CN218307852U - A kind of 68 Automatic Ga drug synthesis module - Google Patents
A kind of 68 Automatic Ga drug synthesis module Download PDFInfo
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- CN218307852U CN218307852U CN202221244532.6U CN202221244532U CN218307852U CN 218307852 U CN218307852 U CN 218307852U CN 202221244532 U CN202221244532 U CN 202221244532U CN 218307852 U CN218307852 U CN 218307852U
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Abstract
The utility model relates to a synthetic field of medicine, concretely relates to 68 The Ga medicament automatic synthesis module comprises a sample adding component, a flushing component, a reaction component, a synthesis and purification component and an elution and transfer component, wherein the sample adding component and the flushing component are respectively connected with the reaction component through pipelines, and the elution and transfer component is connected with a synthesis and purification system through a pipeline; the sample adding component comprises a multi-channel switching valve, at least one reagent bottle and at least one syringe pump, and the syringe pump is connectedOn the multichannel diverter valve, the reagent bottle is connected with the reaction component through the multichannel diverter valve, and the sample adding component is connected with the washing component, the reaction component, the synthesis and purification component and the elution and transfer component through the multichannel diverter valve and a pipeline. The utility model discloses automatic synthetic success rate and output are all higher, and the synthesis time obviously shortens, and operating personnel need not the reaction liquid of direct contact high activity degree simultaneously, very big reduction radiation dose, relatively safety.
Description
Technical Field
The utility model relates to a synthetic field of medicine, concretely relates to 68 And a Ga medicament automatic synthesis module.
Background
68 Ga is a labeled polypeptide tracer and is suitable for pharmacokinetic study of small molecule drugs, and 18 F、 11 compared with biological micromolecules such as C and the like nonmetal nuclide labeled polypeptide, 68 ga labeling has the advantages of simple method, mild condition, rapidness and the like, and 68 ga can more accurately screen patients, make treatment strategies, calculate nuclide treatment dosage and evaluate curative effects, realize individualized diagnosis and treatment, and simultaneously, 68 the Ga has low cost and is suitable for popularization and promotion.
Whether in basic research or in clinical trials initiated by researchers, 68 the synthesis of Ga is mainly dependent on manually leaching a germanium-gallium generator, but the synthesis is carried out by using the manually leaching germanium-gallium generator 68 The yield of Ga is not stable and the operator needs to manually add the reactants, which are exposed to higher doses of radiation. At present, a part of commercial gallium synthesizers mainly adopt a cutting sleeve type automatic or semi-automatic mode for leaching, but still need to manually extract hydrochloric acid for adding, the manual extraction of the hydrochloric acid not only increases the occupational exposure of workers, but also can cause the insufficient accuracy of the volume, possibly influence the pH value of a mark, and reduce the pH value 68 The labeling rate of Ga reacting with the prodrug, resulting in 68 The Ga drug concentration is low, and even the medication requirement is difficult to meet.
SUMMERY OF THE UTILITY MODEL
In order to improve the defects of the prior art, the utility model provides a 68 The Ga medicament automatic synthesis module can realize automatic and accurate extraction of eluent, automatic elution of the germanium-gallium generator, efficient marking and purification, and the prepared product 68 The radiochemical purity, ethanol content, endotoxin content and sterility indexes of Ga medicine all meet the requirements of injection.
An object of the utility model is to provide a 68 The Ga medicament automatic synthesis module comprises a sample adding component, a flushing component, a reaction component, a synthesis and purification component and an elution and transfer component, wherein the sample adding component and the flushing component are respectively connected with the reaction component through pipelines, and the elution and transfer component is connected with a synthesis and purification system through a pipeline;
the sample adding component comprises a multi-channel switching valve, at least one reagent bottle and at least one injection pump, the injection pump is connected to the multi-channel switching valve, the reagent bottle is connected with the reaction component through the multi-channel switching valve, and the sample adding component is connected with the washing component, the reaction component, the synthesis and purification component and the elution and transfer component through the multi-channel switching valve and a pipeline.
