CN218307932U - Metronidazole crystallization reaction kettle - Google Patents
Metronidazole crystallization reaction kettle Download PDFInfo
- Publication number
- CN218307932U CN218307932U CN202222244988.9U CN202222244988U CN218307932U CN 218307932 U CN218307932 U CN 218307932U CN 202222244988 U CN202222244988 U CN 202222244988U CN 218307932 U CN218307932 U CN 218307932U
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- Prior art keywords
- kettle body
- reaction kettle
- metronidazole
- reation kettle
- stirring
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- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229960000282 metronidazole Drugs 0.000 title claims abstract description 59
- 238000002425 crystallisation Methods 0.000 title claims abstract description 40
- 230000008025 crystallization Effects 0.000 title claims abstract description 40
- 238000006243 chemical reaction Methods 0.000 title claims description 50
- 238000004321 preservation Methods 0.000 claims abstract description 25
- 238000010438 heat treatment Methods 0.000 claims abstract description 23
- 238000003756 stirring Methods 0.000 claims description 77
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 238000010030 laminating Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 21
- 230000002349 favourable effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 5
- 230000002093 peripheral effect Effects 0.000 abstract description 2
- 239000013078 crystal Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 230000002277 temperature effect Effects 0.000 description 2
- 206010048685 Oral infection Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model discloses a metronidazole crystallization reation kettle, including reation kettle body and supporting leg, reation kettle body below is provided with the supporting leg, and the supporting leg bottom surface all laminates and is provided with the slipmat, reation kettle body top is provided with the feed inlet, and reation kettle body bottom surface is provided with the discharge gate, and the discharge gate side is provided with control flap, the inside puddler that is provided with of reation kettle body, and the puddler utilizes driving motor to constitute revolution mechanic. This metronidazole crystallization reation kettle passes through the setting of heating resistor silk, wherein heating resistor silk evenly distributed is peripheral in reation kettle body, the heating resistor silk of being convenient for heats the inside metronidazole of reation kettle body, be favorable to the crystallized production of metronidazole, and the heating resistor silk periphery is provided with the heat preservation, the heat preservation sets up in the reation kettle body outside, make the inside constant temperature that keeps of reation kettle body, the production to the metronidazole crystallization has good effect, the crystallized production efficiency of metronidazole has been improved.
Description
Technical Field
The utility model relates to a metronidazole crystallization technical field specifically is a metronidazole crystallization reation kettle.
Background
Metronidazole is a chemical substance with white to slightly yellow appearance, can be prepared into crystals through chemical reaction, is commonly used for preventing and treating diseases such as oral infection, digestive tract infection and the like, and can not be prepared in a crystallization reaction kettle as common in most medicine manufacturing. However, the existing metronidazole crystallization reaction kettle has the following defects:
1. in the production process of the existing metronidazole crystallization reaction kettle, because metronidazole crystallization needs to be performed at 75-80 ℃, the amplitude of crystallization temperature cannot be too large, otherwise the crystallization effect and yield of metronidazole are affected, and the existing reaction kettle does not have a constant temperature function, so that the metronidazole crystallization production effect is affected;
2. current metronidazole crystallization reation kettle is in process of production, because the metronidazole volume is less, in reation kettle, easily appear that metronidazole adsorbs the phenomenon in the reation kettle inner wall, leads to having reduced metronidazole crystallization efficiency, and has improved metronidazole crystallization manufacturing cost.
Therefore, we propose a metronidazole crystallization reaction kettle so as to solve the problems mentioned above.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a metronidazole crystallization reation kettle to current metronidazole crystallization reation kettle who proposes in solving above-mentioned background art does not possess the constant temperature function, and easily appears the metronidazole and adsorb in reation kettle inner wall phenomenon, leads to influencing metronidazole crystallization effect and improvement in production cost's problem.
