiency of the whole machine is improved. When the device is used, the column switching valve A and the column switching valve B are switched together to realize the switching of the chromatographic column.
Optionally, the chromatographic column thermostatic storage module is used for chromatographic column storage and temperature control, and ensures that the chromatographic column works under the optimal use environment.
Optionally, the column thermostatic storage module comprises a plurality of column cards for fixing the column.
Optionally, the liquid chromatography column maintenance system further comprises an alarm module, wherein the alarm module comprises a pressure alarm, a leakage alarm and a liquid shortage alarm, the leakage alarm is installed at the bottom of the box body, and leakage alarm is achieved after leakage at each position is collected.
Optionally, the liquid chromatography column maintenance system further includes a control system and a display screen, and the control system controls each component of the liquid chromatography column maintenance system through the touch display screen.
The embodiment of the utility model provides a technical scheme can include following beneficial effect:
the utility model discloses utilize the combination of column diverter valve A, column diverter valve B and high-pressure advection pump to use, can realize that the chromatographic column washes and can realize the continuous maintenance of many chromatographic columns automatically under the condition of being connected with the liquid chromatogram pipeline, saved the occupation time of liquid chromatograph, improved the efficiency of analysis experiment; the utility model discloses take high-pressure advection pump and system's diverter valve to make up and use, realize flow path automatic switch-over, utilize control system and display screen to realize different maintenance schemes and select, solved and can only maintain the problem of chromatographic column on liquid chromatograph at present. The utility model discloses in the waste liquid that well waste liquid diverter valve can realize washing the chromatographic column directly arranges the waste liquid bucket in, waste liquid diverter valve and liquid chromatograph's switching realizes that the chromatographic column washes and maintains a key switch after accomplishing to liquid chromatograph and verifies and the analysis. The chromatographic column maintenance system has the advantages of convenient use, stable pressure, small stable fluctuation of the flow path, high efficiency, free configuration by adopting a modular design, and simple and convenient maintenance; the utility model discloses an equipment miniaturization and compactification.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
FIG. 1 is a front view of an integrated whole liquid chromatography column maintenance system of the present invention;
FIG. 2 is a side view of the integrated whole liquid chromatography column maintenance system of the present invention;
figure 3 is the internal layout of the integrated removal front panel of the liquid chromatography column maintenance system of the present invention.
Reference numerals are as follows: 1. the device comprises a front panel, 2, a display screen, 3, a box body, 4, a chromatographic column constant-temperature storage module, 5, column switching valves A and 6, a column card, 7, a chromatographic column, 8, column switching valves B and 9, a waste liquid switching valve, 10, a system switching valve, 11, an emptying valve, 12, a high-pressure advection pump, 13 and a reagent switching valve.
Detailed Description
The following description and the drawings sufficiently illustrate specific embodiments herein to enable those skilled in the art to practice them. Portions and features of some embodiments may be included in or substituted for those of others. The scope of the embodiments herein includes the full ambit of the claims, as well as all available equivalents of the claims.
A liquid chromatography column maintenance system, as shown in fig. 1-3, includes a box 3, and the box 3 includes a reagent switching valve 13, a high-pressure constant-flow pump 12, a column switching valve module, a system flow path switching module, and a chromatography column constant-temperature storage module 4, where the high-pressure constant-flow pump 12 is installed at the upper right inside the box 3, a front panel of the high-pressure constant-flow pump 12 and a front panel 1 of the box 3 are on the same plane, and the high-pressure constant-flow pump 12 is used to input a reagent into a chromatography column 7; the reagent switching valve 13 is used for controlling the on-off of channels of different reagent types and is positioned above the high-pressure advection pump 12; the system flow path switching module comprises a system switching valve 10 and a waste liquid switching valve 9, the system switching valve 10 and the waste liquid switching valve 9 are both positioned at the lower end of the high-pressure constant flow pump 12, and the system switching valve 10 is used for realizing the online combination of a liquid chromatographic column maintenance system and a liquid chromatograph; the column switching valve module comprises a column switching valve A5 and a column switching valve B8, the column switching valve A5 and the column switching valve B8 are respectively located at the top end and the bottom end of the chromatographic column constant-temperature storage module 4 and used for achieving flow path switching of different chromatographic columns 6, each outlet of the column switching valve A5 is connected with an inlet of the chromatographic column 7, and each inlet of the column switching valve B8 is connected with an outlet of the chromatographic column 7.
Optionally, the high-pressure constant-current pump 12 is a power source of a chromatographic column maintenance system, and is used for stably inputting a reagent into the chromatographic column 7 at a specified flow rate, the high-pressure constant-current pump 12 includes a pump body, an emptying valve 11 integrated with a pressure sensor, and a corresponding pump control circuit, the high-pressure constant-current pump 12 adopts a push rod in a double-plunger series mode, so as to ensure the stability of the flow rate of an input solution, and the pump is provided with a pressure feedback function, so that the pressure of the input solution can be fed back to a control system in real time, and the flow rate and the pressure of the input solution are stable.