According to an embodiment of the present invention, said 68 The Ga medicament automatic synthesis module is 68 Automatic synthesizer of Ga medicine.
According to the utility model discloses an embodiment, the washing subassembly includes that at least one flush fluid deposits bottle and at least one waste liquid bottle, flush fluid deposits bottle, waste liquid bottle and is connected with the syringe pump through pipeline and multichannel diverter valve.
According to an embodiment of the present invention, the reaction assembly comprises at least one reaction flask, preferably the reaction assembly further comprises a heater for providing the reactant with a temperature required for the reaction.
According to the utility model discloses an embodiment, synthetic purification subassembly includes the generator, the generator passes through the multichannel diverter valve and the pipeline is connected with reaction flask, syringe pump.
According to the utility model discloses an embodiment, the elution shifts the subassembly including elution post, elution post advances the appearance end and is connected with the multichannel diverter valve, and the appearance end passes through valve, pipeline and elution and shifts the subassembly and be connected.
According to the utility model discloses an embodiment, the elution shifts the subassembly including drenching washing bottle, waste liquid bottle and product bottle, be provided with the filter membrane on the product bottle, drench washing bottle and pass through pipeline and multichannel diverter valve, elution column connection, the waste liquid bottle passes through the pipeline and is connected with the multichannel diverter valve, the product bottle passes through the pipeline and is connected with the elution column.
According to the utility model discloses an embodiment, still be provided with a syringe pump on the washing bottle.
According to the utility model discloses an embodiment, germanium gallium generator is chooseed for use to the generator.
According to an embodiment of the present invention, the elution column is a solid phase extraction column, such as a C18 solid phase extraction cartridge.
According to an embodiment of the present invention, the channel of the multi-channel switching valve is greater than or equal to 6, for example 6 or 9.
According to the utility model discloses an embodiment, the quantity of valve is 1-3, prefers the valve is the multichannel valve, for example is two three-way solenoid valves or two-position three-way diverter valve.
According to an embodiment of the present invention, the filter membrane on the product bottle is an air filter membrane and/or a sterile filter membrane.
According to the utility model discloses an embodiment, automatic synthesis module still includes the host computer, and automatic syringe pump, multichannel diverter valve and valve all are connected with the host computer.
Preferably, the automatic injection pump is connected with an upper computer through a cable, the upper computer controls the action of the automatic injection pump through programs or instructions, the multi-channel switching valve and the valve are electrically connected with the upper computer, and the upper computer controls the corresponding valve or channel to be opened and closed.
Preferably, the upper computer is a computer, a touch screen or an industrial personal computer.
As an example, the automated synthesis module includes an automatic syringe pump, a multi-channel switching valve, a first reagent bottle, a second reagent bottle, a rinse bottle, a waste liquid bottle, a product bottle, a reaction bottle, a heater, a generator, a first valve, a second valve, and a third valve, the automatic syringe pump is connected to the first reagent bottle, the second reagent bottle, the rinse bottle, the waste liquid bottle, the product bottle, the reaction bottle, and the generator through the multi-channel switching valve, the reaction bottle is located in the heater, the reaction bottle is connected to the generator, and different components are connected through teflon pipelines.
Preferably, the first valve, the second valve and the third valve are two-position three-way electromagnetic valves or two-position three-way switching valves, a solid phase extraction column is arranged between a channel of the multi-channel switching valve and the first valve, and an air filter membrane and/or a sterile filter membrane is arranged on the product bottle.
Preferably, the multi-channel switching valve comprises a central hole and 5 connecting channels, wherein the automatic injection pump is connected with the central common hole of the multi-channel switching valve, and the channel 1 of the multi-channel switching valve is connected with the leaching bottle; the channel 2 is connected with an inlet of a germanium-gallium generator, and an outlet of the germanium-gallium generator is connected with a reaction bottle; the channel 3 is directly connected with the reaction bottle, the channel 4 is connected with the solid-phase extraction small column, and the C18 solid-phase extraction small column is connected with the waste liquid bottle and the product bottle through a first valve; the channel 5 is connected with the first reagent bottle and the second reagent bottle through a second valve; the channel 6 passes through a third valve vent or waste bottle.
