CN218351407U - Sectional type multipole rod collision reaction tank and mass spectrometer - Google Patents

Abstract

The utility model relates to the technical field of mass spectrometers, in particular to a sectional type multipole rod collision reaction tank and a mass spectrometer, wherein the sectional type multipole rod collision reaction tank comprises a plurality of multipole rod structures; each multi-pole structure comprises at least two pole groups, each pole group comprises two pole sections which are arranged at intervals, and the pole sections of each pole group are arranged in a central symmetry mode relative to the same central line; first radio frequency is all applied to each pole section in one of them pole group in the multipole rod structure, second radio frequency is all applied to each pole section in wherein another pole group, the frequency of first radio frequency and second radio frequency is the same and opposite phase, can carry out radial restraint to sample ion, direct current voltage is all applied to every multipole rod structure, and have pressure differential between two adjacent multipole rod structures, two adjacent pole structures all can apply axial acceleration field for sample ion, promote sample ion's kinetic energy and transmission efficiency, increase detectivity, and with low costs, the structure is simplified.

Description

Sectional type multipole collision reaction tank and mass spectrometer

Technical Field

The utility model relates to a mass spectrograph technical field especially relates to a sectional type multipole pole collision reaction pond and mass spectrograph.

Background

During analysis of a sample by a mass spectrometer, target ions to be detected may coexist in the ion stream with interferent ions having the same mass-to-nuclear ratio. The interfering ions can cause serious mass spectrum interference on the positive ions to be measured, so that the measurement accuracy of the interfered target ions is seriously influenced. Therefore, the mass spectrometer is provided with a multipole rod collision reaction cell as the most effective means for removing the interference of polyatomic ions.

The theoretical basis of the multipole rod collision reaction tank technology is that gas is introduced into the tank, gas molecules and ions entering the tank collide with each other to generate a reaction, and after polyatomic ions influencing ions to be detected are removed, target ions are transmitted to a mass analyzer, so that the mass screening and detection of the target ions are completed.

The multipole rods in the collision reaction cell equipped in the existing mass spectrometer are generally only provided with multipole rods (quadrupole rods, hexapole rods or octopole rods), and an RF voltage is applied to the multipole rods through a radio frequency power supply to form a multipole field inside the multipole field so as to radially restrain ion flow entering from an inlet end to an outlet end of the cell body. When the mass spectrometer is operated in a collision or reaction mode, a large number of collision or reaction gas molecules exist in the collision reaction tank, and after ions enter the collision reaction tank, the ions collide with the gas molecules for multiple times, so that the kinetic energy of partial ions, particularly ions of light elements, is greatly reduced, and the ions cannot fly out of an outlet of the collision reaction tank, and therefore the ion passing efficiency is reduced, namely the sensitivity of the instrument is reduced.

In order to ensure the ion passage rate, auxiliary electrodes are added in the prior art, namely a group of auxiliary electrodes are added between the multipole rods, and the auxiliary electrodes are arranged on the top and the trunk parts which extend inwards along the radial direction towards the longitudinal axis of the multipole rod device. The radial depth of the stem blade portion varies along the longitudinal axis to provide a tapered profile along the length of the auxiliary electrode. That is, the trunk portion of the auxiliary electrode is expanded from the inlet end to the outlet end of the collision reaction tank toward the inner diameter direction and becomes larger gradually from the outlet end. By applying direct current voltage to the set of auxiliary electrodes, an axial field is generated, and the axial field can effectively push positively charged ions with energy reduced due to collision with gas molecules to the outlet end of the cell, so that the ion passing efficiency is improved, and the sensitivity of the instrument is improved. But the cost of the mass spectrometer is increased due to the addition of the auxiliary electrode, and the structure becomes complicated.

Based on the above problems, a sectional type multipole collision reaction cell and a mass spectrometer are needed to solve the above technical problems.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a: the utility model provides a sectional type multipole pole collision reaction pond and mass spectrograph, reduces with low costs, simplified structure under the prerequisite of guaranteeing the transmission efficiency of ion.

