CN218401874U

CN218401874U - Tumour ctDNA methylation detection device convenient to sealed accomodating

Info

Publication number: CN218401874U
Application number: CN202221680878.0U
Authority: CN
Inventors: 刘鹏飞; 田彩娟; 施晓波
Original assignee: Tianjin Marvel Biotechnology Co ltd
Current assignee: Tianjin Marvel Biotechnology Co ltd
Priority date: 2022-07-01
Filing date: 2022-07-01
Publication date: 2023-01-31
Anticipated expiration: 2032-07-01

Abstract

The utility model belongs to the technical field of tumour CTDNA methylation detection technique and specifically relates to a tumour CTDNA methylation detection device convenient to sealed storage, including detector and casing, the lower terminal surface inboard of casing is provided with the backup pad, the draw-in groove has been seted up to the inboard of backup pad, the one end of the first spring of the right-hand member face inboard downside position department fixed connection of casing, the other end and the backup pad of first spring contact, first spacing groove has been seted up to the lower part of casing, the one end of the inboard fixedly connected with second spring of first spacing groove, the first fixture block of the other end fixedly connected with of second spring, the outside and the draw-in groove looks block of first fixture block, the one end of the first trigger bar of right-hand member face fixedly connected with of first fixture block, can utilize the block and the block that breaks away from the block of first fixture block and draw-in groove like this, make taking out and accomodating that the detector can be convenient, in order to solve the in-process that makes the detector expose in externally open environment, the problem that can influence final testing result possibly.

Description

Tumour ctDNA methylation detection device convenient to sealed accomodating

Technical Field

The utility model relates to a tumour CTDNA methylation detects technical field, specifically is a tumour ctDNA methylation detection device convenient to sealed accomodating.

Background

DNA methylation is an important mechanism for gene expression regulation, DNA methylation detection refers to the measurement of tumor cell DNA methylation degree by various methods, during the development of malignant tumors, methylation state is not invariable, the hypomethylation degree of the whole genome in tumor cells has close relation with disease progression, tumor size and malignancy degree, and DNA methylation detection has important significance for the determination of tumor malignancy degree.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a tumour ctDNA methylation detection device convenient to sealed storage to solve and make the detector expose in externally open environment at the in-process that detects, probably can influence the problem of final testing result, have better spreading value.

In order to achieve the above purpose, the utility model provides a following technical scheme:

the utility model provides a tumour ctDNA methylation detection device convenient to sealed storage, includes detector and casing, the left part hinged joint of casing has the side cap, the lower terminal surface inboard of casing is provided with the backup pad, the draw-in groove has been seted up to the inboard of backup pad, the one end of the first spring of right-hand member face inboard downside position department fixed connection of casing, the other end and the backup pad of first spring contact, first spacing groove has been seted up to the lower part of casing, the one end of the inboard fixedly connected with second spring of first spacing groove, the other end fixedly connected with first fixture block of second spring, the outside and the draw-in groove looks block of first fixture block, the one end of the first trigger bar of right-hand member face fixedly connected with of first fixture block, the other end fixedly connected with first blotter of first trigger bar, the lower terminal surface fixedly connected with sealing strip of side cap, the outside and the backup pad of sealing strip contact.

Preferably, the following components: the lower part inboard of backup pad is inlayed and is had the ball, the outside of ball and the lower extreme in-plane sliding connection of casing, the ball has five, five the even distribution of ball is in the inboard of backup pad.

Preferably, the following components: the utility model discloses a novel seal structure of a piston, including casing, piston plate, through-hole, the inboard sliding connection of through-hole has the piston board, the sealed one end that fills up and the piston rod of up end fixedly connected with of piston plate, the through-hole has been seted up to the right side upside of casing, the one end and the cavity of through-hole are linked together, the other end of through-hole is linked together with the inboard of casing, the one end of left wall upside fixedly connected with fourth spring of cavity, the other end fixedly connected with shrouding of fourth spring, the left end fixedly connected with seal block of shrouding, the left end face and the through-hole of seal block laminate mutually.