According to the utility model discloses an embodiment, automatic synthetic module's multichannel diverter valve is one to lead to nine valves, and the air vent directly sets up on 9 passageways and 5 passageways of multichannel diverter valve, and the intercommunication atmosphere, 8 passageways and the first reagent bottle of multichannel diverter valve are connected, and 7 passageways are connected with the second reagent bottle, and 6 passageways are connected with the waste liquid bottle.
According to the utility model discloses an embodiment, automatic synthesis module includes multichannel diverter valve, first reagent bottle, second reagent bottle, drenches washing bottle, waste liquid bottle, product bottle, reaction flask, heater, generator, first valve, second valve, first automatic syringe pump and the automatic syringe pump of second, and first automatic syringe pump passes through the multichannel diverter valve and is connected with first reagent bottle, second reagent bottle, waste liquid bottle, product bottle, reaction flask, the generator, drench the washing bottle and be connected with the automatic syringe pump of second, and the reaction flask is arranged in the heater, and the reaction flask is connected with the generator.
According to an embodiment of the present invention, the first reagent bottle comprises an ethanol solution (aqueous ethanol solution); the second reagent bottle contains normal saline; the leaching bottle contains hydrochloric acid.
Advantageous effects
The utility model discloses 68 The Ga medicament automatic synthesis template or the device extracts liquid by using an injection pump connected with a multi-channel switching valve, controls the injection speed, and overcomes the defects that the volume of hydrochloric acid is extracted, the injection speed is not stable and the like in manual synthesis in the prior art, the difference between batches of the speed of rinsing the C18 solid phase extraction small column by an ethanol solution and a physiological saline solution is large during purification, so that the yield is not stable, the phenomenon of unsuccessful marking is easy to occur, and the medicament is hung on the C18 solid phase extraction small column. The utility model discloses a 68 The automatic synthesis efficiency, success rate and output of the Ga medicament automatic synthesis template or device are high, the synthesis time is obviously shortened, meanwhile, an operator does not need to directly contact the reaction liquid with high activity, the radiation dose is greatly reduced, and the device is safe.
Drawings
FIG. 1 shows the results of example 1 68 A schematic structural diagram of a Ga medicament automatic synthesis module;
FIG. 2 is a drawing of example 2 68 A schematic structural diagram of a Ga medicament automatic synthesis module;
FIG. 3 shows the results of example 3 68 A schematic structural diagram of a Ga medicament automatic synthesis module;
fig. 4 is a graph showing the radioactive chemical purity test of the drug prepared in example 4.
The reference symbols have the following meanings: s1: an automatic syringe pump; SV: a multi-channel switching valve (one-way six); b1: a first reagent bottle; b2: a second reagent bottle; b3: washing the bottle; b4: a waste liquid bottle; b5: a product bottle; b6: a reaction bottle; v1: a first valve; v2: a second valve; v3: a third valve.
Detailed Description
The structure of the present invention will be described in further detail with reference to specific embodiments. It is to be understood that the following examples are illustrative only and are not to be construed as limiting the scope of the invention. All the technologies realized based on the above mentioned contents of the present invention are covered in the protection scope of the present invention.
Example 1
Referring to fig. 1, a 68 The Ga medicament automatic synthesis module comprises an automatic injection pump S1, a multi-channel switching valve SV (one-to-six), a first reagent bottle B1, a second reagent bottle B2, a leaching bottle B3, a waste liquid bottle B4, a product bottle B5, a reaction bottle B6, a heater, a generator, a first valve V1, a second valve V2 and a third valve V3, wherein the automatic injection pump S1 is connected with the first reagent bottle B1, the second reagent bottle B2, the leaching bottle B3, the waste liquid bottle B4, the product bottle B5 and the reaction bottle B6 through the multi-channel switching valve SV, the reaction bottle B6 is positioned in the heater, the reaction bottle B6 is connected with the generator, and different bottle bodies, the multi-channel switching valve SV and different bottle bodies, different valves and bottle bodies are connected through polytetrafluoroethylene pipelines.