In order to achieve the above object, the utility model provides a following technical scheme: a metronidazole crystallization reaction kettle comprises a reaction kettle body and supporting legs;
the reaction kettle body is of a cylindrical structure, supporting legs are arranged below the reaction kettle body, anti-slip pads are attached to the bottom surfaces of the supporting legs, and four groups of the supporting legs are arranged;
a feed port is arranged above the reaction kettle body, the bottom end of the feed port penetrates through the upper surface of the reaction kettle body, a discharge port is arranged on the bottom surface of the reaction kettle body, and a control valve is arranged on the side surface of the discharge port;
the inside puddler that is provided with of reation kettle body, and the puddler utilizes driving motor to constitute revolution mechanic.
Preferably, reation kettle body top is provided with driving motor, and the driving motor axle head constitutes the key-type connection with the puddler to the puddler periphery is provided with the agitator frame, and the agitator frame sets up in reation kettle body inside top, and driving motor's axle head drive puddler outlying agitator frame constitutes revolution mechanic.
Adopt above-mentioned technical scheme, constitute the key-type connection through driving motor axle head and puddler, the puddler periphery is provided with the stirring frame, is convenient for utilize driving motor's axle head drive stirring frame to constitute revolution mechanic.
Preferably, stirring frame below is provided with the stirring leaf, and the stirring leaf is U type structure to the stirring leaf sets up in the stirring frame outside, stirring leaf fixed mounting in puddler bottom, and the stirring leaf passes through driving motor and constitutes revolution mechanic.
Adopt above-mentioned technical scheme, be provided with the stirring leaf through stirring frame below, stirring leaf fixed mounting carries out revolution mechanic simultaneously in the puddler bottom in the stirring frame of being convenient for and stirring leaf, is favorable to intensive mixing metronidazole.
Preferably, stirring leaf outside fixed mounting has the scraper blade, and the scraper blade is the silica gel material to the setting of scraper blade outside laminating reation kettle body inner wall, scraper blade and reation kettle body inner wall constitution friction structure, and the stirring leaf surface is provided with the through-hole, and the through-hole evenly runs through in the setting of stirring leaf.
Adopt above-mentioned technical scheme, through stirring leaf outside fixed mounting have the scraper blade, the scraper blade constitutes the friction structure with reation kettle body inner wall, is favorable to striking off that the metronidazole that adsorbs in reation kettle body inside is remained, has reduced the manufacturing cost of metronidazole crystallization.
Preferably, the inner side of the stirring blade is provided with crushing rods, the two groups of crushing rods are fixedly arranged on two sides of the stirring rod, the crushing rods form a rotating structure through a driving motor, crushing blades are uniformly distributed on the surface of each crushing rod, the crushing blades are provided with two sizes, and the crushing blades of different sizes are arranged in a staggered mode.
Adopt above-mentioned technical scheme, have two sets ofly at puddler both sides fixed mounting through the broken pole, broken pole surface evenly distributed has broken blade, is convenient for carry out broken handle with the great metronidazole crystal of volume, has good practicality.
Preferably, the periphery of the reaction kettle body is provided with a heat preservation layer, the heat preservation layer is matched with the reaction kettle body in shape, supporting legs are fixedly mounted on the bottom surface of the heat preservation layer, and heating resistance wires are arranged on the inner side of the heat preservation layer and are uniformly distributed between the reaction kettle body and the heat preservation layer.
Adopt above-mentioned technical scheme, through heating resistor silk evenly distributed between reation kettle body and heat preservation, wherein the heat preservation sets up in the heating resistor silk outside, has avoided the inside thermal loss of reation kettle body, has the constant temperature effect, is favorable to the production of metronidazole crystal.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the utility model discloses a setting through the heating resistor silk, wherein heating resistor silk evenly distributed is peripheral in reation kettle body, the heating resistor silk of being convenient for heats the inside metronidazole of reation kettle body, be favorable to the crystalline production of metronidazole, and the heating resistor silk periphery is provided with the heat preservation, the heat preservation sets up in the reation kettle body outside, make the inside constant temperature that keeps of reation kettle body, production to the metronidazole crystallization has good effect, and the production efficiency is improved, and the inside broken pole that is provided with of reation kettle body, broken pole surface is crisscross to be provided with not unidimensional broken blade, be convenient for carry out crushing treatment with the great metronidazole crystallization of volume, and has good practicality.