Preferably, the following components: the other end of the piston rod is fixedly connected with a pressing block, the upper end face of the pressing block is fixedly connected with a second cushion pad, a second limiting groove is formed in the inner side of the piston rod, one end of a fifth spring is fixedly connected to the inner side of the second limiting groove, the other end of the fifth spring is fixedly connected with a second clamping block, a second trigger rod is in contact with the right end face of the second clamping block, the other end of the second trigger rod is fixedly connected with a connecting block, the left end face of the connecting block is fixedly connected with a sixth spring, and the other end of the sixth spring is fixedly connected with the right end face of the shell.

Preferably, the following components: the left end face fixedly connected with third blotter of backup pad, the thickness of third blotter is 5 millimeters, the third blotter comprises the silica gel cushion.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses in, through backup pad, ball, first fixture block, draw-in groove, first spring, the first trigger lever that sets up, can utilize the block of first fixture block and draw-in groove and break away from the block, make taking out and accomodating that the detector can be convenient to the solution makes the detector expose in externally open environment at the in-process that detects, probably can influence the problem of final testing result, has better spreading value.

2. The utility model discloses in, through cavity, piston plate, piston rod, second fixture block and the sealed piece that sets up, the negative pressure environment that forms when can utilizing the piston plate motion makes in the inboard air of casing is taken out into the cavity to the solution shifts the detector to a great vacuum environment in, can increase the problem that detects use cost, improved the practicality of integrated device.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the structure at A of FIG. 1 according to the present invention;

FIG. 3 is a schematic view of the structure of FIG. 1 at B according to the present invention;

FIG. 4 is a schematic view of the structure of FIG. 1 at C according to the present invention;

fig. 5 is a schematic structural diagram of fig. 1 at D according to the present invention;

fig. 6 is a schematic view of the structure at E of fig. 1 according to the present invention.

In the figure: the device comprises a shell 1, a detector 2, a side cover 3, a support plate 4, a clamping groove 5, a first spring 6, a first limiting groove 7, a second spring 8, a first clamping block 9, a first trigger rod 10, a first cushion 11, a sealing strip 12, a ball 13, a cavity 14, a piston plate 15, a sealing pad 16, a piston rod 17, a through hole 18, a fourth spring 19, a sealing plate 20, a sealing block 21, a pressing block 22, a second cushion 23, a second limiting groove 24, a fifth spring 25, a second clamping block 26, a second trigger rod 27, a connecting block 28, a sixth spring 29 and a third cushion 30.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an", and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as exemplary only and not as limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

In the description of the present invention, it is to be understood that the directions or positional relationships indicated by the directional terms such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal" and "top, bottom", etc., are generally based on the directions or positional relationships shown in the drawings, and are for convenience of description and simplicity of description only, and in the case of not making a reverse description, these directional terms do not indicate and imply that the device or element referred to must have a particular orientation or be constructed and operated in a particular orientation, and therefore, should not be considered as limiting the scope of the present invention; the terms "inner and outer" refer to the inner and outer relative to the profile of the respective component itself.

For ease of description, spatially relative terms such as "over 8230 \ 8230;,"' over 8230;, \8230; upper surface "," above ", etc. may be used herein to describe the spatial relationship of one device or feature to another device or feature as shown in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary terms "at 8230; \8230; 'above" may include both orientations "at 8230; \8230;' above 8230; 'at 8230;' below 8230;" above ". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

It should be noted that the terms "first", "second", and the like are used to define the components, and are only used for convenience of distinguishing the corresponding components, and the terms have no special meanings unless otherwise stated, and therefore, the scope of the present invention should not be construed as being limited.