In this embodiment, the generator is a germanium-gallium generator, and the first reagent bottle B1, the second reagent bottle B2, and the rinsing bottle B3 are used for storing reagents, such as an ethanol solution or a physiological saline solution; the waste liquid bottle B4 is used for storing reaction waste liquid, and the reaction bottle B6 is used for providing different liquid reaction places.
The solid phase extraction column is a C18 solid phase extraction column or other solid phase extraction columns for purification, and an air filter membrane and/or a sterile filter membrane are arranged on the product bottle B5.
The multi-channel switching valve SV comprises a central hole and 6 connecting channels, wherein an automatic injection pump S1 is connected with the central common hole of the multi-channel switching valve SV, and the channel 1 of the multi-channel switching valve SV is connected with a shower bottle B3 through a pipeline; the channel 2 is connected with an inlet of a germanium-gallium generator through a pipeline, and an outlet of the germanium-gallium generator is connected with a reaction bottle B6 through a pipeline; the channel 3 is connected with the reaction bottle B6 through a pipeline, the channel 4 is connected with the C18 solid-phase extraction column through a pipeline, and the C18 solid-phase extraction column is connected with the waste liquid bottle B4 and the product bottle B5 through a first valve V1.
When in use, the first valve V1 is only communicated with one of the waste liquid bottle B4 and the product bottle B5; the channel 5 is connected with the first reagent bottle B1 and the second reagent bottle B2 through a second valve V2 and a pipeline, and when the device is used, the second valve V2 is only communicated with one of the first reagent bottle B1 and the second reagent bottle B2; the channel 6 is connected with the vent hole or the waste liquid bottle B4 through a third valve V3, and when the device is used, the third valve V3 is only communicated with one of the vent hole or the waste liquid bottle B4.
The first valve V1, the second valve V2 and the third valve V3 are two-position three-way electromagnetic valves or two-position three-way switching valves.
Meanwhile, the embodiment further comprises an upper computer, the automatic injection pump S1, the multi-channel switching valve SV, the first valve V1, the second valve V2 and the third valve V3 are all connected with the upper computer, wherein the automatic injection pump S1 is connected with the upper computer through a cable, the upper computer controls the action of the automatic injection pump S1 through a program or an instruction, the multi-channel switching valve SV, the first valve V1, the second valve V2 and the third valve V3 are electrically connected with the upper computer, and the corresponding valves or channels are controlled to be opened and closed through the upper computer.
The upper computer is a computer, a touch screen or an industrial personal computer.
Example 2
Referring to fig. 2, one of the embodiments 68 The Ga drug automated synthesis module has the same structure as in example 1 except that the multi-channel switching valve SV is a one-to-nine valve, the vent holes are directly provided in the 9-channel and 5-channel of the multi-channel switching valve SV to communicate with the atmosphere, the 8-channel of the multi-channel switching valve SV is connected to the first reagent bottle B1, the 7-channel is connected to the second reagent bottle B2, and the 6-channel is connected to the waste liquid bottle B4.
In this embodiment, through the multichannel diverter valve SV who adopts more passageways, only use a two-position three-way diverter valve, avoid the use of a plurality of two-position three-way diverter valves, reduce the use degree of difficulty.