2. The utility model discloses a setting through the puddler, wherein the puddler utilizes driving motor's axle head drive rotation, the puddler upper end is provided with the agitator frame, the agitator frame below is provided with the stirring leaf, stirring leaf fixed mounting is in the puddler bottom, it is rotatory simultaneously to be convenient for make agitator frame and stirring leaf, be favorable to metronidazole fast crystallization, and the stirring leaf surface runs through and is provided with the through-hole, the resistance has been reduced at the stirring in-process, stirring leaf outside fixed mounting has the scraper blade, the scraper blade constitutes the friction structure with reation kettle body inner wall, be convenient for strike off reation kettle body inner wall absorbent metronidazole, the manufacturing cost of metronidazole crystallization has been reduced.
Drawings
FIG. 1 is a schematic sectional view of the front view of the present invention;
fig. 2 is a schematic view of the structure of the present invention;
FIG. 3 is a schematic view of the structure of the stirring rod of the present invention;
FIG. 4 is a schematic view of the structure of the heating resistance wire of the present invention;
fig. 5 is an enlarged schematic structural diagram of a point a in fig. 1 of the present invention.
In the figure: 1. a reaction kettle body; 2. supporting legs; 3. a feed inlet; 4. a discharge port; 5. a stirring rod; 6. a drive motor; 7. a stirring frame; 8. stirring blades; 9. a squeegee; 10. a through hole; 11. a breaking bar; 12. crushing the blade; 13. a heat-insulating layer; 14. heating the resistance wire.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.
Referring to fig. 1-5, the present invention provides an embodiment: the utility model provides a metronidazole crystallization reation kettle, including reation kettle body 1 and supporting leg 2, reation kettle body 1 is the cylinder structure, 1 below of reation kettle body is provided with supporting leg 2, and 2 bottom surfaces of supporting leg are all laminated and are provided with the slipmat, supporting leg 2 is provided with four groups, 1 top of reation kettle body is provided with feed inlet 3, 1 upper surface setting in reation kettle body is run through to 3 bottoms of feed inlet, and 1 bottom surface of reation kettle body is provided with discharge gate 4, discharge gate 4 side is provided with control flap, 1 inside puddler 5 that is provided with of reation kettle body, and puddler 5 utilizes driving motor 6 to constitute revolution mechanic.
Referring to fig. 1-3, a driving motor 6 is disposed above the reaction kettle body 1, the shaft end of the driving motor 6 is in key connection with the stirring rod 5, a stirring frame 7 is disposed on the periphery of the stirring rod 5, the stirring frame 7 is disposed above the interior of the reaction kettle body 1, and the shaft end of the driving motor 6 drives the stirring frame 7 on the periphery of the stirring rod 5 to form a rotating structure. Constitute the key-type connection through 6 axle heads of driving motor and puddler 5, 5 peripheries of puddler are provided with stirring frame 7, are convenient for utilize driving motor 6's axle head drive stirring frame 7 to constitute revolution mechanic. Stirring frame 7 below is provided with stirring leaf 8, and stirring leaf 8 is U type structure to stirring leaf 8 sets up in the stirring frame 7 outside, and 8 fixed mounting of stirring leaf are in 5 bottoms of puddler, and stirring leaf 8 constitutes revolution mechanic through driving motor 6. Be provided with stirring leaf 8 through stirring frame 7 below, 8 fixed mounting in 5 bottoms of puddler of stirring leaf are convenient for stir frame 7 and stir leaf 8 and carry out revolution mechanic simultaneously, are favorable to intensive mixing metronidazole.