On one hand, the utility model provides a sectional type multipole rod collision reaction tank, which comprises a plurality of multipole rod structures arranged at intervals along the linear direction;

each multi-pole structure comprises at least two pole groups, each pole group comprises two pole sections which are arranged at intervals, and the two pole sections of each pole group are arranged in a central symmetry mode around the same central line;

the number of pole rod sections in the adjacent multi-pole rod structures is the same and the pole rod sections are coaxially arranged in a one-to-one correspondence manner;

each pole section in one pole group in the multipole rod structure is applied with a first radio frequency, each pole section in the other pole group is applied with a second radio frequency, and the frequencies of the first radio frequency and the second radio frequency are the same and the phases of the first radio frequency and the second radio frequency are opposite;

direct-current voltage is applied to each multipole rod structure, and a voltage difference exists between every two adjacent multipole rod structures.

As a preferable technical scheme of the sectional type multipole rod collision reaction tank, in the structure of adjacent multipole rods, high-voltage resistant insulators or conductive materials with resistance are arranged between two coaxial and adjacent pole rod sections.

As a preferable technical scheme of the sectional type multipole rod collision reaction tank, voltage dividing resistors are arranged between two coaxial and adjacent pole rod sections.

As a preferred technical scheme of the sectional type multipole rod collision reaction tank, the sectional type multipole rod collision reaction tank is provided with an inlet end and an outlet end; the segmented multipole rod collision reaction tank further comprises an inlet electrode arranged at the inlet end and an outlet electrode arranged at the outlet end;

and each pole section of the multi-pole structure positioned at the inlet end is connected with the inlet electrode, and each pole section of the multi-pole structure positioned at the outlet end is connected with the outlet electrode.

As a preferable technical scheme of the sectional type multipole rod collision reaction tank, the sectional type multipole rod collision reaction tank further comprises a reaction tank main body and a plurality of insulating bases, wherein the coaxial pole rod sections are all installed on the insulating bases, and the insulating bases are all installed on the reaction tank main body.

As a preferred technical solution of the segmented multipole rod collision reaction cell, the segmented multipole rod collision reaction cell further comprises an inlet ion mirror and an outlet ion mirror arranged at two ends of the reaction cell main body;

the sectional type multipole rod collision reaction tank further comprises an inlet focusing ion mirror arranged on the reaction tank main body, and the inlet focusing ion mirror and the inlet ion mirror are sequentially arranged along the movement path of ions.

As a preferred technical solution of the segmented multipole rod collision reaction cell, the segmented multipole rod collision reaction cell further comprises a first radio frequency electrode and a second radio frequency electrode mounted on the reaction cell body;

the first radio frequency electrode is used for providing a first radio frequency, and the second radio frequency electrode is used for providing a second radio frequency.

As a preferred technical scheme of the sectional type multipole rod collision reaction tank, the pole rod section is a round rod, a square rod, a double-curved-surface rod or a concave-surface rod.

As a preferable technical scheme of the sectional type multipole rod collision reaction tank, the multipole rod structure comprises four, six or eight pole rod sections.

On the other hand, the utility model provides a mass spectrometer, including the multistage pole collision reaction cell of sectional type among the above-mentioned arbitrary scheme.

The utility model has the advantages that:

the utility model provides a sectional type multipole rod collision reaction tank and a mass spectrometer, wherein the sectional type multipole rod collision reaction tank comprises a plurality of multipole rod structures which are arranged at intervals along the linear direction; each multi-pole rod structure comprises at least two pole rod groups, each pole rod group comprises two pole rod sections which are arranged at intervals, and the two pole rod sections of each pole rod group are arranged in a central symmetry mode around the same central line; the number of pole rod sections in the adjacent multi-pole rod structures is the same and the pole rod sections are coaxially arranged in a one-to-one correspondence manner; each pole section in one pole group in the multipole rod structure is applied with a first radio frequency, each pole section in the other pole group is applied with a second radio frequency, the frequencies of the first radio frequency and the second radio frequency are the same, the phases of the first radio frequency and the second radio frequency are opposite, and the multipole rod structure can carry out radial confinement on sample ions. Direct current voltage is applied to each multipole rod structure, and a voltage difference exists between two adjacent multipole rod structures. Two adjacent pole structures can all exert axial acceleration field for sample ion, promote sample ion's kinetic energy and transmission efficiency, increase detectivity to the cost is lower, and the structure is retrencied more.