Example 3
Referring to FIG. 3, one of the embodiments 68 The Ga medicament automatic synthesis module comprises two automatic injection pumps S1 and S2 and two switching valves V1 and V2, wherein 6 channels of a multi-channel switching valve SV are air holes and are directly connected with the atmosphere, 5 channels are connected with a waste liquid bottle B4, 1 channel is connected with a second reagent bottle B2, and 2 channelsThe configuration is the same as that of embodiment 1 except that the syringe is connected to a first reagent bottle B1 and an automatic syringe pump S2 is connected to a generator and a shower bottle B3 through a switching valve V2.
In the embodiment, an automatic injection pump S2 and a switching valve are added to form a germanium-gallium generator leaching unit, which is specially used for automatically extracting leaching solution and automatically leaching the germanium-gallium generator, so that the occurrence of generator cross contamination possibly caused by a common injection pump is avoided.
Example 4
Synthesis Using the Synthesis Module of example 1 68 A method for Ga-PSMA617 drug comprising the steps of:
1. preparation work: preheating a heater to 100 ℃, adding 20 micrograms of PSMA617 precursor (a radiolabeled small molecule) and 1mL0.25M sodium acetate buffer solution into a reaction bottle B6, adding 50% ethanol solution into a first reagent bottle B1, adding a proper amount of normal saline into a second reagent bottle B2, adding 0.05M hydrochloric acid into a leacheate bottle B3, installing a C18 solid-phase extraction column between a 4-channel and a first valve V1, emptying a waste liquid bottle B4, installing a product bottle B5, and inserting an air filter membrane and a sterile filter membrane into the product bottle B5.
2. Cleaning the injection pump: the syringe pump S1 pumps 1-5mL of the leacheate from the leacheate bottle B3 into the syringe pump S1 through the channel 1 of the multi-channel switching valve SV at the speed of 5-20mL/min, and then the leacheate is injected into the waste liquid bottle B4 through the channel 6 and the third valve V3, and the process can be repeated for 1-3 times to clean the syringe pump S1 and eliminate air bubbles in the syringe pump S1.
3. And (3) automatically extracting eluent and eluting the germanium and gallium generator: the syringe pump S1 extracts 4mL of leacheate (taking an ITM germanium gallium generator as an example) from the leacheate bottle B3 at the speed of 5-15mL/min through the channel 1 of the multi-channel switching valve SV, then injects the leacheate into the germanium gallium leaching generator at the speed of 2-6mL/min through the channel 2, and then flows into the reaction bottle B6 filled with the precursor and the buffer solution through the channel to perform temperature control reaction for a specified time.
During the temperature-controlled reaction, the activation of the C18 solid-phase extraction cartridge was completed:
a: the syringe pump S1 pumps 5mL of 50% ethanol solution from the first reagent bottle B1 to the syringe pump S1 at a rate of 10-30mL/min through the channel 5 of the multi-channel switching valve SV and the second valve V2, and then injects the solution into the waste liquid bottle B4 through the channel 6 and the third valve V3 to clean the syringe pump S1.
b: the cleaned syringe pump S1 pumps 5mL of 50% ethanol solution from the first reagent bottle B1 through the channel 5 of the multi-channel switching valve SV and the second valve V2, flows through the C18 solid phase extraction column through the channel 4, and then enters the waste liquid bottle B4 through the first valve V1.
c: the syringe pump S1 extracts 10mL of a physiological saline solution from the second reagent bottle B2 through the channel 5 of the multi-channel switching valve SV and the second valve V2, flows through the C18 solid-phase extraction cartridge through the channel 4, and enters the waste liquid bottle B4 through the first valve V1.
d: the syringe pump S1 pumps 10mL of air from the vent hole through the channel 6 of the multi-channel switching valve SV and the third valve V3, flows through the C18 solid-phase extraction cartridge through the channel 4, and enters the waste liquid bottle B4 through the first valve V1 to blow away the residual physiological saline in the C18 solid-phase extraction cartridge.