Referring to fig. 1 and fig. 3-5, a scraper 9 is fixedly installed on the outer side of the stirring blade 8, the scraper 9 is made of silica gel, the outer side of the scraper 9 is attached to the inner wall of the reaction kettle body 1, the scraper 9 and the inner wall of the reaction kettle body 1 form a friction structure, a through hole 10 is formed in the surface of the stirring blade 8, and the through hole 10 uniformly penetrates through the stirring blade 8. The scraping plate 9 is fixedly arranged on the outer side of the stirring blade 8, and the scraping plate 9 and the inner wall of the reaction kettle body 1 form a friction structure, so that the residual metronidazole adsorbed in the reaction kettle body 1 can be scraped off, and the production cost of metronidazole crystals is reduced; 8 inboards of stirring leaf are provided with crushing pole 11, and crushing pole 11 has two sets ofly at 5 both sides fixed mounting on the puddler, and crushing pole 11 constitutes revolution mechanic through driving motor 6 to 11 surface evenly distributed on the crushing pole have crushing blade 12, and crushing blade 12 is provided with two sizes of big or small, and the crisscross setting of crushing blade 12 of unidimensional. Two groups of crushing blades 12 are uniformly distributed on the surface of the crushing rod 11, so that the metronidazole crystal with a larger volume can be conveniently crushed, and the crushing rod has good practicability; the periphery of the reaction kettle body 1 is provided with a heat preservation layer 13, the heat preservation layer 13 is matched with the reaction kettle body 1 in shape, supporting legs 2 are fixedly mounted on the bottom surface of the heat preservation layer 13, heating resistance wires 14 are arranged on the inner side of the heat preservation layer 13, and the heating resistance wires 14 are uniformly distributed between the reaction kettle body 1 and the heat preservation layer 13. Evenly distributed between reation kettle body 1 and heat preservation 13 through heating resistor silk 14, wherein heat preservation 13 sets up in the heating resistor silk 14 outside, has avoided the inside thermal loss of reation kettle body 1, has the constant temperature effect, is favorable to the production of metronidazole crystal.
The working principle is as follows: when the metronidazole crystallization reaction kettle is used, the heating resistance wires 14 are uniformly distributed on the periphery of the reaction kettle body 1 through the arrangement of the heating resistance wires 14, the heating resistance wires 14 can conveniently heat metronidazole inside the reaction kettle body 1, the production of metronidazole crystallization is facilitated, the periphery of the heating resistance wires 14 is provided with the heat preservation layer 13, the heat preservation layer 13 is arranged on the outer side of the reaction kettle body 1, so that the inside of the reaction kettle body 1 is kept at a constant temperature, the production of metronidazole crystallization is well effective, the production efficiency is improved, the crushing rods 11 are arranged inside the reaction kettle body 1, the crushing blades 12 with different sizes are arranged on the surfaces of the crushing rods 11 in a staggered mode, the metronidazole crystallization with larger volume can be conveniently crushed, and the high practicability is achieved; through setting of puddler 5, wherein puddler 5 utilizes driving motor 6's axle head drive rotation, 5 upper ends of puddler are provided with agitator frame 7, agitator frame 7 below is provided with stirring leaf 8, 8 fixed mounting in 5 bottoms of puddler of stirring leaf, be convenient for make agitator frame 7 and stirring leaf 8 rotatory simultaneously, be favorable to the rapid crystallization of metronidazole, and 8 surfaces of stirring leaf are run through and are provided with through-hole 10, the resistance has been reduced at the stirring in-process, 8 outside fixed mounting of stirring leaf have scraper blade 9, scraper blade 9 constitutes friction structure with 1 inner wall of reation kettle body, be convenient for strike off the absorbent metronidazole of 1 inner wall of reation kettle body, the manufacturing cost of metronidazole crystallization has been reduced.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (6)
1. The utility model provides a metronidazole crystallization reation kettle, includes reation kettle body (1) and supporting leg (2), its characterized in that:
the reaction kettle body (1) is of a cylindrical structure, the supporting legs (2) are arranged below the reaction kettle body (1), the bottom surfaces of the supporting legs (2) are respectively provided with an anti-skid pad in a fitting manner, and four groups of the supporting legs (2) are arranged;
a feed inlet (3) is arranged above the reaction kettle body (1), the bottom end of the feed inlet (3) penetrates through the upper surface of the reaction kettle body (1) and is provided with a discharge outlet (4), and a control valve is arranged on the side surface of the discharge outlet (4);
a stirring rod (5) is arranged inside the reaction kettle body (1), and the stirring rod (5) forms a rotating structure by means of a driving motor (6).