Optionally, the high-pressure advection pump 12 is a binary high-pressure gradient pump or a multi-element low-pressure gradient pump, wherein the multi-element low-pressure gradient is a low pressure before the pump.
Optionally, the reagent switching valve 13 is a rotary switching valve or a proportional valve for achieving reagent compatibility.
Alternatively, the outlet of the high-pressure advection pump 12 is connected to the inlet of the system switching valve 10, the outlet of the system switching valve 10 is connected to the inlet of the column switching valve A5, the outlet of the column switching valve A5 is connected to the inlet of the chromatographic column 7, the outlet of the chromatographic column 7 is connected to the inlet of the column switching valve B8, and the outlet of the column switching valve B8 is connected to the waste liquid switching valve 9. Through the switching of the system switching valve 10, the direct connection between the chromatographic column maintenance system and the chromatographic column 7 can be realized, maintenance or testing can be performed, the maintenance and analysis efficiency can be greatly improved, and the risk of liquid leakage or damage to the chromatographic column caused by the disassembly of the chromatographic column 7 is also reduced.
Optionally, the column switching valve module is used for realizing continuous maintenance of a plurality of different types of chromatographic columns in the chromatographic column maintenance system, and the service efficiency of the whole machine is improved. When in use, the column switching valve A5 and the column switching valve B8 are switched together to switch the column 7.
Optionally, the chromatographic column thermostatic storage module 4 is used for storage and temperature control of the chromatographic column 7, so as to ensure that the chromatographic column 7 works under the optimal use environment.
Optionally, the column thermostatic storage module 4 comprises a number of column cards 6 for holding the chromatography columns 7.
Optionally, the liquid chromatography column maintenance system further comprises an alarm module, wherein the alarm module comprises a pressure alarm, a leakage alarm and a liquid shortage alarm, the leakage alarm is installed at the bottom of the box body 3, and the leakage alarm can be realized after the leakage at each position is collected.
Optionally, the liquid chromatography column maintenance system further includes a control system and a display screen 2, and the control system controls each component of the liquid chromatography column maintenance system by touching the display screen 2.
The present invention is not limited to the structures that have been described above and shown in the drawings, and various modifications and changes can be made without departing from the scope thereof. The scope of the invention is limited only by the appended claims.
Claims (6)
1. A liquid chromatographic column maintenance system comprises a box body and is characterized in that a reagent switching valve, a high-pressure constant-current pump, a column switching valve module, a system flow path switching module and a chromatographic column constant-temperature storage module are arranged in the box body, wherein the high-pressure constant-current pump is arranged at the upper right inside the box body, a front panel of the high-pressure constant-current pump and a front panel of the box body are on the same plane, and the high-pressure constant-current pump is used for inputting a reagent into a chromatographic column; the reagent switching valve is used for controlling the on-off of channels of different reagent types and is positioned above the high-pressure advection pump; the system flow path switching module comprises a system switching valve and a waste liquid switching valve, the system switching valve and the waste liquid switching valve are both positioned at the lower end of the high-pressure constant-current pump, and the system switching valve is used for realizing the online combination of the liquid chromatographic column maintenance system and the liquid chromatograph; the column switching valve module comprises a column switching valve A and a column switching valve B, the column switching valve A and the column switching valve B are respectively located at the top end and the bottom end of the chromatographic column constant-temperature storage module and used for achieving flow path switching of different chromatographic columns, each outlet of the column switching valve A is connected with an inlet of the chromatographic column, and each inlet of the column switching valve B is connected with an outlet of the chromatographic column.
2. The liquid chromatography column maintenance system of claim 1, wherein the high pressure advection pump is a binary high pressure gradient pump or a multi-element low pressure gradient pump.
3. The liquid chromatography column maintenance system of claim 1, wherein the reagent switching valve is a rotary switching valve or a proportional valve for reagent compatibility.
4. The liquid chromatography column maintenance system of claim 1, wherein the column thermostatic storage module comprises a plurality of column cards for securing the column.
5. The liquid chromatography column maintenance system of claim 1, further comprising an alarm module comprising a pressure alarm, a leak alarm, and a starvation alarm, wherein the leak alarm is mounted at the bottom of the tank.
6. The liquid chromatography column maintenance system of claim 1, further comprising a control system and a display screen, the control system controlling components of the column maintenance system by touching the display screen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222665142.2U CN218412404U (en) | 2022-10-10 | 2022-10-10 | Liquid chromatographic column maintenance system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222665142.2U CN218412404U (en) | 2022-10-10 | 2022-10-10 | Liquid chromatographic column maintenance system |
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| Publication Number | Publication Date |
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| CN218412404U true CN218412404U (en) | 2023-01-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202222665142.2U Active CN218412404U (en) | 2022-10-10 | 2022-10-10 | Liquid chromatographic column maintenance system |
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| CN (1) | CN218412404U (en) |
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- 2022-10-10 CN CN202222665142.2U patent/CN218412404U/en active Active
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