Referring to fig. 1-6, the present invention provides a technical solution:

a tumor ctDNA methylation detection device convenient for sealed storage comprises a detector 2 and a shell 1, wherein the left part of the shell 1 is hinged with a side cover 3, the inner side of the lower end face of the shell 1 is provided with a support plate 4, the inner side of the support plate 4 is provided with a clamping groove 5, the inner side of the right end face of the shell 1 is fixedly connected with one end of a first spring 6 at a lower deflection position, the other end of the first spring 6 is contacted with the support plate 4, the lower part of the shell 1 is provided with a first limiting groove 7, the inner side of the first limiting groove 7 is fixedly connected with one end of a second spring 8, the other end of the second spring 8 is fixedly connected with a first clamping block 9, the outer side of the first clamping block 9 is clamped with the clamping groove 5, the right end face of the first clamping block 9 is fixedly connected with one end of a first trigger rod 10, the other end of the first trigger rod 10 is fixedly connected with a first cushion pad 11, the lower end face of the side cover 3 is fixedly connected with a sealing strip 12, the outer side of the sealing strip 12 is in contact with the supporting plate 4, so that the first clamping block 9 can be clamped with and separated from the clamping groove 5, the detector 2 can be conveniently taken out and stored, the problem that the final detection result is possibly influenced when the detector 2 is exposed in an external open environment in the detection process is solved, the popularization value is good, balls 13 are inlaid in the inner side of the lower portion of the supporting plate 4, the outer sides of the balls 13 are in sliding connection with the inner side of the lower end face of the shell 1, five balls 13 are arranged, the five balls 13 are uniformly distributed on the inner side of the supporting plate 4, the movement of the supporting plate 4 is smoother, a cavity 14 is formed in the upper right portion of the shell 1, a piston plate 15 is in sliding connection with the inner side of the cavity 14, a sealing gasket 16 and one end of a piston rod 17 are fixedly connected to the upper end face of the piston plate 15, a through hole 18 is formed in the upper right portion of the shell 1, one end of the through hole 18 is communicated with the cavity 14, the other end of the through hole 18 is communicated with the inner side of the shell 1, one end of a fourth spring 19 is fixedly connected to the upper side of the left wall of the cavity 14, a sealing plate 20 is fixedly connected to the other end of the fourth spring 19, a sealing block 21 is fixedly connected to the left end face of the sealing block 20, the left end face of the sealing block 21 is attached to the through hole 18, a pressing block 22 is fixedly connected to the other end of the piston rod 17, a second cushion pad 23 is fixedly connected to the upper end face of the pressing block 22, a second limiting groove 24 is formed in the inner side of the piston rod 17, one end of a fifth spring 25 is fixedly connected to the inner side of the second limiting groove 24, a second clamping block 26 is fixedly connected to the other end face of the fifth spring 25, a second trigger rod 27 is in contact with the right end face of the second clamping block 26, a connecting block 28 is fixedly connected to the other end face of the second trigger rod 27, a sixth spring 29 is fixedly connected to the left end face of the connecting block 28, the other end face of the sixth spring 29 is fixedly connected to the right end face of the shell 1, negative pressure environment formed when the piston plate 15 moves can be utilized, air in the cavity 14 is drawn into the cavity 14, so as to transfer the cushion pad 2 to a relatively large environment, the vacuum detector 2, the thickness of the cushion pad 30 is increased, the thickness detection device, the third cushion pad, the thickness detection device is increased, and the thickness detection cost of the third cushion pad 30 is increased, and the whole detection device is increased.