Drawings

Fig. 1 is a first schematic structural diagram of a sectional type multipole rod collision reaction tank according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram II of a sectional type multipole rod collision reaction tank according to an embodiment of the present invention;

FIG. 3 is a schematic structural diagram III of a sectional type multipole rod collision reaction tank according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of a segmented multipole rod collision reaction tank according to an embodiment of the present invention;

fig. 5 is a schematic structural diagram of a sectional type multipole rod collision reaction tank in an embodiment of the present invention;

fig. 6 is a schematic structural diagram six of the sectional type multipole rod collision reaction tank according to the embodiment of the present invention.

In the figure:

1. a multipole rod structure; 101. a pole set; 1001. a pole section;

2. a voltage dividing resistor; 3. a resonant capacitor; 4. an inlet electrode; 5. an exit electrode; 6. a reaction tank main body; 7. an insulating base; 8. an entrance ion mirror; 9. an exit ion mirror; 10. a focusing ion mirror; 11. a first radio frequency electrode; 12. a second radio frequency electrode.

Detailed Description

The technical solution of the present invention will be described clearly and completely with reference to the accompanying drawings, and obviously, the described embodiments are some, but not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Where the terms "first position" and "second position" are two different positions, and where a first feature is "over", "above" and "on" a second feature, it is intended that the first feature is directly over and obliquely above the second feature, or simply means that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood as a specific case by those skilled in the art.

Reference will now be made in detail to the embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary only for explaining the present invention, and should not be construed as limiting the present invention.

The present embodiment provides a segmented multipole rod collision reaction cell, as shown in fig. 1 to 6, which includes a plurality of multipole rod structures 1 arranged at intervals in a linear direction. Each multipole structure 1 comprises at least two pole groups 101, each pole group 101 comprises two pole sections 1001 arranged at intervals, and the two pole sections 1001 of each pole group 101 are arranged symmetrically with respect to the same center line.

In particular, the multipole rod structure 1 may comprise four, six or eight pole segments 1001. That is, the multipole rod structure 1 may comprise two, three or more pole rod sets 101. As shown in fig. 1, fig. 2, fig. 5, and fig. 6, the present embodiment exemplarily shows that the multipole rod structure 1 includes four pole segments 1001. The pole section 1001 may be a round bar, a square bar, a hyperbolic bar, or a concave bar. As shown in fig. 4 to 6, in this embodiment, a square rod is used as the pole section 1001.

In this implementation, the pole rod section 1001 quantity in the adjacent multipole rod structure 1 is the same and the coaxial setting of one-to-one, so set up, form the passageway that supplies the ion to pass through between a plurality of pole rod sections 1001 of multipole rod structure 1, the passageway of each multipole rod structure communicates in proper order and forms the reaction tank, let in reactant gas in the reaction tank, sample ion is from the entry end input back of reaction tank, get rid of through reactant gas and disturb the ion and keep target ion, target ion can follow the exit end output of reaction tank. It should be noted that the plurality of pole segments 1001 of the multi-pole structure 1 are located on the same circumference and are evenly distributed.

As shown in fig. 2, in the present embodiment, a first radio frequency is applied to each pole section 1001 in one pole group 101 of the multi-pole structure 1, and a second radio frequency is applied to each pole section 1001 in the other pole group 101, where the first radio frequency and the second radio frequency have the same frequency and opposite phases. The polar rod group 101 with the first radio frequency is applied to the plurality of multipole rod structures 1, the polar rod group 101 with the second radio frequency is applied to the plurality of multipole rod structures 1, the radio frequency can be applied to the corresponding polar rods through the radio frequency source to form a radial electric field, and then the radial constraint can be performed on sample ions entering the reaction cell, so that the sample ions can perform radial vibration, the moving path of the sample ions in the reaction cell is increased, and the sample ions can be fully contacted with reaction gas in the reaction cell to ensure that interference ions are eliminated completely.