2. The metronidazole crystallization reaction kettle according to claim 1, characterized in that: reaction kettle body (1) top is provided with driving motor (6), and driving motor (6) axle head constitutes the key-type connection with puddler (5) to puddler (5) periphery is provided with stirring frame (7), and stirring frame (7) set up in reaction kettle body (1) inside top, and the axle head of driving motor (6) drives stirring frame (7) of puddler (5) periphery and constitutes revolution mechanic.
3. The metronidazole crystallization reaction kettle according to claim 2, characterized in that: stirring frame (7) below is provided with stirring leaf (8), and stirs leaf (8) and be U type structure to stirring leaf (8) set up in stirring frame (7) outside, and stirs leaf (8) fixed mounting in puddler (5) bottom, and stirs leaf (8) and pass through driving motor (6) and constitute revolution mechanic.
4. The metronidazole crystallization reaction kettle according to claim 3, characterized in that: stirring leaf (8) outside fixed mounting has scraper blade (9), and scraper blade (9) are the silica gel material to scraper blade (9) outside laminating reation kettle body (1) inner wall sets up, and scraper blade (9) and reation kettle body (1) inner wall constitution friction structure, and stirring leaf (8) surface is provided with through-hole (10), and through-hole (10) evenly run through in stirring leaf (8) setting.
5. The metronidazole crystallization reaction kettle of claim 3, characterized in that: stirring leaf (8) inboard is provided with crushing pole (11), and crushing pole (11) have two sets ofly at puddler (5) both sides fixed mounting, and crushing pole (11) constitute revolution mechanic through driving motor (6) to crushing pole (11) surface evenly distributed has crushing blade (12), and crushing blade (12) are provided with two sizes of size, and not unidimensional crushing blade (12) crisscross setting.
6. The metronidazole crystallization reaction kettle of claim 1, characterized in that: the reaction kettle is characterized in that a heat preservation layer (13) is arranged on the periphery of the reaction kettle body (1), the shape of the heat preservation layer (13) is matched with that of the reaction kettle body (1), supporting legs (2) are fixedly mounted on the bottom surface of the heat preservation layer (13), heating resistance wires (14) are arranged on the inner side of the heat preservation layer (13), and the heating resistance wires (14) are uniformly distributed between the reaction kettle body (1) and the heat preservation layer (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222244988.9U CN218307932U (en) | 2022-08-25 | 2022-08-25 | Metronidazole crystallization reaction kettle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222244988.9U CN218307932U (en) | 2022-08-25 | 2022-08-25 | Metronidazole crystallization reaction kettle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218307932U true CN218307932U (en) | 2023-01-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222244988.9U Active CN218307932U (en) | 2022-08-25 | 2022-08-25 | Metronidazole crystallization reaction kettle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218307932U (en) |
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2022
- 2022-08-25 CN CN202222244988.9U patent/CN218307932U/en active Active
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Address after: 430000 room 01, 17 / F, building 11, phase 3.2, Wuhan Optical Valley International Biomedical enterprise accelerator, No. 388, Gaoxin Second Road, Donghu New Technology Development Zone, Wuhan, Hubei Province (Wuhan area of free trade zone) Patentee after: Wuhan Runxin Technology Co.,Ltd. Country or region after: China Address before: 430000 room 01, 17 / F, building 11, phase 3.2, Wuhan Optical Valley International Biomedical enterprise accelerator, No. 388, Gaoxin Second Road, Donghu New Technology Development Zone, Wuhan, Hubei Province (Wuhan area of free trade zone) Patentee before: WUHAN RUNXIN TECHNOLOGY CO.,LTD. Country or region before: China |