The working process is as follows: when a tumor sample needs to be subjected to DNA methylation detection, the first buffer pad 11 is pressed down, the first trigger rod 10 drives the first fixture block 9 to move downwards, after the first fixture block 9 is disengaged from the clamping groove 5, the support plate 4 slides leftwards under the auxiliary cooperation of the elastic potential energy of the first spring 6 and the balls 13, then the sample is placed on the inner side of the detector 2, the detector 2 is started to detect the tumor sample, the third buffer pad 30 is pressed to clamp the first fixture block 9 with the clamping groove 5, the second buffer pad 23 is pressed, when the piston rod 17 moves downwards, the piston plate 15 is driven to move downwards, so that negative pressure is formed above the piston plate 15, at the moment, the sealing plate 20 drives the sealing block 21 to move rightwards, so that air on the inner side of the shell 1 is pumped into the cavity 14, when the second fixture block 26 is flush with the second trigger rod 27 on the lower side in the downward movement process, the second fixture block 26 is clamped with the shell 1 under the elastic potential energy of the fifth spring 25, when the detector 2 finishes detection on the sample, the side cover 3 is opened, and then the side cover component 2 is reset after detection is taken out.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a tumour ctDNA methylation detection device convenient to sealed storage, includes detector (2) and casing (1), its characterized in that: the left end hinge connection of casing (1) has side cap (3), the lower extreme facial features inboard of casing (1) is provided with backup pad (4), draw-in groove (5) have been seted up to the inboard of backup pad (4), the one end of the first spring of the inboard lower position department fixed connection (6) of right end face of casing (1), the other end and backup pad (4) of first spring (6) contact, first spacing groove (7) have been seted up to the lower part of casing (1), the one end of the inboard fixedly connected with second spring (8) of first spacing groove (7), the first fixture block (9) of other end fixedly connected with of second spring (8), the outside and the draw-in groove (5) looks block of first fixture block (9), the one end of the right-hand member face fixedly connected with first trigger lever (10) of first fixture block (9), the other end fixedly connected with first blotter (11) of first trigger lever (10), the lower extreme facial features fixedly connected with (12) of side cap (3), the outside and the backup pad (12) contacts.

2. The device for detecting methylation of ctDNA of tumor, which is convenient for being hermetically stored according to claim 1, wherein: ball (13) have been inlayed to the lower part inboard of backup pad (4), the outside of ball (13) and the lower extreme in-plane sliding connection of casing (1), ball (13) have five, five the even distribution of ball (13) is in the inboard of backup pad (4).

3. The device for detecting methylation of ctDNA of tumor, which is convenient for being hermetically stored according to claim 1, wherein: cavity (14) have been seted up to the right side upside of casing (1), the inboard sliding connection of cavity (14) has piston board (15), the sealed one end of filling up pad (16) and piston rod (17) of up end fixedly connected with of piston board (15), through-hole (18) have been seted up to the right side upside of casing (1), the one end and cavity (14) of through-hole (18) are linked together, the other end of through-hole (18) is linked together with the inboard of casing (1), the one end of the left wall upside fixedly connected with fourth spring (19) of cavity (14), the other end fixedly connected with shrouding (20) of fourth spring (19), the left end face fixedly connected with seal block (21) of shrouding (20), the left end face and the through-hole (18) of seal block (21) are laminated mutually.

4. The device for detecting methylation of tumor ctDNA, which is convenient to be hermetically stored according to claim 3, wherein: the other end of the piston rod (17) is fixedly connected with a pressing block (22), the upper end face of the pressing block (22) is fixedly connected with a second cushion pad (23), the inner side of the piston rod (17) is provided with a second limiting groove (24), the inner side of the second limiting groove (24) is fixedly connected with one end of a fifth spring (25), the other end of the fifth spring (25) is fixedly connected with a second clamping block (26), the right end face of the second clamping block (26) is in contact with a second trigger rod (27), the other end of the second trigger rod (27) is fixedly connected with a connecting block (28), the left end face of the connecting block (28) is fixedly connected with a sixth spring (29), and the other end of the sixth spring (29) is fixedly connected with the right end face of the shell (1).

5. The device for detecting methylation of ctDNA of tumor, which is convenient for being hermetically stored according to claim 1, wherein: the left end face fixedly connected with third blotter (30) of backup pad (4), the thickness of third blotter (30) is 5 millimeters, third blotter (30) comprise the silica gel cushion.