As shown in fig. 3, in the present embodiment, a direct current voltage is applied to each multipole rod structure 1, and a voltage difference exists between two adjacent multipole rod structures 1. Specifically, the plurality of pole segments 1001 of the multipole rod structure 1 are all applied with dc voltages of the same magnitude, but the dc voltages of the plurality of pole segments 1001 coaxial in the segmented multipole rod collision reaction cell are different from each other and gradually decrease from the inlet end to the outlet end. So set up, after the entry end input of sample ion from the reaction cell, two pole rod sections 1001 adjacent to the axial all can exert the axial acceleration field for sample ion, promote sample ion's kinetic energy and transmission efficiency, increase detectivity. And compared with the scheme of adopting the auxiliary electrode in the prior art, the cost is lower, and the structure is more simplified.

All set up divider resistance 2 between coaxial and two adjacent pole sections 1001 in this implementation to coaxial a plurality of pole sections 1001, only need insert the direct current at two pole sections 1001 access direct current of the entry end of reaction tank and exit end and can make coaxial each pole section 1001 all be applyed direct current voltage, simple structure. As shown in fig. 3, the dc voltage of the plurality of coaxial pole sections 1001 is gradually decreased from the inlet end to the outlet end, so that the direction of the axial acceleration field is consistent with the input and output directions of the sample ions, so as to continuously increase the kinetic energy of the sample ions in the reaction cell during the transmission process. Moreover, by adjusting the resistance of the voltage dividing resistor 2, the voltage of the direct current at the inlet end and the voltage of the direct current at the outlet end can be adjusted to the direct current voltage carried by the pole section 1001, so that different use requirements can be met.

Optionally, in the adjacent multi-pole rod structure 1, a high voltage resistant insulator or a conductive material with a certain resistance value is disposed between the two coaxial adjacent pole rod sections 1001, so as to avoid direct contact between the two axially adjacent pole rod sections 1001, and ensure stability of an axial acceleration field. In other embodiments, two pole segments 1001 adjacent to each other in the axial direction may be kept at a certain safety distance.

As shown in fig. 5, the segmented multipole rod collision reaction tank further comprises a reaction tank main body 6 and a plurality of insulating bases 7, wherein each coaxial pole rod section 1001 is installed on the insulating base 7, and each insulating base 7 is installed on the reaction tank main body 6. This enables the integral assembly of a plurality of multipole rod structures 1.

Optionally, with continued reference to fig. 5, the segmented multipole collision reaction cell further comprises an inlet electrode 4 disposed at the inlet end and an outlet electrode 5 disposed at the outlet end; each pole segment 1001 of the multipole structure 1 at the inlet end is connected to an inlet electrode 4 and each pole segment 1001 of the multipole structure 1 at the outlet end is connected to an outlet electrode 5. Thus, a direct current can be supplied to the individual pole sections 1001 of the multipole structure 1 at the inlet end via the inlet electrode 4 and a direct current can be supplied to the individual pole sections 1001 of the multipole structure 1 at the outlet end via the outlet electrode 5.

Optionally, with continued reference to fig. 5, the segmented multipole collision cell further comprises an inlet ion mirror 8 and an outlet ion mirror 9 disposed at both ends of the cell body 6; the segmented multipole rod collision reaction cell further comprises an inlet focusing ion mirror 10 disposed in the reaction cell body 6, the inlet focusing ion mirror 10 and the inlet ion mirror 8 being sequentially disposed along a movement path of ions.

Optionally, with continued reference to fig. 5, the segmented multipole collision cell further comprises a first rf electrode 11 and a second rf electrode 12 mounted on the cell body 6; the first rf electrode 11 is arranged to provide a first rf and the second rf electrode 12 is arranged to provide a second rf, the first and second rf being in opposite phase.

Specifically, as shown in fig. 4 to 6, taking the example that the multipole rod structure 1 includes two pole rod sets 101, two pole rod sections 1001 of one pole rod set 101 are arranged at intervals along a first direction, two pole rod sections 1001 of the other pole rod set 101 are arranged at intervals along a second direction, and an included angle between the first direction and the second direction is 90 °.

The multi-pole structure 1 comprises four poles, and each pole comprises a plurality of coaxial pole sections 1001. In each pole, a voltage dividing resistor 2 is provided between any two adjacent pole segments 1001. In four poles, four pole segments 1001 at the inlet end are all connected with the inlet electrode 4, and four pole segments 1001 at the outlet end are all connected with the outlet electrode 5, so that each pole segment 1001 in a pole will carry a dc voltage to form an axial acceleration field.