4. Fixing the drug to a C18 solid phase extraction cartridge: after the reaction of the step 3 reaches the set time, 5mL of reaction liquid is extracted from the reaction bottle B6 by the syringe pump S1 through the channel 3 of the multi-channel switching valve SV at the speed of 10-30mL, enters the waste liquid bottle B4 through the channel 4, the C18 solid phase extraction column and the first valve V1 in sequence at the speed of 5-15mL/min, the labeled drug is fixed on the C18 solid phase extraction column, and the rest of the reaction liquid enters the waste liquid bottle B4.
The syringe pump S1 pumps 1-5mL of physiological saline in the second reagent bottle B2 through the channel 2 of the multi-channel switching valve SV, and injects the saline into the reaction bottle B6 through the channel 3 to clean the reaction bottle B6. The injection pump S1 extracts 5mL from the reaction bottle B6 at the speed of 5-15mL/min through the channel 3 of the multi-channel switching valve SV, and enters the waste liquid bottle B4 after sequentially passing through the channel 4, the C18 solid phase extraction column and the first valve V1, the labeled drug is fixed on the C18 solid phase extraction column, and the rest of the reaction liquid enters the waste liquid bottle B4.
5. And (3) eluting free gallium: the syringe pump S1 pumps 5mL of physiological saline in the second reagent B2 bottle through the channel 2 of the multi-channel switching valve SV, and then the physiological saline enters the waste liquid bottle B4 through the channel 4, the C18 solid phase extraction small column and the first valve V1 at the speed of 5-15mL/min to elute the unmarked free 68 Ga。
6. Eluting the drug to product vial: syringe pump S1 draws 2mL of 50% ethanol solution from vial B1 via channel 5 and second valve V2 of multi-channel switching valve SV, then flows through C18 solid phase extraction cartridge via channel 4 at a rate of 5-15mL/min, and enters product vial B5 via first valve V1 and sterile filter membrane.
7. Diluting the medicine: the syringe pump S1 draws 8mL of physiological saline solution from the second reagent bottle B2 through the channel 5 of the multi-channel switching valve SV and the second valve V2, then flows through the C18 solid phase extraction cartridge through the channel 4 at a rate of 5-15mL/min, and enters the product bottle B5 through the first valve V1 and the sterile filter membrane.
Table 1 shows the comparison of the parameters of the automated synthesis of this example with the parameters of the manual labeling.
TABLE 1 comparison of Manual labeling with automated Synthesis
| Hand operated mark | Automated Synthesis (example 4) | |
| Success rate 1 | 81.8％(18/22) | 100％35/35 |
| Mark rate 2 (uncorrected) | 40-60％ | 60-70％ |
| Time of synthesis | 25-30min | 15min |
| Purity of radiochemistry | >98％ | >98％ |
In the context of Table 1, the following examples are given, 1 the drug yield is more than 5mCi and the radiochemical purity is>95% of the results were regarded as successful labeling; 2 the successful batches are marked.
Referring to fig. 4, the radiochemical purity of the drug synthesized in this example was 100%.
As can be seen from table 1 and fig. 4, the volume of hydrochloric acid is extracted during manual synthesis, the injection speed is controlled, and the like, and the speed of eluting the C18 solid-phase extraction cartridge with the ethanol solution and the physiological saline solution during purification has large difference between batches, which results in unstable yield, and 4 times of unsuccessful labeling occurs during 22 times of manual labeling, and the drug is hung on the C18 solid-phase extraction cartridge. The success rate and the yield of the automatic synthesis are higher than those of manual synthesis, the synthesis time is obviously shortened, and meanwhile, an operator does not need to directly contact the reaction liquid with high activity, so that the radiation dose is greatly reduced.
The embodiments of the present invention have been described above by way of examples. However, the scope of the present invention is not limited to the exemplary embodiments described above. Any modification, equivalent replacement, improvement, etc. made by those skilled in the art within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. A kind of 68 The Ga medicament automatic synthesis module is characterized by comprising a sample adding component, a flushing component, a reaction component, a synthesis and purification component and an elution and transfer component, wherein the sample adding component and the flushing component are respectively connected with the reaction component through pipelines, and the elution and transfer component is connected with a synthesis and purification system through a pipeline;
the sample adding component comprises a multi-channel switching valve, at least one reagent bottle and at least one injection pump, the injection pump is connected to the multi-channel switching valve, the reagent bottle is connected with the reaction component through the multi-channel switching valve, and the sample adding component is connected with the washing component, the reaction component, the synthesis and purification component and the elution and transfer component through the multi-channel switching valve and a pipeline.