Each of the two pole segments 1001 facing in the first direction is connected to a first rf electrode 11 via a resonant capacitor 3. Each pole section 1001 of two poles facing in the second direction is connected to a second RF electrode 12 via a resonant capacitor 3, wherein the first RF electrode 11 is used for loading RF-RF, and the second RF electrode 12 is used for loading RF + RF, and the RF-RF has the same frequency as the RF + RF but is 180 ° out of phase. Thus, a radial electric field can be formed, and further, the sample ions entering the reaction cell can be radially restrained.

Under the action of the axial acceleration field and the radial electric field, sample ions entering the reaction cell can fully react with reaction gas and can be accelerated to be pushed to the outlet end, so that the transmission efficiency of the sample ions is ensured, and the sensitivity of the instrument is increased.

The embodiment also provides a mass spectrometer which comprises the segmented multipole collision reaction cell.

It is obvious that the above embodiments of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (10)

1. A sectional type multipole rod collision reaction tank is characterized by comprising a plurality of multipole rod structures (1) which are arranged at intervals along a linear direction;

each multi-pole structure (1) comprises at least two pole groups (101), each pole group (101) comprises two pole sections (1001) arranged at intervals, and the two pole sections (1001) of each pole group (101) are arranged in central symmetry around the same central line;

the pole rod sections (1001) in the adjacent multi-pole rod structures (1) are same in number and are coaxially arranged in a one-to-one correspondence manner;

each pole section (1001) in one pole group (101) in the multi-pole structure (1) is applied with a first radio frequency, each pole section (1001) in the other pole group (101) is applied with a second radio frequency, and the frequencies of the first radio frequency and the second radio frequency are the same and the phases of the first radio frequency and the second radio frequency are opposite;

direct-current voltage is applied to each multipole rod structure (1), and a voltage difference exists between every two adjacent multipole rod structures (1).

2. The segmented multipole collision reaction cell according to claim 1, characterised in that in adjacent multipole structures (1) a high voltage resistant insulator or a conductive material with electrical resistance is arranged between two coaxial and adjacent pole segments (1001).

3. The segmented multipole collision reaction cell according to claim 2, characterised in that a voltage dividing resistor (2) is arranged between two coaxial and adjacent pole segments (1001).

4. The segmented multipole collision reaction cell according to claim 3, wherein the segmented multipole collision reaction cell has an inlet end and an outlet end; the segmented multipole collision reaction cell further comprises an inlet electrode (4) arranged at the inlet end and an outlet electrode (5) arranged at the outlet end;

each pole section (1001) of the multi-pole structure (1) at the inlet end is connected with the inlet electrode (4), and each pole section (1001) of the multi-pole structure (1) at the outlet end is connected with the outlet electrode (5).

5. The segmented multipole rod collision reaction cell according to claim 1, further comprising a reaction cell body (6) and a plurality of insulating mounts (7), each coaxial pole segment (1001) being mounted to the insulating mount (7), each insulating mount (7) being mounted to the reaction cell body (6).

6. The segmented multipole rod collision reaction cell according to claim 5, further comprising an inlet ion mirror (8) and an outlet ion mirror (9) disposed at both ends of the reaction cell body (6);

the segmented multipole rod collision reaction cell further comprises an inlet focusing ion mirror (10) arranged in the reaction cell body (6), the inlet focusing ion mirror (10) and the inlet ion mirror (8) being arranged in sequence along a movement path of ions.

7. The segmented multipole collision reaction cell according to claim 5, further comprising a first radiofrequency electrode (11) and a second radiofrequency electrode (12) mounted to the reaction cell body (6);

the first radio frequency electrode (11) is used for providing the first radio frequency, and the second radio frequency electrode (12) is used for providing the second radio frequency.

8. The segmented multipole collision reaction cell according to any of claims 1 to 7, characterised in that the pole segments (1001) are round, square, hyperbolic or concave.

9. The segmented multipole collision reaction cell according to any of claims 1 to 7, characterised in that the multipole structure (1) comprises four, six or eight said pole segments (1001).

10. A mass spectrometer comprising the segmented multipole collision reaction cell of any of claims 1 to 9.

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