2. The method of claim 1 68 The Ga drug automatic synthesis module is characterized in that the flushing component comprises at least one flushing fluid storage bottle and at least one waste liquid bottle, and the flushing fluid storage bottle and the waste liquid bottle are connected with an injection pump through pipelines and a multi-channel switching valve.
3. The method of claim 1 68 The Ga drug automatic synthesis module is characterized in that the reaction assembly comprises a heater and at least one reaction bottle, wherein the heater is used for providing the temperature required by the reaction for reactants.
4. The method of claim 1 68 The Ga drug automatic synthesis module is characterized in that the synthesis and purification component comprises a generator, and the generator is connected with a reaction bottle and an injection pump through a multi-channel switching valve and a pipeline.
5. The method of claim 4 68 The Ga medicament automatic synthesis module is characterized in that the elution transfer component comprises an elution column, a sample introduction end of the elution column is connected with the multi-channel switching valve, and a sample outlet end is connected with the elution transfer component through a valve and a pipeline.
6. The method of claim 5 68 Ga medicine automated synthesis module, its characterized in that, elution transfer assembly still includes drench wash bottle, waste liquid bottle and product bottle, be provided with the filter membrane on the product bottle, drench the wash bottle and pass through the pipeline and be connected with multichannel diverter valve, elution post, the waste liquid bottle passes through the pipeline and is connected with multichannel diverter valve, the productThe bottle is connected with the elution column through a pipeline.
7. The method of claim 6 68 The Ga medicament automatic synthesis module is characterized in that the shower bottle is also provided with an injection pump, the generator is a germanium-gallium generator, and a filter membrane on the product bottle is an air filter membrane and/or a sterile filter membrane;
the automatic synthesis module further comprises an upper computer, and the injection pump, the multi-channel switching valve and the valve are all connected with the upper computer.
8. A method according to any one of claims 1 to 3 68 The Ga drug automatic synthesis module is characterized by comprising an automatic injection pump, a multi-channel switching valve, a first reagent bottle, a second reagent bottle, a leaching bottle, a waste liquid bottle, a product bottle, a reaction bottle, a heater, a generator, a first valve, a second valve and a third valve, wherein the automatic injection pump is connected with the first reagent bottle, the second reagent bottle, the leaching bottle, the waste liquid bottle, the product bottle, the reaction bottle and the generator through the multi-channel switching valve, the reaction bottle is positioned in the heater, and the reaction bottle is connected with the generator.
9. The method of claim 8 68 The Ga drug automatic synthesis module is characterized in that the first valve, the second valve and the third valve are two-position three-way electromagnetic valves or two-position three-way switching valves, a solid phase extraction column is arranged between a channel of the multi-channel switching valve and the first valve, and an air filter membrane and/or a sterile filter membrane is/are arranged on a product bottle.
10. A method according to any one of claims 1 to 3 68 The Ga drug automatic synthesis module is characterized by comprising a multi-channel switching valve, a first reagent bottle, a second reagent bottle, a spray washing bottle, a waste liquid bottle, a product bottle, a reaction bottle, a heater, a generator, a first valve, a second valve, a first automatic injection pump and a second automatic injection pump, wherein the first automatic injection pump is used for cutting through multiple channelsThe change valve is connected with a first reagent bottle, a second reagent bottle, a waste liquid bottle, a product bottle and a reaction bottle, the generator and the spray washing bottle are connected with a second automatic injection pump, the reaction bottle is positioned in the heater, and the reaction bottle is connected with the generator.
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